公开(公告)号：US20190153019A1

公开(公告)日：2019-05-23

申请号：US15816187

申请日：2017-11-17

申请人： International Business Machines Corporation

发明人： James L. Hedrick ,  Nathaniel H. Park

IPC分类号： C07J9/00 ,  C08G65/333 ,  C08G73/02 ,  C08G64/42

摘要： The subject disclosure is directed to functionalized bile acids, preparation thereof, and usage thereof for therapeutic and material applications. In one embodiment, a method of generating functionalized bile acid materials can comprise directly activating a carboxylic acid of a bile acid compound using a coupling agent comprising an amide or ester compound, thereby generating an intermediate bile acid derivative material. The method can further comprise attaching a functional group material to the intermediate bile acid derivative material by reacting the functional group material and the intermediate bile acid derivative material, thereby generating a functionalized bile acid material.

公开(公告)号：US10167367B2

公开(公告)日：2019-01-01

申请号：US15332010

申请日：2016-10-24

申请人： International Business Machines Corporation

发明人： Dylan J. Boday ,  Mareva B. Fevre ,  Jeannette M. Garcia ,  James L. Hedrick ,  Nathaniel H. Park ,  Rudy J. Wojtecki ,  Mu San Zhang

IPC分类号： C08G64/18 ,  C08G81/00 ,  C08L87/00 ,  C08G64/16 ,  A61K47/34

摘要： A block copolymer includes a water-soluble block that is bonded to one or more hydrophobic polycarbonate blocks that include pendant fluoroaryl substituents.

公开(公告)号：US11975290B2

公开(公告)日：2024-05-07

申请号：US17655206

申请日：2022-03-17

申请人： International Business Machines Corporation ,  The Trustees of Columbia University in the City of New York

发明人： James L. Hedrick ,  Nathaniel H. Park ,  Luis M. Campos ,  Dino Wu ,  Daniel Malinowski

IPC分类号： B01D53/62 ,  B01D53/14 ,  B01D53/78

CPC分类号： B01D53/62 ,  B01D53/1475 ,  B01D53/1493 ,  B01D53/78 ,  B01D2252/2053 ,  B01D2257/504

摘要： A process, composition, and apparatus for carbon dioxide (CO2) sequestration are disclosed. The process includes passing air containing the CO2 through a cyclopropeneimine (CPI)-functionalized material. The composition includes a CPI-functionalized material that reacts with CO2 when mixed with air containing the CO2. The apparatus includes a component for providing a CPI-functionalized material and mixing the material with CO2 gas.

公开(公告)号：US20240075454A1

公开(公告)日：2024-03-07

申请号：US17821074

申请日：2022-08-19

申请人： International Business Machines Corporation ,  The Trustees of Columbia University in the City of New York

发明人： Dino Wu ,  Luis M. Campos ,  Nathaniel H. Park ,  James L. Hedrick ,  Junho Kwon

IPC分类号： B01J20/26 ,  B01D53/62 ,  B01D53/78 ,  B01D53/96 ,  B01J20/34

CPC分类号： B01J20/26 ,  B01D53/62 ,  B01D53/78 ,  B01D53/96 ,  B01J20/3425 ,  B01J20/3475 ,  B01D2251/206 ,  B01D2257/504 ,  B01D2258/06

摘要： A process, composition, and apparatus for carbon dioxide (CO2) conversion are disclosed. The CO2 conversion comprises reacting CO2 with a cyclopropenimine (CPI) to activate the CO2 and transferring the activated CO2 to generate a product of the transferring. The transferring also generates a conjugate acid of the CPI. The process further comprises regenerating the CPI from the conjugate acid.

公开(公告)号：US20240002594A1

公开(公告)日：2024-01-04

申请号：US18465334

申请日：2023-09-12

申请人： International Business Machines Corporation ,  The Board of Trustees of the Leland Stanford Junior University

发明人： Nathaniel H. Park ,  James L. Hedrick ,  Victoria A. Piunova ,  Dmitry Zubarev ,  Gavin O. Jones ,  Robert M. Waymouth ,  Binhong Lin

IPC分类号： C08G63/82 ,  C08G64/02 ,  C08G79/04 ,  C08G75/26 ,  C08G67/00 ,  C08G63/685 ,  C08G64/20 ,  C08G63/78 ,  C08G64/30

CPC分类号： C08G63/823 ,  C08G64/0208 ,  C08G79/04 ,  C08G75/26 ,  C08G67/00 ,  C08G63/685 ,  C08G64/205 ,  C08G63/785 ,  C08G64/30

摘要： Techniques regarding the synthesis of one or more polymers through one or more ring-opening polymerizations conducted within a flow reactor and facilitated by one or more anionic catalysts are provided. For example, one or more embodiments can comprise a method, which can comprise polymerizing, via a ring-opening polymerization within a flow reactor, a cyclic monomer in the presence of one or more anionic organocatalysts.

公开(公告)号：US11560484B2

公开(公告)日：2023-01-24

申请号：US16678076

申请日：2019-11-08

申请人： International Business Machines Corporation ,  Institute of Bioengineering and Nanotechnology

发明人： Amos Cahan ,  Hariklia Deligianni ,  Xin Ding ,  Mareva B. Fevre ,  James L. Hedrick ,  Pei-Yun S. Hsueh ,  Zhen Chang Liang ,  Nathaniel H. Park ,  Theodore G. van Kessel ,  Rudy J. Wojtecki ,  Yi Yan Yang

IPC分类号： C09D5/14 ,  A61M5/142 ,  C09D7/65 ,  B05D1/36 ,  C08G73/02 ,  A61C8/00 ,  A61F2/30 ,  B05D5/00 ,  A01N33/12 ,  A61B5/00 ,  A61F2/28 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61M5/14 ,  A61M27/00 ,  A61N1/378 ,  B05D3/00 ,  C08J3/24 ,  B05D1/02 ,  A61F2/07 ,  A61B1/00 ,  A61N1/36 ,  A61B17/56 ,  A61M25/00 ,  A61F2/01 ,  A61F2/48 ,  A61F2/06 ,  A61F2/14 ,  A61F2/24 ,  A61F2/82 ,  A61N1/362 ,  C09D179/02

摘要： Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

公开(公告)号：US20210406314A1

公开(公告)日：2021-12-30

申请号：US16917638

申请日：2020-06-30

申请人： International Business Machines Corporation

发明人： Daniel Gruhl ,  Linda Ha Kato ,  Petar Ristoski ,  Steven R. Welch ,  Chad Eric DeLuca ,  Anna Lisa Gentile ,  Alfredo Alba ,  Dmitry Zubarev ,  Chandrasekhar Narayan ,  Nathaniel H. Park

IPC分类号： G06F16/9038 ,  G06F16/9032 ,  G06F16/906 ,  G06F16/93 ,  G06F16/903 ,  G06N3/08

摘要： A method for ranking relevance of documents includes using a set of queries, searching a corpus of documents for a set of candidate documents with information relevant to the set of queries. The method further includes ranking the set of candidate documents by a deep learning processing system according to relevance to respective ones of the set of queries. The method additionally includes responsive to user input, revising the ranked set of candidate documents to produce a revised ranked set of candidate documents. The method further includes using the revised ranked set of candidate documents to retrain the deep learning processing system. The method still further includes performing a categorization of the set of candidate documents by the retrained deep learning processing system.

公开(公告)号：US20210303762A1

公开(公告)日：2021-09-30

申请号：US16835892

申请日：2020-03-31

申请人： International Business Machines Corporation

发明人： Petar Ristoski ,  Dmitry Zubarev ,  Linda Ha Kato ,  Anna Lisa Gentile ,  Nathaniel H. Park ,  Daniel Gruhl ,  Steven R. Welch ,  Daniel Paul Sanders ,  James L. Hedrick ,  Chandrasekhar Narayan ,  Chad Eric DeLuca ,  Alfredo Alba

IPC分类号： G06F30/27 ,  G06N5/04 ,  G06N3/04 ,  G06N20/10

摘要： A set of material candidates expected to yield materials with target properties can be generated. A subject matter expert's decision indicating accepted and rejected material candidates from the set of material candidates can be received. Based on the subject matter expert's input, a machine learning model can be trained to replicate the subject matter expert's decision.

公开(公告)号：US10563069B2

公开(公告)日：2020-02-18

申请号：US15474330

申请日：2017-03-30

申请人： International Business Machines Corporation ,  Institute of Bioengineering and Nanotechnology

发明人： Amos Cahan ,  Hariklia Deligianni ,  Xin Ding ,  Mareva B. Fevre ,  James L. Hedrick ,  Pei-Yun S. Hsueh ,  Zhen Chang Liang ,  Nathaniel H. Park ,  Theodore G. van Kessel ,  Rudy J. Wojtecki ,  Yi Yan Yang

IPC分类号： C09D5/14 ,  A01N33/12 ,  A61B5/00 ,  A61C8/00 ,  A61F2/28 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61M5/14 ,  A61M27/00 ,  A61N1/378 ,  B05D3/00 ,  C08J3/24 ,  A61F2/06 ,  A61F2/14 ,  A61F2/24 ,  A61F2/82 ,  A61F2/30 ,  A61M25/00 ,  A61N1/362 ,  C09D179/02

摘要： Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

公开(公告)号：US20200010613A1

公开(公告)日：2020-01-09

申请号：US16029025

申请日：2018-07-06

申请人： International Business Machines Corporation ,  The Board of Trustees of the Leland Stanford Junior University

发明人： Nathaniel H. Park ,  James L. Hedrick ,  Victoria A. Piunova ,  Dmitry Zubarev ,  Gavin O. Jones ,  Robert M. Waymouth ,  Binhong Lin

IPC分类号： C08G64/08

摘要： Techniques regarding the synthesis of one or more polymers through one or more ring-opening polymerizations conducted within a flow reactor and facilitated by one or more anionic catalysts are provided. For example, one or more embodiments can comprise a method, which can comprise functionalizing, via a post-polymerization reaction within a flow reactor, a chemical compound by covalently bonding a trimethylsilyl protected thiol to a pendent functional group of the chemical compound in a presence of a catalyst. The pendent functional group can comprise a perfluoroaryl group and a methylene group.