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    Reovirus for the treatment of cellular proliferative disorders
    2.
    发明授权
    Reovirus for the treatment of cellular proliferative disorders 有权
    用于治疗细胞增殖性疾病的呼肠孤病毒

    公开(公告)号：US08066985B2

    公开(公告)日：2011-11-29

    申请号：US12323223

    申请日：2008-11-25

    申请人： Patrick W. K. Lee ,  James Strong ,  Matthew C. Coffey

    发明人： Patrick W. K. Lee ,  James Strong ,  Matthew C. Coffey

    IPC分类号： A61K49/00 ,  A61K39/15

    CPC分类号： A61K9/0019 ,  A61K35/765 ,  C12N2720/12032 ,  C12N2720/12232

    摘要： Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

    摘要翻译： 公开了通过向Ras介导的增殖性病症施用呼肠孤病毒来治疗增殖性疾病的方法。 施用呼肠孤病毒使其最终直接接触ras介导的增殖细胞。 增生性疾病包括但不限于赘生物。 可以使用人呼肠病毒，非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。 如果呼肠孤病毒是人呼肠病毒，则可以使用血清型1（例如，菌株Lang），血清型2（例如菌株琼斯），血清型3（例如，菌株Dearing或菌株Abney）以及呼肠孤病毒的其它血清型或菌株。 可以使用多于一种类型和/或菌株的呼肠病病毒的组合，以及来自不同动物种类的呼肠弧病毒。 可以治疗实体肿瘤或造血赘生物。

    Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders
    6.
    发明申请
    Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders 有权

    公开(公告)号：US20060073166A1

    公开(公告)日：2006-04-06

    申请号：US11255849

    申请日：2005-10-21

    申请人： Matthew Coffey ,  Bradley Thompson

    发明人： Matthew Coffey ,  Bradley Thompson

    IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/38

    CPC分类号： A61K35/765 ,  A61K38/13 ,  C07K16/081 ,  C07K16/10 ,  C07K16/4216 ,  C12N9/1205 ,  C12N2720/12232 ,  Y10S435/948 ,  Y10S435/975 ,  A61K2300/00

    摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The mammal may be selected from dogs, cats, sheep, goats, cattle, horses, pigs, mice, humans and non-human primates. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. In particular, the methods provide for reovirus treatment of immunosuppressed or immuno-deficient mammals to treat the proliferative disorders. Immunosuppression, immunoinhibition or otherwise inducing an immunodeficient state in a mammal renders the reovirus more effective. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells. Immune systems may be compromised by one or more of the following: an HIV infection; as a side effect of chemotherapy or radiation therapy; by selective removal of B and/or T cell populations; by removal of antibodies (anti-antireovirus antibodies or all antibodies), and the like.

    Reovirus for the treatment of ral-mediated cellular proliferative disorders
    8.
    发明申请
    Reovirus for the treatment of ral-mediated cellular proliferative disorders 有权
    用于治疗ral介导的细胞增殖性疾病的呼肠弧病毒

    公开(公告)号：US20040146491A1

    公开(公告)日：2004-07-29

    申请号：US10704531

    申请日：2003-11-06

    发明人： Kara L. Norman ,  Patrick W.K. Lee

    IPC分类号： A61K045/00

    CPC分类号： A61K35/765 ,  C12N2720/12232

    摘要： Methods for treating proliferative disorders, by administering reovirus to a ral-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts target cancer cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), other serotypes or strains of reovirus, and recombinant reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

    摘要翻译： 公开了通过将呼肠孤病毒施用于ral介导的增殖性疾病来治疗增殖性疾病的方法。 呼肠病毒的施用使其最终直接接触目标癌细胞。 增生性疾病包括但不限于赘生物。 可以使用人呼肠病毒，非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。 如果呼肠孤病毒是人呼肠病毒，可以使用血清型1（例如，菌株Lang），血清型2（例如菌株琼斯），血清型3（例如，菌株Dearing或菌株Abney），其他血清型或呼肠孤病毒菌株和重组呼肠弧病毒 。 可以使用多于一种类型和/或菌株的呼肠病病毒的组合，以及来自不同动物种类的呼肠弧病毒。 可以治疗实体肿瘤或造血赘生物。

    Oncolytic virus
    9.
    发明申请
    Oncolytic virus 审中-公开
    溶瘤病毒

    公开(公告)号：US20040115170A1

    公开(公告)日：2004-06-17

    申请号：US10433064

    申请日：2004-01-08

    发明人： Earl Garnet Brown ,  Jean Lutamyo Mbisa ,  John Cameron Bell ,  David Francis Stojdl

    IPC分类号： A61K048/00 ,  C12N015/86

    CPC分类号： C12N7/00 ,  A61K35/765 ,  A61K35/768 ,  C12N2720/12032 ,  C12N2720/12232

    摘要： Methods of reducing the viability of a tumor cell, infecting a neoplasm in a mammal, utilizing certain non-naturally occuring viruses are disclosed. Viral reassortants, for example reovirus reassortants, and techniques for identifying PKR-sensitive viruses are also disclosed.

    摘要翻译： 公开了利用某些非天然存在的病毒降低哺乳动物肿瘤细胞生存力，感染哺乳动物肿瘤的方法。 还公开了病毒重配体，例如呼肠孤病毒重配体，以及鉴定PKR敏感型病毒的技术。

    Method for reducing pain using oncolytic viruses
    10.
    发明申请
    Method for reducing pain using oncolytic viruses 审中-公开
    使用溶瘤病毒减轻疼痛的方法

    公开(公告)号：US20040091458A1

    公开(公告)日：2004-05-13

    申请号：US10431580

    申请日：2003-05-08

    申请人： Oncolytics Biotech Inc.

    发明人： Donald Morris ,  Matthew C. Coffey ,  Bradley G. Thompson

    IPC分类号： A61K048/00 ,  A61K031/485

    CPC分类号： A61K35/765 ,  A61K45/06 ,  C12N2720/12232 ,  A61K2300/00

    摘要： The present invention provides a method for reducing pain associated with neoplasms in a mammal, comprising administering an effective amount of one or more oncolytic viruses. Preferably, the mammal also receives an analgesic, and the amount of analgesic required by the mammal is reduced when the oncolytic virus is administered. The oncolytic virus is preferably reovirus. The mammal may be additionally subject to other therapies, such as chemotherapy, immunotherapy, hormonal and/or radiation therapy.

    摘要翻译： 本发明提供了减少与哺乳动物赘生物相关的疼痛的方法，包括施用有效量的一种或多种溶瘤病毒。 优选地，哺乳动物还接受止痛剂，并且当施用溶瘤病毒时，哺乳动物所需的止痛剂的量减少。 溶瘤病毒优选为呼肠孤病毒。 哺乳动物可以另外进行其他治疗，例如化学疗法，免疫治疗，激素和/或放射治疗。