公开(公告)号：US06683178B2

公开(公告)日：2004-01-27

申请号：US10257877

申请日：2002-10-17

申请人： Frank Ohlbach ,  Andreas Ansmann ,  Peter Bassler ,  Rolf-Hartmuth Fischer ,  Hermann Luyken ,  Stefan Maixner ,  Johann-Peter Melder

发明人： Frank Ohlbach ,  Andreas Ansmann ,  Peter Bassler ,  Rolf-Hartmuth Fischer ,  Hermann Luyken ,  Stefan Maixner ,  Johann-Peter Melder

IPC分类号： C07D20108

CPC分类号： C07D201/08 ,  C07D201/16

摘要： The invention relates to a method for producing cyclic lactams of formula (II) by reacting a compound (I) of formula (I) with water in the presence of an organic, liquid dilution agent in the liquid phase. In formula (II), n and m respectively can have the values 0, 1, 2, 3, 4, 5, 6, 7, 8 and 9 and the sum of n+m is at least 3, preferably at least 4 and R1 and R2 represent C1-C6 alkyl, C5-C7 cycloalkyl or C6-C12 aryl groups. In formula (I), R1, R2, m and n are defined as above and R represents nitrile, carboxylic acid amide and carboxylic acid groups. The inventive method is characterized in that a) compound (I) is reacted with water in the liquid phase in the presence of an organic, liquid dilution agent (III) to form a mixture (IV) containing a lactam (II) and said mixture (IV) is subjected to an aqueous treatment to obtain a two-phase system.

摘要翻译： 本发明涉及在液相中有机液体稀释剂存在下使式（I）化合物（I）与水反应制备式（II）的环状内酰胺的方法。 在式（II）中，n和m分别具有0,1,2,3,4,5,6,7,8和9的值，并且n + m的和至少为3，优选至少为4，并且 R 1和R 2代表C 1 -C 6烷基，C 5 -C 7环烷基或C 6 -C 12芳基。 在式（I）中，R 1，R 2，m和n如上定义，R代表腈，羧酸酰胺和羧酸基团。 本发明的方法的特征在于：a）化合物（I）在液相中在有机液体稀释剂（III）的存在下与水反应，形成含有内酰胺（II）的混合物（IV），所述混合物 （IV）进行水处理以获得两相体系。

公开(公告)号：US06683177B1

公开(公告)日：2004-01-27

申请号：US08952208

申请日：1997-11-06

申请人： Eberhard Fuchs ,  Johann-Peter Melder ,  Werner Schnurr ,  Rolf Fischer

发明人： Eberhard Fuchs ,  Johann-Peter Melder ,  Werner Schnurr ,  Rolf Fischer

IPC分类号： C07D20108

CPC分类号： C07D201/08 ,  C07D223/12

摘要： A process for preparing caprolactam by reacting 6-aminocapronitrile with water in the presence of catalysts comprises using a starting mixture of 6-aminocapronitrile and the tetrahydroazepine derivative of the formula and conducting the reaction in liquid phase in the presence of a heterogeneous catalyst. Also describes a process for preparing said tetrahydroazepine derivative I and its use for preparing caprolactam and polycaprolactam.

摘要翻译： 在催化剂存在下使6-氨基己腈与水反应制备己内酰胺的方法包括使用6-氨基己腈和下式的四氢氮杂衍生物的起始混合物，并在非均相催化剂存在下进行液相反应。 还描述了制备所述四氢氮杂衍生物I的方法及其制备己内酰胺和聚己内酰胺的用途。

公开(公告)号：US06563004B2

公开(公告)日：2003-05-13

申请号：US09729461

申请日：2000-12-05

申请人： Jan Nouwen ,  Stefan Käshammer ,  Arthur Höhn ,  Frank Funke ,  Johann-Peter Melder ,  Frank Gutschoven ,  Philip Buskens

发明人： Jan Nouwen ,  Stefan Käshammer ,  Arthur Höhn ,  Frank Funke ,  Johann-Peter Melder ,  Frank Gutschoven ,  Philip Buskens

IPC分类号： C07C20926

CPC分类号： C07C209/26 ,  C07C211/06

摘要： Monoisopropylamine is prepared by reacting acetone with ammonia and with hydrogen at elevated temperature and elevated pressure in the presence of a catalyst, wherein the catalytically active mass of the catalyst comprises, after its preparation and before the treatment with hydrogen, from 20 to 90% by weight of aluminum oxide (Al2O3), zirconium dioxide (ZrO2), titanium dioxide (TiO2) and/or silicon dioxide (SiO2), from 1 to 70% by weight of oxygen-containing compounds of copper, calculated as CuO, from 1 to 70% by weight of oxygen-containing compounds of nickel, calculated as NiO, and from 1 to 70% by weight of oxygen-containing compounds of cobalt, calculated as CoO.

摘要翻译： 通过使丙酮与氨和氢气在升高的温度和升高的压力下在催化剂存在下反应制备单异丙胺，其中催化活性物质在其制备之后和在用氢处理之前包含20-90％ 氧化铝（Al 2 O 3），二氧化锆（ZrO 2），二氧化钛（TiO 2）和/或二氧化硅（SiO 2）的重量，1至70重量％的以CuO计的氧含氧化合物，1至 70重量％的以NiO计的含氧化合物的镍和1-70重量％的以CoO计的钴的含氧化合物。

公开(公告)号：US06469214B2

公开(公告)日：2002-10-22

申请号：US09995751

申请日：2001-11-29

申请人： Johann-Peter Melder ,  Gerhard Schulz

发明人： Johann-Peter Melder ,  Gerhard Schulz

IPC分类号： C07C20954

CPC分类号： C07C213/08 ,  C07C213/00 ,  C07C215/08 ,  C07C215/12

摘要： A process for the preparation of one or more ethanolamines (I), chosen from the group consisting of monoethanolamine, diethanolamine and triethanolamine, by conversion of one or more ethanolamines (II) different from the ethanolamine(s) (I), chosen from the group consisting of monoethanolamine, diethanolamine, triethanolamine. O,N,N-tris(2-hydroxyethyl) ethanol-N-(2-aminoethyl)-ethanolamine, N-(2-amine, hydroxy ethyl) piperazine, N-(2-hydroxyethyl)morpholine and N,N′-bis(2-hydroxyethyl)piperazine, where the ethanolamine(s) (II), optionally in the presence of ammonia, is/are treated with a strong base.

摘要翻译： 一种或多种选自单乙醇胺，二乙醇胺和三乙醇胺的一种或多种乙醇胺（I）的制备方法，通过转化一种或多种不同于乙醇胺（I）的乙醇胺（II），其选自 由单乙醇胺，二乙醇胺，三乙醇胺组成的组。 O，N，N-三（2-羟乙基）乙醇-N-（2-氨基乙基） - 乙醇胺，N-（2-胺，羟基乙基）哌嗪，N-（2-羟乙基）吗啉和N， 双（2-羟乙基）哌嗪，其中乙醇胺（II）（任选在氨存在下）用强碱处理。

公开(公告)号：US06417353B1

公开(公告)日：2002-07-09

申请号：US09520908

申请日：2000-03-07

申请人： Frank Funke ,  Joachim Wulff-Döring ,  Gerhard Schulz ,  Wolfgang Siegel ,  Andreas Kramer ,  Johann-Peter Melder ,  Arthur Höhn ,  Philipp Buskens ,  Wolfgang Reif ,  Jan Nouwen

发明人： Frank Funke ,  Joachim Wulff-Döring ,  Gerhard Schulz ,  Wolfgang Siegel ,  Andreas Kramer ,  Johann-Peter Melder ,  Arthur Höhn ,  Philipp Buskens ,  Wolfgang Reif ,  Jan Nouwen

IPC分类号： C07B4304

CPC分类号： C07C209/26 ,  B01J23/885 ,  B01J37/03 ,  C07C213/02 ,  C07C2601/08 ,  C07C2602/10 ,  C07C211/06 ,  C07C211/07 ,  C07C211/17 ,  C07C211/27 ,  C07C211/30 ,  C07C211/35 ,  C07C211/38 ,  C07C217/58

摘要： Amines are prepared by reacting aldehydes or ketones at elevated temperature under elevated pressure with nitrogen compounds selected from the group of ammonia, primary and secondary amines, and with hydrogen in the presence of a catalyst containing copper, wherein the catalytically active mass of the catalyst contains, before the reduction with hydrogen, 20 to 85% by weight of oxygen-containing compounds of zirconium, calculated as ZrO2, 1 to 30% by weight of oxygen-containing compounds of copper, calculated as CuO, 14 to 70% by weight of oxygen-containing compounds of nickel, calculated as NiO, 0 to 5% by weight of oxygen-containing compounds of molybdenum, calculated as MoO3, and 0 to 10% by weight of oxygen-containing compounds of aluminum, calculated as Al2O3.

摘要翻译： 胺在升高的温度下在升高的温度下与选自氨，伯胺和仲胺的氮化合物和氢气在含催化剂的聚合物的存在下反应制备，其中催化剂活性物质含有， 在用氢还原之前，以ZrO 2计为20〜85重量％的含氧化合物，以30重量％计，氧化铝为14〜70重量％，氧化铝为100重量％ 以NiO表示的镍化合物，以MoO 3计为0〜5重量％的含氧化合物的钼和0〜10重量％的按Al 2 O 3计算的含氧化合物的铝。

公开(公告)号：US06346641B1

公开(公告)日：2002-02-12

申请号：US09720882

申请日：2001-01-02

申请人： Hermann Luyken ,  Frank Ohlbach ,  Andreas Ansmann ,  Peter Bassler ,  Rolf Fischer ,  Johann-Peter Melder ,  Martin Merger ,  Alwin Rehfinger ,  Guido Voit ,  Günther Achhammer

发明人： Hermann Luyken ,  Frank Ohlbach ,  Andreas Ansmann ,  Peter Bassler ,  Rolf Fischer ,  Johann-Peter Melder ,  Martin Merger ,  Alwin Rehfinger ,  Guido Voit ,  Günther Achhammer

IPC分类号： C07C25500

CPC分类号： C07C253/30 ,  C07C209/48 ,  C07C211/12 ,  C07C255/24

摘要： A process for the coproduction of 6-aminocapronitrile and hexamethylenediamine starting from adiponitrile by a) hydrogenating adiponitrile in the presence of a catalyst comprising an element of the eighth transition group as catalytically active component, to obtain a mixture comprising 6-aminocapronitrile, hexamethylenediamine, adiponitrile and high boilers, b) distillatively removing hexamethylenediamine from the mixture comprising 6-aminocapronitrile, hexamethylenediamine, adiponitrile and high boilers, and either c1) distillatively removing 6-aminocapronitrile, and then d1) distillatively removing adiponitrile, or c2) simultaneously distillatively removing 6-aminocapronitrile and adiponitrile into separate fractions is characterized by base of column temperatures below 185° C. in steps d1) or c2).

摘要翻译： 一种从己二腈开始共生产6-氨基己腈和六亚甲基二胺的方法，其中a）在包含第八过渡基团的元素的催化剂作为催化活性组分的存在下氢化己二腈，得到包含6-氨基己腈，己二胺，己二腈和 高锅炉，b）从包含6-氨基己腈，己二胺，己二腈和高沸点的混合物中蒸馏除去六亚甲基二胺，和c）蒸馏除去6-氨基己腈，然后d1）蒸馏除去己二腈，orc2）同时蒸馏除去6-氨基己腈和己二腈 在步骤d1）或c2）中，单独馏分的特征在于塔温度低于185℃的碱。

公开(公告)号：US06323371B2

公开(公告)日：2001-11-27

申请号：US09805725

申请日：2001-03-07

申请人： Günther Ruider ,  Karl-Heinz Ross ,  Johann-Peter Melder ,  Gerhard Schulz ,  Frank Gutschoven ,  Philip Buskens

发明人： Günther Ruider ,  Karl-Heinz Ross ,  Johann-Peter Melder ,  Gerhard Schulz ,  Frank Gutschoven ,  Philip Buskens

IPC分类号： C07C20984

CPC分类号： C07C213/10 ,  C07C215/12

摘要： Preparation of alkanolamines having improved color quality by treating the alkanolamine with an effective amount of phosphorous acid or hypophosphorous acid or compounds thereof initially at elevated temperature over a period of at least 5 min (step a), and then distilling it in the presence of an effective amount of one of these phosphorus compounds (step b).

公开(公告)号：US5801267A

公开(公告)日：1998-09-01

申请号：US846239

申请日：1997-04-28

申请人： Klemens Flick ,  Johann-Peter Melder ,  Werner Schnurr ,  Klaus Ebel ,  Tom Witzel ,  Wolfgang Harder ,  Alwin Rehfinger ,  Rolf Fischer

发明人： Klemens Flick ,  Johann-Peter Melder ,  Werner Schnurr ,  Klaus Ebel ,  Tom Witzel ,  Wolfgang Harder ,  Alwin Rehfinger ,  Rolf Fischer

IPC分类号： B01J23/76 ,  B01J23/78 ,  B01J23/889 ,  B01J37/02 ,  C07C253/30 ,  C07C255/24 ,  C07C255/03

CPC分类号： B01J23/76 ,  B01J23/78 ,  B01J23/8892 ,  B01J23/8898 ,  B01J37/0201 ,  C07C253/30

摘要： Aliphatic alpha,omega-aminonitriles are prepared by partial hydrogenation of aliphatic alpha,omega-dinitriles at elevated temperatures and superatmospheric pressure in the presence of a solvent and of a catalyst by a process in which the catalyst (a) contains a compound based on a metal selected from the group consisting of nickel, cobalt, iron, ruthenium and rhodium and (b) contains from 0.01 to 25% by weight, based on (a), of a promoter based on a metal selected from the group consisting of palladium, platinum, iridium, osmium, copper, silver, gold, chromium, molybdenum, tungsten, manganese, rhenium, zinc, cadmium, lead, aluminum, tin, phosphorus, arsenic, antimony, bismuth and rare earth metals and (c) from 0 to 5% by weight, based on (a), of a compound based on an alkali metal or on an alkaline earth metal, with the proviso that the component (a) is not based on iron or iron and one of the metals selected from the group consisting of cobalt, ruthenium and rhodium when (b) is a promoter based on a metal selected from the group consisting of titanium, manganese, chromium and molybdenum, and with the further proviso that, when a compound based on only ruthenium or ruthenium and rhodium or nickel and rhodium is selected as component (a), the promoter (b) may be dispensed with.

摘要翻译： 脂肪族α，ω-氨基腈通过脂肪族α，ω-二腈在升高的温度和超大气压下，在溶剂和催化剂存在下通过其中催化剂（a）含有基于 选自镍，钴，铁，钌和铑的金属和（b）含有基于（a）0.01至25重量％的选自钯， 铂，铱，锇，铜，银，金，铬，钼，钨，锰，铼，锌，镉，铅，铝，锡，磷，砷，锑，铋和稀土金属，（c） 基于（a）的基于碱金属或碱土金属的化合物为5重量％，条件是组分（a）不以铁或铁为基准，并且其中一种金属选自 （b）为舞会时由钴，钌和铑组成的组 基于选自钛，锰，铬和钼的金属，另外条件是当仅选择仅钌，钌和铑或镍和铑的化合物作为组分（a）时， 启动子（b）可以不用。

公开(公告)号：US5756808A

公开(公告)日：1998-05-26

申请号：US648702

申请日：1996-05-16

申请人： Klemens Flick ,  Johann-Peter Melder ,  Werner Schnurr ,  Klaus Ebel ,  Tom Witzel ,  Wolfgang Harder ,  Alwin Rehfinger ,  Rolf Fischer

发明人： Klemens Flick ,  Johann-Peter Melder ,  Werner Schnurr ,  Klaus Ebel ,  Tom Witzel ,  Wolfgang Harder ,  Alwin Rehfinger ,  Rolf Fischer

IPC分类号： B01J23/76 ,  B01J23/78 ,  B01J23/889 ,  B01J37/02 ,  C07C253/30 ,  C07C255/24 ,  C07C255/03

CPC分类号： B01J23/76 ,  B01J23/78 ,  B01J23/8892 ,  B01J23/8898 ,  B01J37/0201 ,  C07C253/30

摘要： Aliphatic alpha,omega-aminonitriles are prepared by partial hydrogenation of aliphatic alpha,omega-dinitriles at elevated temperatures and superatmospheric pressure in the presence of a solvent and of a catalyst by a process in which the catalyst (a) contains a compound based on a metal selected from the group consisting of nickel, cobalt, iron, ruthenium and rhodium and (b) contains from 0.01 to 25% by weight, based on (a), of a promoter based on a metal selected from the group consisting of palladium, platinum, iridium, osmium, copper, silver, gold, chromium, molybdenum, tungsten, manganese, rhenium, zinc, cadmium, lead, aluminum, tin, phosphorus, arsenic, antimony, bismuth and rare earth metals and (c) from 0 to 5% by weight, based on (a), of a compound based on an alkali metal or on an alkaline earth metal, with the proviso that the component (a) is not based on iron or iron and one of the metals selected from the group consisting of cobalt, ruthenium and rhodium when (b) is a promoter based on a metal selected from the group consisting of titanium, manganese, chromium and molybdenum, and with the further proviso that, when a compound based on only ruthenium or ruthenium and rhodium or nickel and rhodium is selected as component (a), the promoter (b) may be dispensed with.

摘要翻译： 脂肪族α，ω-氨基腈通过脂肪族α，ω-二腈在升高的温度和超大气压下，在溶剂和催化剂存在下通过其中催化剂（a）含有基于 选自镍，钴，铁，钌和铑的金属和（b）含有基于（a）0.01至25重量％的选自钯， 铂，铱，锇，铜，银，金，铬，钼，钨，锰，铼，锌，镉，铅，铝，锡，磷，砷，锑，铋和稀土金属，（c） 基于（a）的基于碱金属或碱土金属的化合物为5重量％，条件是组分（a）不以铁或铁为基准，并且其中一种金属选自 （b）为舞会时由钴，钌和铑组成的组 基于选自钛，锰，铬和钼的金属，另外条件是当仅选择仅钌，钌和铑或镍和铑的化合物作为组分（a）时， 启动子（b）可以不用。

公开(公告)号：US5585496A

公开(公告)日：1996-12-17

申请号：US570557

申请日：1995-12-11

申请人： Joaquim H. Teles ,  Johann-Peter Melder ,  Eugen Gehrer ,  Wolfgang Harder ,  Klaus Ebel ,  Carsten Groening ,  Regina Meyer

发明人： Joaquim H. Teles ,  Johann-Peter Melder ,  Eugen Gehrer ,  Wolfgang Harder ,  Klaus Ebel ,  Carsten Groening ,  Regina Meyer

IPC分类号： B01J31/02 ,  C07B61/00 ,  C07C45/75 ,  C07C47/19 ,  C07C49/17 ,  C07D249/08 ,  C07D249/10 ,  C07D249/12 ,  C07D249/14 ,  C07D471/06

CPC分类号： C07C45/75

摘要： A process for the catalytical preparation of condensation products of formaldehyde, in which formaldehyde or a formaldehyde-forming compound is caused to undergo reaction using a catalyst which has been produced, in the presence of an auxiliary base, from a triazolium salt of formula I ##STR1## in which R.sup.1 and R.sup.3 are the same or different and stand for aliphatic groups having from 1 to 30 carbon atoms, optionally substituted aryl groups, optionally substituted aralkyl groups, and/or optionally substituted heteroaryl groups,R.sup.2 represents hydrogen, the hydroxymethylene group --CH.sub.2 OH or the hydroxy-hydroxymethylene-methylidyne group --CH(OH)(CH.sub.2 OH), andR.sup.4 denotes hydrogen, a halogen atom, a nitro or cyano group, an aliphatic group having from 1 to 30 carbon atoms, an optionally substituted aryl group, an optionally substituted aralkyl group, an optionally substituted heteroaryl group, an alkoxy group --OR.sup.5, a thioether group --SR.sup.6, an amino group --NR.sup.7 R.sup.8, an acyl group--COR.sup.9 or an ester group --COOR.sup.10, where R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.9 stand for radicals such as those stated above for R.sup.1, and R.sup.10 is a C.sub.1 -C.sub.10 alkyl group or an optionally substituted aryl or aralkyl group, orR.sup.3 and R.sup.4 together form a C.sub.3 -C.sub.5 alkylene or C.sub.3 -C.sub.5 alkenylene group or a C.sub.6 -C.sub.14 alkylene group, or a C.sub.7 -C.sub.14 aralkylene or C.sub.8 -C.sub.14 aralkenylene bridging member, andA is the equivalent of an anion having one or more negative charges for electrical neutralization of the charge on the triazolium cation.

摘要翻译： 催化制备甲醛缩合产物的方法，其中使甲醛或形成甲醛的化合物在辅助碱存在下由式I的三唑鎓盐生产的催化剂进行反应， （I）其中R1和R3相同或不同，代表具有1至30个碳原子的脂族基团，任选取代的芳基，任选取代的芳烷基和/或任选取代的杂芳基，R 2表示氢， 羟基亚甲基-CH 2 OH或羟基 - 羟基亚甲基 - 亚甲基基团-CH（OH）（CH 2 OH），R 4表示氢，卤素原子，硝基或氰基，具有1至30个碳原子的脂族基团， 取代的芳基，任选取代的芳烷基，任选取代的杂芳基，烷氧基-OR 5，硫醚基-SR 6，氨基-NR 7 R 8，酰基-C COR 9或酯gr 其中R 5，R 6，R 7，R 8和R 9分别代表上述R 1的基团，R 10是C 1 -C 10烷基或任意取代的芳基或芳烷基，或者R 3和R 4一起形成 C3-C5亚烷基或C3-C5亚烯基或C6-C14亚烷基，或C7-C14亚芳基或C8-C14芳亚烷基桥连元件，A相当于具有一个或多个负电荷用于电中和的阴离子 的三唑鎓阳离子的电荷。