公开(公告)号：US20090326359A1

公开(公告)日：2009-12-31

申请号：US12375776

申请日：2007-07-11

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Ruth Wihelmine Ireen De Boer ,  Gerhard Spekowius ,  Stein Kuipeer ,  Nijs Cornelis Van Der Vaart

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Ruth Wihelmine Ireen De Boer ,  Gerhard Spekowius ,  Stein Kuipeer ,  Nijs Cornelis Van Der Vaart

IPC分类号： A61B6/00

CPC分类号： G01N21/33 ,  A61B5/0066 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B5/6852 ,  G01N15/1475 ,  G01N21/6458

摘要： The invention relates to a method of determining in vivo in a human or animal subject the amount of nuclear DNA by first localizing cell nuclei of living tissue and subsequently measuring the nuclear UV absorbance using confocal scanning microscopy. The invention relates also to a method for detecting cancerous cells in vivo in a human or animal subject by first identifying the localization of cell nuclei in living tissue and subsequently determining the nuclear UV absorbance by laser scanning confocal microscopy. Furthermore, the invention relates to a method of diagnosing cancer in a human or animal subject in vivo relying on a combination of identifying the localization of cell nuclei in living tissue and measuring nuclear UV absorbance by laser scanning confocal microscopy.

摘要翻译： 本发明涉及一种通过首先定位活组织的细胞核并随后使用共聚焦扫描显微镜测量核紫外吸收光，在人体或动物体内测定核DNA数量的方法。 本发明还涉及通过首先识别活体组织中细胞核的定位并随后通过激光扫描共焦显微镜确定核紫外吸收光，来检测人或动物受试者体内癌细胞的方法。 此外，本发明涉及一种通过识别活体组织中细胞核的定位和通过激光扫描共焦显微镜测量核紫外吸收的组合来诊断人或动物受试者的癌症的方法。

公开(公告)号：US20090185281A1

公开(公告)日：2009-07-23

申请号：US12373083

申请日：2007-07-02

申请人： Bernardus Hendrikus Wilhelmus Hendriks

发明人： Bernardus Hendrikus Wilhelmus Hendriks

IPC分类号： G02B15/177 ,  G02B3/14

CPC分类号： G02B3/14 ,  G02B13/0045 ,  G02B13/006 ,  G02B13/009 ,  G02B26/005

摘要： The invention provides a zoom optical system comprising two fluid lenses (22, 40) and a first fixed lens group (20) of negative optical power, positioned at the object side of the zoom optical system. The first negative lens (20) ensures that a beam in the zoom optical system is relatively narrow, which allows the further elements, in particular the fluid lenses (22, 40) to be smaller in diameter, which is advantageous for their optical quality and for their susceptibility to temperature differences, gravitational influences et cetera.

摘要翻译： 本发明提供了一种变焦光学系统，其包括位于变焦光学系统的物体侧的两个流体透镜（22,40）和负光焦度的第一固定透镜组（20）。 第一负透镜（20）确保变焦光学系统中的光束相对较窄，这允许其他元件，特别是流体透镜（22,40）的直径更小，这有利于其光学质量和 因为它们对温差的敏感性，引力影响等等。

公开(公告)号：US20080043578A1

公开(公告)日：2008-02-21

申请号：US10598876

申请日：2005-03-08

申请人： Frank Cornelis Penning ,  Ferry Zijp ,  Aukje Arianne Annette Kastelijn ,  Bernardus Hendrikus Wilhelmus Hendriks

发明人： Frank Cornelis Penning ,  Ferry Zijp ,  Aukje Arianne Annette Kastelijn ,  Bernardus Hendrikus Wilhelmus Hendriks

IPC分类号： G11B7/22

CPC分类号： G11B11/10554 ,  G11B11/10536 ,  G11B11/10545 ,  G11B11/1058

摘要： A Method of Manufacturing an Integrated Magneto-Optical Element for use in a Digital Magneto-Optical Signal write/Read Head and an Integrated Magneto-Optical Element Manufactured According to the Method A method of manufacturing an integrated magneto-optical element for use in a digital magneto-optical signal read/write head, in which the manufacturing techniques of thin film coils are combined with lens-making techniques to realise a high performance, reliable and cost-effective lens-MFM coil combination for use in a slider having an air bearing surface for “flying” just above a surface of a storage medium (102) during operation. The method comprises two principal steps: Step I is to make an MFM coil (106) by means of a thin film technique, and Step 2 is to make an objective lens (114) on top of the transparent (e.g. glass) plate (109) in which the MFM coil (106) is located.

摘要翻译： 一种制造用于数字磁光信号写/读头和集成磁光元件的集成磁光元件的制造方法根据该方法制造用于数字化的集成磁光元件的方法 磁光信号读/写头，其中薄膜线圈的制造技术与透镜制造技术相结合，以实现用于具有空气轴承的滑块的高性能，可靠和成本有效的透镜MFM线圈组合 在运行期间恰好在存储介质（102）的表面上方“飞行”的表面。 该方法包括两个主要步骤：步骤I是通过薄膜技术制造MFM线圈（106），步骤2是在透明（例如玻璃）板（109）的顶部上制成物镜（114） ），其中MFM线圈（106）位于其中。

公开(公告)号：US07170681B2

公开(公告)日：2007-01-30

申请号：US10501422

申请日：2002-12-18

申请人： Bernardus Hendrikus Wilhelmus Hendriks

发明人： Bernardus Hendrikus Wilhelmus Hendriks

IPC分类号： G02B27/44

CPC分类号： G02B5/1833 ,  G02B5/1876 ,  G11B7/1353 ,  G11B7/1367 ,  G11B7/1374 ,  G11B2007/0006 ,  G11B2007/13727

摘要： An optical scanning device (1) for scanning three information layer (2, 2′, 2″) with three respective radiation beams (4, 4′, 4″) having three respective wavelengths (λ1, λ2, λ3) and polarizations (p1, p2, p3). The three wavelengths differ from each other. At least one of the three polarizations differs from the others. The device comprises a diffractive part (24) including a pattern of pattern elements which have one stepped profile for forming three diffracted beams (15, 15′, 15″) from the three radiation beams, the part comprising birefringent material, sensitive to the three polarizations. The stepped profile is designed such that the heights (hj) of the steps of a pattern element introduce phase changes that equal at least two different multiples of 2π for one (λ1) of the three wavelengths and equal at least two different phase changes modulo 2π for one (λ2) of the two other wavelengths.

摘要翻译： 一种光扫描装置（1），用于用具有三个相应波长（λ<1/2）的三个相应辐射束（4,4'，4“）扫描三个信息层（2,2'，2”） λ，λ2，λ3）和极化（p 1，p 2，p 3）。 三个波长彼此不同。 三个极化中的至少一个与其他极化不同。 该装置包括具有图形元件图案的衍射部分（24），该图形元件具有一个阶梯轮廓，用于从三个辐射束形成三个衍射光束（15,15'，15“），该部分包括双折射材料 三极化。 阶梯轮廓被设计成使得图案元件的台阶的高度引入相位变化，相位变化等于两个不同倍数的2pi，一个（λ1 SUB / >），并且对于两个其它波长的一个（λ<2> 2 ），等于至少两个不同相位变化为2pi。

公开(公告)号：US07130134B2

公开(公告)日：2006-10-31

申请号：US10498300

申请日：2002-12-06

申请人： Bernardus Hendrikus Wilhelmus Hendriks

发明人： Bernardus Hendrikus Wilhelmus Hendriks

IPC分类号： G02B13/18 ,  G11B7/00

CPC分类号： G11B7/0956 ,  G11B7/1374 ,  G11B7/1378 ,  G11B7/13927 ,  G11B2007/13727

摘要： The invention relates to an optical scanning device (1) for scanning an information layer (2) by means of a radiation beam (4). The device includes: a radiation source (6) for providing said radiation beam, a lens system (7) for transforming said radiation beam to a converging beam (16), and a wavefront modifier including a first element (301) and a second element (302) having each an aspheric surface and being mutually movable in a plane perpendicular to an optical axis (12) of said lens system for introducing a wavefront modification (W1) in said converging beam. According to the invention, the aspheric surfaces of said first and second elements are shaped so that a mutual rotational displacement of the elements about an axis of rotation (ZA) which is parallel to said optical axis (12) generates said wavefront modification (W1).

摘要翻译： 本发明涉及一种用于通过辐射束（4）扫描信息层（2）的光学扫描装置（1）。 该装置包括：用于提供所述辐射束的辐射源（6），用于将所述辐射束变换成会聚束（16）的透镜系统（7），以及包括第一元件（301）和第二元件 （302），其具有每个非球面并且可以在垂直于所述透镜系统的光轴（12）的平面中相互移动，以在所述会聚光束中引入波前修正（W 1> 1）。 根据本发明，所述第一和第二元件的非球面形状被成形为使得元件围绕平行于所述光轴（12）的旋转轴线（Z SUB）的相互旋转位移 ）产生所述波前修正（W 1> 1）。

公开(公告)号：US07126900B2

公开(公告)日：2006-10-24

申请号：US10497343

申请日：2002-12-05

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jorrit Ernst De Vries

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jorrit Ernst De Vries

IPC分类号： G11B7/00

CPC分类号： G11B7/13925 ,  G11B7/1362 ,  G11B7/1367 ,  G11B7/1369 ,  G11B2007/0013

摘要： An optical scanning device for scanning a dual-layer optical record carrier. The device includes a spherical aberration compensation optical subsystem having a switchable liquid crystal cell (10) for altering a wavefront deviation generated in a folding mirror (32) including a non-periodic phase structure (NPS) located behind a polarization-selective reflective layer.

摘要翻译： 一种用于扫描双层光学记录载体的光学扫描装置。 该装置包括球面像差补偿光学子系统，其具有用于改变在包括位于偏振选择反射层之后的非周期相位结构（NPS）的折叠镜（32）中产生的波前偏差的可切换液晶单元（10）。

公开(公告)号：US06928043B2

公开(公告)日：2005-08-09

申请号：US10008196

申请日：2001-11-08

申请人： Jorrit Ernst De Vries ,  Bernardus Hendrikus Wilhelmus Hendriks

发明人： Jorrit Ernst De Vries ,  Bernardus Hendrikus Wilhelmus Hendriks

IPC分类号： G02B5/18 ,  G11B7/00 ,  G11B7/135

CPC分类号： G11B7/1374 ,  G11B7/1353 ,  G11B7/139 ,  G11B7/13922 ,  G11B2007/0006

摘要： A device for scanning a first and second type of optical record carriers (2, 40) generators a first and a second radiation beam for scanning the first and second type of record carriers, respectively. The information layers (4, 42) of the first and second type of record carriers is scanned through transparent layers (3, 41) of different thickness. The first radiation beam (17) has a first wavelength and a first numerical aperture NA−1. The second radiation beam (46) has a different, second wavelength and an effective second numerical aperture NA2 smaller NA1. The rays of the second radiation beam having an NA smaller than NA2 form a central sub-beam (48), the rays having a larger NA form an outer sub-beam (49). The device includes a non-periodic phase structure that does not affect the first radiation beam. The phase structure introduces an amount of spherical aberration in the central sub-beam (48). The phase structure is transparent for the central and outer sub-beam (48, 49). The introduced spherical aberration compensates the difference in spherical aberration caused by the difference in thickness of the transparent layer (3, 41) of the first and second type of record carriers (2, 40). To reduce the amount of stray light falling on the detection system (25) from rays in the outer sub-beam (49), the phase structure introduces an amount of defocus in the second radiation beam (17). The defocus displaces the focus of the central sub-beam with respect to the focus of the outer sub-beam, causing the intensity distribution of the central and outer sub-beam split in two separate distributions. If the position and size of the detection system are properly chosen, the detection system will capture mainly rays from the central sub-beam and not from the outer sub-beam. Hence, the displacement of the foci allows spatial filtering in the plane of the detection system (25) of the desired and undesired rays of the second radiation beam.

公开(公告)号：US09945915B2

公开(公告)日：2018-04-17

申请号：US13265387

申请日：2010-04-13

申请人： Mareike Klee ,  Axel Winkel ,  John Brean Mills ,  Ronald Dekker ,  Bernardus Hendrikus Wilhelmus Hendriks

发明人： Mareike Klee ,  Axel Winkel ,  John Brean Mills ,  Ronald Dekker ,  Bernardus Hendrikus Wilhelmus Hendriks

IPC分类号： G01R33/28 ,  G01R33/34

CPC分类号： G01R33/287 ,  G01R33/34007 ,  G01R33/34084 ,  Y10T29/4902

摘要： An elongate device, such as a catheter, for interventional MRI has one or more passive LC-circuits attached to its distal tip portion for position tracking. The LC-circuits includes an inductor winding and a three-dimensional “trench” capacitor. The LC-circuits are integrated in a piece of silicon. Optical fibers may be included in the device for optical probing of tissue surrounding the distal tip portion.

公开(公告)号：US09468379B2

公开(公告)日：2016-10-18

申请号：US13641229

申请日：2011-04-18

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

IPC分类号： G01N21/359 ,  A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/4869 ,  G01N21/359

摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.

摘要翻译： 本发明涉及一种用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。 具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。 这使得能够确定散射参数。 在第三波长处的进一步测量使得能够测定水 - 油比。 根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水比和散射来检查组织。

公开(公告)号：US08553839B2

公开(公告)日：2013-10-08

申请号：US13134537

申请日：2009-12-04

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Adrien Desjardins ,  Drazenko Babic

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Adrien Desjardins ,  Drazenko Babic

IPC分类号： G01N23/04

CPC分类号： A61B6/5235 ,  A61B6/4423 ,  A61B6/4441 ,  A61B6/5247 ,  A61B90/361 ,  A61B2090/364 ,  A61B2090/366 ,  A61B2090/371 ,  A61B2090/376

摘要： A system for generating an image including information of both an interior and an exterior of a patient. The system includes an X ray device for providing an X ray image of a patient's interior, and a camera responsive to a wavelength for providing a camera image of a patient's exterior. The camera may be supported by the X ray device for establishing a determined spatial relationship between the camera and the X ray device. The system further includes a spatial reference for spatially correlating the X ray image and the camera image, where the spatial reference is detectable in the X ray image and in the camera image. A data processor configured for rendering the camera image and the X ray image into a composite image on the basis of the spatial reference.

摘要翻译： 一种用于生成包括患者的内部和外部的信息的图像的系统。 该系统包括用于提供患者内部的X射线图像的X射线装置和响应于用于提供患者外部的照相机图像的波长的照相机。 照相机可以由X射线装置支持，以建立照相机和X射线装置之间确定的空间关系。 该系统还包括用于空间上相关X射线图像和相机图像的空间参考，其中空间参考在X射线图像和相机图像中是可检测的。 一种数据处理器，被配置为基于空间参考将相机图像和X射线图像渲染成合成图像。