Methods and compositions to treat myocardial conditions
    93.
    发明授权
    Methods and compositions to treat myocardial conditions 有权
    治疗心肌病症的方法和组合物

    公开(公告)号:US08821473B2

    公开(公告)日:2014-09-02

    申请号:US12632612

    申请日:2009-12-07

    CPC classification number: A61K9/0019 A61K9/0024 A61K31/7088

    Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

    Abstract translation: 用于治疗心肌梗塞的方法,装置,试剂盒和组合物。 在一个实施例中,该方法包括防止脑室梗死区的重塑。 在其它实施方案中,该方法包括引入结构上增强剂。 在其它实施方案中,将药剂引入心室以增加心室的依从性。 在替代实施例中,预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中,预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中,结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

    Hot-Melt Sealing Glass Compositions And Devices Using The Same
    96.
    发明申请
    Hot-Melt Sealing Glass Compositions And Devices Using The Same 有权
    热熔胶封玻璃组合物和使用它的设备

    公开(公告)号:US20130062712A1

    公开(公告)日:2013-03-14

    申请号:US13608022

    申请日:2012-09-10

    Abstract: Hot-melt sealing glass compositions that include one or more glass frits dispersed in a polymeric binder system. The polymeric binder system is a solid at room temperature, but melts at a temperature of from about 35° C. to about 90° C., thereby forming a flowable liquid dispersion that can be applied to a substrate (e.g., a cap wafer and/or a device wafer of a MEMS device) by screen printing. Hot-melt sealing glass compositions according to the invention rapidly re-solidify and adhere to the substrate after being deposited by screen printing. Thus, they do not tend to spread out as much as conventional solvent-based glass frit bonding pastes after screen printing. And, because hot-melt sealing glass compositions according to the invention are not solvent-based systems, they do not need to be force dried after deposition.

    Abstract translation: 包括分散在聚合物粘合剂体系中的一种或多种玻璃料的热熔密封玻璃组合物。 聚合物粘合剂体系在室温下为固体,但在约35℃至约90℃的温度下熔融,由此形成可流动的液体分散体,其可施加到基底(例如盖片和 /或MEMS器件的器件晶片)。 根据本发明的热熔密封玻璃组合物在通过丝网印刷沉积之后快速再固化并附着到基底上。 因此,它们在丝网印刷后不会像常规的溶剂型玻璃料粘合膏一样扩散。 而且,由于根据本发明的热熔密封玻璃组合物不是溶剂型体系,它们在沉积后不需要强力干燥。

    Hybrid intravascular stent
    99.
    发明授权
    Hybrid intravascular stent 有权
    混合血管内支架

    公开(公告)号:US07674416B2

    公开(公告)日:2010-03-09

    申请号:US11020826

    申请日:2004-12-22

    Abstract: A hybrid stent is formed which exhibits both high flexibility and high radial strength. The expandable hybrid stent for implantation in a body lumen, such as a coronary artery, consists of radially expandable cylindrical rings generally aligned on a common longitudinal axis and interconnected by one or more links. In one embodiment, a dip-coated covered stent is formed by encapsulating cylindrical rings within a polymer material. In other embodiments, at least some of the rings and links are formed of a polymer material which provides longitudinal and flexural flexibility to the stent. These polymer rings and links are alternated with metallic rings and links in various configurations to attain sufficient column strength along with the requisite flexibility in holding open the target site within the body lumen. Alternatively, a laminated, linkless hybrid stent is formed by encapsulating cylindrical rings within a polymer tube.

    Abstract translation: 形成具有高柔性和高径向强度的混合支架。 用于植入体腔(例如冠状动脉)中的可扩张混合支架由径向可扩展的圆柱形环构成,其通常在公共纵向轴线上对齐并且由一个或多个连杆相互连接。 在一个实施例中,通过将圆柱形环封装在聚合物材料内而形成浸涂的覆盖支架。 在其它实施例中,至少一些环和链节由聚合物材料形成,该聚合物材料向支架提供纵向和弯曲的柔性。 这些聚合物环和链环与金属环和各种结构的链接交替,以获得足够的柱强度以及在体腔内保持打开靶部位所需的灵活性。 或者,通过在聚合物管内封装圆柱形环来形成层压的无环式混合支架。

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