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    REPLENISHING UREASE IN DIALYSIS SYSTEMS USING UREASE POUCHES
    93.
    发明申请
    REPLENISHING UREASE IN DIALYSIS SYSTEMS USING UREASE POUCHES 审中-公开
    使用UREASE POUCHES在透析系统中进行补救

    公开(公告)号：US20150367060A1

    公开(公告)日：2015-12-24

    申请号：US14644576

    申请日：2015-03-11

    Applicant: Medtronic, Inc.

    Inventor： Martin T. Gerber ,  Christopher M. Hobot

    IPC: A61M1/34 ,  B01D15/20 ,  A61M1/36

    CPC classification number: B01D15/203 ,  A61M1/1696 ,  A61M2202/0057 ,  A61M2205/18 ,  A61M2205/33

    Abstract: An apparatus and method for replenishing urease in a sorbent cartridge for use in sorbent dialysis using urease pouches. The sorbent cartridge is configured to allow insertion of a urease pouch or injection of a urease solution into the sorbent cartridge containing a urease pouch. The sorbent module can also comprise other, rechargeable, sorbent materials for removing toxins other than urea from spent dialysate.

    Abstract translation: 用于在吸附剂盒中补充尿素酶的装置和方法，用于使用脲酶袋的吸附剂透析。 吸附剂盒构造成允许将脲酶袋插入或将尿素酶溶液注入含有脲酶袋的吸附剂盒中。 吸附剂模块还可以包含用于从废透析液中去除尿素以外的毒素的其它可再充电的吸附剂材料。

    SORBENT POUCH
    94.
    发明申请
    SORBENT POUCH 审中-公开

    公开(公告)号：US20150367052A1

    公开(公告)日：2015-12-24

    申请号：US14637606

    申请日：2015-03-04

    Applicant: Medtronic, Inc.

    Inventor： Martin T. Gerber ,  Christopher M. Hobot

    IPC: A61M1/14

    CPC classification number: B01J20/28052 ,  A61M1/1696

    Abstract: A sorbent pouch for use in sorbent dialysis. The sorbent pouch allows for fluid to freely pass into and through the sorbent materials, while keeping the sorbent materials inside the sorbent pouch.

    Abstract translation: 用于吸附剂透析的吸附剂袋。 吸附剂袋允许流体自由地进入和穿过吸附剂材料，同时将吸附剂材料保持在吸附剂袋内。

    Methods and compositions for treating post-operative pain comprising clonidine
    95.
    发明授权
    Methods and compositions for treating post-operative pain comprising clonidine 有权
    用于治疗包括可乐定的术后疼痛的方法和组合物

    公开(公告)号：US09211285B2

    公开(公告)日：2015-12-15

    申请号：US14097983

    申请日：2013-12-05

    Applicant: WARSAW ORTHOPEDIC, INC. ,  Medtronic, Inc.

    Inventor： William F. McKay ,  Amira Wohabrebbi ,  Vanja Margareta King ,  Phillip Edward McDonald ,  Christopher M. Hobot ,  Troy Carter

    IPC: A61K31/4168 ,  A61K9/00 ,  A61K9/20 ,  A61K31/4162 ,  A61K47/34

    CPC classification number: A61L31/16 ,  A61K9/0024 ,  A61K9/204 ,  A61K31/4162 ,  A61K31/4168 ,  A61K47/34 ,  A61L31/06 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/604

    Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

    Abstract translation: 本发明涉及可用于减少，预防或治疗需要这种治疗的患者的手术后疼痛的可植入药物贮存库，所述可植入药物储库包含治疗有效量的可乐定或其药学上可接受的盐和聚合物; 其中所述贮存库可植入皮肤下面的部位以减少，预防或治疗手术后疼痛，并且所述贮库能够释放（i）约5％至约45％的可乐定或其药学上可接受的盐相对于 在最多48小时的第一时间内装载在药物贮库中的可乐定或其药学上可接受的盐的总量和（ii）可乐定或其药学上可接受的盐的约55％至约95％相对于 至少3天的随后期间，将可乐定或其药学上可接受的盐装载在药物贮库中。

    Peritoneal dialysis intracycle osmotic agent adjustment
    96.
    发明授权
    Peritoneal dialysis intracycle osmotic agent adjustment 有权

    公开(公告)号：US11883576B2

    公开(公告)日：2024-01-30

    申请号：US17024039

    申请日：2020-09-17

    Applicant: Medtronic, Inc.

    Inventor： Martin T. Gerber ,  Christopher M. Hobot

    IPC: A61M1/28 ,  A61K31/7004 ,  A61K31/718 ,  A61M1/16

    CPC classification number: A61M1/282 ,  A61K31/7004 ,  A61K31/718 ,  A61M1/1656 ,  A61M2202/0486 ,  A61M2205/3344 ,  A61M2205/50 ,  A61M2230/30

    Abstract: The invention relates to systems and methods for making intracycle adjustments to an osmotic agent concentration of peritoneal dialysate inside the peritoneal cavity of a patient. The systems and methods include osmotic agent sources, flow paths, and processors to adjust the osmotic agent concentration of dialysate in the peritoneal cavity of the patient. The method can include infusing peritoneal dialysate containing an osmotic agent into the peritoneal cavity of a patient; monitoring one or more patient parameters; and adjusting the osmotic agent concentration of the peritoneal dialysate in the peritoneal cavity of the patient by infusing a concentrated osmotic agent solution or by infusing sterile fluid into the peritoneal cavity of the patient using an on-line peritoneal dialysis machine. The system can include a peritoneal dialysis cycler.

    PERITONEAL DIALYSIS FLUID TESTING SYSTEM
    98.
    发明申请
    PERITONEAL DIALYSIS FLUID TESTING SYSTEM 有权

    公开(公告)号：US20210220541A1

    公开(公告)日：2021-07-22

    申请号：US17201569

    申请日：2021-03-15

    Applicant: Medtronic, Inc.

    Inventor： Martin T. Gerber ,  Christopher M. Hobot

    IPC: A61M1/28 ,  A61M1/16 ,  A61B5/145 ,  A61B5/00

    Abstract: The invention relates to a testing system and related methods for detecting peritonitis or infection in peritoneal dialysate removed from a patient. The testing system can include a fluid sensor apparatus in a fluid line of a peritoneal dialysis cycler through which spent peritoneal dialysate can be pumped. The fluid sensor apparatus can detect one or more markers associated with peritonitis or infection.

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