公开(公告)号：US20170157069A1

公开(公告)日：2017-06-08

申请号：US15440738

申请日：2017-02-23

Applicant: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： Mi-La CHO ,  Seon-Yeong LEE ,  Min-Jung PARK ,  Jae-Seon LEE ,  Eun-Ji YANG ,  Eun-Kyung KIM ,  Jun-Geol RYU ,  Hye-Jin SON

IPC: A61K31/155

CPC classification number: A61K31/155

Abstract: The present invention relates to a composition for preventing or treating immune diseases through the suppression of B cell activity induced by metformin. More particularly, the present invention relates to a composition comprising a metformin compound or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating immune diseases, wherein the composition is characterized by suppression or reduction of B cell activity which is a cause of disease. The present invention can be valuable in the use thereof for various autoimmune diseases as an immunosuppressant which can prevent or treat immune diseases by suppressing or reducing B cell activity and Th17 cell activity, which are causes of disease, or by promoting or increasing regulatory T cell activity.

公开(公告)号：US20170035601A1

公开(公告)日：2017-02-09

申请号：US15304234

申请日：2015-03-25

Applicant: CATHOLIC UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Sang Hwa LEE

IPC: A61F5/56

Abstract: The present invention relates to an oral device for treatment of sleep disordered breathing that includes an upper body in which at least a part of upper teeth is housed; a lower body in which at least a part of the lower teeth is housed; at least one or more elastic members that connect the upper body and the lower body to provide the elastic force in a direction in which the upper body and the lower body come closer to each other; and a support jaw that protrudes downward from the rear end of the upper body to support the rear end of the lower body. Thus, according to the present invention, it is possible to prevent the sleep disordered breathing such as an obstructive sleep apnea syndrome that may occur during sleep, enable a patient to more comfortably wear, and minimize the discomfort in a state of wearing.

Abstract translation: 本发明涉及一种用于治疗睡眠呼吸障碍的口腔装置，其包括容纳至少一部分上牙的上身; 其中容纳至少一部分下齿的下体; 至少一个或多个弹性构件，其连接上身和下体，以在上身和下身彼此靠近的方向上提供弹性力; 以及从上身的后端向下突出以支撑下身的后端的支撑爪。 因此，根据本发明，可以防止睡眠期间可能发生的阻塞性睡眠呼吸暂停综合征等睡眠呼吸紊乱，能够使患者更舒适地佩戴，并且使穿着状态下的不适最小化。

公开(公告)号：US20160374537A1

公开(公告)日：2016-12-29

申请号：US15111656

申请日：2015-01-27

Applicant: CATHOLIC UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Hiun Suk CHAE

IPC: A61B1/00 ,  A61M25/09 ,  A61B1/32 ,  A61B1/012 ,  A61B1/31

Abstract: The present invention relates to an endoscope. The present invention may include an endoscope main body; and a guide cap that is mounted to be fixed to a front end of the endoscope main body when inserting the endoscope main body into a human body and slides to protrude toward the front of the endoscope main body when withdrawing the endoscope main body inserted into the human body. An object of the present invention is to facilitate insertion of the endoscope by freely varying a length of the cap from the front end of the endoscope, and to enhance the detection rate of polyp.

Abstract translation: 内窥镜技术领域本发明涉及内窥镜。 本发明可以包括内窥镜主体; 以及引导帽，当将所述内窥镜主体插入到所述内窥镜主体中时，当将所述内窥镜主体插入到所述内窥镜主体中时，所述引导帽被安装成固定到所述内窥镜主体的前端，并且在所述内窥镜主体插入时， 人体。 本发明的目的是通过从内窥镜的前端自由地改变盖的长度，便于插入内窥镜，并且提高息肉的检测率。

公开(公告)号：US20160007975A1

公开(公告)日：2016-01-14

申请号：US14769911

申请日：2014-01-03

Applicant: DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： Sung Min KIM ,  In Chul Yang ,  In Sung Moon ,  Ji Il Kim ,  Sun Cheol Park ,  Jeong Kye Hwang

IPC: A61B10/02 ,  A61M5/32 ,  A61B8/12

CPC classification number: A61B10/0275 ,  A61B8/0833 ,  A61B8/12 ,  A61B10/0283 ,  A61B2010/0208 ,  A61B2010/045 ,  A61B2017/00495 ,  A61B2017/0065 ,  A61B2017/3413 ,  A61B2090/3925 ,  A61M5/32

Abstract: The present invention relates to a biological tissue biopsy device including a body extending in a longitudinal direction, an outer needle installed to be connected to one side of the body and be extended in a longitudinal direction and including a first tube having a hollow portion formed therein and a second tube disposed in a direction parallel to the first tube to guide a hemostatic substance, an inner needle provided inside the first tube and extending in a longitudinal direction, and a sliding means provided in the body and installed to be connected to one end of the inner needle so as to enable the inner needle to move forward and backward. Here, the sliding means causes the inner needle to move a predetermined distance from the hollow portion of the first tube and be inserted into a target site.

Abstract translation: 本发明涉及一种生物组织活检装置，其包括沿纵向方向延伸的主体，外针安装成连接到主体的一侧并沿纵向方向延伸，并且包括形成有中空部的第一管 以及第二管，其设置在与所述第一管平行的方向上，以引导止血物质，设置在所述第一管内并沿纵向方向延伸的内针，以及设置在所述主体中并安装成连接到所述第一管的一端的滑动装置 以使内针能够向前后移动。 这里，滑动装置使内针从第一管的中空部移动预定距离并插入目标位置。

公开(公告)号：US20150317918A1

公开(公告)日：2015-11-05

申请号：US14542605

申请日：2014-11-16

Applicant: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： YOUNG NAM KANG ,  HONG SEOK JANG ,  JA CHOON KOO ,  JI NA KIM ,  HUN JOO SHIN ,  YOUNG KYU LEE ,  JAE CHOON LEE ,  HYOUNG WOOK PARK ,  HYUK JIN LEE ,  HAE JIN LEE

IPC: G09B23/32

CPC classification number: G09B23/32 ,  G09B23/288 ,  G09B23/303

Abstract: The present invention relates to a respiration mimic device, and includes a chamber having an interior space filled with fluid, a lung mimic, to be contracted or expanded, accommodated at the interior space in the chamber; a lung copying unit including a tumor mimic distributed in the lung mimic; a driving unit for copying motion patterns of the lung according to actual respiration and contracting or expanding the lung mimic; and an abdomen copying unit for elevating vertically according to contraction or expansion of the lung mimic and copying an abdomen.

Abstract translation: 呼吸模拟装置技术领域本发明涉及一种呼吸模拟装置，并且包括具有填充有流体的内部空间的腔室，待收缩或膨胀的肺模拟物，容纳在腔室内部空间中; 包括分布在肺模拟物中的肿瘤模拟物的肺复制单元; 用于根据实际呼吸复制肺的运动模式和收缩或扩大肺部模拟物的驱动单元; 以及腹部复印单元，用于根据肺的模仿和腹部的收缩或膨胀垂直升高。

公开(公告)号：US20150297676A1

公开(公告)日：2015-10-22

申请号：US14426324

申请日：2013-09-02

Applicant: Catholic University Industry Academic Cooperation Foundation

Inventor： Mi-La CHO ,  Joo-Yeon Jhun ,  Seon-Yeong Lee ,  Yeong-Mi Mun ,  Jun-Geol Ryu ,  Jae-Kyeong Byun ,  Hye-Jin Son ,  Eun-Kyung Kim ,  Eun-Ji Yang ,  Jeong-Hee Jeong

IPC: A61K38/17 ,  G01N33/68 ,  C07K14/47

CPC classification number: A61K38/1709 ,  A61K38/1761 ,  C07K14/47 ,  G01N33/6872 ,  G01N33/6893 ,  G01N2333/4704 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2800/044

Abstract: The present invention relates to a composition comprising GRIM-19 protein as an active ingredient for preventing or treating obesity or lipid-related metabolic diseases. More particularly, the present invention relates to a composition for preventing or treating obesity or lipid-related metabolic diseases wherein the composition comprises GRIM-19 protein as an active ingredient for preventing or treating metabolic diseases caused by immune response disorders or interactions between genetic, metabolic, or environmental complex factors. The GRIM-19 protein according to the present invention exhibits excellent effectiveness not only in reducing lipocytes and total cholesterol content in the body, but also in suppressing the differentiation of cytotoxic Th17 cells that produce and secrete inflammatory cytokines. Also, GRIM-19 has been found to have excellent effectiveness in regulating a STAT3 mediated inflammatory response in an inflammatory environment related to obesity. Thus, the present invention can be used for preparing a treatment agent and a functional food that can effectively treat obesity or lipid-related metabolic diseases.

Abstract translation: 本发明涉及包含GRIM-19蛋白作为预防或治疗肥胖症或与脂质有关的代谢疾病的活性成分的组合物。 更具体地说，本发明涉及用于预防或治疗肥胖症或与脂质有关的代谢性疾病的组合物，其中组合物包含GRIM-19蛋白作为预防或治疗由免疫应答障碍引起的代谢疾病或遗传代谢之间的相互作用的活性成分 ，或环境复杂因素。 根据本发明的GRIM-19蛋白质不仅在体内减少脂肪细胞和总胆固醇含量方面表现出优异的效果，而且在抑制产生和分泌炎性细胞因子的细胞毒性Th17细胞的分化方面表现出优异的效果。 此外，已经发现GRIM-19在与肥胖相关的炎症环境中调节STAT3介导的炎症反应具有优异的有效性。 因此，本发明可用于制备能够有效治疗肥胖症或与脂质有关的代谢疾病的治疗剂和功能性食品。

公开(公告)号：US20150251025A1

公开(公告)日：2015-09-10

申请号：US14517998

申请日：2014-10-20

Applicant: Center Of Human-Centered Interaction For Coexistence ,  Korea Institute of Science and Technology ,  Catholic University Industry Academic Cooperation Foundation

Inventor： Bum Jae You ,  Sung On Lee ,  Yong An Chung

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B5/4064 ,  A61N2007/0021 ,  A61N2007/0026 ,  G06F1/00

Abstract: The present invention relates to an apparatus for creating a tactile sensation through non-invasive brain stimulation by using ultrasonic waves. The apparatus includes: an ultrasonic transducer module for inputting the ultrasonic waves to stimulate a specific part of the brain of a specified user non-invasively through at least one ultrasonic transducer unit; a compensating module for acquiring information on a range of tactile perception areas in the brain of the specified user and compensating properties of ultrasonic waves to be inputted to the specified user through the ultrasonic transducer unit by referring to the acquired information thereon; and an ultrasonic waves generating module for generating ultrasonic waves to be inputted to the specified user through the ultrasonic transducer unit by referring to a compensating value decided by the compensating module.

公开(公告)号：US20150038500A1

公开(公告)日：2015-02-05

申请号：US14359624

申请日：2012-11-09

Applicant: CATHOLIC UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： In-Beom Kim ,  Muyan Kim ,  Sung Won Jung ,  Eojin Jeong ,  Sooyeon Sim

IPC: A61K31/541 ,  A01N43/84

CPC classification number: A61K31/541 ,  A01N43/38 ,  A01N43/60 ,  A01N43/84 ,  A61K9/0048 ,  A61K31/416 ,  A61L12/08 ,  C07D209/08 ,  C07D231/56

Abstract: The invention relates to a pharmaceutical composition for preventing or treating an ophthalmologic disease comprising a compound of formula (1) as defined in the specification, or a pharmaceutically acceptable salt or isomer thereof as an active ingredient. Also, the invention relates to a composition for cleansing or preserving a contact lens comprising the above active ingredient.

Abstract translation: 本发明涉及用于预防或治疗眼科疾病的药物组合物，其包含如说明书中定义的式（1）化合物或其药学上可接受的盐或异构体作为活性成分。 此外，本发明涉及一种用于清洁或保存包含上述活性成分的隐形眼镜的组合物。

公开(公告)号：US20140375779A1

公开(公告)日：2014-12-25

申请号：US14483342

申请日：2014-09-11

Applicant: Catholic University Industry Academic Cooperation Foundation

Inventor： Hang-Bong Kang

IPC: H04N17/00 ,  G06T3/00 ,  H04N13/00

CPC classification number: H04N17/004 ,  G06T3/0093 ,  G06T7/97 ,  G06T2200/04 ,  G06T2207/10012 ,  H04N13/106 ,  H04N13/30 ,  H04N2013/0074

Abstract: The invention relates to a method for measuring recognition warping with respect to a three-dimensional (3D) image. The method according to the invention comprises: (a) a step of selecting any one from a plurality of 3D parameters for a scale for recognizing a 3D image in a 3D manner; (b) a step of displaying a test stereoscopic image corresponding to the selected 3D parameter on a screen; (c) a step of displaying, on a screen, a plurality of sample images obtained by varying the value of the selected 3D parameter for the test stereoscopic image; (d) a step of selecting at least one of the plurality of sample images; and (e) a step of performing the steps (b) to (d) at least two times on different test stereoscopic images, and measuring a 3D recognition scale for the selected 3D parameter based on the sample image selected in the step (d). Therefore, it is possible to measure whether a viewer distortedly recognizes a 3D image or the degree to which a viewer recognizes the 3D image three-dimensionally in connection with the 3D parameter such as the size of the 3D image, the depth of the 3D image, etc. by means of the 3D recognition ability of each viewer.

Abstract translation: 本发明涉及一种用于测量相对于三维（3D）图像的识别扭曲的方法。 根据本发明的方法包括：（a）从用于以3D方式识别3D图像的比例的多个3D参数中选择任意一个的步骤; （b）在屏幕上显示与所选择的3D参数对应的测试立体图像的步骤; （c）在屏幕上显示通过改变测试立体图像的所选3D参数的值而获得的多个样本图像的步骤; （d）选择所述多个样本图像中的至少一个的步骤; 以及（e）在不同的测试立体图像上执行至少两次步骤（b）至（d）的步骤，以及基于在步骤（d）中选择的样本图像来测量所选择的3D参数的3D识别量表， 。 因此，可以测量观看者是否失真地识别3D图像或观看者与三维参数相关联地三维地识别3D图像的程度，诸如3D图像的尺寸，3D图像的深度 等等，借助于每个观众的3D识别能力。

公开(公告)号：US20140134138A1

公开(公告)日：2014-05-15

申请号：US14073561

申请日：2013-11-06

Applicant: Catholic University Industry Academic Cooperation Foundation

Inventor： Jin Hee Shin ,  Kyung Soo Kim ,  Il Kyu Lee

IPC: A61K35/28 ,  A61K31/343

CPC classification number: A61K35/28 ,  A61K31/343 ,  C12N5/0654 ,  C12N2501/999 ,  C12N2506/1384

Abstract: Provided are a composition for stimulating differentiation of MSCs into osteoblasts, which includes cryptotanshinone, and an osteogenesis stimulator including cryptotanshinone and MSCs. When the cryptotanshinone is treated to the MSCs, the differentiation into osteoblasts is stimulated, and thus osteogenesis of a patient may be stimulated by directly transplanting the differentiation-induced MSCs to the patient. Accordingly, the composition or osteogenesis stimulator may be used to treat patients having disability requiring stimulation of osteogenesis such as osteoporosis, bone fracture, bone grafting including alveolar bone grafting for implant placement, or other bone defects.

Abstract translation: 提供了用于刺激MSC分化成成骨细胞的组合物，其包括隐丹参酮和包括隐丹参酮和MSC的成骨刺激物。 当将隐丹参酮处理到MSC时，刺激成骨细胞的分化，因此可以通过将分化诱导的MSC直接移植到患者来刺激患者的骨形成。 因此，组合物或成骨刺激剂可用于治疗需要刺激成骨的患者，例如骨质疏松症，骨折，骨移植，包括用于植入物放置的牙槽骨移植或其它骨缺损。