公开(公告)号：US20080057152A1

公开(公告)日：2008-03-06

申请号：US11868743

申请日：2007-10-08

Applicant: Andrew Miller ,  Sandy Bollengier-Lee ,  Simon Hall

Inventor： Andrew Miller ,  Sandy Bollengier-Lee ,  Simon Hall

IPC: A23K1/18 ,  A23D7/005 ,  A23D7/02

CPC classification number: A23K50/40 ,  A23K40/00

Abstract: The present invention relates to a method of ensuring acceptance of a foodstuff to said cat by providing said foodstuff with specific macronutrient content parameters. The present invention provides a method of ensuring the acceptance of a foodstuff to a cat, the method comprising feeding to said cat, a foodstuff having a protein:energy ratio of from 40 to 60%, a carbohydrate:energy ratio of 25% or less and a fat:energy ratio of from 15 to 60%, wherein the energy ratios are based on the total energy content of the foodstuff.

Abstract translation: 本发明涉及通过向所述食品提供特定的大量营养素含量参数来确保食品接受所述猫的方法。 本发明提供了一种确保食品接受猫的方法，该方法包括向所述猫喂食蛋白质：能量比为40〜60％，碳水化合物：能量比为25％以下的食品 脂肪：能量比为15〜60％，其中能量比基于食品的总能量含量。

公开(公告)号：US20070190634A1

公开(公告)日：2007-08-16

申请号：US11786150

申请日：2007-04-11

Applicant: David Bebbington ,  Hayley Binch ,  Jean-Damien Charrier ,  Simon Everitt ,  Julian Golec ,  David Kay ,  Ronald Knegtel ,  Andrew Miller ,  Francoise Pierard

Inventor： David Bebbington ,  Hayley Binch ,  Jean-Damien Charrier ,  Simon Everitt ,  Julian Golec ,  David Kay ,  Ronald Knegtel ,  Andrew Miller ,  Francoise Pierard

IPC: C02F3/34

CPC classification number: C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

公开(公告)号：US20070044357A1

公开(公告)日：2007-03-01

申请号：US11530302

申请日：2006-09-08

Applicant: John Biondo ,  Jeffrey DeMarb ,  Steven Flank ,  Andrew Miller ,  Glenn Ostrom ,  Stephen Spelbring

Inventor： John Biondo ,  Jeffrey DeMarb ,  Steven Flank ,  Andrew Miller ,  Glenn Ostrom ,  Stephen Spelbring

IPC: G09F13/22

CPC classification number: G09F9/33 ,  G09F9/3026 ,  G09F13/20 ,  G09F13/22 ,  G09F19/22 ,  G09F21/04

Abstract: An illuminated sign includes a plurality of sections. Each section includes a mesh of conductors having illuminating pixels located at conductor intersections. The mesh is surrounded by a frame connected to the frame of another section. Once frame sections of the display are unfolded, the display can be supported by a structure attached to a car or other vehicle. A support structure for an illuminated display includes a base which is placed on the ground and over which the tire of a vehicle (e.g., a police car) is parked. A column extends from the base, and a display can be attached to the top of that extending column.

Abstract translation: 照明标志包括多个部分。 每个部分包括具有位于导体交叉处的照明像素的导体网格。 网格被连接到另一部分的框架的框架包围。 一旦显示器的框架部分展开，显示器可以由附接到汽车或其他车辆的结构来支撑。 用于照明显示器的支撑结构包括放置在地面上并且车辆（例如警车）的轮胎被停放的基座。 列从基座延伸，显示器可以附着到该延伸柱的顶部。

公开(公告)号：US20070010457A1

公开(公告)日：2007-01-11

申请号：US11522375

申请日：2006-09-14

Applicant: Anita Diu-Hercend ,  Julian Golec ,  Thierry Hercend ,  Ronald Knegtel ,  Paul Lang ,  Andrew Miller ,  Karen Miller ,  Michael Mortimore ,  Peter Weber

Inventor： Anita Diu-Hercend ,  Julian Golec ,  Thierry Hercend ,  Ronald Knegtel ,  Paul Lang ,  Andrew Miller ,  Karen Miller ,  Michael Mortimore ,  Peter Weber

IPC: A61K38/04 ,  A61K31/497 ,  A61K31/4709 ,  A61K31/454

CPC classification number: C07D401/06 ,  C07D211/60 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

Abstract: The present invention relates to novel classes of compounds of formula I which are caspase and TNF-alpha inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase and TNF-alpha activity and consequently, can be advantageously used as agents against caspase-, interleukin-1-(“IL-1”), apoptosis-, interferon-y inducing factor-(IGIF), interferon-γ-(“IFN-γ”), or TNF-alpha mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to processes for preparing the compounds of this invention. This invention also relates to methods for inhibiting caspase and TNF-alpha activity and decreasing IGIF production and IFN-γ production and methods for treating caspase-, interleukin-1, apoptosis-, and interferon-γ-, and TNF-alpha mediated diseases using the compounds and compositions of this invention.

Abstract translation: 本发明涉及新型的式I化合物，其为半胱天冬酶和TNF-α抑制剂。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制半胱天冬酶和TNF-α活性，因此可有利地用作抗半胱天冬酶，白细胞介素-1（“IL-1”），细胞凋亡 - 干扰素 - γ诱导因子（IGIF），干扰素-γ-（“IFN-γ”）或TNF-α介导的疾病，包括炎性疾病，自身免疫性疾病，破坏性骨病，增殖性疾病，感染性疾病和退行性疾病。 本发明还涉及制备本发明化合物的方法。 本发明还涉及用于抑制半胱天冬酶和TNF-α活性并减少IGIF产生和IFN-γ产生的方法以及用于治疗半胱天冬酶，白细胞介素-1，细胞凋亡和干扰素γ和TNF-α介导的疾病的方法，其使用 本发明的化合物和组合物。

公开(公告)号：US20060270660A1

公开(公告)日：2006-11-30

申请号：US11500981

申请日：2006-08-09

Applicant: Jean-Damien Charrier ,  Francesca Mazzei ,  David Kay ,  Andrew Miller

Inventor： Jean-Damien Charrier ,  Francesca Mazzei ,  David Kay ,  Andrew Miller

IPC: A61K31/551 ,  A61K31/5377 ,  A61K31/513 ,  C07D403/14 ,  C07D413/14

CPC classification number: C07D403/14 ,  C07D239/34 ,  C07D401/14 ,  C07D403/12 ,  C07D453/02

Abstract: The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.

Abstract translation: 本发明提供了制备三取代和四取代嘧啶的简便方法。 该方法可用于制备蛋白激酶抑制剂，特别是Aurora激酶。 这些抑制剂可用于治疗或减轻Aurora介导的疾病或病症的严重性。

公开(公告)号：US20060156247A1

公开(公告)日：2006-07-13

申请号：US11026349

申请日：2004-12-30

Applicant: Michael McCormack ,  Christopher Bryant ,  Andrew Miller ,  Robert Coggins ,  Scott Gardner

Inventor： Michael McCormack ,  Christopher Bryant ,  Andrew Miller ,  Robert Coggins ,  Scott Gardner

IPC: G06F17/00 ,  G06F3/00 ,  G06F9/00

CPC classification number: G06F3/048 ,  G06F3/0481

Abstract: A user interface (UI) includes floating action buttons. Respective hot zones are established for associated respective UI elements. When a focus is targeting (e.g., located at) a given hot zone, one or more floating action buttons that are associated therewith are presented as part of the UI. Activation of a particular action button of the one or more floating action buttons causes an action corresponding to the particular action button to be implemented. In an example implementation, the actions available through the one or more floating action buttons may be context-sensitive such that the actions thereof are tailored to the type of item corresponding to the UI element (e.g., an icon, a graphical element, a text portion, a screen area, etc.).

Abstract translation: 用户界面（UI）包括浮动操作按钮。 针对相应的UI元素建立各个热区。 当焦点瞄准（例如位于）给定的热区时，与其相关联的一个或多个浮动动作按钮被呈现为UI的一部分。 激活一个或多个浮动动作按钮的特定动作按钮将导致与特定动作按钮对应的动作被实现。 在示例实现中，通过一个或多个浮动动作按钮可用的动作可以是上下文相关的，使得其动作被定制为与UI元素相对应的项目的类型（例如，图标，图形元素，文本 部分，屏幕区域等）。

公开(公告)号：US20060017658A1

公开(公告)日：2006-01-26

申请号：US11079474

申请日：2005-03-15

Applicant: John Biondo ,  Ravi Sawhney ,  Kurt Botsai ,  Lance Hussey ,  Craig Steele ,  Simon Risley ,  Michael Schuffert ,  Jeffrey Demarb ,  Shalom Flank ,  Andrew Miller ,  Glenn Ostrom ,  Stephen Spelbring ,  Stephen Velte

Inventor： John Biondo ,  Ravi Sawhney ,  Kurt Botsai ,  Lance Hussey ,  Craig Steele ,  Simon Risley ,  Michael Schuffert ,  Jeffrey Demarb ,  Shalom Flank ,  Andrew Miller ,  Glenn Ostrom ,  Stephen Spelbring ,  Stephen Velte

IPC: G09G3/00

CPC classification number: G09F9/33 ,  G09F9/3026 ,  G09F13/20 ,  G09F13/22 ,  G09F19/22 ,  G09F21/04

Abstract: An illuminated sign includes a plurality of sections. Each section includes a mesh of conductors having illuminating pixels located at conductor intersections. The mesh is surrounded by a frame connected to the frame of another section. Once frame sections of the display are unfolded, the display can be supported by a structure attached to a car or other vehicle. A support structure for an illuminated display includes a base which is placed on the ground and over which the tire of a vehicle (e.g., a police car) is parked. A column extends from the base, and a display can be attached to the top of that extending column. The support structure can take the form of a collapsible stand having a trunk which is pivotally attached to a base and which contains a telescoping section.

Abstract translation: 照明标志包括多个部分。 每个部分包括具有位于导体交叉处的照明像素的导体网格。 网格被连接到另一部分的框架的框架包围。 一旦显示器的框架部分展开，显示器可以由附接到汽车或其他车辆的结构来支撑。 用于照明显示器的支撑结构包括放置在地面上并且车辆（例如警车）的轮胎被停放的基座。 列从基座延伸，显示器可以附着到该延伸柱的顶部。 支撑结构可以采用具有枢转地附接到基座并且包含伸缩部分的躯干的可折叠支架的形式。

公开(公告)号：US20060003968A1

公开(公告)日：2006-01-05

申请号：US11098751

申请日：2005-04-04

Applicant: Jeremy Green ,  Andrew Miller ,  Juan-Miguel Jimenez ,  Craig Marhefka ,  Jingrong Cao ,  John Court ,  Upul Bandarage ,  Huai Gao ,  Suganthini Nanthakumar

Inventor： Jeremy Green ,  Andrew Miller ,  Juan-Miguel Jimenez ,  Craig Marhefka ,  Jingrong Cao ,  John Court ,  Upul Bandarage ,  Huai Gao ,  Suganthini Nanthakumar

IPC: A61K31/675 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：US20050184053A1

公开(公告)日：2005-08-25

申请号：US10978314

申请日：2004-10-28

Applicant: Andrew Wilkinson ,  Faye Smith ,  Andrew Miller

Inventor： Andrew Wilkinson ,  Faye Smith ,  Andrew Miller

IPC: B29C65/34 ,  B29C65/36 ,  H05B6/02 ,  H05B3/34

CPC classification number: B29C65/3636 ,  B29C65/344 ,  B29C65/3492 ,  B29C65/3496 ,  B29C65/364 ,  B29C65/3676 ,  B29C65/3684 ,  B29C66/1122 ,  B29C66/1142 ,  B29C66/43 ,  B29C66/5221 ,  B29C66/71 ,  B29C66/7212 ,  B29C66/73921 ,  B29C66/91411 ,  B29C66/91423 ,  B29C66/9161 ,  B29C66/91651 ,  B29C66/91653 ,  B29K2101/12 ,  B29K2307/00 ,  B29K2077/00 ,  B29K2309/08 ,  B29K2023/10 ,  B29K2075/00 ,  B29K2067/00

Abstract: A method for bonding thermoplastic substrates is provided. A thin, porous, resistive heater is provided between layers of thermoplastic substrates to be bonded in the absence of an adhesive. The fabric heater is in intimate contact with the substrates at the joint by application of pressure. When the heater is energized, the thermoplastic material at the joint is melted or softened, and becomes uniformly distributed in the weld. After cooling, the fabric heater remains within the weld area and provides increased reinforcement to the weld bond.

Abstract translation: 提供了一种用于粘合热塑性基材的方法。 在不存在粘合剂的情况下，在要接合的热塑性基材层之间提供薄的，多孔的电阻加热器。 织物加热器通过施加压力与接头处的基底紧密接触。 当加热器通电时，接头处的热塑性材料熔化或软化，并均匀分布在焊缝中。 冷却后，织物加热器保持在焊接区域内，并为焊接接合提供增强的加固。

公开(公告)号：US20050112663A1

公开(公告)日：2005-05-26

申请号：US10976647

申请日：2004-10-29

Applicant: Andrew Miller ,  Ping Hu ,  Mark Curran ,  Marc Rutter ,  Jian-Yang Wang

Inventor： Andrew Miller ,  Ping Hu ,  Mark Curran ,  Marc Rutter ,  Jian-Yang Wang

IPC: C07K14/705 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/22

CPC classification number: C07K14/705 ,  A01K2217/05

Abstract: Methods for isolating K+Hnov genes are provided. The K+Hnov nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.