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    Antisense oligonucleotide inhibition of the RAS gene
    94.
    发明授权
    Antisense oligonucleotide inhibition of the RAS gene 失效
    反义寡核苷酸抑制RAS基因

    公开(公告)号：US5576208A

    公开(公告)日：1996-11-19

    申请号：US297248

    申请日：1994-08-26

    申请人： Brett P. Monia ,  Susan M. Freier ,  David J. Ecker

    发明人： Brett P. Monia ,  Susan M. Freier ,  David J. Ecker

    IPC分类号： A61K38/00 ,  C07K14/82 ,  C12N9/02 ,  C12N15/113 ,  C12Q1/68 ,  C12N5/06 ,  C07H21/04

    CPC分类号： C12N15/1135 ,  C07K14/82 ,  C12N9/0069 ,  C12Q1/6886 ,  A61K38/00 ,  C07K2319/61 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/333 ,  C12N2310/3521 ,  C12N2310/3527 ,  C12N2310/3533 ,  C12N2310/3535 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： Compositions and methods are provided for the modulation of expression of the human ras gene in both the normal and activated forms. Oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from the human ras gene, having nucleotide units sufficient in identity and number to effect such specific hybridization. Oligonucleotides specifically hybridizable with a translation initiation site or with the codon-12 mutation of activated ras are provided. Such oligonucleotides can be used for diagnostics as well as for research purposes. Methods are also disclosed for modulating ras gene expression in cells and tissues using the oligonucleotides provided, and for specific modulation of expression of the activated ras gene. Methods for diagnosis, detection and treatment of conditions arising from the activation of the H-ras gene are also disclosed.

    摘要翻译： 提供组合物和方法用于调节正常和活化形式的人ras基因的表达。 提供了与来自人ras基因的RNA或DNA特异性杂交的寡核苷酸，其具有足以实现这种特异性杂交的同一性和数目的核苷酸单元。 提供了与翻译起始位点或活化ras的密码子-12突变特异性杂交的寡核苷酸。 这样的寡核苷酸可用于诊断以及用于研究目的。 还公开了使用提供的寡核苷酸调节细胞和组织中的ras基因表达以及用于特异性调节活化的ras基因的表达的方法。 还公开了用于诊断，检测和治疗由H-ras基因激活引起的病症的方法。

    Methods for modulating factor 12 expression
    95.
    发明授权
    Methods for modulating factor 12 expression 有权
    调节因子12表达的方法

    公开(公告)号：US09150864B2

    公开(公告)日：2015-10-06

    申请号：US13884067

    申请日：2011-11-08

    申请人： Brett P. Monia ,  Robert A. MacLeod ,  Jeffrey R. Crosby

    发明人： Brett P. Monia ,  Robert A. MacLeod ,  Jeffrey R. Crosby

    IPC分类号： C07H21/04 ,  C12N15/113

    CPC分类号： C12N15/1137 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/321 ,  C12N2310/3525

    摘要： Disclosed herein are methods for decreasing Factor 12 and treating or preventing thromboembolic conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 12 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, and mesenteric thrombosis. Methods for inhibiting Factor 12 can also be used as a prophylactic treatment to prevent individuals at risk for thrombosis and embolism.

    摘要翻译： 本文公开了减少因子12并治疗或预防有此需要的个体血栓栓塞症状的方法。 通过施用靶向因子12的反义化合物可以改善的疾病状况的实例包括血栓形成，栓塞和血栓栓塞，例如深静脉血栓形成，肺栓塞，心肌梗塞，中风和肠系膜血栓形成。 抑制因子12的方法也可用作预防性治疗以预防患有血栓栓塞和栓塞危险的个体。

    COMPOSITIONS AND THEIR USES DIRECTED TO DIACYLGLYCEROL ACYLTRANSFERASE 1
    98.
    发明申请
    COMPOSITIONS AND THEIR USES DIRECTED TO DIACYLGLYCEROL ACYLTRANSFERASE 1 失效
    组合物及其用途指向二乙酰胆碱酯酶1

    公开(公告)号：US20120029050A1

    公开(公告)日：2012-02-02

    申请号：US13177457

    申请日：2011-07-06

    申请人： Xing-Xian Yu ,  Sanjay Bhanot ,  Brett P. Monia

    发明人： Xing-Xian Yu ,  Sanjay Bhanot ,  Brett P. Monia

    IPC分类号： A61K31/713 ,  A61P1/16

    CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12Y203/0102

    摘要： Disclosed herein are compounds, compositions and methods for modulating DGAT-1 activity. Preferably, the expression of DGAT-1 from a nucleic acid is inhibited. Methods are provided for treating, ameliorating or treating liver fibrosis, either directly or by treating an underlying etiological factor. Preferably, the treatment, amelioration or prevention comprises administering a DGAT-1 activity modulator.

    摘要翻译： 本文公开了用于调节DGAT-1活性的化合物，组合物和方法。 优选地，来自核酸的DGAT-1的表达被抑制。 提供了直接治疗或改善肝纤维化或通过治疗潜在病因的方法。 优选地，治疗，改善或预防包括施用DGAT-1活性调节剂。