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公开(公告)号：US10822692B2
公开(公告)日：2020-11-03
申请号：US15676189
申请日：2017-08-14
Applicant: University of North Texas
Inventor： Sundeep Mukherjee , Santanu Das
Abstract: An interconnect and a method of making an interconnect between one or more features on a substrate comprises: sputtering a noble metal-copper eutectic thin film under controlled power on an oxide grown or deposited on a substrate; and forming an amorphous alloy structure from the noble metal-copper eutectic thin film in the shape of the interconnect and the interconnect comprising no grain or grain boundaries without temperature sensitive resistivity.
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公开(公告)号：US20200340006A1
公开(公告)日：2020-10-29
申请号：US16831138
申请日：2020-03-26
Applicant: University of North Texas
Inventor： JYOTI SHAH , MONIKA ASHWINKUMAR PATEL , VIJEE MOHAN
IPC: C12N15/82 , C07K14/415
Abstract: Described herein are recombinant polynucleotides and vectors that can encode and/or express WRKY transcription factor polypeptides. Also described herein are recombinant WRKY transcription factor polypeptides. Also described herein are transgenic plant cells and plants that can overexpress a WRKY transcription factor polypeptide and methods of increasing tolerance to abiotic and/or biotic stressors in plants.
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公开(公告)号：US10774328B2
公开(公告)日：2020-09-15
申请号：US16317473
申请日：2017-07-11
Inventor： Gulab Zode
IPC: C07H21/02 , C07H21/04 , C12N15/113 , A61K38/17 , A61K45/06 , A61K31/436 , C07K14/47 , A61K31/5377 , A61K31/4745 , A61K31/155 , A61P27/02
Abstract: The present invention includes a composition and method for the treatment of an eye disease comprising a therapeutically effective amount of an autophagy stimulator that treats or slows the progression of the eye disease by enhancing or stimulating autophagy or correcting an autophagy deficiency.
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公开(公告)号：US10766866B2
公开(公告)日：2020-09-08
申请号：US16175568
申请日：2018-10-30
Inventor： John A. Schetz
IPC: C07D233/64 , A01N33/10 , A01N43/50 , C07C225/10 , A61K31/135 , A61K31/506 , A61K31/137 , A61K31/4164 , A61K45/06 , A61P35/00 , A61K31/4174
Abstract: The present invention related to compounds, compositions, methods of use, and processes for preparing compound which are useful as deterrents for terrestrial arthropods and marine organisms.
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公开(公告)号：US10729497B2
公开(公告)日：2020-08-04
申请号：US16310917
申请日：2017-06-19
Applicant: University of North Texas
Inventor： Narendra Dahotre , Soundarapandian Santhanakrishnan
Abstract: An apparatus and method for laser-assisted machining (LAM) of non-monolithic composite bone material is described. A high intensity focused laser beam conducts bone material removal in extremely short time duration without causing any thermal (necrosis) and mechanical damage to the material surrounding the bone-laser interaction region. A computer associated with the apparatus for machining bone preferably employs a Multiphysics computational modeling approach which takes into account physical phenomena such as heat transfer, fluid flow, convection mixing, and surface tension when determining bone target volume, calculating material properties of the multicomponent and multicomposition composite bone material, determining parameters for the laser-assisted machining based on the material properties, and performing the laser-assisted cutting/shaping/machining of bone.
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Patent Agency Ranking
公开(公告)号：US20200208129A1
公开(公告)日：2020-07-02
申请号：US16645254
申请日：2018-09-10
Inventor： Jin LIU , Zhicheng ZUO , Yu-Chieh Wang
Abstract: Certain embodiments are directed to modified or variant Cas9 proteins, and/or methods of using the same.
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97.发明申请公开(公告)号：US20200181632A1
公开(公告)日：2020-06-11
申请号：US16476895
申请日：2018-01-17
Applicant: UNIVERSITY OF NORTH TEXAS
Inventor： Richard A. DIXON , Nan LU
IPC: C12N15/82
Abstract: The amount of proanthocyanidins (PAs) found in cells of plants can be engineered or adjusted through regulation of transcription factors that affect PA biosynthesis. Increasing expression of genes encoding TT2-type MYB transcription factors, including homologs of AtTT2 of Arabidopsis thaliana such as GHMYB36 or GHMYB IO of cotton plants or GmTT2A or GmTT2B of soybean plants, leads to increased PA content. Expression of these genes can be increased through any suitable methods, including mutation of the genes and transformation of plant cells to include exogenous genes resulting in increased expression.
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公开(公告)号：US20190292156A1
公开(公告)日：2019-09-26
申请号：US16175568
申请日：2018-10-30
Inventor： John A. Schetz
IPC: C07D233/64 , A01N33/10 , A01N43/50 , C07C225/10
Abstract: The present invention related to compounds, compositions, methods of use, and processes for preparing compound which are useful as deterrents for terrestrial arthropods and marine organisms.
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公开(公告)号：US20190247649A1
公开(公告)日：2019-08-15
申请号：US16271209
申请日：2019-02-08
Applicant: UNIVERSITY OF NORTH TEXAS
Inventor： Lingqian CHANG , Yongcun HAO , Ifana MAHBUB , Donghui ZHU , Honglong CHANG
IPC: A61N1/32 , G03F7/32 , A61N1/05 , B32B7/12 , B32B17/06 , B32B27/28 , B32B37/12 , B32B37/18 , B32B38/10 , C23C14/20 , C23C14/35 , H04B5/00 , H01Q1/38
CPC classification number: A61N1/327 , A61N1/0502 , B32B7/12 , B32B17/064 , B32B27/281 , B32B37/12 , B32B37/182 , B32B38/10 , B32B2255/10 , B32B2255/205 , B32B2310/0806 , B32B2311/04 , B32B2379/08 , B32B2457/00 , B32B2535/00 , C23C14/205 , C23C14/35 , G03F7/325 , H01Q1/38 , H04B5/0081
Abstract: In alternative embodiments, provided are products of manufacture and kits, and methods, for delivering macromolecules, including nucleic acids such as DNA and RNA, including genes and protein-encoding nucleic acids, to the skin, or the dermis or epidermis, and mucosa. In alternative embodiments, provided are products of manufacture and kits, and methods, for detecting macromolecules, including nucleic acids such as DNA and RNA, including genes and protein-encoding nucleic acids, in skin, epidermal or mucosal cells. In alternative embodiments, exemplary products of manufacture are physically flexible nanodelivery devices that are wearable, e.g., they can be worn as patches on the skin or mucosa. In alternative embodiments, nanodelivery devices provided herein are fabricated in a microelectrode—microfluidic—nanochannel configuration which can precisely deliver cargo into the ‘touched’ cells upon localized and safe-voltage electroporation. The on-skin electroporation can be wirelessly powered and controlled via on-chip near field communication (NFC) module. An accessory skin sensor can be simultaneously implemented on the same chip for skin impedance detection at the same time.
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公开(公告)号：US20190234967A1
公开(公告)日：2019-08-01
申请号：US16312346
申请日：2017-06-22
Inventor： Sid E. O'Bryant
IPC: G01N33/68
CPC classification number: G01N33/6896 , G01N2333/5409 , G01N2333/5412 , G01N2333/5428 , G01N2333/7151 , G01N2800/2821 , G01N2800/52
Abstract: The present invention includes a method for excluding patients from the need for further analysis of Alzheimer's Disease comprising: obtaining a blood or serum sample from a patient in a primary care setting; determining the expression levels of at least 4 of the following proteins: FABP, beta 2 microglobulin, PPY, soluble tumor necrosis factor receptor 1 (sTNFR1), CRP, VCAM-1, thrombopoietin, α2 macroglobulin, eotaxin 3, tumor necrosis factor-alpha (TNF-α), tenascin C (TNC), IL-5, IL-6, IL-7, IL-10, IL-18, 1309, Factor VII, thymus and activation-regulated chemokine (TARC), serum amyloid A (SAA), and intercellular cell-adhesion molecule-1 (ICAM-1); comparing the level of expression from the sample with a statistically locked-down, multi-ethnic, broad age spectrum statistical sample; and determining if the patient is excluded from further testing for Alzheimer's Disease, thereby eliminating the need for further testing of the patient.
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