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    Method and apparatus for a microscope image selector
    1.
    发明授权
    Method and apparatus for a microscope image selector 有权
    显微镜图像选择器的方法和装置

    公开(公告)号：US07283241B2

    公开(公告)日：2007-10-16

    申请号：US11045080

    申请日：2005-01-31

    申请人： Xinghua Wang ,  Thomas C. Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick J. Treado

    发明人： Xinghua Wang ,  Thomas C. Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick J. Treado

    IPC分类号： G01N21/25

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/59 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/656

    摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.

    摘要翻译： 本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。 在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像 选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

    Method and apparatus for compact Fabry-Perot imaging spectrometer
    2.
    发明授权
    Method and apparatus for compact Fabry-Perot imaging spectrometer 有权
    紧凑法布里 - 珀罗成像光谱仪的方法和装置

    公开(公告)号：US06985233B2

    公开(公告)日：2006-01-10

    申请号：US10893230

    申请日：2004-07-19

    申请人： David Tuschel ,  Patrick J. Treado ,  Chenhui Wang

    发明人： David Tuschel ,  Patrick J. Treado ,  Chenhui Wang

    IPC分类号： G01B9/02

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/10 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/6456 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/6471 ,  G01N2201/0221 ,  G01N2201/0627 ,  G02F1/133371 ,  G02F1/1347

    摘要： A method and apparatus for compact Fabry-Perot imaging spectrometer is presented. More specifically, in one embodiment, a tunable Fabry-Perot optical filter for providing a spatially accurate wavelength-resolved image of a sample having two spatial dimensions is presented. The optical filter may include plural filter elements having an initial predetermined spacing between adjacent filter elements; and a micro electro-mechanical system (“MEMS”) actuator. One of the plural filter elements may be attached to the MEMS actuator so that the actuator is capable of moving the one filter element relative to another of the plural filter elements to thereby tune the Fabry-Perot optical filter.

    摘要翻译： 提出了一种紧凑法布里 - 珀罗成像光谱仪的方法和装置。 更具体地，在一个实施例中，提出了一种用于提供具有两个空间维度的样本的空间上准确的波长分辨图像的可调谐法布里 - 珀罗滤光器。 滤光器可以包括在相邻滤光元件之间具有初始预定间隔的多个滤光元件; 和微机电系统（“MEMS”）致动器。 多个滤波器元件中的一个可以附接到MEMS致动器，使得致动器能够相对于多个滤波器元件中的另一个移动一个滤波器元件，从而调节法布里 - 珀罗滤光器。

    Dynamic imaging of biological cells and other subjects
    3.
    发明授权
    Dynamic imaging of biological cells and other subjects 有权
    生物细胞和其他科目的动态成像

    公开(公告)号：US07564546B2

    公开(公告)日：2009-07-21

    申请号：US10556038

    申请日：2005-06-30

    申请人： John S. Maier ,  Patrick J. Treado ,  David Tuschel ,  Thomas C. Voigt

    发明人： John S. Maier ,  Patrick J. Treado ,  David Tuschel ,  Thomas C. Voigt

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/6456 ,  G01J3/2803 ,  G01J3/32 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/6486 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656

    摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.

    摘要翻译： 本发明涉及动态化学成像方法，包括细胞成像方法。 该方法包括以基本上单色的光照亮电池的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。 可以在每个离散时间处以多个拉曼位移（RS）值评估拉曼移位的光，并且可以将每个离散时间的RS值选择为预选择的分量的特征。 如此获得的图像的拉曼光谱特征的多变量分析可以产生视场中部件的位置和化学特性。 该信息可以与从视野获得的其他光谱数据（例如，可见显微镜图像）组合或覆盖。