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100 条记录 (耗时 0.035 秒)

    Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester and its hydrochloride
    1.
    发明授权
    Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester and its hydrochloride 失效
    制备α-L-天冬氨酰-L-苯丙氨酸甲酯及其盐酸盐的方法

    公开(公告)号：US4606854A

    公开(公告)日：1986-08-19

    申请号：US611531

    申请日：1984-05-17

    申请人： Yoichi Ozawa ,  Shinichi Kishimoto ,  Emiko Shinohara ,  Tadashi Takemoto ,  Chikahiko Eguchi

    发明人： Yoichi Ozawa ,  Shinichi Kishimoto ,  Emiko Shinohara ,  Tadashi Takemoto ,  Chikahiko Eguchi

    IPC分类号： C07K1/113 ,  C07K1/02 ,  C07K5/06 ,  C07K5/075

    CPC分类号： C07K5/0613

    摘要： A method for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester and its hydrochloride which comprises dissolving .alpha.-L-aspartyl-L-phenylalanine dimethyl ester in a mixture of 0-10% (v/v) methanol, 8-55% (v/v) of concentrated hydrochloric acid, and water (remainder) to a concentration of 0.01 mol/dl to 0.30 mol/dl; holding the resulting solution at one or more temperatures between 0.degree. and 60.degree. C. for a time sufficient for crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride to precipitate out, and isolating the crystals. The hydrochloride may then be treated with alkali to yield .alpha.-L-aspartyl-L-phenylalanine methyl ester.

    摘要翻译： 制备α-L-天冬氨酰-L-苯丙氨酸甲酯及其盐酸盐的方法，其包括将α-L-天冬氨酰基-L-苯丙氨酸二甲酯溶解在0-10％（v / v）甲醇，8-55 ％（v / v）浓盐酸和水（剩余物）至0.01mol / dl至0.30mol / dl的浓度; 将所得溶液保持在0℃至60℃之间的一个或多个温度下，足以使α-L-天冬氨酰基-L-苯丙氨酸甲酯盐酸盐的晶体沉淀出来，并分离晶体。 然后用碱处理盐酸盐，得到α-L-天冬氨酰基-L-苯丙氨酸甲酯。

    Method of preparing methyl ester and its hydrochloride
    2.
    发明授权
    Method of preparing methyl ester and its hydrochloride 失效
    制备甲酯及其盐酸盐的方法

    公开(公告)号：US4618695A

    公开(公告)日：1986-10-21

    申请号：US611548

    申请日：1984-05-17

    申请人： Yoichi Ozawa ,  Shinichi Kishimoto ,  Emiko Shinohara ,  Tadashi Takemoto ,  Chikahiko Eguchi

    发明人： Yoichi Ozawa ,  Shinichi Kishimoto ,  Emiko Shinohara ,  Tadashi Takemoto ,  Chikahiko Eguchi

    IPC分类号： C07K5/075 ,  C07C101/02

    CPC分类号： C07K5/0613

    摘要： A method of preparing .alpha.-L-phenylalanine methyl ester and its hydrochloride, which comprises dissolving .alpha.-L-aspartyl-L-phenylalanine .beta.-methyl ester in a methanol/hydrochloric acid mixture solvent which contains, when hydrochloric acid is expressed in terms of concentrated hydrochloric acid and water, 0 to 20% by volume of methanol, 8 to 55% by volume of concentrated hydrochloric acid and water (balance) in a concentration from 0.01 mol/dl to 0.3 mol/dl; holding the solution at 0.degree. to 60.degree. C. to effect intramolecular ester exchange reaction and crystallize out the formed .alpha.-L-aspartyl-L-phenylalanine methyl ester as its hydrochloride; isolating the hydrochloride; and obtaining, when required, the free ester by neutralization with an alkali, is disclosed.

    摘要翻译： 一种制备α-L-苯丙氨酸甲酯及其盐酸盐的方法，其包括将α--L-天冬氨酰基-L-苯丙氨酸β-甲酯溶于甲醇/盐酸混合物溶剂中，所述溶剂含有当盐酸以 浓盐酸和水，0至20体积％甲醇，8至55体积％浓盐酸和水（余量），浓度为0.01mol / dl至0.3mol / dl; 将溶液保持在0〜60℃，进行分子内酯交换反应，结晶形成的α-L-天冬氨酰-L-苯丙氨酸甲酯为盐酸盐; 分离盐酸盐; 并且当需要时通过用碱中和获得游离酯。

    Method for producing monatin
    8.
    发明授权
    Method for producing monatin 失效
    生产莫纳甜的方法

    公开(公告)号：US07396941B2

    公开(公告)日：2008-07-08

    申请号：US11505997

    申请日：2006-08-18

    申请人： Ken-ichi Mori ,  Tadashi Takemoto

    发明人： Ken-ichi Mori ,  Tadashi Takemoto

    IPC分类号： C07D209/18

    CPC分类号： C07D209/20 ,  A23L27/31

    摘要： By simultaneously carrying out an isomerization reaction at position 2 of monatin in different configurations at positions 2 and 4 in the presence of an aldehyde under a condition of pH 4 to 11 in a mixture solvent of water and an organic solvent, and the crystallization of monatin in the same configurations at positions 2 and 4 or a salt thereof, monatin useful as a sweetener, particularly optically active monatin can efficiently be produced.

    摘要翻译： 通过在水和有机溶剂的混合溶剂中，在pH为4〜11的条件下，在醛的存在下，在位置2和4的莫纳甜2位上同时进行异构化反应和莫纳甜结晶 在2和4位的相同构型或其盐中，可以有效地制备用作甜味剂，特别是光学活性莫纳甜的莫纳甜。

    Process for producing cinnamaldehyde derivatives, use thereof and the like
    10.
    发明申请
    Process for producing cinnamaldehyde derivatives, use thereof and the like 有权
    制备肉桂醛衍生物的方法及其用途等

    公开(公告)号：US20050245759A1

    公开(公告)日：2005-11-03

    申请号：US11154658

    申请日：2005-06-17

    申请人： Kenichi Mori ,  Shinji Fujita ,  Nao Funakoshi ,  Tadashi Takemoto

    发明人： Kenichi Mori ,  Shinji Fujita ,  Nao Funakoshi ,  Tadashi Takemoto

    IPC分类号： A23L27/30 ,  C07C45/62 ,  C07C45/73 ,  C07C45/74 ,  C07C47/277 ,  C07K5/072 ,  C07K5/075 ,  C07K5/04 ,  C07C45/90

    CPC分类号： C07C45/62 ,  C07C45/73 ,  C07C45/74 ,  C07C47/277 ,  C07K5/06113 ,  C07C47/27

    摘要： A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such as isovanillin and the like, with acetaldehyde in the presence of an alkali, in particular preferably, dropping acetaldehyde little by little thereto in an aqueous solution at a low temperature for the reaction thereof. The cinnamaldehyde derivative thus obtained is selectively reduced to produce 3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl)propionaldehyde. Further, through a reductive alkylation reaction of the compound thus produced with an aspartame, N-[N-[3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl)propyl]-L-aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener having a high sweetening potency, can be industrially and efficiently produced. The processes therefor are also provided.

    摘要翻译： 方便有效地制备高纯度肉桂醛衍生物的方法，例如（2E） - （3-羟基-4-甲氧基）肉桂醛，其包括使苯甲醛衍生物如异喹啉腈等与乙醛在存在下反应 的碱，特别优选在低温下在水溶液中逐滴滴加乙醛进行反应。 由此得到的肉桂醛衍生物被选择性地还原以产生3-（3-羟基-4-取代的（与甲氧基等）苯基）丙醛。 此外，通过如此制备的化合物与天冬甜素的还原烷基化反应，N- [N- [3-（3-羟基-4-取代的（与甲氧基等）苯基）丙基] -L-天冬氨酰基] - 作为具有高甜味效力的甜味剂可用的L-苯丙氨酸1-甲酯可以在工业上有效地生产。 还提供了其工艺。