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公开(公告)号:US20250064724A1
公开(公告)日:2025-02-27
申请号:US18718963
申请日:2022-11-18
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor: Martin J. MANGINO , Loren K. LIEBRECHT , Jad KHORAKI
Abstract: Bio-artificial blood substitutes are provided for intravenous medical use to restore or increase tissue perfusion and oxygen delivery in a pre-hospital or hospital setting. The bio-artificial blood substitutes comprise three modular components (polyethylene glycol (PEG) polymers to increase perfusion, a hemoglobin-based oxygen carrier (HBOC) plus L-arginine to prove oxygen carrying capacity, and a lyophilized fibrinogen or plasma component to provide hemostasis potential, all of which are administered sequentially in modules to treat low perfusion states with possible coagulopathy as seen in blood loss and shock. The three solutions are stable at ambient temperature and are well-suited for use in the field, e.g., when immediate, critical care is needed such as on the battlefield, during natural disasters or other mass casualty events. Other use may include clinical need for transfusion or for peri-surgical resuscitation in patients unable to receive standard blood products.
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公开(公告)号:US20250034413A1
公开(公告)日:2025-01-30
申请号:US18716703
申请日:2022-12-06
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor: Lucas C. OLSON , Michael J. MCCLURE , Zvi SCHWARTZ , Tri M. NGUYEN , Barbara D. BOYAN
Abstract: A method of decellularizing in an animal tissue includes digesting the animal tissue; treating the animal tissue with a surfactant: treating the animal tissue with at least one zwitterionic detergent to form a decellularized animal tissue; and treating the decellularized animal tissue with at least one advanced glycation end-product (AGE) inhibitor to reduce AGE crosslinking in the decellularized animal tissue. The decellularized animal tissue may be ground into a powder and dissolved in a digest solution to form a bioink composition useful for 3D printing an in vitro model of healthy or diseased tissue.
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公开(公告)号:US20250026892A1
公开(公告)日:2025-01-23
申请号:US18581769
申请日:2024-02-20
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor: Youzhong GUO , Weihua QIU , Thi Kim Hoang TRINH
Abstract: Provided is a functionalized polymer useful for extracting, isolating, and/or purifying membrane proteins with their native protein structures being retained. Also provided are a Native Cell Membrane Nanoparticle (NCMN) system which contains the above functionalized polymer and a membrane protein and a method to characterize and/assess the native structure of the membrane protein.
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94.
公开(公告)号:US20250001697A1
公开(公告)日:2025-01-02
申请号:US18575488
申请日:2022-07-01
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor: Chirayu NIMONKAR , Eli KNIGHT , Ivan C. CARMONA , Ravi L. HADIMANI
Abstract: Anatomically accurate rodent brain models and phantoms, processes for constructing an anatomically correct computer simulation model of a rodent head, and fabricating the accurate rodent brain models and phantoms, and methods for leveraging the accurate rodent brain models and phantoms production are disclosed, and which may be used for simulated and experimental verification of induced electric fields and for experimentally testing neuromodulation and neuroimaging procedures.
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公开(公告)号:US20240328840A1
公开(公告)日:2024-10-03
申请号:US18621317
申请日:2024-03-29
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor: Philip GLASS , Daeha JOUNG
IPC: G01F1/54 , B29C64/106 , B29K105/16 , B29K507/04 , B29L31/34 , B33Y10/00 , B33Y70/10 , B33Y80/00
CPC classification number: G01F1/54 , B29C64/106 , B33Y10/00 , B33Y70/10 , B33Y80/00 , B29K2105/16 , B29K2507/04 , B29L2031/3406
Abstract: Examples include an artificial conductive cilia based sensor having, on a substrate, a conductive pad and a neighbor conductive pad spaced in a direction. A first conductive cilium has a distal end, and a base end conductively secured to the conductive pad, and is particularly structured with bendability and elasticity. A second conductive cilium has a base end conductively secured to the neighbor conductive pad. A terminal is electrically connected to the conductive pad. Another terminal is electrically connected to the neighbor conductive pad. The first conducive cilium, in accordance with the bendability, is bent by a bending force directed in the spacing direction, to a bent state configured to establish a conductive path to the second conductive cilium and via the elasticity, to self-return to a relaxed state configured to terminate the conductive path.
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公开(公告)号:US12071410B2
公开(公告)日:2024-08-27
申请号:US16975434
申请日:2019-02-25
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor: Frank B. Gupton , Saeed Ahmad , Hari P. R. Gunuru , Nakul S. Telang
IPC: C07D215/46 , B01J8/04 , B01J19/00 , B01J19/18 , B01J19/24
CPC classification number: C07D215/46 , B01J8/0492 , B01J19/0013 , B01J19/0066 , B01J19/1862 , B01J19/245 , B01J2219/00033 , B01J2219/0004
Abstract: Cost effective, semi-continuous flow methods and systems for synthesizing the antimalarial drug hydroxychloroquine (HCQ) in high yield are provided. The synthesis method that uses simple, inexpensive reagents to obtain the crucial intermediate 5-(ethyl(2-hydroxyethyl)-amino)pentan-2-one, vertical-integration of the starting material 5-iodopentan-2-one and the integration of continuous stirred tank reactors.
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97.
公开(公告)号:US20240238871A1
公开(公告)日:2024-07-18
申请号:US18440289
申请日:2024-02-13
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor: Hong ZHAO , Radhika BARUA , Ravi L. HADIMANI , Lilly BALDERSON
IPC: B22F10/22 , B22F1/105 , B22F1/107 , B22F5/10 , B22F10/50 , B22F10/60 , B33Y10/00 , B33Y40/20 , B33Y70/00 , B33Y80/00 , H01F1/01 , B22F3/10
CPC classification number: B22F10/22 , B22F1/105 , B22F1/107 , B22F5/10 , B22F10/50 , B22F10/60 , B33Y10/00 , B33Y40/20 , B33Y70/00 , B33Y80/00 , H01F1/015 , B22F3/1021 , B22F2202/05 , B22F2301/355
Abstract: A polymer-assisted 3D printing method and ink compositions are used to manufacture magnetocaloric devices having many applications including in heat pumps, refrigerators, etc. The ink compositions and printing methods can produce compositionally graded, anisotropically aligned magnetocaloric architectures with designed pores and channels, to bring forth significant improvement in heat exchange efficiency.
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98.
公开(公告)号:US20240174612A1
公开(公告)日:2024-05-30
申请号:US18386724
申请日:2023-11-03
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY , IllExcor Therapeutics, LLC , KING ABDULAZIZ UNIVERSITY , CHILDREN'S HOSPITAL OF PHILADELPHIA (CHOP)
Inventor: Martin SAFO , Yan ZHANG , Andrew FLEISCHMAN , David LIGHT , Moustafa EL-ARABY , Abdelsattar OMAR , Osheiza ABDULMALIK
IPC: C07D213/30 , A61P7/06 , C07D239/26
CPC classification number: C07D213/30 , A61P7/06 , C07D239/26
Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are chemically modified to increase bioavailability and activity, e.g., so that the compounds prevent adhesion and sickling of red blood cells (RBCs).
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公开(公告)号:US11899015B1
公开(公告)日:2024-02-13
申请号:US18049022
申请日:2022-10-24
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor: Richard Marconi
IPC: G01N33/569 , C12Q1/6883 , C12Q1/689 , C07K14/20
CPC classification number: G01N33/56911 , C07K14/20 , C12Q1/689 , C12Q1/6883 , C07K2319/21 , G01N2333/20
Abstract: Chimeric recombinant proteins for the detection of infection by Borreliella and/or diagnosis of Lyme disease are provided. Methods and devices for conducting immunoassays with the chimeric recombinant proteins are also provided.
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公开(公告)号:US20230372445A1
公开(公告)日:2023-11-23
申请号:US17945993
申请日:2022-09-15
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor: Kirsty J. Dixon
IPC: A61K38/19 , C12N5/0775 , A61P25/00 , A61K47/10
CPC classification number: A61K38/191 , C12N5/0668 , A61P25/00 , A61K47/10
Abstract: A method for treating a subject suffering from chronic multisystem illness, specifically gulf war illness, includes administering to the subject a therapeutically effective amount of a selective inhibitor of solTNF, whereby the subject is treated. In some embodiments, the selective inhibitor of solTNF includes a DN-TNF protein variant and/or a nucleic acid encoding the DN-TNF protein variant. In some embodiments, the DN-TNF protein variant includes XPro1595.
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