公开(公告)号：US07994152B2

公开(公告)日：2011-08-09

申请号：US12587608

申请日：2009-10-09

申请人： Makoto Koizumi ,  Koji Morita

发明人： Makoto Koizumi ,  Koji Morita

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： C12N15/113 ,  C07H21/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/319 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3515 ,  Y02P20/55 ,  C12N2310/3521

摘要： A method of treating a tumor or a viral disease by administering to a human the following 2′,5′-oligoadenylate analog: Wherein m is 0; n is 0 or 1; R1 is alkoxy substituted by hydroxyl, mercapto, alkylthio substituted by hydroxyl or X1—X2—X3—S—; R2, R3, R4, R5 and R6 are hydroxyl, mercapto, alkylthio substituted by hydroxyl or X1—X2—X3—S—; R7 is oxygen, sulfur, —NH—, or —O(CH2CH2O)q-, wherein q is 2 to 6, or oxyalkyleneoxy; R8 is hydrogen or a 5′-phosphorylated oligonucleotide which has one hydroxyl removed from the 5′-phosphoric acid; E1 is K2; E2 is K1; E3 is K2 or K3 and E4 is K1, K2 or K3; K1 is K2 is K3 is B is adeninyl; A is alkylene; D is alkyl or alkenyl; X1 is alkyl or phenyl; X2 is —C(═O)O—, —OC(═O)— or —C(═O)S—; and X3 is alkylene.

摘要翻译： 一种通过向人施用以下2'，5'-寡聚腺苷酸类似物来治疗肿瘤或病毒性疾病的方法：其中m为0; n为0或1; R1是被羟基取代的烷氧基，巯基，被羟基或X1-X2-X3-S-取代的烷硫基; R2，R3，R4，R5和R6是羟基，巯基，被羟基或X1-X2-X3-S-取代的烷硫基; R 7为氧，硫，-NH-或-O（CH 2 CH 2 O）q - ，其中q为2-6，或氧亚烷氧基; R8是从5'-磷酸除去一个羟基的氢或5'-磷酸化寡核苷酸; E1为K2; E2为K1; E3为K2或K3，E4为K1，K2或K3; K1是K2是K3是B是腺苷酸; A是亚烷基; D是烷基或烯基; X1是烷基或苯基; X2是-C（= O）O-，-OC（= O） - 或-C（= O）S-; X3是亚烷基。

公开(公告)号：US07884265B2

公开(公告)日：2011-02-08

申请号：US11815400

申请日：2006-03-02

申请人： Toyoshige Morita ,  Koji Morita ,  Koichiro Komai

发明人： Toyoshige Morita ,  Koji Morita ,  Koichiro Komai

IPC分类号： A01H1/00 ,  A23L1/236

CPC分类号： A01H5/10 ,  A01H5/12 ,  A23L27/36

摘要： A novel plant belonging to the Stevia Rebaudiana Bertoni variety which contains at least 4 parts by weight or more of Rebaudioside A with respect to one part by weight of Stevioside, and allows a sweetener of a good quality to be easily produced from said plant or dried leaves thereof.

摘要翻译： 一种属于甜菊甜叶菊品种的新植物，相对于1重量份的甜菊苷，含有至少4重量份或更多的雷鲍迪甙A，并且允许从所述植物容易地产生高质量的甜味剂或干燥 叶子。

公开(公告)号：US20110023192A1

公开(公告)日：2011-01-27

申请号：US12863847

申请日：2009-01-21

申请人： Toyoshige Morita ,  Koji Morita ,  Shinya Kanzaki

发明人： Toyoshige Morita ,  Koji Morita ,  Shinya Kanzaki

IPC分类号： A01H5/00 ,  C07H15/24 ,  A23L1/221 ,  C12Q1/68

CPC分类号： C12Q1/6895 ,  A01H5/12 ,  A23L27/36 ,  C12Q2600/13 ,  C12Q2600/156

摘要： High-purity stevioside sweeteners are being provided. Stevia Rebaudiana Bertoni varieties were identified using DNA analysis after cross and selective breeding were implemented. By crossing these varieties, a novel variety which enables continuous cultivation of the specific variety was developed (Deposition No. FERM BP-10870). Extracting the dried leaves of this variety assures consistent high-concentration of stevioside, which makes it possible to produce various favorable stevioside sweeteners.

摘要翻译： 正在提供高纯度甜菊糖甜味剂。 使用DNA分析鉴定了经过交叉选育育种后的甜叶菊甜叶菊品种。 通过交叉这些品种，开发了能够连续培养特定品种的新品种（保藏号FERM BP-10870）。 提取这种品种的干燥叶子可确保一致的高浓度的甜菊苷，这使得可以生产各种有利的甜菊糖甜味剂。

公开(公告)号：US20110009518A1

公开(公告)日：2011-01-13

申请号：US12787626

申请日：2010-05-26

申请人： Naoya Yabuuchi ,  Koji Morita ,  Hirofumi Yamashita ,  Hitomi Ohara ,  Shiro Kobayashi ,  Masahiko Ishii

发明人： Naoya Yabuuchi ,  Koji Morita ,  Hirofumi Yamashita ,  Hitomi Ohara ,  Shiro Kobayashi ,  Masahiko Ishii

IPC分类号： C08F2/46

CPC分类号： C09D167/07 ,  C08F2/48

摘要： There are provided a photosetting type bio-based coating composition and its coated article, wherein the coating composition has a sufficient hydrolysis resistance and a sufficient crosslinking density so as to be excellent in such as long-term stability, and is inexpensive, and is applicable also to an aqueous solvent. The photosetting type bio-based coating composition according to the present invention is characterized by comprising: a bio-based photopolymerizable compound as a film-forming ingredient which compound has at least one lactic acid unit and at least one photopolymerizable group together in a molecule; and a photopolymerization initiator. The coated article according to the present invention is characterized by being obtained by being coated with the aforementioned coating composition.

摘要翻译： 提供了一种光固化型生物基涂料组合物及其涂布制品，其中涂料组合物具有足够的耐水解性和足够的交联密度，从而具有优异的长期稳定性，并且价格便宜，适用 还涉及水性溶剂。 根据本发明的光固化型生物基涂料组合物的特征在于包括：化合物在分子中具有至少一个乳酸单元和至少一个光聚合基团的成膜成分的生物基光聚合化合物; 和光聚合引发剂。 根据本发明的涂布制品的特征在于通过涂覆上述涂料组合物获得。

公开(公告)号：US20110009471A1

公开(公告)日：2011-01-13

申请号：US12804500

申请日：2010-07-22

申请人： Masakatsu Kaneko ,  Koji Morita ,  Takeshi Imanishi

发明人： Masakatsu Kaneko ,  Koji Morita ,  Takeshi Imanishi

IPC分类号： A61K31/7088 ,  A61K31/7084 ,  A61P29/00 ,  A61P17/06 ,  A61P31/18 ,  A61P31/22 ,  A61P31/16 ,  A61P35/00 ,  C07H21/04 ,  C12P19/34 ,  G01N33/50

CPC分类号： C07H19/10 ,  C07H19/06 ,  C07H19/16 ,  C07H19/20 ,  Y02P20/55 ,  Y10T436/143333

摘要： A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.

摘要翻译： 一种用于预防或治疗哺乳动物的疾病，其可通过所述哺乳动物体内的寡核苷酸类似物或其药理学上可接受的盐的药理学上有用的反义或反应活性可预防或治疗的疾病，所述方法包括向需要的所述哺乳动物施用 这样的预防或治疗药物有效量的包含两个或多个核苷单位的寡核苷酸类似物，其中所述核苷单元中的至少一个是式（2）的结构：其中A是亚甲基; 和B是未取代的嘌呤-9-基，未取代的2-氧代 - 嘧啶-1-基或取代的嘌呤-9-基; 或其药理学上可接受的盐。

公开(公告)号：US07816333B2

公开(公告)日：2010-10-19

申请号：US11881775

申请日：2007-07-27

申请人： Masakatsu Kaneko ,  Koji Morita ,  Takeshi Imanishi

发明人： Masakatsu Kaneko ,  Koji Morita ,  Takeshi Imanishi

IPC分类号： A01N43/04 ,  A61K31/70

CPC分类号： C07H19/10 ,  C07H19/06 ,  C07H19/16 ,  C07H19/20 ,  Y02P20/55 ,  Y10T436/143333

摘要： A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.

摘要翻译： 一种用于预防或治疗哺乳动物的疾病，其可通过所述哺乳动物体内的寡核苷酸类似物或其药理学上可接受的盐的药理学上有用的反义或反应活性可预防或治疗的疾病，所述方法包括向需要的所述哺乳动物施用 这样的预防或治疗药物有效量的包含两个或多个核苷单位的寡核苷酸类似物，其中所述核苷单元中的至少一个是式（2）的结构：其中A是亚甲基; 和B是未取代的嘌呤-9-基，未取代的2-氧代 - 嘧啶-1-基或取代的嘌呤-9-基; 或其药理学上可接受的盐。

公开(公告)号：US07651999B2

公开(公告)日：2010-01-26

申请号：US11131412

申请日：2005-05-16

申请人： Makoto Koizumi ,  Koji Morita

发明人： Makoto Koizumi ,  Koji Morita

IPC分类号： A61K31/70 ,  C07H21/02

CPC分类号： C12N15/113 ,  C07H21/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/319 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3515 ,  Y02P20/55 ,  C12N2310/3521

摘要： A 2-5A analog represented by the formula (1): wherein m is 0 or 1; n is 0 to 2; R1 represents an alkoxy group having from 1 to 6 carbon atoms which may be substituted, an unprotected mercapto group, a mercapto group protected by a nucleic acid synthesis protecting group, or an alkylthio group having from 1 to 4 carbon atoms which may be substituted; R2, R3, R4, R5 and R6 represent an unprotected hydroxyl group, a hydroxyl group protected by a nucleic acid synthesis protecting group, an alkoxy group having from 1 to 6 carbon atoms which may be substituted, an unprotected mercapto group, a mercapto group protected by a nucleic acid synthesis protecting group, or an alkylthio group having from 1 to 4 carbon atoms which may be substituted; R7 represents an oxygen atom, or a —O(CH2CH2O)q- group, wherein q is 2 to 6; R8 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms which may be substituted, or a 5′-phosphorylated oligonucleotide analog which has one hydroxyl group removed from the 5′-phosphoric acid group; E1, E2, E3 and E4 represent a naturally occurring or modified nucleic acid unit, or a pharmacologically acceptable salt thereof.

摘要翻译： 由式（1）表示的2-5A类似物：其中m为0或1; n为0〜2; R1表示可被取代的具有1至6个碳原子的烷氧基，未保护的巯基，被核酸合成保护基保护的巯基或可被取代的具有1至4个碳原子的烷硫基; R2，R3，R4，R5和R6表示未被保护的羟基，被核酸合成保护基保护的羟基，可被取代的具有1至6个碳原子的烷氧基，未保护的巯基，巯基 被核酸合成保护基保护，或可以被取代的具有1至4个碳原子的烷硫基; R 7表示氧原子，或-O（CH 2 CH 2 O）q-基，其中q为2-6。 R8表示氢原子，可以被取代的碳原子数为1〜6的烷基或从5'-磷酸基除去一个羟基的5'-磷酸化寡核苷酸类似物; E1，E2，E3和E4表示天然存在或修饰的核酸单元或其药理学上可接受的盐。

公开(公告)号：US07629045B2

公开(公告)日：2009-12-08

申请号：US11044533

申请日：2005-01-28

申请人： Kenji Takai ,  Norio Moriike ,  Kenichi Kamiyama ,  Takako Watanabe ,  Shin Takanezawa ,  Koji Morita ,  Katsuyuki Masuda ,  Kiyoshi Hasegawa

发明人： Kenji Takai ,  Norio Moriike ,  Kenichi Kamiyama ,  Takako Watanabe ,  Shin Takanezawa ,  Koji Morita ,  Katsuyuki Masuda ,  Kiyoshi Hasegawa

IPC分类号： B32B3/00

CPC分类号： H05K3/4655 ,  H05K3/108 ,  H05K3/28 ,  H05K3/386 ,  H05K3/389 ,  H05K3/4652 ,  H05K2201/0133 ,  H05K2201/0154 ,  H05K2201/0195 ,  H05K2201/0212 ,  H05K2201/0358 ,  H05K2203/0759 ,  Y10T428/12431 ,  Y10T428/24917 ,  Y10T428/2804 ,  Y10T428/287 ,  Y10T428/31681

摘要： The invention relates to an adhesion assisting agent-bearing metal foil comprising a layer of an adhesion assisting agent containing an epoxy resin as an indispensable component on a metal, wherein the adhesion assisting agent layer has a thickness of 0.1 to 10 μm. The invention also relates to a printed wiring board being a multilayer wiring board having a plurality of layers, wherein an adhesion assisting agent layer is formed between insulating layers.

摘要翻译： 本发明涉及一种粘附辅助剂金属箔，其包含在金属上含有环氧树脂作为不可或缺成分的粘合助剂层，其中粘合助剂层的厚度为0.1-10μm。 本发明还涉及作为具有多层的多层布线基板的印刷布线板，其中在绝缘层之间形成粘附辅助剂层。

公开(公告)号：US20090271091A1

公开(公告)日：2009-10-29

申请号：US12301625

申请日：2007-07-23

申请人： Koji Morita

发明人： Koji Morita

IPC分类号： F02D41/30 ,  F02B17/00

CPC分类号： F02D41/064 ,  F02D41/3064 ,  F02D41/3076 ,  F02D41/3094 ,  F02D2200/0406 ,  Y02T10/128

摘要： A fuel injection control apparatus for an internal combustion engine includes a fuel injection portion that performs each of first fuel injection for performing stratified-charge combustion, and second fuel injection for performing homogeneous-charge combustion; and an injection distribution ratio control portion that controls an injection distribution ratio. The injection distribution ratio control portion controls the injection distribution ratio to a target injection distribution ratio set based on a predetermined engine condition after start of the engine. An initial injection distribution ratio is set based on an engine condition at a time of start of the engine, and a change in the injection distribution ratio is controlled by referring to the engine condition after the start of the engine, when the injection distribution ratio is changed from the initial injection distribution ratio to the target injection distribution ratio.

摘要翻译： 一种用于内燃机的燃料喷射控制装置，包括执行各自进行分层充气燃烧的第一燃料喷射的燃料喷射部和进行均匀充气燃烧的第二燃料喷射; 以及控制喷射分配比的喷射分配比控制部。 喷射分配比率控制部分将喷射分配比控制为基于发动机起动之后的预定发动机状态设定的目标喷射分配比。 基于发动机起动时的发动机状态来设定初始喷射分配比，并且通过参照发动机起动后的发动机状态来控制喷射分配比的变化，当喷射分配比为 从初始喷射分配比改变为目标喷射分配比。

公开(公告)号：US20090214753A1

公开(公告)日：2009-08-27

申请号：US11815400

申请日：2006-03-02

申请人： Toyoshige Morita ,  Koji Morita ,  Koichiro Komai

发明人： Toyoshige Morita ,  Koji Morita ,  Koichiro Komai

IPC分类号： A23L1/28

CPC分类号： A01H5/10 ,  A01H5/12 ,  A23L27/36

摘要： A novel plant belonging to the Stevia Rebaudiana Bertoni variety which contains at least 4 parts by weight or more of Rebaudioside A with respect to one part by weight of Stevioside, and allows a sweetener of a good quality to be easily produced from said plant or dried leaves thereof.

摘要翻译： 一种属于甜菊甜叶菊品种的新植物，相对于1重量份的甜菊苷，含有至少4重量份或更多的雷鲍迪甙A，并且允许从所述植物容易地产生高质量的甜味剂或干燥 叶子。