公开(公告)号：US12290436B2

公开(公告)日：2025-05-06

申请号：US17316885

申请日：2021-05-11

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Elena Sherman ,  Tamir S. Levi ,  Ziv Yohanan ,  Gil Senesh ,  Dikla Kersh ,  Alexey Tsypenyuk ,  Waina Michelle Chu ,  Alexander Barash

IPC: A61F2/24 ,  A61F2/90

Abstract: A prosthetic heart valve can include a radially expandable and compressible frame having an inflow end portion and an outflow end portion, the frame comprising a plurality of struts defining openings between them. The prosthetic valve can further include a valvular structure comprising a plurality of leaflets, each leaflet comprising a main body, opposing tabs on opposite sides of the main body, a coaptation edge portion, and a cusp edge portion. Each tab can be paired with an adjacent tab of an adjacent leaflet to form a plurality of commissures that are fixed relative to the frame, and each leaflet can have opposing edge portions between the opposing tabs and the cusp edge portion that are unattached to the frame, each unattached edge portion defining a gap that extends radially into the main body of the leaflet.

公开(公告)号：US12226312B2

公开(公告)日：2025-02-18

申请号：US18316942

申请日：2023-05-12

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Elena Sherman ,  Tamir S. Levi ,  Ziv Yohanan ,  Gil Senesh ,  Dikla Kersh ,  Alexey Tsypenyuk ,  Waina Michelle Chu ,  Alexander Barash

IPC: A61F2/24 ,  A61F2/90

Abstract: A prosthetic heart valve can include a radially expandable and compressible frame having an inflow end, an outflow end, and a plurality of struts. The prosthetic valve can further include a valvular structure comprising a plurality of leaflets, each leaflet comprising a coaptation edge portion and a cusp edge portion. The cusp edge portion of each leaflet can be folded toward the outflow end of the frame along a bending axis and a reinforcing member extends along an outflow surface of the cusp edge portion along the bending axis. The prosthetic heart valve can include a plurality of connecting skirts, each disposed between the cusp edge portion of an adjacent leaflet and the frame. First stitching secures the reinforcing member and the connecting skirts to the cusp edge portions and second stitching secures the connecting skirts to selected struts of the frame.

公开(公告)号：US20250041053A1

公开(公告)日：2025-02-06

申请号：US18920663

申请日：2024-10-18

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi ,  Shahram Zamani ,  Michael Bukin ,  Ziv Yohanan ,  Noam Nir ,  Tyler Dale O'Dell ,  Elena Sherman

IPC: A61F2/24

Abstract: A method of assembling a valvular structure can include folding an upper tab of a first leaflet onto a lower tab of the first leaflet, disposing a first end of a reinforcing member on the upper tab, disposing a commissure member adjacent the lower tab, and coupling the first end of the reinforcing member, the tabs of the first leaflet, and the commissure member to one another. The method can further include folding an upper tab of a second leaflet onto a lower tab of the second leaflet, disposing the second leaflet adjacent the first leaflet such that the commissure member is positioned between the lower tabs, disposing a second end of the reinforcing member on the upper tab of the second leaflet, and coupling the reinforcing member, the upper and lower tabs of the second leaflet, and the commissure member to one another to form a commissure.

公开(公告)号：US12201522B2

公开(公告)日：2025-01-21

申请号：US18207822

申请日：2023-06-09

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Alexander Barash ,  Yair A. Neumann ,  Tomer Saar ,  Ziv Yohanan ,  Noam Nir

IPC: A61F2/24 ,  A61F2/844 ,  A61F2/95

Abstract: In one embodiment, a method of assembling a prosthetic valve can comprise forming a radially expandable and compressible frame by pivotally joining together a plurality of struts without requiring individual rivets. In some embodiments, the frame is formed by interweaving the struts, which can be joined using integral hinges formed in the struts, such as by performing alternate cuts on the struts, bending the struts to form stopper tabs adjacent to joints and/or drilling holes in the struts to facilitate interconnecting struts at joints, or otherwise forming integral hinges and corresponding holes at junction points between the struts. In other embodiments, separate hinges are provided to interconnect the struts. In still other embodiments, separate flanged rivets are provided to connect the struts.

公开(公告)号：US20240415645A1

公开(公告)日：2024-12-19

申请号：US18817003

申请日：2024-08-27

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Alexander Barash ,  Yair A. Neumann ,  Tomer Saar ,  Ziv Yohanan ,  Noam Nir

IPC: A61F2/24 ,  A61F2/844 ,  A61F2/95

Abstract: In one embodiment, a method of assembling a prosthetic valve can comprise forming a radially expandable and compressible frame by pivotally joining together a plurality of struts without requiring individual rivets. In some embodiments, the frame is formed by interweaving the struts, which can be joined using integral hinges formed in the struts, such as by performing alternate cuts on the struts, bending the struts to form stopper tabs adjacent to joints and/or drilling holes in the struts to facilitate interconnecting struts at joints, or otherwise forming integral hinges and corresponding holes at junction points between the struts. In other embodiments, separate hinges are provided to interconnect the struts. In still other embodiments, separate flanged rivets are provided to connect the struts.

公开(公告)号：US20240299171A1

公开(公告)日：2024-09-12

申请号：US18664182

申请日：2024-05-14

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi ,  Ziv Yohanan ,  Assaf Bash

IPC: A61F2/24

CPC classification number: A61F2/2463 ,  A61F2/2418 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0075 ,  A61F2250/0063 ,  A61F2250/0098

Abstract: A method of valve implantation includes installing a leaflet lasso on a host leaflet assembly at an implantation site within a patient's body. The method includes positioning an expandable prosthetic heart valve in a crimped state within a central region of the host leaflet assembly. The method includes radially expanding the prosthetic heart valve to a working diameter. During at least a portion of radially expanding the prosthetic heart valve, the prosthetic heart valve contacts a central lasso portion of the leaflet lasso and applies a radial force to the central lasso portion that results in folding of at least one leaflet of the leaflet assembly.

公开(公告)号：US20230270541A1

公开(公告)日：2023-08-31

申请号：US18195288

申请日：2023-05-09

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi ,  Shahram Zamani ,  Michael Bukin ,  Ziv Yohanan ,  Noam Nir ,  Tyler Dale O'Dell ,  Elena Sherman

IPC: A61F2/24

CPC classification number: A61F2/2415 ,  A61F2/2418 ,  A61F2220/0075

Abstract: A method of assembling a valvular structure can include folding an upper tab of a first leaflet onto a lower tab of the first leaflet, disposing a first end of a reinforcing member on the upper tab, disposing a commissure member adjacent the lower tab, and coupling the first end of the reinforcing member, the tabs of the first leaflet, and the commissure member to one another. The method can further include folding an upper tab of a second leaflet onto a lower tab of the second leaflet, disposing the second leaflet adjacent the first leaflet such that the commissure member is positioned between the lower tabs, disposing a second end of the reinforcing member on the upper tab of the second leaflet, and coupling the reinforcing member, the upper and lower tabs of the second leaflet, and the commissure member to one another to form a commissure.

公开(公告)号：US11717400B2

公开(公告)日：2023-08-08

申请号：US17114251

申请日：2020-12-07

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander Barash ,  Yair A. Neumann ,  Tomer Saar ,  Ziv Yohanan ,  Noam Nir

IPC: A61F2/24 ,  A61F2/95 ,  A61F2/844

CPC classification number: A61F2/2418 ,  A61F2/243 ,  A61F2/2439 ,  A61F2/2436 ,  A61F2/844 ,  A61F2/9517 ,  A61F2002/9511

Abstract: In one embodiment, a method of assembling a prosthetic valve can comprise forming a radially expandable and compressible frame by pivotally joining together a plurality of struts without requiring individual rivets. In some embodiments, the frame is formed by interweaving the struts, which can be joined using integral hinges formed in the struts, such as by performing alternate cuts on the struts, bending the struts to form stopper tabs adjacent to joints and/or drilling holes in the struts to facilitate interconnecting struts at joints, or otherwise forming integral hinges and corresponding holes at junction points between the struts. In other embodiments, separate hinges are provided to interconnect the struts. In still other embodiments, separate flanged rivets are provided to connect the struts.

公开(公告)号：US20230190459A1

公开(公告)日：2023-06-22

申请号：US18108259

申请日：2023-02-10

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Nir ,  Tamir S. Levi ,  Ziv Yohanan ,  Michael Bukin ,  Elena Sherman ,  Yana Mayatskaya

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/243 ,  A61F2220/0075

Abstract: A prosthetic valve includes a radially expandable and compressible annular frame and a valvular structure. The frame includes a first strut and an adjacent second strut that overlap at a pivot joint. Radial expansion or compression of the frame causes the first strut to pivot relative to the second strut at the pivot joint. The valvular structure includes first and second leaflets attached to the first and second struts with a suture. The first and second struts define four strut segments connected by the pivot joint. The suture comprises three interconnected locking knots that are respectively attached to three of the four strut segments.

公开(公告)号：US11628062B2

公开(公告)日：2023-04-18

申请号：US17707127

申请日：2022-03-29

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolai Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.