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公开(公告)号：US20170035871A1
公开(公告)日：2017-02-09
申请号：US15299859
申请日：2016-10-21
发明人： Ryuji UENO , Wataru AKAHATA
IPC分类号： A61K39/015 , A61K39/193 , A61K39/12
CPC分类号： A61K39/015 , A61K38/162 , A61K39/12 , A61K39/193 , A61K2039/5258 , C07K14/005 , C07K14/445 , C07K2319/85 , C12N2770/36034 , C12N2770/36123 , C12N2770/36134 , Y02A50/412 , A61K2300/00
摘要： The present invention provides a particle comprising a polypeptide and at least one malaria antigen, and a composition or vaccine comprising thereof, its use in medicine, particularly in the prevention or treatment of malaria infections.
摘要翻译： 本发明提供了包含多肽和至少一种疟疾抗原的颗粒及其组合物或疫苗，其在医学中的用途，特别是在预防或治疗疟疾感染中。
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公开(公告)号：US20180214538A1
公开(公告)日：2018-08-02
申请号：US15892247
申请日：2018-02-08
发明人： David KIRN , John BELL , Caroline BREITBACH , Anne MOON , Tae-Ho HWANG , Yu Kyoung LEE , Mi-kyung KIM
IPC分类号： A61K39/285 , A61K35/26
CPC分类号： A61K39/285 , A61K35/26 , A61K35/76 , A61K35/761 , A61K35/763 , A61K35/768 , A61K39/0011 , A61K39/12 , A61K39/125 , A61K39/145 , A61K39/165 , A61K39/17 , A61K39/205 , A61K39/235 , A61K39/245 , A61K39/395 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/55522 , C07K16/18 , C07K16/30 , C07K2317/14 , C07K2317/734 , C12N7/00 , C12N2710/10034 , C12N2710/16632 , C12N2710/16634 , C12N2710/24034 , C12N2710/24132 , C12N2720/12232 , C12N2750/14034 , C12N2760/16034 , C12N2760/18134 , C12N2760/18434 , C12N2760/18734 , C12N2760/20034 , C12N2760/20232 , C12N2770/32034 , C12N2770/32334 , C12N2770/36034 , G01N33/574
摘要： The present invention relates to methods and compositions for use in inducing tumor-specific antibody mediated complement-dependent cytotoxic response in an animal having a tumor comprising administering to said animal a composition comprising a replication competent oncolytic virus wherein administration of the composition induces in the animal production of antibodies that mediate a CDC response specific to said tumor.
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公开(公告)号：US20150284448A1
公开(公告)日：2015-10-08
申请号：US14651740
申请日：2013-12-13
CPC分类号： C07K16/1081 , A61K31/7088 , A61K39/12 , A61K39/21 , A61K48/00 , C07K16/1063 , C07K16/32 , C07K2317/14 , C07K2317/21 , C07K2317/55 , C07K2317/76 , C12N7/00 , C12N2740/16034 , C12N2740/16134 , C12N2770/24134 , C12N2770/36034 , Y02A50/383 , Y02A50/386
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
摘要翻译： 本文公开了包含编码抗体的重组核酸序列的组合物。 本文还公开了通过将所述组合物施用于受试者来在受试者中产生合成抗体的方法。 本公开还提供了使用所述组合物和产生方法预防和/或治疗受试者的疾病的方法。
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公开(公告)号：US09512190B2
公开(公告)日：2016-12-06
申请号：US14294968
申请日：2014-06-03
发明人： Ryuji Ueno , Wataru Akahata
IPC分类号： C07K14/445 , A61K39/12 , A61K39/193 , C07K14/005 , A61K39/015 , A61K38/16 , A61K39/00
CPC分类号： A61K39/015 , A61K38/162 , A61K39/12 , A61K39/193 , A61K2039/5258 , C07K14/005 , C07K14/445 , C07K2319/85 , C12N2770/36034 , C12N2770/36123 , C12N2770/36134 , Y02A50/412 , A61K2300/00
摘要： The present invention provides a particle comprising a polypeptide and at least one malaria antigen, and a composition or vaccine comprising thereof, its use in medicine, particularly in the prevention or treatment of malaria infections.
摘要翻译： 本发明提供了包含多肽和至少一种疟疾抗原的颗粒及其组合物或疫苗，其在医学中的用途，特别是在预防或治疗疟疾感染中。
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公开(公告)号：US20140363458A1
公开(公告)日：2014-12-11
申请号：US14294968
申请日：2014-06-03
发明人： Ryuji UENO , Wataru AKAHATA
IPC分类号： C07K14/445 , C07K14/005 , A61K39/193 , A61K38/16 , A61K39/12
CPC分类号： A61K39/015 , A61K38/162 , A61K39/12 , A61K39/193 , A61K2039/5258 , C07K14/005 , C07K14/445 , C07K2319/85 , C12N2770/36034 , C12N2770/36123 , C12N2770/36134 , Y02A50/412 , A61K2300/00
摘要： The present invention provides a particle comprising a polypeptide and at least one malaria antigen, and a composition or vaccine comprising thereof, its use in medicine, particularly in the prevention or treatment of malaria infections.
摘要翻译： 本发明提供了包含多肽和至少一种疟疾抗原的颗粒及其组合物或疫苗，其在医学中的用途，特别是在预防或治疗疟疾感染中。
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公开(公告)号：US20180346554A1
公开(公告)日：2018-12-06
申请号：US16005997
申请日：2018-06-12
CPC分类号： C07K16/1081 , A61K31/7088 , A61K39/12 , A61K39/21 , A61K48/00 , C07K16/1063 , C07K16/32 , C07K2317/14 , C07K2317/21 , C07K2317/55 , C07K2317/76 , C12N7/00 , C12N2740/16034 , C12N2740/16134 , C12N2770/24134 , C12N2770/36034 , Y02A50/383 , Y02A50/386
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
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公开(公告)号：US09994629B2
公开(公告)日：2018-06-12
申请号：US14651740
申请日：2013-12-13
IPC分类号： A61K48/00 , A61K39/00 , C07K14/485 , C07K16/10 , C07K16/32 , A61K31/7088 , A61K39/12 , A61K39/21 , C12N7/00
CPC分类号： C07K16/1081 , A61K31/7088 , A61K39/12 , A61K39/21 , A61K48/00 , C07K16/1063 , C07K16/32 , C07K2317/14 , C07K2317/21 , C07K2317/55 , C07K2317/76 , C12N7/00 , C12N2740/16034 , C12N2740/16134 , C12N2770/24134 , C12N2770/36034 , Y02A50/383 , Y02A50/386
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
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8.发明申请GENERATION OF ANTIBODIES TO TUMOR ANTIGENS AND GENERATION OF TUMOR SPECIFIC COMPLEMENT DEPENDENT CYTOTOXICITY BY ADMINISTRATION OF ONCOLYTIC VACCINIA VIRUS 有权抗肿瘤抗生素的产生和肿瘤特异性补体的产生依赖于毒理性疫苗病毒的依赖性细胞毒性公开(公告)号：US20150037355A1
公开(公告)日：2015-02-05
申请号：US13978113
申请日：2012-01-04
申请人： David Kirn , John Bell , Caroline Breitback , Anne Moon , Tae-Ho Hwang , Yu Kyoung Lee , Mi-kyung Kim
发明人： David Kirn , John Bell , Caroline Breitback , Anne Moon , Tae-Ho Hwang , Yu Kyoung Lee , Mi-kyung Kim
IPC分类号： A61K39/285 , A61K39/12 , A61K39/145 , A61K39/165 , A61K39/17 , A61K39/125 , A61K39/205 , A61K39/245 , A61K39/235 , A61K35/26 , G01N33/574 , C07K16/18 , A61K45/06 , C12N7/00 , A61K39/395
CPC分类号： A61K39/285 , A61K35/26 , A61K35/76 , A61K35/761 , A61K35/763 , A61K35/768 , A61K39/0011 , A61K39/12 , A61K39/125 , A61K39/145 , A61K39/165 , A61K39/17 , A61K39/205 , A61K39/235 , A61K39/245 , A61K39/395 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/55522 , C07K16/18 , C07K16/30 , C07K2317/14 , C07K2317/734 , C12N7/00 , C12N2710/10034 , C12N2710/16632 , C12N2710/16634 , C12N2710/24034 , C12N2710/24132 , C12N2720/12232 , C12N2750/14034 , C12N2760/16034 , C12N2760/18134 , C12N2760/18434 , C12N2760/18734 , C12N2760/20034 , C12N2760/20232 , C12N2770/32034 , C12N2770/32334 , C12N2770/36034 , G01N33/574
摘要： The present invention relates to methods and compositions for use in inducing tumor-specific antibody mediated complement-dependent cytotoxic response in an animal having a tumor comprising administering to said animal a composition comprising a replication competent oncolytic virus wherein administration of the composition induces in the animal production of antibodies that mediate a CDC response specific to said tumor.
摘要翻译： 本发明涉及用于在具有肿瘤的动物中诱导肿瘤特异性抗体介导的补体依赖性细胞毒性应答的方法和组合物，所述方法和组合物包括向所述动物施用包含可复制的溶瘤病毒的组合物，其中组合物在动物中的诱导 产生介导对所述肿瘤特异性的CDC反应的抗体。
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公开(公告)号：US20180280496A1
公开(公告)日：2018-10-04
申请号：US16009811
申请日：2018-06-15
申请人： ModernaTX, Inc.
发明人： GIUSEPPE CIARAMELLA , ERIC YI-CHUN HUANG , KAPIL BAHL , TAL ZAKS , SUNNY HIMANSU
CPC分类号： A61K39/12 , A61K9/0019 , A61K9/14 , A61K9/51 , A61K9/5123 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/28 , A61K2039/505 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , A61K2039/543 , A61K2039/545 , A61K2039/6056 , A61P31/12 , A61P31/14 , C07K14/005 , C07K16/1081 , C07K16/2851 , C07K2317/33 , C07K2317/76 , C12N7/00 , C12N2770/24122 , C12N2770/24123 , C12N2770/24134 , C12N2770/36034 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , Y02A50/383 , Y02A50/386 , Y02A50/39 , Y02A50/392 , Y02A50/51
摘要： Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
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公开(公告)号：US20180161416A1
公开(公告)日：2018-06-14
申请号：US15579153
申请日：2016-06-03
申请人： INNOVEX THERAPEUTICS, S.L. , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS , FUNDACIÓ PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA (ISGLOBAL) , FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL , UNIVERSITAT DE LLEIDA
发明人： Hernando Antonio DEL PORTILLO OBANDO , Francisco Enrique BORRÁS SERRES , Lorenzo José FRAILE SAUCE , Sergio Roberto MONTANER TARBES , Maria MONTOYA GONZÁLEZ
CPC分类号： A61K39/12 , A61K9/127 , A61K38/1709 , A61K39/00 , A61K2039/55555 , A61K2039/64 , C12N2770/10034 , C12N2770/10051 , C12N2770/10071 , C12N2770/36034 , C12N2770/36051 , C12N2770/36071 , G16C20/20
摘要： The present invention provides exosomes isolated from an animal, wherein the animal (a) has overcome a disease caused by a pathogen, and (b) it is free from the pathogen that causes the diseases. The invention also provides process for obtaining these exosomes and the use thereof in therapy.
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