Integrated Lancing And Measurement Device And Analyte Measuring Methods
    94.
    发明申请
    Integrated Lancing And Measurement Device And Analyte Measuring Methods 有权
    综合起搏和测量装置及分析物测量方法

    公开(公告)号:US20080194990A1

    公开(公告)日:2008-08-14

    申请号:US12021027

    申请日:2008-01-28

    IPC分类号: A61B5/00

    摘要: An integrated lancing and measurement device is provided comprising a sensor designed to determine the amount and/or concentration of analyte in a biological fluid having a volume of less than about 1 μL. A piercing member is adapted to pierce and retract from a site on the patient to cause the fluid to flow therefrom, and the sensor is positioned adjacent to the site on the patient so as to receive the fluid flowing from the site to generate an electrical signal indicative of the concentration of the analyte in the fluid. The sensor is comprised of a working electrode comprising an analyte-responsive enzyme and a redox mediator, and a counter electrode. An analyte monitor is operatively connected to the sensor and adapted to measure the signal generated by the sensor. Also provided are analyte measuring methods that optionally employ the integrated lancing and measurement device.

    摘要翻译: 提供了一种集成的穿刺和测量装置,其包括设计用于确定体积小于约1μL的生物流体中分析物的量和/或浓度的传感器。 刺穿构件适于从患者的位置刺穿和缩回以使流体从其中流出,并且传感器被定位成与患者的位置相邻,以便接收从现场流动的流体以产生电信号 指示流体中分析物的浓度。 传感器由包括分析物响应酶和氧化还原介体的工作电极和对电极组成。 分析物监测器可操作地连接到传感器并适于测量由传感器产生的信号。 还提供了可选地使用集成的穿刺和测量装置的分析物测量方法。

    Integrated lancing and measurement device and analyte measuring methods
    95.
    发明授权
    Integrated lancing and measurement device and analyte measuring methods 有权
    集成的穿刺和测量装置和分析物测量方法

    公开(公告)号:US07335294B2

    公开(公告)日:2008-02-26

    申请号:US10629348

    申请日:2003-07-28

    IPC分类号: G01N27/327 A61B5/05

    摘要: An integrated lancing and measurement device is provided comprising a sensor designed to determine the amount and/or concentration of analyte in a biological fluid having a volume of less than about 1 μL. A piercing member is adapted to pierce and retract from a site on the patient to cause the fluid to flow therefrom, and the sensor is positioned adjacent to the site on the patient so as to receive the fluid flowing from the site to generate an electrical signal indicative of the concentration of the analyte in the fluid. The sensor is comprised of a working electrode comprising an analyte-responsive enzyme and a redox mediator, and a counter electrode. An analyte monitor is operatively connected to the sensor and adapted to measure the signal generated by the sensor. Also provided are analyte measuring methods that optionally employ the integrated lancing and measurement device.

    摘要翻译: 提供了一种集成的穿刺和测量装置,其包括设计用于确定体积小于约1μL的生物流体中分析物的量和/或浓度的传感器。 刺穿构件适于从患者的位置刺穿和缩回以使流体从其中流出,并且传感器被定位成与患者的位置相邻,以便接收从现场流动的流体以产生电信号 指示流体中分析物的浓度。 传感器由包括分析物响应酶和氧化还原介体的工作电极和对电极组成。 分析物监测器可操作地连接到传感器并适于测量由传感器产生的信号。 还提供了可选地使用集成的穿刺和测量装置的分析物测量方法。

    Small volume in vitro analyte sensor
    99.
    发明申请
    Small volume in vitro analyte sensor 有权
    体积小体积分析物传感器

    公开(公告)号:US20050164322A1

    公开(公告)日:2005-07-28

    申请号:US11035131

    申请日:2005-01-13

    摘要: A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable. The amount of analyte can be determined by coulometry. One particular coulometric technique includes the measurement of the current between the working electrode and a counter or reference electrode at two or more times. The charge passed by this current to or from the analyte is correlated with the amount of analyte in the sample. Other electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can also be used. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is provided as a second electron transfer agent.

    摘要翻译: 设计用于确定样品中分析物的量和浓度小于约1μl的传感器。 该传感器具有涂覆有不可浸出的氧化还原介体的工作电极。 氧化还原介体作为分析物和电极之间的电子转移剂。 此外,可以加入第二电子转移剂,例如酶,以促进分析物的电氧化或电还原。 氧化还原介体通常是与聚合物结合的氧化还原化合物。 优选的氧化还原介体是可空气氧化的。 分析物的量可以通过库仑法测定。 一种特定的库仑技术包括两次或更多次测量工作电极与计数器或参考电极之间的电流。 通过该电流流向或来自分析物的电荷与样品中分析物的量相关。 还可以使用其他电化学检测方法,例如电流,伏安和电位技术。 本发明可用于测定生物液体如血液或血清中生物分子如葡萄糖或乳酸盐的浓度。 提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。