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公开(公告)号：US12195715B2
公开(公告)日：2025-01-14
申请号：US17277094
申请日：2019-09-20
Applicant: Cytiva Sweden AB
Inventor： Praveen Paul , Prashanth Hosabettu Mohan , Ajay Gore , Sahebagouda Alagur
Abstract: A perfusion bioprocessing system (10) includes a bioreactor (12) and a recirculation flow path (14) provided with at least in one first feed flow control device (46) and at least one second feed control device (48). The perfusion bioprocessing system (10) further includes a first tangential flow filter (16) coupled to the bioreactor (12) via the recirculation flow path (14) and a second tangential flow filter (18) coupled to the bioreactor (12) via the recirculation flow path (14). The first tangential flow filter and the second tangential flow filter are coupled to a permeate flow path and a retentate flow path. Additionally, the perfusion bioprocessing system (10) includes a control unit (90) coupled to the at least one first feed flow control device (38) and the at least one second feed control device (40).
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公开(公告)号：US12179195B2
公开(公告)日：2024-12-31
申请号：US17281727
申请日：2019-10-16
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer
IPC: B01L3/00
Abstract: The present invention relates to a bioprocessing fluid sensor arrangement (100) for sensing fluidic properties in a process fluid path with a sensor (S), configured for aseptically connecting the sensor with at least one conditioning fluid while separating said sensor from the process fluid to at least one conditioning fluid e.g. for calibration, cleaning, regenerating and/or storing the sensor, the arrangement comprising a process fluid path (PF) having a process fluid inlet (PI) and a process fluid outlet (PO); a sensor (S) arranged in the process fluid path (PF); a bypass fluid path (BF) in the process fluid path (PF), for bypassing the sensor (S); a conditioning or cleaning fluid path (CF) having an inlet (CI) and an outlet (CO) each aseptically and fluidically connected to the process fluid path (PF), one on each side of the sensor (S); and flow controls (FC) for controlling the flow of fluids, whereby fluids can be controlled to flow either in the process fluid path (PF) via the sensor (S), or in the bypass fluid path (BF) omitting the sensor from the fluid path (PF), or in the conditioning or cleaning fluid path (CF) including the sensor in said flow but omitting the remaining process fluid path (PF) and bypass fluid path (BF).
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公开(公告)号：US20240369472A1
公开(公告)日：2024-11-07
申请号：US18775959
申请日：2024-07-17
Applicant: Cytiva Sweden AB
Inventor： Hanno Ehring , Mats Lundkvist , David Carl Martin Bergman , Andreas Marcstrom
Abstract: The invention relates to an optical flow cell comprising a housing forming an enclosed and elongated fluid channel arranged along a first axis, an inlet arranged to connect a first outer surface area of the housing to a first end of the fluid channel and an outlet arranged to connect a second outer surface area to a second end of the fluid channel, a first light guide and a second light guide concentrically arranged along a second axis and on opposite side walls of the fluid channel. The invention further relates to a corresponding method to produce an optical flow cell.
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公开(公告)号：US20240207758A1
公开(公告)日：2024-06-27
申请号：US18594938
申请日：2024-03-04
Applicant: Cytiva Sweden AB
Inventor： Karol Maciej Lacki
CPC classification number: B01D15/163 , B01D15/1807 , B01D15/1871 , B01D15/20 , B01D15/3809 , G01N30/42 , G01N30/88 , G01N30/56 , G01N2030/889
Abstract: Certain embodiments of the invention provides a method for monitoring level of saturation of a chromatography media in a column, which method comprises measuring a first pressure at the inlet of an unloaded column; measuring a second pressure at the inlet from a loaded column; and comparing the first and second pressure measurement of determine the level of saturation of the chromatography media. Embodiments of the invention also provide related methods for controlling a chromatography system and methods for controlling a periodic counter current chromatography system, as well as a chromatography system suitable for use with the novel methods.
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公开(公告)号：US11987783B2
公开(公告)日：2024-05-21
申请号：US16607544
申请日：2018-04-18
Applicant: Cytiva Sweden AB
Inventor： Suma Memana Narayana Bhat , Veena B N Rao , Andreas Axen , Deepak Aravind , Nagapriya Kavoori Sethumadhavan , Hanish Lakhani , Purbasha Halder , Victor Jose
CPC classification number: C12M27/16 , C12M21/02 , C12M43/08 , C12M47/02 , H02J7/00034 , H02J50/001 , H02J50/80
Abstract: A bio-processing system (100) for wirelessly powering one or more sensors (116-128, 400) is presented. The system (100) includes bio-processing units (106-110), process supporting devices (112-114), energy sources (146-148), and sensors (116-128, 400) including an energy harvesting unit (402) and an energy storage unit (404). The system (100) includes a power management subsystem (104, 200) wirelessly coupled to the sensors (116-128, 400) and including a processor (202) configured to wirelessly monitor energy consumption of the sensors (116-128, 400) and a level of energy stored in corresponding energy storage units (404), select at least one sensor (116-128, 400) based on the energy consumption of the sensors (116-128, 400) and corresponding levels of energy stored in the energy storage units (404), and identify at least one active energy source (146-148) as a power source, where the identified power source is configured to wirelessly transfer power to the selected sensor (116-128, 400).
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Patent Agency Ranking
公开(公告)号：US20240096096A1
公开(公告)日：2024-03-21
申请号：US18525144
申请日：2023-11-30
Applicant: Cytiva Sweden AB
Inventor： Petra Bangtsson , Johan Arthursson , Key Hyckenberg , Lotta Hedkvist
CPC classification number: G06V20/20 , G06T7/001 , G06T11/00 , G06T2207/30164
Abstract: A method of automated configuration in a bioprocess system and to verify a process defined by a flow path representation. The method comprises the steps of: capturing one image of the bioprocess system comprising tubing for the fluid communication between units of the bioprocess system; analyzing the captured image to identify the tubing connecting units of the bioprocess system; producing a processed representation from the captured image wherein at least a part of the tubing is identified; and comparing the processed representation with the flow path representation to verify their functional concordance.
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公开(公告)号：US20240019843A1
公开(公告)日：2024-01-18
申请号：US17864036
申请日：2022-07-13
Applicant: Cytiva Sweden AB
Inventor： Hakan KLANG , Daniel LANDBY , Dave J. Pazzani
IPC: G05B19/4155
CPC classification number: G05B19/4155 , G05B2219/32287
Abstract: The present invention relates to a method performed by a system (110) operable to configure a chemical separation system (120), the method comprising: receiving system hardware configuration data, wherein the system hardware configuration data is at least indicative of fluid manipulation modules (121_1-12N_M) of the chemical separation system (120), desired functionality of the fluid manipulation modules, and a fluid network (210) comprising fluid couplers configured to fluidly couple the fluid manipulation modules (121_1-12N_M), identifying a first set of function blocks to provide the indicated fluid manipulation modules with the desired functionality, generating a second set of function blocks by purging a third set of function blocks from the first set of function blocks to eliminate dead code using the configuration data, sending the second set of function blocks to the system (120).
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公开(公告)号：US20240017252A1
公开(公告)日：2024-01-18
申请号：US18475121
申请日：2023-09-26
Applicant: Cytiva Sweden AB
Inventor： Tuomo Valtteri Frigard , Robert Magnusson , Mats Lundkvist , Karl Axel Jakob Liderfelt , Helena Nordvarg , Andreas Torbjorn Lundin , Peter Arne Reffner
CPC classification number: B01L3/502715 , B01D15/10 , B01D61/145 , B01L3/502738 , B01L3/502761 , B01D2311/2626 , B01D2315/16 , B01L2200/028 , B01L2200/0647 , B01L2300/0627 , B01L2300/0809 , B01L2300/0864 , B01L2400/06
Abstract: Disclosed is a modular bio-processing unit comprising: a housing having one or more internal fluid paths, the housing having at least one inlet and at least one outlet, each in fluid communication with the fluid path or one or more of the fluid paths; one or more sensor elements operatively associated with the or each path, said sensor(s) elements including elements of one or more of: a flow sensor, a flow rate sensor, a conductivity sensor, a pressure sensor, a pH sensor, and a light absorbance sensor such as a UV spectroscopic concentration sensor; one or more fluid flow inducing components operatively associated with the or each fluid path; and plural valves for preventing or reducing flow in the or each path, the housing, inlet(s), outlet(s), flow inducing component(s) and valve(s) being arranged to operate together as a bio-processing unit within or substantially within the housing.
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公开(公告)号：US20230417332A1
公开(公告)日：2023-12-28
申请号：US18462316
申请日：2023-09-06
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer
IPC: F16K7/04 , F16K7/12 , F16K31/12 , F16K31/122 , F16K31/126
CPC classification number: F16K7/04 , F16K7/12 , F16K31/126 , F16K31/122 , F16K31/12
Abstract: A valve configured to be in a first state, which is an open state when a flow through the tube should be allowed; a second state during some parts of a process run in the system, said second state is a closed state were a first closing force is provided; and a third state during some parts of a process run in the system, said third state is a closed state were a second closing force is provided which is a higher force than the first closing force.
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公开(公告)号：US20230357702A1
公开(公告)日：2023-11-09
申请号：US18044859
申请日：2021-10-13
Applicant: CYTIVA SWEDEN AB
Inventor： Tuomo Frigård , Camilla Estmer Nilsson , Patricia Roch , Björn Markus Olovsson , Magnus Wetterhall , Nils Stafström , Inger Salomonsson
Abstract: The present invention relates to a computer implemented method for controlling a fluid coupling network (170), the fluid coupling network (170) being configured to be fluidly couplable to bioreactor (110), a gas source (120), a buffer source (140), a waste port (150), a processing system (160) and a conduit reservoir (208), the fluid coupling network (170) comprising a barrier unit (220) configured to sterilely separate fluid paths within the fluid coupling network (170), the fluid coupling network (170) being controllable to sample the bioreactor (110), the method comprising obtaining (510) a fluid sample from the bioreactor (110), wherein the step of obtaining the fluid sample comprises controlling a flow of fluid from the bioreactor (110) via the conduit reservoir (208) and the fluid coupling network (170) to the waste port (150), to fill the conduit reservoir (208) with the fluid from the bioreactor (110), providing (530) the fluid sample, wherein the step of providing the fluid sample comprises to provide the fluid sample to the processing system (160) from the conduit reservoir (208) via the fluid coupling network (170), and returning (540) residual fluid sample to the bioreactor (110), wherein the residual fluid sample is comprised by a part of the fluid coupling network (170) separated by the barrier unit (220), wherein the step of returning residual fluid sample comprises controlling a flow of gas from a gas source (120) to the bioreactor (110) via the part of the fluid coupling network (170).
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