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公开(公告)号：US11484559B2
公开(公告)日：2022-11-01
申请号：US16956220
申请日：2018-12-21
Applicant: Laboratoires Expanscience
Inventor： Sophie Leclere-Bienfait , Stéphanie Bredif
IPC: A61K36/185 , A61K8/9789 , A61K8/365 , A61Q19/00 , A61Q19/08
Abstract: The invention relates to an extract of flowers, preferably calyxes, from kapok trees, in particular Bombax costatum, to a process for preparing same and to the extract obtainable by said process. The invention also relates to a composition comprising such an extract, the composition being advantageously a cosmetic, pharmaceutical or dermatological composition. The invention also relates to such a composition or such an extract for use in preventing or treating disorders or diseases of the skin, the mucous membranes or keratinous appendages and for use in preventing or treating vascular disorders. The invention finally relates to a cosmetic care process for the skin, the keratinous appendages or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which process consists in administering such a composition or such an extract.
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公开(公告)号：US20220249446A1
公开(公告)日：2022-08-11
申请号：US17624692
申请日：2020-07-13
Applicant: Laboratoires Expanscience
Inventor： Stephanie BREDIF , Sophie LECLERE-BIENFAIT , David DURANCET
Abstract: The present invention relates to a composition comprising at least one oxazoline, such as OX100, for inhibiting the growth of Malassezia yeasts and/or for preventing and/or treating conditions caused by Malassezia yeasts, seborrheic dermatitis, cradle cap, Malassezia folliculitis, dandruff, Pityriasis versicolor or Pityriasis capitis. The present invention also relates to a composition comprising at least one oxazoline such as OX100, at least one compound such as malic acid diester and a vegetable oil oleodistillate and/or arabinogalactan, and to the use of same for preventing and/or treating, in particular, affections caused by Malassezia yeasts, seborrheic dermatitis, cradle cap, Malassezia folliculitis, dandruff, Pityriasis versicolor or Pityriasis capitis.
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公开(公告)号：US10196607B2
公开(公告)日：2019-02-05
申请号：US15110826
申请日：2015-01-12
Applicant: Laboratoires Expanscience
Inventor： Stephanie Bredif , Caroline Baudouin , Philippe Msika , Marisa Meloni
Abstract: A skin model comprises keratinocytes capable of overexpressing filaggrin. A method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, by bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion, and measuring the level of production of at least one biological marker chosen from lactate dehydrogenase (LDH), TNFα, filaggrin, TGFβ1 and β1 integrin.
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公开(公告)号：US20170157019A1
公开(公告)日：2017-06-08
申请号：US15323347
申请日：2015-07-03
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Caroline BAUDOUIN , Sophie LECLERE- BIENFAIT , Philippe MSIKA , Stéphanie BREDIF
CPC classification number: A61K8/645 , A61K8/97 , A61K2800/74 , A61Q19/06 , A61Q19/08
Abstract: The present invention relates to the use of a lupin peptide extract to prevent loss of skin firmness or to increase the firmness of skin. Advantageously, the lupin peptide extract can prevent the appearance of cellulite and/or reduce skin cellulite.
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公开(公告)号：US20160245795A1
公开(公告)日：2016-08-25
申请号：US15023882
申请日：2014-09-24
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Caroline Baudouin , Stephanie Bredif , Philippe MSIKA
CPC classification number: G01N33/5023 , G01N33/5044 , G01N33/6881 , G01N2333/4721 , G01N2333/5421 , G01N2333/545 , G01N2333/96486
Abstract: The invention relates to in vitro methods for testing formulations or active ingredients for preventing the harmful effects of UV on children's skin, in particular children aged three or less. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the harmful effects of UV on the skin of children aged three or less, using a skin model specifically capable of reproducing the characteristics of the skin of children of this age.
Abstract translation: 本发明涉及用于测试制剂或活性成分以防止紫外线对儿童皮肤，特别是三岁以下儿童的有害影响的体外方法。 本发明人已经开发了使用特别能够再现这种年龄的儿童的皮肤特征的皮肤模型来评价制剂在体外预防紫外线对三岁以下儿童皮肤的有害影响的体外功效的方法。
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Patent Agency Ranking
6.发明申请USE OF A COMPOSITION COMPRISING AVOCADO PERSEOSE IN THE PROTECTION OF EPIDERMAL STEM CELLS 审中-公开使用包含AVOCADO相关物质在保护皮肤干细胞中的组合物公开(公告)号：US20150374605A1
公开(公告)日：2015-12-31
申请号：US14766602
申请日：2014-02-11
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Caroline Baudouin
CPC classification number: A61K8/60 , A61K8/97 , A61K31/22 , A61K31/23 , A61K31/232 , A61K31/7012 , A61K31/7024 , A61K36/54 , A61K45/06 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/005 , A61Q19/08 , A61Q19/10 , C07C69/02 , C07C69/52 , C07C69/533 , C07C69/587 , A61K2300/00
Abstract: The invention concerns a use of C7 sugars and derivatives of formula (I), called avocado perseose, which have, inter alia, a protective activity to epidermal skin cells. These C7 sugars and derivatives are capable of maintaining the expression of markers of adult stem cells, in particular basal stem cells. Avocado perseose can also be used for preventing the deleterious effects of environmental damage. Avocado perseose has a beneficial effect on the conservation of the potential of epidermal stem cells and thus helps maintain skin homeostasis.
Abstract translation: 本发明涉及C7糖和式（I）的衍生物，其被称为鳄梨坚果，其特别地对表皮皮肤细胞具有保护性活性。 这些C7糖和衍生物能够维持成体干细胞，特别是基础干细胞的标志物的表达。 鳄梨坚果也可用于防止环境破坏的有害影响。 鳄梨坚果对保护表皮干细胞的潜力有益，从而有助于维持皮肤稳态。
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公开(公告)号：US09125879B2
公开(公告)日：2015-09-08
申请号：US12521371
申请日：2007-12-28
Applicant: Philippe Msika
Inventor： Philippe Msika
CPC classification number: A61K36/21 , A23D9/007 , A23J3/346 , A23L7/198 , A23L33/12 , A23L33/18 , A23V2002/00 , A61K8/922 , A61Q19/08 , A23V2200/318 , A23V2250/21 , A23V2200/304
Abstract: The present invention relates to a composition containing a quinoa grain extract, said extract being a peptidic and osidic extract or a lipidic extract of quinoa grain, said lipid quinoa extract being itself chosen from a group comprising an oil concentrated into its non saponificable fraction, a non saponificable, or a refined oil. The invention also relates to methods for preparing these different extracts and to dermatological or neutraceutic applications of these extracts.
Abstract translation: 本发明涉及含有藜麦籽粒提取物的组合物，所述提取物是肽和油提取物或藜麦粒的脂质提取物，所述脂质藜麦提取物本身选自包含浓缩在其不皂化部分中的油， 不皂化，或精制油。 本发明还涉及制备这些不同提取物的方法以及这些提取物的皮肤病学或中性药物应用。
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公开(公告)号：US20150153328A1
公开(公告)日：2015-06-04
申请号：US14418645
申请日：2013-08-02
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Nadège Lachmann , Joachim Fluhr
IPC: G01N33/50
Abstract: The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.
Abstract translation: 本发明涉及通过检查反映细胞组织的各种参数来确定受试者的皮肤表面的各向同性，从而确定所述皮肤表面的成熟度的方法。 还提供了确定活性剂，原料和制剂的方法。
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9.发明申请USE OF AVOCADO PIT FOR OBTAINING AN AVOCADO OIL ENRICHED WITH ALKYL POLYOLS AND/OR ACETYLATED DERIVATIVES THEREOF 有权使用AVOCADO PIT来获得与亚苄基多酚和/或其乙酰化衍生物相融合的阿卡波醇油公开(公告)号：US20140348967A1
公开(公告)日：2014-11-27
申请号：US14371057
申请日：2013-01-14
Applicant: LABORATORIES EXPANSCIENCE
Inventor： Philippe Msika , Jacques Legrand , Sebastien Garnier
CPC classification number: C11B1/06 , A23D9/007 , A23D9/02 , A23L2/52 , A23L19/07 , A23L33/105 , A23L33/11 , A23L33/115 , A61K8/922 , A61K36/54 , A61Q19/06 , A61Q19/08 , C11B1/08
Abstract: The present invention relates to the use of avocado seeds in order to obtain avocado oil enriched in alkyl polyols and/or acetylated derivatives thereof, said avocado seeds accounting for 10 to 50% by weight relative to the total weight of avocado used. The invention also relates to a method for obtaining avocado oil enriched in alkyl polyols or acetylated derivatives thereof from at least avocado seeds, said avocado seeds accounting for 10 to 50% by weight relative to the total weight of avocado used. The invention also relates to avocado oil enriched in alkyl polyols and/or acetylated derivatives thereof, obtainable by the present method. The invention also relates to the use of avocado oil in order to prepare an avocado oil concentrate enriched in alkyl polyols and/or acetylated derivatives thereof, or to prepare an avocado unsaponifiable enriched in alkyl polyols. Lastly, the invention relates to an avocado unsaponifiable enriched in alkyl polyols or an avocado oil concentrate enriched in alkyl polyols and/or acetylated derivatives thereof, obtainable from said avocado oil, for use as a drug, advantageously in the prevention and/or treatment of conjunctive tissue disorders such as arthrosis, articular pathologies such as rheumatism, or periodontal diseases such as gingivitis or periodontitis.
Abstract translation: 本发明涉及鳄梨种子的使用以获得富含烷基多元醇和/或其乙酰化衍生物的鳄梨油，所述鳄梨种子占所用鳄梨总重量的10至50重量％。 本发明还涉及从至少鳄梨种子获得富含烷基多元醇或其乙酰化衍生物的鳄梨油的方法，所述鳄梨种子占所用鳄梨总重量的10至50重量％。 本发明还涉及通过本方法获得的富含烷基多元醇和/或其乙酰化衍生物的鳄梨油。 本发明还涉及鳄梨油的用途，以制备富含烷基多元醇和/或其乙酰化衍生物的鳄梨油浓缩物，或制备不可皂化的富含烷基多元醇的鳄梨油。 最后，本发明涉及一种不可皂化的富含鳄梨油的富含烷基多元醇的牛油果油或富含其烷基多元醇和/或其乙酰化衍生物的鳄梨油浓缩物，其可从所述鳄梨油获得，有利地用于预防和/或治疗 结膜组织疾病如关节病，关节病变如风湿病，或牙周病如牙龈炎或牙周炎。
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公开(公告)号：US08859617B2
公开(公告)日：2014-10-14
申请号：US11597635
申请日：2005-05-27
Applicant: Antoine Piccirilli , Philippe Msika , Nathalie Piccardi
Inventor： Antoine Piccirilli , Philippe Msika , Nathalie Piccardi
IPC: A61K31/341 , A61P7/12 , A61P3/08
CPC classification number: A61K31/341
Abstract: The invention relates to using one or several synthetic or natural furan alkyls for preparing a drug for preventing and/or treating diabetes and insulin resistance, thereby preventing the risks of cardiovascular, nervous, cutaneous, renal, ocular and infectious diseases. The use of one or several synthetic or natural furan alkyls for cosmetically treating diabetes related skin disorders is also disclosed.
Abstract translation: 本发明涉及使用一种或多种合成或天然呋喃烷基酯制备用于预防和/或治疗糖尿病和胰岛素抵抗的药物，从而防止心血管，神经，皮肤，肾脏，眼睛和感染性疾病的风险。 还公开了使用一种或几种合成或天然呋喃烷基化妆品来治疗糖尿病相关的皮肤病。
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