利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

26 条记录 (耗时 0.029 秒)

    Amylin family polypeptide-6 (AFP-6) analogs and methods of making and using them
    8.
    发明授权
    Amylin family polypeptide-6 (AFP-6) analogs and methods of making and using them 失效
    胰岛淀粉样多肽多肽-6（AFP-6）类似物及其制备和使用方法

    公开(公告)号：US07928060B2

    公开(公告)日：2011-04-19

    申请号：US11664750

    申请日：2005-10-11

    申请人： Mary Erickson ,  Ved Srivastava ,  Sarah McQuaid ,  Andrew Young ,  Richard Pittner ,  Soumitra Ghosh

    发明人： Mary Erickson ,  Ved Srivastava ,  Sarah McQuaid ,  Andrew Young ,  Richard Pittner ,  Soumitra Ghosh

    IPC分类号： A61K38/22 ,  C07K14/575

    CPC分类号： C07K14/575 ,  A61K38/00

    摘要： The present invention relates to Amylin Family Polypeptide-6 (AFP-6) analogs, which include derivatives and fragments, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the AFP-6 analogs. The AFP-6 analogs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent conditions such as metabolic and cardiovascular disorders, e.g., obesity, diabetes, metabolic syndrome, myocardial ischemia, and increased cardiovascular risk.

    摘要翻译： 本发明涉及淀粉蛋白家族多肽-6（AFP-6）类似物，其包括衍生物和片段，相关核酸，表达构建体，宿主细胞和用于重组生产AFP-6类似物的方法。 本发明的AFP-6类似物包括一个或多个氨基酸序列修饰。 此外，公开了治疗和预防诸如代谢和心血管疾病如肥胖症，糖尿病，代谢综合征，心肌缺血和增加的心血管风险的病症的方法和组合物。

    Cobalt-porphyrin complexes and use thereof as an anti-obesity agent
    9.
    发明申请
    Cobalt-porphyrin complexes and use thereof as an anti-obesity agent 审中-公开
    钴 - 卟啉络合物及其作为抗肥胖剂的用途

    公开(公告)号：US20050148768A1

    公开(公告)日：2005-07-07

    申请号：US10984557

    申请日：2004-11-08

    申请人： Tomas Szabo ,  Soumitra Ghosh ,  Robert Davis

    发明人： Tomas Szabo ,  Soumitra Ghosh ,  Robert Davis

    IPC分类号： A61K31/409 ,  A61K33/24 ,  A61P3/04 ,  C07D487/22 ,  C07F15/06

    CPC分类号： C07D487/22

    摘要： Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.

    摘要翻译： 用作抗肥胖剂的钴卟啉（Co-P）络合物，以及与其相关的组合物和方法。 Co-P配合物与钴中卟啉（Co-MP）和钴原卟啉（Co-PP）相比显示出降低的氧化还原活性，其减轻了与施用与氧化应激相关的Co-P相关的有害作用，特别是在注射的情况下 现场毒性。

    Sulfonamide-derivative compounds for tagging nucleic acid probes
    10.
    发明授权
    Sulfonamide-derivative compounds for tagging nucleic acid probes 失效
    用于标记核酸探针的磺酰胺衍生化合物

    公开(公告)号：US5210203A

    公开(公告)日：1993-05-11

    申请号：US879593

    申请日：1992-05-07

    申请人： Gary F. Musso ,  Soumitra Ghosh ,  Emil T. Kaiser

    发明人： Gary F. Musso ,  Soumitra Ghosh ,  Emil T. Kaiser

    IPC分类号： C07F7/18 ,  C07H21/00 ,  C12Q1/68

    CPC分类号： C07H21/00 ,  C07F7/1852 ,  C07F7/1856 ,  C12Q1/6816

    摘要： Nucleic acid hybridization probes are provided which comprise an N.sup.4 -(substituted amino)cytosine moiety, wherein the substituted amino group comprises a tag moiety, whereby the probe is detected. Methods of preparing probes of the invention, intermediates used in such methods, and methods of using the probes of the invention in hybridization assays are also provided. Typical tag moieties employed with the probes of the invention are biotinyl, aminothiadiazole and fluorescein derivatives, connected to N.sup.4 -amino groups of modified cytosines of the probe through linker moieties. Probes tagged with biotin are typically detected by binding to the biotinyl moieties, through a streptavidin or avidin molecule, a reporter group which includes streptavidin or avidin and then detecting a signal due to the reporter group. Probes tagged with aminothiadiazole derivatives are typically detected by essentially the same method as those tagged with biotinyl but employing as reporter group one which binds to the derivative through a carbonic anhydrase molecule. Probes tagged with fluorescein derivatives are detected by a fluorescence spectroscopic method without binding of a reporter group to the tag.

    摘要翻译： 提供了包含N4-（取代氨基）胞嘧啶部分的核酸杂交探针，其中取代的氨基包括标签部分，由此检测探针。 还提供了制备本发明的探针的方法，在这些方法中使用的中间体以及在杂交测定中使用本发明的探针的方法。 与本发明的探针一起使用的典型标签部分是通过接头部分连接到探针的修饰胞嘧啶的N4-氨基的生物素，氨基噻二唑和荧光素衍生物。 用生物素标记的探针通常通过结合生物素部分，通过链霉抗生物素蛋白或抗生物素蛋白分子，包括链霉抗生物素蛋白或抗生物素蛋白的报道基团检测，然后检测由于报告基团引起的信号。 用氨基噻二唑衍生物标记的探针通常用与生物素标记的那些基本上相同的方法来检测，但采用作为通过碳酸酐酶分子与衍生物结合的报告基团。 用荧光素衍生物标记的探针通过荧光光谱法检测，而不将报道基团与标签结合。