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    Hypolipemiant and vasodilatatory methods of use
    91.
    发明授权
    Hypolipemiant and vasodilatatory methods of use 失效
    止血药和血管舒张的使用方法

    公开(公告)号：US3897558A

    公开(公告)日：1975-07-29

    申请号：US49555574

    申请日：1974-08-08

    Applicant: ROUSSEL UCLAF

    Inventor： HARDY MICHAEL ,  HUMBERT DANIEL

    IPC: C07D277/24 ,  A61K27/00

    CPC classification number: C07D277/24 ,  Y10S514/929

    Abstract: Novel hypolipemiant and vasodilatatory compositions containing as the active ingredient, 2-methyl-thiazole-5-methanol which has the formula

    and a method of use.

    Abstract translation: 含有作为活性成分的2-甲基 - 噻唑-5-甲醇的新型降胆固醇和血管舒张组合物具有式N-CH并行平行CC角度CH 3 SCH 2 OH的2-甲基 - 噻唑-5-甲醇及其使用方法。

    Process for the preparation of steroidal spirolactones and intermediates
    92.
    发明授权
    Process for the preparation of steroidal spirolactones and intermediates 失效
    制备甾体内酯和中间体的方法

    公开(公告)号：US3897417A

    公开(公告)日：1975-07-29

    申请号：US43860174

    申请日：1974-02-01

    Applicant: ROUSSEL UCLAF

    Inventor： WARNANT JULIEN ,  JOLLY JEAN

    IPC: C07J31/00 ,  A61K31/585 ,  A61P7/10 ,  C07J21/00 ,  C07C173/00

    CPC classification number: C07J21/00

    Abstract: WHEREIN R is alkyl having 1 to 4 carbon atoms and R2 is defined above, with a thioalkanoic acid of the formula

    WHEREIN R1 is a linear alkyl having 1 to 4 carbon atoms and R2 is hydrogen or methyl comprising the steps reacting a compound of the formula
    The present invention relates to a process for the preparation of steroidal spirolactones having the formula

    Abstract translation: 本发明涉及一种制备具有下式的甾族六酮的方法：其中R 1是具有1至4个碳原子的直链烷基，R 2是氢或甲基，包括使式WHEREIN R为具有1至 4个碳原子和R 2如上定义，与式R 1 COSH的硫代链烷酸，其中R 1如上定义，在中性介质中加热所得产物并回收所述甾体螺内酯; 以及中间体。

    Process for the preparation of vincamine
    93.
    发明授权
    Process for the preparation of vincamine 失效
    长春胺的制备方法

    公开(公告)号：US3884927A

    公开(公告)日：1975-05-20

    申请号：US34525573

    申请日：1973-03-27

    Applicant: ROUSSEL UCLAF

    Inventor： MARTEL JACQUES ,  COSTEROUSSE GERMAIN

    IPC: C07D461/00 ,  C07D57/08

    CPC classification number: C07D461/00

    Abstract: Process for the preparation of vincamine wherein eburnamonine is reacted with an ethynylmagnesium halide to give (20 Alpha ,21 Alpha ) 16 Alpha -ethynyl eburnane 16 Beta -ol, which upon oxidation to vincaminic acid and subsequent methylation provides vincamine. The optically active forms of vincamine can be obtained by using an optically active form of eburnamonine.

    Abstract translation: 用于制备长春胺的方法，其中将本香糖胺与乙炔基卤化镁反应，得到[20α，21α]16α-乙炔基伊本烷16β-醇，其在氧化为半胱氨酸并随后甲基化时提供长春胺。 长春胺的光学活性形式可以通过使用光学活性形式的eburnamonine来获得。

    Cyclopentanone derivatives
    94.
    发明授权
    Cyclopentanone derivatives 失效
    环戊酮衍生物

    公开(公告)号：US3870710A

    公开(公告)日：1975-03-11

    申请号：US33041173

    申请日：1973-02-07

    Applicant: ROUSSEL UCLAF

    Inventor： MARTEL JACQUES ,  TOROMANOFF EDMOND ,  BUENDIA JEAN

    IPC: C07C59/90 ,  C07C405/00 ,  C07D303/42 ,  C07D309/12 ,  C07C69/74 ,  C07D7/04

    CPC classification number: C07C59/90 ,  C07C405/00 ,  C07D303/42 ,  C07D309/12 ,  Y10S514/866

    Abstract: WHEREIN R is selected from the group consisting of hydrogen and alkyl of 1 to 7 carbon atoms, R1 is selected from the group consisting of hydrogen and carbalkoxy of 1 to 7 alkyl carbon atoms, R2 is selected from the group consisting of hydrogen, carboxy and carbalkoxy of 1 to 7 alkyl carbon atoms, R3 is selected from the group consisting of hydrogen and Alpha tetrahydropyranyl, m is 3,4 or 5 and n is 2,3 or 4 with the proviso that when R1 is carbalkoxy, R is alkyl of 1 to 7 carbon atoms, R2 is hydrogen and R3 is Alpha -tetrahydro pyranyl; when R2 is carbalkoxy, R is alkyl of 1 to 7 carbon atoms, R1 is hydrogen and R3 is Alpha -tetrahydropyranyl and when R2 is carboxy, R and R1 are hydrogen and R3 is Alpha tetrahydropyranyl, which possess the physiological activity of prostaglandins, and salts thereof when R, R1, R2 and R3 are hydrogen, with non-toxic, pharmaceutically acceptable bases and their preparation.

    Novel prostanoic acid derivatives of the formula

    Abstract translation: 式WHEREIN R的新型前列腺烷酸衍生物选自氢和1至7个碳原子的烷基，R 1选自氢和1至7个烷基碳原子的烷氧基，R2选自 由1至7个碳原子的氢，羧基和烷氧基组成的基团，R 3选自氢和α-四氢吡喃基，m为3,4或5，n为2,3或4，条件是当 R1是烷氧基，R是1至7个碳原子的烷基，R2是氢，R3是α-四氢吡喃基; 当R 2为烷氧基时，R为1至7个碳原子的烷基，R 1为氢，R 3为α-四氢吡喃基，当R 2为羧基时，R 1和R 1为氢，R 3为具有前列腺素生理活性的α-四氢吡喃基， 当R，R 1，R 2和R 3为氢时，其盐为无毒，药学上可接受的碱及其制备。

    Method of increasing the caliber of poultry eggs
    96.
    发明授权
    Method of increasing the caliber of poultry eggs 失效
    增加磷酸钙标准品的方法

    公开(公告)号：US3845208A

    公开(公告)日：1974-10-29

    申请号：US32312373

    申请日：1973-01-12

    Applicant: ROUSSEL UCLAF

    Inventor： GRANDADAM J

    IPC: A23K1/16 ,  A23K1/165 ,  A23K1/18 ,  A61K31/56 ,  A61K31/565 ,  A61P3/00

    CPC classification number: A23K50/70 ,  A23K20/168 ,  Y10S426/807

    Abstract: 1. A METHOD OF INCREASING THE CALIBER OF EGGS OF POULTRY COMPRISING ORALLY ADMINISTERING TO EGG LAYING POULTRY AN AMOUNT EFFECTIVE TO INCREASE THE CALIBER OF EGGS OF AT LEAST ONE ACTIVE COMPOUND OF THE FORMULA

    3-(O=),13-R,17-R'',17-(HO-)-4,5,9,10,11,12-HEXADEHYDRO-

    GONANE

    WHEREIN R IS LOWER ALKYL OF 1 TO 6 CARBON ATOMS AND R'' IS SELECTED FROM THE GROUP CONSISTING OF ALLYL, 2-METHYLALLYL, 2-BUTENYL, TRIFLUOROVINYL, ETHYNYL, PROPARGYL, PROPYNYL CHLOROETHYNYL BUTADIYNYL AND CYCLOPROPYL.

    Cyclopentanone derivatives
    100.
    发明授权
    Cyclopentanone derivatives 失效
    环戊烷酮衍生物

    公开(公告)号：US3801623A

    公开(公告)日：1974-04-02

    申请号：US3801623D

    申请日：1971-04-28

    Applicant: ROUSSEL UCLAF

    Inventor： MARTEL J ,  TOROMANOFF E ,  BUENDIA J

    IPC: C07C59/90 ,  C07C405/00 ,  C07D309/12 ,  C07C69/36 ,  C07C69/74

    CPC classification number: C07C405/00 ,  C07C59/90 ,  C07D309/12

    Abstract: NOVEL PROSTANOIC ACID DERIVATIVES OF THE FORMULA

    2-R1,2-(R-OOC-(CH2)N-CH=CH-CH2-),3-(CH3-(CH2)M-CH(-O-R3)-

    CH=CH-),5-R2-CYCLOPENTANONE

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