公开(公告)号：US07271170B2

公开(公告)日：2007-09-18

申请号：US10898690

申请日：2004-07-23

申请人： Linghong Xie ,  Bingsong Han ,  Yuelian Xu ,  George Maynard ,  Bertrand L. Chenard ,  Kenneth Shaw ,  Yang Gao

发明人： Linghong Xie ,  Bingsong Han ,  Yuelian Xu ,  George Maynard ,  Bertrand L. Chenard ,  Kenneth Shaw ,  Yang Gao

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/24 ,  A61P25/22 ,  A61P25/20

CPC分类号： C07D487/04

摘要： Compounds of Formula I are provided, as are methods for their preparation. The variables Z1, Z2, Z3, R4, R5, R6, R7, R8 and Ar in the above formula are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).

摘要翻译： 提供了式I化合物，以及其制备方法。 变量Z 1，Z 2，Z 3，R 4，R 5，/或 >，R 6，R 7，R 8和Ar如上所定义。 这样的化合物可用于在体内或体外调节配体与GABA A A受体的结合，并且特别可用于治疗人类中的各种中枢神经系统（CNS）紊乱，驯养伴侣动物 和牲畜。 本文提供的化合物可以单独施用或与一种或多种其它CNS剂组合施用，以增强其它CNS剂的作用。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这种配体检测GABA A受体的方法（例如，受体定位研究）。

公开(公告)号：US07266493B2

公开(公告)日：2007-09-04

申请号：US11251179

申请日：2005-10-13

申请人： Huan-Yu Su ,  Yang Gao

发明人： Huan-Yu Su ,  Yang Gao

IPC分类号： G10L11/04

CPC分类号： G10L19/12 ,  G10L19/0204 ,  G10L19/09 ,  G10L19/18 ,  G10L19/20 ,  G10L25/90 ,  G10L2019/0002 ,  G10L2019/0016

摘要： There is provided a method of selecting a pitch lag value from a plurality of pitch lag candidates for coding a speech signal. The method comprises identifying the plurality of pitch lag candidates from a frame of the speech signal using correlation; classifying the speech signal to obtain a voice classification; determining whether one or more of the plurality of pitch lag candidates are in a temporal neighborhood of one or more previous pitch lag values; favoring the one or more of the plurality of pitch lag candidates determined to be in the temporal neighborhood of the one or more previous pitch lag values, by adaptive weighting, over other ones of the plurality of pitch lag candidates; and selecting the pitch lag value based on the voice classification and the one or more of the plurality of pitch lag candidates favored by the adaptive weighting.

摘要翻译： 提供了一种从用于编码语音信号的多个音调滞后候选中选择音调滞后值的方法。 该方法包括使用相关性从语音信号的帧中识别多个音调滞后候选; 对语音信号进行分类以获得语音分类; 确定所述多个音调滞后候选中的一个或多个是否在一个或多个先前音调滞后值的时间邻域中; 通过对多个音调滞后候选中的其他音调滞后候选，通过自适应加权来确定被确定为处于一个或多个先前音调滞后值的时间邻域中的多个音调滞后候选中的一个或多个; 以及基于所述语音分类和由所述自适应加权优选的所述多个音调滞后候选中的一个或多个来选择所述音调滞后值。

公开(公告)号：US20070049571A1

公开(公告)日：2007-03-01

申请号：US11495986

申请日：2006-07-28

申请人： Linghong Xie ,  Joseph Ochterski ,  Yang Gao ,  Bingsong Han ,  Timothy Caldwell ,  Yuelian Xu ,  John Peterson ,  Ping Ge ,  Robert Ohliger

发明人： Linghong Xie ,  Joseph Ochterski ,  Yang Gao ,  Bingsong Han ,  Timothy Caldwell ,  Yuelian Xu ,  John Peterson ,  Ping Ge ,  Robert Ohliger

IPC分类号： A61K31/551 ,  A61K31/55 ,  A61K31/497 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/454 ,  C07D403/02

CPC分类号： C07D403/06 ,  C07D207/09 ,  C07D207/14 ,  C07D211/14 ,  C07D211/34 ,  C07D211/52 ,  C07D211/58 ,  C07D211/64 ,  C07D211/72 ,  C07D213/74 ,  C07D213/82 ,  C07D215/48 ,  C07D217/02 ,  C07D237/20 ,  C07D237/22 ,  C07D237/24 ,  C07D239/47 ,  C07D241/08 ,  C07D241/20 ,  C07D243/08 ,  C07D263/32 ,  C07D271/06 ,  C07D277/56 ,  C07D277/82 ,  C07D295/033 ,  C07D295/185 ,  C07D295/192 ,  C07D295/215 ,  C07D333/70 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/08 ,  C07D491/10 ,  C07D491/107

摘要： Dipiperazinyl ketones and related analogues are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).

摘要翻译： 提供了二吡嗪基酮和相关的类似物，以及它们的制备和使用方法。 这样的化合物通常可用于在体内或体外调节配体与组胺H3受体的结合，并且特别可用于治疗人类，驯养的伴侣动物和家畜中的各种疾病。 提供药物组合物和治疗方法，以及使用这种配体检测组胺H3受体的方法（例如，受体定位研究）。

公开(公告)号：US07152203B2

公开(公告)日：2006-12-19

申请号：US09916248

申请日：2001-07-30

申请人： Yang Gao ,  Zheng John Shi ,  Shun Gao ,  Armeen Mazda

发明人： Yang Gao ,  Zheng John Shi ,  Shun Gao ,  Armeen Mazda

IPC分类号： G06N3/00

CPC分类号： G06F17/30902 ,  H04L29/06 ,  H04L67/02 ,  H04L67/34 ,  H04L69/329

摘要： The invention permits assembly of Web pages for display, to include text elements received from discrete network locations, and permits independent update of individual text elements of a Web page without reassembling the entire Web page, and permits independent update of all types of page elements without a client side agent other than a browser. In one aspect of the invention, a browser at a client device updates the display of a Web page containing at least one first element by transmitting a request to a server for a second element that is related to the first element, receiving the second element, and then displaying the second element with the Web page, without reassembling the Web page. In another aspect of the invention, the transmitting, receiving, and displaying are accomplished without a client side agent other than the browser.

公开(公告)号：US07132392B1

公开(公告)日：2006-11-07

申请号：US10111192

申请日：2000-10-20

申请人： Donald P. Bottaro ,  Safiye N. Atabey ,  Jesus V. Soriano ,  Diane E. Breckenridge ,  Zhu-Jun Yao ,  Yang Gao ,  Terrence R. Burke, Jr.

发明人： Donald P. Bottaro ,  Safiye N. Atabey ,  Jesus V. Soriano ,  Diane E. Breckenridge ,  Zhu-Jun Yao ,  Yang Gao ,  Terrence R. Burke, Jr.

IPC分类号： A61K38/08 ,  A61K38/07 ,  A61K38/06 ,  C07K7/04 ,  C07K5/10 ,  C07K5/08

CPC分类号： A61K38/07 ,  A61K38/05 ,  A61K38/06 ,  C07K5/0819 ,  C07K5/0827

摘要： Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. The present invention further provides methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking HGF, VEGF, or bFGF-stimulated migration, cell proliferation, and formation of capillary-like structures

摘要翻译： 公开了抑制细胞运动性的方法，例如通过抑制细胞内换能器和受体蛋白酪氨酸激酶之间的结合，更具体地通过抑制肝细胞生长因子（HGF）诱导的细胞运动性。 本发明还提供抑制血管发生的方法。 本发明的方法使用诸如磷酸二甲酰基模拟物之类的肽。 本发明还提供了预防和/或治疗诸如癌症，特别是转移性癌症的疾病，病症，状态或病症的方法，其包括向感兴趣的哺乳动物施用本发明的一种或多种肽。 还公开了阻断HGF，VEGF或bFGF刺激的迁移，细胞增殖和毛细血管样结构的形成的方法

公开(公告)号：US07117146B2

公开(公告)日：2006-10-03

申请号：US09940904

申请日：2001-08-27

申请人： Yang Gao

发明人： Yang Gao

IPC分类号： G01L19/00 ,  G01L11/04

CPC分类号： G10L19/265 ,  G10L19/08 ,  G10L21/0364

摘要： A speech compression system capable of encoding a speech signal into a bitstream for subsequent decoding to generate synthesized speech is disclosed. The speech compression system optimizes the bandwidth consumed by the bitstream by balancing the desired average bit rate with the perceptual quality of the reconstructed speech. The speech compression system comprises a full-rate codec, a half-rate codec, a quarter-rate codec and an eighth-rate codec. The codecs are selectively activated based on a rate selection. In addition, the full and half-rate codec are selectively activated based on a type classification. Each codec is selectively activated to encode and decode the speech signals at different bit rates emphasizing different aspects of the speech signal to enhance overall quality of the synthesized speech. The overall quality of the system is strongly related to the excitation. In order to enhance the excitation, the system contains a fixed codebook comprising several subcodebooks. The invention reveals a way to apply a pitch enhancement efficiently and differently for different subcodebooks without using additional bits. The technique is particularly applicable to selectable mode vocoder (SMV) systems.

公开(公告)号：US07013268B1

公开(公告)日：2006-03-14

申请号：US09625088

申请日：2000-07-25

申请人： Yang Gao

发明人： Yang Gao

IPC分类号： G10L19/12 ,  G10L19/10

CPC分类号： G10L19/12

摘要： There is provided a speech encoder comprising a first weighting means for performing an error weighting on a speech input. The first weighting means is configured to reduce an error signal resulting from a difference between a first synthesized speech signal and the speech input. In addition, the speech encoder includes a means for generating the first synthesized speech signal from a first excitation signal, and a second weighting means for performing an error weighting on the first synthesized speech signal. The second weighting means is also configured to reduce the error signal resulting from the difference between the speech input and the first synthesized speech signal. There is also included a first difference means for taking the difference between the first synthesized speech signal and the speech input, where the first difference means is configured to produce a first weighted error signal. The speech encoder also includes a means for generating a second synthesized speech signal from a second excitation signal, and a third weighting means for performing an error weighting on the second synthesized speech signal. The third weighting means is configured to reduce a second error signal resulting from the difference between the first weighted error signal and the second synthesized speech signal. Then there is included a second difference means for taking the difference between the second synthesized speech signal and the first error signal, where the second difference means is configured to produce a second weighted error signal. Finally, there is included a feedback means for using the second weighted error signal to control the selection of the first excitation signal, and the selection of the second excitation signal.

摘要翻译： 提供了一种语音编码器，包括用于对语音输入执行误差加权的第一加权装置。 第一加权装置被配置为减少由第一合成语音信号和语音输入之间的差引起的误差信号。 此外，语音编码器包括用于从第一激励信号产生第一合成语音信号的装置和用于对第一合成语音信号执行误差加权的第二加权装置。 第二加权装置还被配置为减少由语音输入和第一合成语音信号之间的差引起的误差信号。 还包括用于获取第一合成语音信号和语音输入之间的差的第一差异装置，其中第一差异装置被配置为产生第一加权误差信号。 语音编码器还包括用于从第二激励信号产生第二合成语音信号的装置和用于对第二合成语音信号执行误差加权的第三加权装置。 第三加权装置被配置为减少由第一加权误差信号和第二合成语音信号之间的差产生的第二误差信号。 然后，包括用于获取第二合成语音信号和第一误差信号之间的差的第二差分装置，其中第二差分装置被配置为产生第二加权误差信号。 最后，包括用于使用第二加权误差信号来控制第一激励信号的选择和第二激励信号的选择的反馈装置。

公开(公告)号：US06944827B2

公开(公告)日：2005-09-13

申请号：US09916251

申请日：2001-07-30

申请人： Yang Gao ,  Zheng John Shi ,  Shun Gao ,  Armeen Mazda

发明人： Yang Gao ,  Zheng John Shi ,  Shun Gao ,  Armeen Mazda

IPC分类号： G06F17/30 ,  H04L29/08 ,  G09G5/00

CPC分类号： G06F17/30899 ,  H04L67/02 ,  H04L69/329

摘要： The present invention permits textual data to be exchanged between a Web page displayed in a standard Microsoft Web browser window and a server, utilizing a non-persistent HTTP connection. Traditionally, each time textual data is received to the displayed Web page a record is added to the history list. This is problematic as it clutters the history list, compromises the functionality of the browser “Back” and “Forward” buttons, and results in undesirable server operations to be executed. The present invention utilizes several methods for loading textual data to a displayed Web page, without adding a URL to the history list. In one aspect of the invention, a element is used to transmit a HTTP request for new data and receive the HTTP response. The present invention can be used to build a lightweight Web page that offers real-time data and interactivity.

摘要翻译： 本发明允许在标准Microsoft Web浏览器窗口中显示的网页与服务器之间利用非持久HTTP连接来交换文本数据。 传统上，每当文本数据被接收到显示的网页时，记录被添加到历史列表中。 这是有问题的，因为它混合了历史列表，损害了浏览器“返回”和“转发”按钮的功能，并导致不期望的服务器操作被执行。 本发明利用几种将文本数据加载到所显示的网页的方法，而不向历史列表添加URL。 在本发明的一个方面，使用元素来发送用于新数据的HTTP请求并接收HTTP响应。 本发明可用于构建提供实时数据和交互性的轻量级网页。

公开(公告)号：US06912715B2

公开(公告)日：2005-06-28

申请号：US09916252

申请日：2001-07-30

申请人： Yang Gao ,  Zheng John Shi ,  Shun Gao ,  Armeen Mazda

发明人： Yang Gao ,  Zheng John Shi ,  Shun Gao ,  Armeen Mazda

IPC分类号： G06F9/46 ,  G06F9/54 ,  H04L29/06 ,  H04L29/08

CPC分类号： G06F9/547 ,  H04L67/02 ,  H04L67/40

摘要： The present invention permits a Remote Procedure Call (RPC) to be executed from a Web page displayed in a standard Microsoft Web browser window, without adding a URL to the Web browser's history list. In one aspect of the invention, a HTML element is used to transmit the HTTP request to the server and a HTML element is used to receive the HTTP response. Traditionally, each data transmission received by a HTML element is logged to the history list. This is problematic as it clutters the history list, compromises the functionality of the browser “Back” and “Forward” buttons, and results in undesirable server operations to be executed. The present invention utilizes the HTML element such that data is received without adding a URL to the history list. The present invention can be used to build a lightweight Web page that offers real-time data and interactivity.

摘要翻译： 本发明允许从标准Microsoft Web浏览器窗口中显示的网页执行远程过程调用（RPC），而不向Web浏览器的历史列表添加URL。 在本发明的一个方面，使用HTML