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    Ion chromatography systems with flow-delay eluent recycle
    91.
    发明申请
    Ion chromatography systems with flow-delay eluent recycle 审中-公开
    具有流动延迟洗脱液回收的离子色谱系统

    公开(公告)号：US20090289009A1

    公开(公告)日：2009-11-26

    申请号：US12511788

    申请日：2009-07-29

    Applicant: Yan Liu ,  Kannan Srinivasan ,  Christopher A. Pohl ,  Sheetal Bhardwaj ,  Zhongqing Lu

    Inventor： Yan Liu ,  Kannan Srinivasan ,  Christopher A. Pohl ,  Sheetal Bhardwaj ,  Zhongqing Lu

    IPC: G01N30/00 ,  B01D15/08 ,  B01J23/38

    CPC classification number: B01D15/10 ,  G01N30/26 ,  G01N30/96 ,  G01N2030/965

    Abstract: A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.

    Abstract translation: 一种色谱方法，包括在洗脱液流中色谱分离样品离子物质，检测分离的样品离子物质，催化结合氢气和氧气，或催化分解催化气体消除室中的过氧化氢，并将来自室的流出物流再循环至色谱 分离柱。 检测器和腔室之间的停留时间至少约1分钟。 此外，使循环物依次流过电解膜抑制器的两个检测器流出物流动通道。 此外，在检测器和室之间施加热或UV能量。 另外，在室后检测气泡。 此外，铂族金属催化剂和离子交换介质在室内。 用于执行方法的装置。

    ION CHROMATOGRAPHY SYSTEMS WITH FLOW-DELAY ELUENT RECYCLE
    92.
    发明申请
    ION CHROMATOGRAPHY SYSTEMS WITH FLOW-DELAY ELUENT RECYCLE 有权
    离子色谱系统与流延迟回收

    公开(公告)号：US20090211980A1

    公开(公告)日：2009-08-27

    申请号：US12036147

    申请日：2008-02-22

    Applicant: Yan Liu ,  Kannan Srinivasan ,  Christopher A. Pohl ,  Sheetal Bhardwaj ,  Zhongqing Lu

    Inventor： Yan Liu ,  Kannan Srinivasan ,  Christopher A. Pohl ,  Sheetal Bhardwaj ,  Zhongqing Lu

    IPC: B01D15/08

    CPC classification number: B01D15/10 ,  G01N30/26 ,  G01N30/96 ,  G01N2030/965

    Abstract: A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.

    Abstract translation: 一种色谱方法，包括在洗脱液流中色谱分离样品离子物质，检测分离的样品离子物质，催化结合氢气和氧气，或催化分解催化气体消除室中的过氧化氢，并将来自室的流出物流再循环至色谱 分离柱。 检测器和腔室之间的停留时间至少约1分钟。 此外，使循环物依次流过电解膜抑制器的两个检测器流出物流动通道。 此外，在检测器和室之间施加热或UV能量。 另外，在室后检测气泡。 此外，铂族金属催化剂和离子交换介质在室内。 用于执行方法的装置。

    Pulsed electrochemical detection method
    93.
    发明授权
    Pulsed electrochemical detection method 有权
    脉冲电化学检测方法

    公开(公告)号：US07566392B2

    公开(公告)日：2009-07-28

    申请号：US11403565

    申请日：2006-04-12

    Applicant: Jun Cheng ,  Petr Jandik ,  Xiaodong Liu ,  Christopher A. Pohl

    Inventor： Jun Cheng ,  Petr Jandik ,  Xiaodong Liu ,  Christopher A. Pohl

    IPC: G01N27/403

    CPC classification number: G01N27/49

    Abstract: In one embodiment, the present invention is directed to a pulsed electrochemical detection method comprising (a) flowing a liquid sample stream including at least one analyte past a working electrode in a flow-through cell; (b) applying at least three pulsed electrical potentials to the working electrode, (1) a first conditioning potential, (2) a second detection and oxidative cleaning potential, and (3) a third reductive cleaning potential, said second potential being higher than said first and third potentials and said first potential being higher than said third potential; and (c) detecting the output from said working electrode during the time period of applying said second potential.

    Abstract translation: 在一个实施方案中，本发明涉及脉冲电化学检测方法，其包括（a）将包含至少一种分析物的液体样品流流过流通池中的工作电极; （b）向工作电极施加至少三个脉冲电势，（1）第一调节电位，（2）第二检测和氧化清洗电位，和（3）第三还原清洗电位，所述第二电位高于 说第一和第三个潜力，并说第一个潜力高于第三个潜力; 以及（c）在施加所述第二电位的时间段期间检测来自所述工作电极的输出。

    Chemical suppressors and method of use
    96.
    发明授权
    Chemical suppressors and method of use 有权
    化学抑制剂及其使用方法

    公开(公告)号：US07517696B2

    公开(公告)日：2009-04-14

    申请号：US10356345

    申请日：2003-01-30

    Applicant: Kannan Srinivasan ,  Christopher A. Pohl

    Inventor： Kannan Srinivasan ,  Christopher A. Pohl

    IPC: G01N30/84

    CPC classification number: G01N30/96 ,  B01D15/367 ,  B01D61/48 ,  Y10T436/25

    Abstract: A non-electrolytic method and apparatus for treating an aqueous sample stream including analyte ions and matrix ions of opposite charge, for pretreatment or suppression. The apparatus includes an ion exchange membrane capable of passing only ions of opposite charge to the analyte ions, a sample stream flow channel, a first aqueous stream ion receiving flow channel adjacent one side of the sample stream flow channel and separated therefrom by the first ion exchange membrane, and stationary flow-through ion exchange packing disposed in the sample stream flow channel. The ion receiving channel has an ion exchange capacity for the matrix ions less than about 25% of the ion exchange capacity for the matrix ions.

    Abstract translation: 一种用于处理包含分析物离子和相反电荷的基质离子的水样品流的非电解方法和装置，用于预处理或抑制。 该装置包括能够仅将相反电荷的离子通过到分析物离子的离子交换膜，样品流流动通道，邻近样品流流动通道的一侧的第一含水流离子接收流动通道，并由第一离子 交换膜和设置在样品流流动通道中的固定流通离子交换填料。 离子接收通道对于基质离子的离子交换容量小于基质离子的离子交换容量的约25％。

    Latex based adsorbent chip
    97.
    发明授权
    Latex based adsorbent chip 失效
    乳胶基吸附剂芯片

    公开(公告)号：US07517496B2

    公开(公告)日：2009-04-14

    申请号：US09908518

    申请日：2001-07-17

    Applicant: Christopher A. Pohl

    Inventor： Christopher A. Pohl

    IPC: B01D15/10 ,  G01N30/00

    CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00576 ,  B01J2219/00648 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0887 ,  C07B2200/11 ,  C40B40/06 ,  C40B40/10 ,  G01N33/54393

    Abstract: The present invention provides an adsorbent chip, which includes three components, a substrate, an intermediate layer of linker arms and an adsorbent film, which is attached to the linker arms. The adsorbent film is made up of a plurality of adsorbent particles, each of which includes a binding functionality. The invention also provides a method of making the chips of the invention in which the substrate-intermediate film cassette is formed and the adsorbent film is subsequently immobilized thereon. When the adsorbent film is from the same preparation across a particular batch of chips, the chips provide for the acquisition of data that are highly reproducible from one chip to the next throughout the particular batch of chips. Additionally, the invention provides methods for using the chips to perform assays.

    Abstract translation: 本发明提供了一种吸附剂芯片，其包括三个组分，一个底物，一个连接臂的中间层和一个吸附膜，该吸附剂膜连接在连接臂上。 吸附剂膜由多个吸附剂颗粒组成，每个吸附剂颗粒包括结合功能。 本发明还提供一种制造本发明的芯片的方法，其中形成衬底 - 中间膜盒并随后将吸附膜固定在其上。 当吸附剂薄膜来自相同的制剂时，芯片提供了在整个特定批次的芯片中从一个芯片到下一个芯片高度可重现的数据采集。 另外，本发明提供了使用芯片进行测定的方法。

    COMPOSITIONS USEFUL AS CHROMATOGRAPHY STATIONARY PHASES
    98.
    发明申请
    COMPOSITIONS USEFUL AS CHROMATOGRAPHY STATIONARY PHASES 有权
    组合物作为色谱固定相使用

    公开(公告)号：US20080293959A1

    公开(公告)日：2008-11-27

    申请号：US11753934

    申请日：2007-05-25

    Applicant: Xiaodong Liu ,  Christopher A. Pohl ,  Jinhua Chen

    Inventor： Xiaodong Liu ,  Christopher A. Pohl ,  Jinhua Chen

    IPC: C07F7/08

    CPC classification number: B01J20/288 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3257 ,  B01J20/3259 ,  B01J20/3263 ,  B01J20/3285

    Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC). The compositions include a substrate (e.g., silica gel), covalently bound to a compound, which includes both a hydrophobic moiety and a hydrophilic moiety, which is preferably a 1,2-diol moiety. The hydrophobic moiety is sufficiently hydrophobic for the compositions to exhibit reversed phase characteristics and typically incorporates at least 5 carbon atoms in sequence. Based on having both hydrophilic and hydrophobic functionalities, the new stationary phases exhibit unique chromatographic properties. For example, these media can be used in either hydrophilic (HILIC) mode, in which the mobile phase includes a high percentage of an organic solvent, or in reversed phase mode, in which the mobile phase contains a higher percentage of an aqueous solvent. The current invention also provides methods of making and using the compounds and compositions of the invention.

    Abstract translation: 本发明提供组合物，其可用作多种色谱应用的固定相，例如高效液相色谱（HPLC）。 组合物包括与包含疏水部分和亲水部分的化合物共价结合的底物（例如硅胶），其优选为1,2-二醇部分。 疏水部分足够疏水以使组合物显示反相特性，并通常依次包含至少5个碳原子。 基于具有亲水和疏水官能度，新的固定相显示出独特的色谱性质。 例如，这些介质可用于亲水（HILIC）模式，其中流动相包含高百分比的有机溶剂，或以相反模式使用，其中流动相含有较高百分比的水性溶剂。 本发明还提供了制备和使用本发明化合物和组合物的方法。

    Preformed polymer coating process and product
    100.
    发明授权
    Preformed polymer coating process and product 失效

    公开(公告)号：US5792331A

    公开(公告)日：1998-08-11

    申请号：US770628

    申请日：1996-12-19

    Applicant: Kannan Srinivasan ,  Neboisa Avdalovic ,  Christopher A. Pohl

    Inventor： Kannan Srinivasan ,  Neboisa Avdalovic ,  Christopher A. Pohl

    IPC: B01J20/286 ,  B01J20/32 ,  G01N27/447 ,  G01N27/26

    CPC classification number: B01J20/286 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3278 ,  B01J20/3282 ,  G01N27/44704 ,  G01N27/44752

    Abstract: A method of coating a solid support (e.g. a capillary or chromatography packing) to alter the properties of the support surface for separating components in a fluid stream. The method comprises (a) covalently binding a coupling agent (including functional groups capable of forming free radical sites under hydrogen abstraction conditions) to the support surface in a uniform layer, and (b) thereafter, contacting the bound coupling agent with a solution of preformed polymer comprising totally saturated carbon chain backbones including leaving groups, under hydrogen abstraction conditions of elevated temperature in the presence of a free radical catalyst to remove leaving groups from the carbon chains to form free radical carbon binding sites which covalently bond to the coupling agent layer and to crosslink at least some of the preformed polymer through the free radical carbon binding sites to form a dimensional polymer network coating on said solid support surface. Alternatively, the coating is applied directly to an organic solid support without an intermediate coupling agent.

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