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公开(公告)号：US11576623B2
公开(公告)日：2023-02-14
申请号：US16716991
申请日：2019-12-17
发明人： Dwaipayan Biswas , Luke Everson , Mario Konijnenburg , Christiaan Van Hoof , Nick Van Helleputte
摘要： A method of generating a model for generating a synthetic electrocardiography (ECG) signal comprises: receiving subject-specific training data for machine learning, said training data comprising a photoplethysmography (PPG) signal acquired from the subject and an ECG signal acquired from the subject, wherein the ECG signal provides a ground truth of the subject for associating the ECG signal with the PPG signal; using associated pairs of a time-series of the PPG signal and a corresponding time-series of the ECG signal as input to a deep neural network, DNN; and determining, through the DNN, a subject-specific model relating the PPG signal of the subject to the ECG signal of the subject for converting the PPG signal to a synthetic ECG signal using the subject-specific model.
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公开(公告)号：US11573194B2
公开(公告)日：2023-02-07
申请号：US17095426
申请日：2020-11-11
发明人： Xin Chen , Andreas Stein , Philippe Buhlmann
IPC分类号： G01N27/30
摘要： Reference electrodes that include a solid electron conductor; an interlayer; and a polymeric membrane layer comprising a polymer composition, the polymer composition comprising at least one silicone-containing polymer and at least one ionic liquid, wherein the polymeric membrane layer and the polymer composition are essentially plasticizer free and the silicone-containing polymer and the ionic liquid are miscible as determined using a thermodynamic method that shows a single glass transition temperature (Tg) of a composition including the at least one silicone-containing polymer and the at least one ionic liquid, wherein the interlayer is disposed between the solid electron conductor and the polymeric membrane layer. Also disclosed are electrochemical measurement systems including such reference electrodes.
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公开(公告)号：US11566149B2
公开(公告)日：2023-01-31
申请号：US16258567
申请日：2019-01-26
申请人： Toyota Motor Engineering & Manufacturing North America, Inc. , Toyota Motor Corporation , Regents of the University of Minnesota
发明人： Hongfei Jia , Ping Wang , Liting Zhang , Andreas Buthe , Xueyan Zhao , Songtao Wu , Masahiko Ishii , Minjuan Zhang
IPC分类号： C12N9/14 , C12N9/20 , C12N9/54 , C12N9/96 , C09D5/16 , A61K47/60 , C09D7/40 , C12N11/06 , C12N11/089 , C09D189/00 , C12N9/26 , C08G65/333 , C09D5/02 , C09D175/16
摘要： Bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.
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公开(公告)号：US11560432B2
公开(公告)日：2023-01-24
申请号：US15952965
申请日：2018-04-13
摘要： Phycoerythrin (PE) and peptide:MHCII (p:MHCII) reactive monoclonal antibodies; methods to generate monoclonal antibodies including, for example, peptide:MHC (p:MHC) reactive monoclonal antibodies; compositions including monoclonal antibodies; and uses thereof.
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公开(公告)号：US20230009133A1
公开(公告)日：2023-01-12
申请号：US17859645
申请日：2022-07-07
发明人： David Nedrelow , Ishaan Duggal
摘要： Treatment of palatal defects is accomplished through devices that have controlled start time. The devices expand directionally to provide appropriate levels of stress and strain to a target tissue to promote tissue growth over the course of days or weeks, even as the defect repairs itself.
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公开(公告)号：US20230000473A1
公开(公告)日：2023-01-05
申请号：US17659442
申请日：2022-04-15
发明人： Michael A. Greminger , Anastasia Zink , Brian Krohn , Amit Goyal , Roy Joseph Cho , H. Erhan Dincer , Felix Zamora , Gills Fai , Sarah Ostlie
摘要： According to embodiments, a substantially coaxial arrangement of a camera, a light source, and an ultrasonic sensor can be positioned in an housing of a system that can be deployed from the tool port of a standard bronchoscope. Illumination from the light source facilitates positioning of the system by an operator using information from the camera. The ultrasonic system can determine when an object to be biopsied is adjacent to a biopsy needle.
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97.发明授权公开(公告)号：US11543475B2
公开(公告)日：2023-01-03
申请号：US16859771
申请日：2020-04-27
发明人： Myung Kyun Woo , Gregor Adriany , Kamil Ugurbil , Russell L. Lagore , Lance DelaBarre , Jerahmie Radder
IPC分类号： G01R33/28 , H01Q7/00 , G01R33/341 , H01Q1/36 , H01Q21/29
摘要： An antenna apparatus for a radio frequency (RF) coil to transmit signals to and to receive signal from a subject in a magnetic resonance imaging (MRI) system includes a distal surface facing away from the subject, a proximal surface facing towards the subject, a high permittivity material (HPM) having a shape, and an antenna coupled to the HPM and positioned on the proximal surface such that the antenna is positioned between the HPM and the subject.
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公开(公告)号：US20220395827A1
公开(公告)日：2022-12-15
申请号：US17756403
申请日：2020-11-20
IPC分类号： B01L3/00
摘要： A microfluidic device includes a bottom electrode, a dielectric layer on the bottom electrode, one or more top electrodes on a region of the dielectric layer, Each of the one or more top electrodes has a sidewall that forms a sidewall angle with an outer surface of the dielectric layer that is less than 180 degrees. The sidewall of each of the one or more top electrodes and a portion of the outer surface of the dielectric layer adjacent to the sidewall define a microchannel region for transporting an open microchannel of a fluid. Such microfluidic devices may enable transport of small microchannels using low voltages.
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公开(公告)号：US20220395501A1
公开(公告)日：2022-12-15
申请号：US17692753
申请日：2022-03-11
IPC分类号： A61K31/506 , C07D401/12 , C07D239/42 , C07D491/052 , C07D413/14 , C07D403/14 , C07D498/04 , C07D495/04 , C07D239/30 , C07D403/12 , C07D401/14 , C07D417/14 , C07D491/048 , C07D471/04 , C07D519/00 , C07D513/04 , C07D487/04 , C07D409/14 , C07D239/48 , C07D239/47 , A61K31/519 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/551
摘要： The invention relates to treatment of graft versus host disease (GVHD) using compounds that inhibit ROCK2. In preferred aspects, the present invention provides methods for the treatment of GVHD, including chronic GVHD (cGVHD) using compounds having the formulae I-XXV, as set forth herein.
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公开(公告)号：US20220393328A1
公开(公告)日：2022-12-08
申请号：US17339267
申请日：2021-06-04
摘要： A complementary metal-oxide-semiconductor (CMOS) device includes a metal oxide layer comprising anodic aluminum oxide (AAO) and one or more nanowires (NW) of an electrically conducting material each formed within a corresponding pore extending through the AAO from a first side of the layer to a second side of the layer opposite the first side, a first electrically conducting layer disposed on the first side of the metal oxide layer, and a second electrically conducting layer disposed on the second side of the metal oxide layer. The nanowires form a via electrically connecting first electrically conducting layer and the second electrically conducting layer.
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