公开(公告)号：US10208331B2

公开(公告)日：2019-02-19

申请号：US15965040

申请日：2018-04-27

Applicant: Research Triangle Institute

Inventor： David Samuel Ensor ,  Howard Jerome Walls ,  Karin K. Foarde

IPC: C12Q1/00 ,  C12Q1/24 ,  B82Y15/00 ,  G01N1/22 ,  G01N33/497

Abstract: A bioparticle collection device and an aerosol collection system. The bioparticle collection device includes a collection medium including a plurality of fibers formed into a fiber mat and configured to collect bioparticles thereon, and includes a viability enhancing material provider disposed in a vicinity of the plurality of fibers and configured to provide a viability enhancing material to the collected bioparticles to maintain viability of the bioparticles collected by the fiber mat. The aerosol collection system includes an aerosol pumping device configured to entrain particles in an gas stream, an aerosol saturation device configured to saturate the particles in the gas stream with a biocompatible liquid, and an aerosol collection medium downstream from the aerosol saturation device and including a plurality of fibers formed into a fiber mat for collection of the saturated aerosol particles.

公开(公告)号：US10188973B2

公开(公告)日：2019-01-29

申请号：US14646165

申请日：2013-12-06

Applicant: Research Triangle Institute

Inventor： Anthony Clint Clayton ,  Howard Jerome Walls ,  Adam Joseph Rieth ,  David Samuel Ensor

IPC: B01D39/00

Abstract: A filtration device including a base filtration material having openings for fluid flow there through and a filtration medium. The filtration medium includes a plurality of patterned nanofibers formed on the base filtration material. The filtration medium has a figure of merit greater than 30 kPa−1, where the figure of merit is given by −Log (Pt)/ΔP, where Pt is the fractional penetration of a specific aerosol particle diameter and ΔP is a pressure drop across the filtration medium corresponding to a face velocity of 5.3 cm/s and particle size of 0.3 microns.

公开(公告)号：US20180245126A1

公开(公告)日：2018-08-30

申请号：US15965040

申请日：2018-04-27

Applicant: Research Triangle Institute

Inventor： David Samuel Ensor ,  Howard Jerome Walls ,  Karin K. Foarde

IPC: C12Q1/24 ,  B82Y15/00 ,  G01N1/22

CPC classification number: C12Q1/24 ,  B01D2239/025 ,  B01D2239/0604 ,  B82Y15/00 ,  G01N1/2205 ,  G01N1/2208 ,  G01N1/2214 ,  G01N33/497 ,  G01N2001/2223

Abstract: A bioparticle collection device and an aerosol collection system. The bioparticle collection device includes a collection medium including a plurality of fibers formed into a fiber mat and configured to collect bioparticles thereon, and includes a viability enhancing material provider disposed in a vicinity of the plurality of fibers and configured to provide a viability enhancing material to the collected bioparticles to maintain viability of the bioparticles collected by the fiber mat. The aerosol collection system includes an aerosol pumping device configured to entrain particles in an gas stream, an aerosol saturation device configured to saturate the particles in the gas stream with a biocompatible liquid, and an aerosol collection medium downstream from the aerosol saturation device and including a plurality of fibers formed into a fiber mat for collection of the saturated aerosol particles.

公开(公告)号：US09994759B2

公开(公告)日：2018-06-12

申请号：US14911542

申请日：2014-08-12

Applicant: Research Triangle Institute

Inventor： Ginger D. Rothrock ,  Leah Marie Johnson

IPC: C09K8/588 ,  C09K8/58 ,  C09K8/92 ,  B01J13/14 ,  C09K8/584 ,  E21B43/16 ,  C09K8/03 ,  C09K8/516 ,  C09K8/536 ,  C09K8/70 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: C09K8/588 ,  B01J13/14 ,  B82Y30/00 ,  B82Y40/00 ,  C09K8/03 ,  C09K8/516 ,  C09K8/536 ,  C09K8/58 ,  C09K8/584 ,  C09K8/70 ,  C09K8/92 ,  C09K2208/10 ,  E21B43/16

Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a carrier element forming an outer shell that defines an inner core. The core can include a reactive agent that is adapted to react with the shell, particularly at an inner interface of the shell with the core materials. The reaction can provide an inside-out degradation of the shell and release of one or more materials therein. The reactive agent may be separated from the shell, such as using a phase change material (PCM). Upon reaching specific environmental conditions, the PCM can change so as the release the reactive agent for reaction with the shell. The systems can be used in various methods to deliver a material to various environments, including underground reservoirs.

公开(公告)号：US20180149578A1

公开(公告)日：2018-05-31

申请号：US15877991

申请日：2018-01-23

Applicant: Research Triangle Institute

Inventor： Howard Jerome Walls ,  Anthony Clint Clayton ,  Randall J. Newsome ,  Paul G. Hoertz

IPC: G01N15/14 ,  G01N15/02 ,  G01N21/47 ,  G01N21/64 ,  G01N21/53 ,  G01N15/00

CPC classification number: G01N15/1436 ,  G01N15/0205 ,  G01N15/1459 ,  G01N21/53 ,  G01N21/645 ,  G01N21/6486 ,  G01N2015/0046 ,  G01N2015/1486 ,  G01N2015/1493 ,  G01N2021/4721 ,  G01N2201/06113 ,  G01N2201/062

Abstract: A particle detector includes a housing, a light source, and a photo-responsive material. The housing includes a sample inlet and a sample outlet, and encloses a detection cavity. The light source directs irradiating light along a longitudinal axis to particles of a sample fluid flowing in the detection cavity. The photo-responsive material surrounds at least a portion of the detection cavity, and receives measurement light propagating from the particles in a plurality of measurement light paths angled relative to the longitudinal axis. The particle detector may be utilized to measure scattered light and/or light emitted due to autofluorescence. Fluids sampled may include aerosols, bio-aerosols, and liquids.

公开(公告)号：US20180065114A1

公开(公告)日：2018-03-08

申请号：US15808514

申请日：2017-11-09

Applicant: Research Triangle Institute

Inventor： Jian-ping Shen ,  Marty Lail ,  Brian Turk ,  Paul D. Mobley ,  Jason S. Norman ,  Laura DOUGLAS ,  Jonathan PETERS

IPC: B01J23/835 ,  C01B3/40 ,  C10G27/00 ,  C07C29/156 ,  B01J35/00 ,  B01J23/89 ,  B01J23/83 ,  B01J23/80 ,  B01J23/78 ,  B01J23/00 ,  B01J23/889

CPC classification number: B01J23/835 ,  B01J23/002 ,  B01J23/74 ,  B01J23/76 ,  B01J23/78 ,  B01J23/80 ,  B01J23/83 ,  B01J23/8892 ,  B01J23/8906 ,  B01J35/002 ,  B01J37/03 ,  B01J37/14 ,  B01J37/18 ,  B01J2523/00 ,  B01J2523/821 ,  C01B3/40 ,  C01B32/40 ,  C01B2203/0238 ,  C01B2203/1047 ,  C01B2203/1064 ,  C01B2203/1088 ,  C01B2203/1235 ,  C07C2/84 ,  C07C5/42 ,  C07C9/06 ,  C07C11/02 ,  C07C11/04 ,  C07C11/06 ,  C07C11/22 ,  C07C13/20 ,  C07C15/46 ,  C07C29/156 ,  C07C31/04 ,  C07C2521/04 ,  C07C2521/06 ,  C07C2521/08 ,  C07C2523/46 ,  C07C2523/74 ,  C07C2523/78 ,  C07C2523/80 ,  C07C2523/83 ,  C07C2523/835 ,  C07C2523/889 ,  C07C2523/89 ,  C07C2601/16 ,  C07D301/03 ,  C10G27/00 ,  C10G2400/22 ,  C10G2400/30 ,  C10J3/463 ,  C10J3/725 ,  C10J2300/0969 ,  C10J2300/0986 ,  C10J2300/1653 ,  Y02E20/18 ,  Y02P20/52 ,  B01J2523/31 ,  B01J2523/43 ,  B01J2523/842 ,  B01J2523/24 ,  B01J2523/3706 ,  B01J2523/845 ,  B01J2523/72 ,  B01J2523/13 ,  B01J2523/17 ,  B01J2523/22 ,  B01J2523/27

Abstract: This invention is directed to novel mixed transition metal iron (II/III) catalysts for the extraction of oxygen from CO2 and the selective reaction with organic compounds.

公开(公告)号：US09750738B2

公开(公告)日：2017-09-05

申请号：US14968258

申请日：2015-12-14

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Frank Ivy Carroll ,  Juan P. Cueva ,  James B. Thomas ,  S. Wayne Mascarella ,  Scott P. Runyon

IPC: A61K31/495 ,  A61K31/496 ,  C07D241/04 ,  C07D401/12 ,  C07D295/096

CPC classification number: A61K31/495 ,  A61K31/496 ,  C07D241/04 ,  C07D295/096 ,  C07D401/12

Abstract: Provided are opioid receptor antagonists represented by the formula (I): where R, Y3, R1, R2, R3, R4 and R5 are as defined herein.

公开(公告)号：US20170050140A1

公开(公告)日：2017-02-23

申请号：US15118722

申请日：2015-02-13

Applicant: Research Triangle Institute

Inventor： Luke Coleman ,  Marty Lail ,  Kelly E. Amato ,  Jak Tanthana

IPC: B01D53/14

CPC classification number: B01D53/1412 ,  B01D53/1425 ,  B01D53/1475 ,  B01D53/1493 ,  B01D2252/202 ,  B01D2252/2026 ,  B01D2252/2028 ,  B01D2252/204 ,  B01D2252/20405 ,  B01D2252/20421 ,  B01D2252/20426 ,  B01D2252/30 ,  B01D2252/40 ,  B01D2258/0233 ,  B01D2258/0283 ,  Y02C10/06

Abstract: This invention is directed to methods and systems for controlling water in acid gas removal processes comprising the steps of a) treating the gas stream in an absorption zone with the NAS absorption liquid; b) direction the acid gas-loaded NAS absorption liquid to a regeneration zone; c) directing the regenerated NAS absorption liquid to step a); and d) controlling the first and second set of conditions.

Abstract translation: 本发明涉及用于控制酸性气体去除方法中的水的方法和系统，包括以下步骤：a）用NAS吸收液体处理吸收区中的气流; b）将载有酸性气体的NAS吸收液体导向再生区; c）将再生的NAS吸收液引导到步骤a）; 以及d）控制第一和第二组条件。

公开(公告)号：US09304117B2

公开(公告)日：2016-04-05

申请号：US14354426

申请日：2012-10-26

Applicant: Research Triangle Institute

Inventor： Charles E. Rodes ,  J. Randall Newsome

IPC: G01N33/00 ,  G01N21/53 ,  G01N1/22 ,  G01N15/02 ,  G01N21/51

CPC classification number: G01N33/0027 ,  G01N1/2273 ,  G01N15/0255 ,  G01N21/51 ,  G01N21/53 ,  G01N33/0016

Abstract: A gas processing device such as an aerosol exposure monitor is configured for acquiring chronic data, acute data, or both simultaneously, and may include a pump and a noise dampening device. The noise dampening device may include an elastomeric membrane between an inlet chamber and an outlet chamber. In another aspect, an aerosol exposure monitor may include an impactor, a collection filter, and a nephelometer that includes a sample chamber integrated with an aerosol flow path associated with the impactor and collection filter.

Abstract translation: 诸如气溶胶曝光监视器的气体处理装置被配置用于同时获取慢性数据，急性数据或两者，并且可以包括泵和噪声衰减装置。 噪声抑制装置可以包括在入口室和出口室之间的弹性膜。 在另一方面，气溶胶曝光监测器可以包括冲击器，收集过滤器和浊度计，其包括与与冲击器和收集过滤器相关联的气溶胶流动路径集成的样品室。

公开(公告)号：US20150307502A9

公开(公告)日：2015-10-29

申请号：US14368111

申请日：2012-12-26

Applicant: RESEARCH TRIANGLE INSTITUTE ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Frank Ivy Carroll ,  Pauline Wanjiku Ondachi ,  Hernan A. Navarro ,  M. Imad Damaj ,  James H. Woods ,  Emily M. Jutkiewicz

IPC: C07D487/08

CPC classification number: C07D487/08

Abstract: Compounds and compositions for promoting smoking cessation or decreasing tobacco use or nicotine addiction are provided. The compounds are 2′-fluoro-3′-(substituted phenyl) deschloroepibatidine analogs. The compounds have been found to modulate neuronal nicotine acetylcholine receptors and are useful in methods for the treatment of conditions or disorders influenced by the modulation of neuronal nicotinic acetylcholine receptors.

Abstract translation: 提供了用于促进戒烟或减少烟草使用或尼古丁成瘾的化合物和组合物。 这些化合物是2'-氟-3' - （取代苯基）脱氯替巴替坦类似物。 已经发现这些化合物调节神经元尼古丁乙酰胆碱受体，并且可用于治疗受神经元烟碱乙酰胆碱受体调节影响的病症或障碍的方法。