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    Dynamic imaging of biological cells and other subjects
    1.
    发明授权
    Dynamic imaging of biological cells and other subjects 有权
    生物细胞和其他科目的动态成像

    公开(公告)号：US07564546B2

    公开(公告)日：2009-07-21

    申请号：US10556038

    申请日：2005-06-30

    申请人： John S. Maier ,  Patrick J. Treado ,  David Tuschel ,  Thomas C. Voigt

    发明人： John S. Maier ,  Patrick J. Treado ,  David Tuschel ,  Thomas C. Voigt

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/6456 ,  G01J3/2803 ,  G01J3/32 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/6486 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656

    摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.

    摘要翻译： 本发明涉及动态化学成像方法，包括细胞成像方法。 该方法包括以基本上单色的光照亮电池的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。 可以在每个离散时间处以多个拉曼位移（RS）值评估拉曼移位的光，并且可以将每个离散时间的RS值选择为预选择的分量的特征。 如此获得的图像的拉曼光谱特征的多变量分析可以产生视场中部件的位置和化学特性。 该信息可以与从视野获得的其他光谱数据（例如，可见显微镜图像）组合或覆盖。

    Method and apparatus for a microscope image selector
    2.
    发明授权
    Method and apparatus for a microscope image selector 有权
    显微镜图像选择器的方法和装置

    公开(公告)号：US07283241B2

    公开(公告)日：2007-10-16

    申请号：US11045080

    申请日：2005-01-31

    申请人： Xinghua Wang ,  Thomas C. Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick J. Treado

    发明人： Xinghua Wang ,  Thomas C. Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick J. Treado

    IPC分类号： G01N21/25

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/59 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/656

    摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.

    摘要翻译： 本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。 在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像 选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

    System and method for the deposition, detection and identification of threat agents using a fiber array spectral translator
    8.
    发明授权
    System and method for the deposition, detection and identification of threat agents using a fiber array spectral translator 有权
    使用光纤阵列光谱转换器的威胁剂的沉积，检测和鉴定的系统和方法

    公开(公告)号：US07480033B2

    公开(公告)日：2009-01-20

    申请号：US11351269

    申请日：2006-02-09

    申请人： Patrick J. Treado ,  Charles W. Gardner, Jr. ,  John S. Maier

    发明人： Patrick J. Treado ,  Charles W. Gardner, Jr. ,  John S. Maier

    IPC分类号： G01N21/00 ,  G01N21/65 ,  G01J3/44

    CPC分类号： G01J3/44 ,  G01N21/65

    摘要： A system and method for depositing a sample of a threat agent is deposited onto a substrate. A first optical collection device collects at least one of the following: elastic scattered light produced by the threat agent, and Raman scattered light produced by the threat agent. A second optical collection device collects Raman scattered light produced by the threat agent, wherein the second optical collection device comprises a two dimensional non-linear array of optical fibers drawn into a one dimensional fiber stack that converts a non-linear field of view into a linear field of view, wherein the one dimensional fiber stack is coupled to an entrance slit of a Raman imaging spectrometer. The threat agent deposited on the substrate is identified.

    摘要翻译： 将用于沉积威胁剂的样品的系统和方法沉积在基底上。 第一光学收集装置收集以下至少一种：由威胁剂产生的弹性散射光和由威胁剂产生的拉曼散射光。 第二光学收集装置收集由威胁剂产生的拉曼散射光，其中第二光学收集装置包括被拉入一维光纤堆叠的二维非线性光纤阵列，其将非线性视场转换为 线性视野，其中所述一维光纤堆叠被耦合到拉曼成像光谱仪的入口狭缝。 鉴定沉积在基底上的威胁剂。