公开(公告)号：US20140356906A1

公开(公告)日：2014-12-04

申请号：US14296220

申请日：2014-06-04

Applicant: FACTOR BIOSCIENCE INC.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12P21/00 ,  C12N15/87

CPC classification number: C12N5/0647 ,  A61K35/28 ,  A61K2035/124 ,  C08G77/08 ,  C08K5/5399 ,  C12N5/0657 ,  C12N9/16 ,  C12N9/22 ,  C12N15/87 ,  C12N15/907 ,  C12N2500/25 ,  C12N2500/44 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/2303 ,  C12N2501/26 ,  C12N2501/91 ,  C12N2501/998 ,  C12N2506/09 ,  C12N2800/80 ,  C12P21/00 ,  C12Y301/21 ,  H01L31/048 ,  Y02E10/50 ,  C08L83/04

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.

Abstract translation: 本发明部分地涉及编码蛋白质的核酸，含有非规范核苷酸，治疗剂包括用于诱导细胞以表达蛋白质，方法，试剂盒，以及用于转染设备，基因编辑核酸，方法，试剂盒和装置的核酸， 并使用这些方法，试剂盒和装置重新编程细胞，细胞，生物体和治疗剂。 公开了诱导细胞表达蛋白质和使用RNA重编程和基因编辑细胞的方法。 还公开了从患者样品中产生细胞的方法，使用这些方法产生的细胞，以及包含使用这些方法产生的细胞的治疗剂。

公开(公告)号：US12201675B2

公开(公告)日：2025-01-21

申请号：US16562494

申请日：2019-09-06

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: A61K48/00 ,  A61B18/18 ,  A61G19/00 ,  A61K8/60 ,  A61K9/00 ,  A61K9/127 ,  A61K31/573 ,  A61K31/575 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  A61K38/38 ,  A61K38/39 ,  A61K38/44 ,  A61K38/45 ,  A61K45/06 ,  A61K47/46 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/08 ,  C12N15/87 ,  C12N15/90 ,  A61B18/00

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US12006508B2

公开(公告)日：2024-06-11

申请号：US16912321

申请日：2020-06-25

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C07H21/04 ,  A61K31/7115 ,  A61K35/14 ,  A61K38/46 ,  A61K48/00 ,  C07K14/195 ,  C12N9/14 ,  C12N9/22 ,  C12N15/00 ,  C12N15/10 ,  C12N15/86 ,  C12N15/90 ,  G01N33/50 ,  A01K67/00 ,  A61K35/12

CPC classification number: C12N15/907 ,  A61K31/7115 ,  A61K35/14 ,  A61K38/465 ,  A61K48/005 ,  C07K14/195 ,  C12N9/22 ,  C12N15/1024 ,  C12N15/86 ,  C12Y301/00 ,  C12Y301/21004 ,  G01N33/5014 ,  A61K2035/124 ,  C07K2319/80 ,  C12N2800/80

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US20240182856A1

公开(公告)日：2024-06-06

申请号：US18461368

申请日：2023-09-05

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE ,  Mitchell KOPACZ ,  Jasmine HARRIS ,  James PAN

IPC: C12N5/0783 ,  C12N15/10

CPC classification number: C12N5/0646 ,  C12N15/102 ,  C12N2506/1307 ,  C12N2510/00

Abstract: The present disclosure relates in part to engineered immune cells that are, inter alia, silenced from a host immune response.

公开(公告)号：US20240156987A1

公开(公告)日：2024-05-16

申请号：US18328598

申请日：2023-06-02

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: A61K48/00 ,  A61K9/00 ,  A61K31/7115 ,  A61P1/16 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P11/00 ,  A61P29/00 ,  A61P35/00 ,  C07K14/00 ,  C12N9/22

CPC classification number: A61K48/005 ,  A61K9/0019 ,  A61K31/7115 ,  A61K48/0058 ,  A61K48/0066 ,  A61P1/16 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P11/00 ,  A61P29/00 ,  A61P35/00 ,  C07K14/001 ,  C12N9/22 ,  C07K14/003 ,  C12N2310/20 ,  C12Y301/21

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.

公开(公告)号：US20240035025A1

公开(公告)日：2024-02-01

申请号：US18480405

申请日：2023-10-03

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE ,  Aisha SVIHLA

IPC: C12N15/11 ,  C07K14/47 ,  C12N15/10 ,  C12N9/22

CPC classification number: C12N15/11 ,  C07K14/4702 ,  C12N15/102 ,  C12N9/22 ,  C12N2310/20

Abstract: The present disclosure relates, in part, to circular RNAs and engineered variants thereof.

公开(公告)号：US20230373903A1

公开(公告)日：2023-11-23

申请号：US18362789

申请日：2023-07-31

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Franklin KOSTAS ,  Christopher ROHDE

IPC: C07C215/24 ,  A61K9/127

CPC classification number: C07C215/24 ,  A61K9/1272

Abstract: The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.

公开(公告)号：US20230304044A1

公开(公告)日：2023-09-28

申请号：US18332620

申请日：2023-06-09

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N15/87 ,  C08K5/5399 ,  C12N5/074 ,  H01L31/048 ,  C12P21/00 ,  C12N9/16 ,  C12N5/0789 ,  C12N5/077 ,  C12N15/90 ,  C12N9/22 ,  A61K35/28

CPC classification number: C12N15/87 ,  C08K5/5399 ,  C12N5/0696 ,  H01L31/048 ,  C12P21/00 ,  C12N9/16 ,  C12Y301/21 ,  C12N5/0647 ,  C12N5/0657 ,  C12N15/907 ,  C12N9/22 ,  A61K35/28 ,  C08G77/08

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US20220243228A1

公开(公告)日：2022-08-04

申请号：US17718668

申请日：2022-04-12

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N15/90 ,  A61K31/7115 ,  C12N9/22 ,  C07K14/195 ,  C12N15/10 ,  A61K35/14 ,  A61K38/46 ,  A61K48/00 ,  C12N15/86 ,  G01N33/50

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US11339409B2

公开(公告)日：2022-05-24

申请号：US16654532

申请日：2019-10-16

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C07H21/04 ,  C12N15/63 ,  C12N15/90 ,  A61K31/7115 ,  C12N9/22 ,  C07K14/195 ,  C12N15/10 ,  A61K35/14 ,  A61K38/46 ,  A61K48/00 ,  C12N15/86 ,  G01N33/50 ,  A61K31/70 ,  A61K35/12

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.