摘要:
Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要:
A class of pyrazole derivatives is described for use in treating p38 kinase medicated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
摘要:
Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要:
A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
摘要:
Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要:
The present invention provides T helper cell epitopes and compositions for use in inducing an immune response comprising at least one of these epitopes. The epitopes are contained within a peptide sequence selected from the group consisting of SSKTQTHTQQDRPPQPS (SEQ ID NO: 1); QPSTELEETRTSRARHS (SEQ ID NO: 2); QSLRTSLEQSNKAIEEI (SEQ ID NO: 18); and DESSCVFVSESAICSQN (SEQ ID NO: 23).
摘要翻译:本发明提供了用于诱导包含这些表位中的至少一个的免疫应答的T辅助细胞表位和组合物。 表位包含在选自SSKTQTHTQQDRPPQPS(SEQ ID NO:1)的肽序列中; QPSTELEETRTSRARHS(SEQ ID NO:2); QSLRTSLEQSNKAIEEI(SEQ ID NO:18); 和DESSCVFVSESAICSQN(SEQ ID NO:23)。
摘要:
An accurate blending module for adjusting the pH of solutions containing therapeutic proteins includes a recirculation loop that receives the therapeutic protein solution via a feed pump and an acid solution via an adjusting pump. The recirculation loop includes a recirculation pump and a pH sensor that detects the pH of the solution in the recirculation loop. A controller communicates with the pH sensor and the adjusting pump. The adjusting pump adds acid to the recirculation loop based on the pH readings taken by the pH sensor. The recirculation pump recirculates the therapeutic protein solution and acid in the recirculation loop so that it is mixed. As a result, the pH of the therapeutic protein solution is precisely controlled and adjusted in a non-destructive fashion.
摘要:
Disclosed are compounds of Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要:
The present invention relates to sample presentation devices useful in performing analytical measurements. These devices have been configured to enable various aspects of liquid handling such as: retention, storage, transport, concentration, positioning, and transfer. Additionally, these devices can enhance the detection and characterization of analytes. The sample presentation devices of the present invention are comprised of one or more substrates having a plurality of zones of differing wettability. Methods of analyzing samples using the sample presentation device of the invention, as well as methods of making the sample presentation devices are disclosed.
摘要:
An apparatus and method for providing Single Sign-On services to a user when accessing a selected Service Provider from a plurality of Service Providers. An Authentication Provider authenticates the user at with a user-identity, provides the user with a token as proof of the authentication, and assigns a temporary alias-identity to the user for use when the user accesses the selected Service Provider. The Authentication Provider and the selected Service Provider link the assigned alias-identity and the user-identity to identify the user at respective sites. The user accesses the selected Service Provider by presenting the token along with a local user-identity valid for the selected Service Provider. When the user attempts a subsequent access at the selected Service Provider, the user is identified by the shared alias-identity, if the user allowed permanent linking. If the user did not allow permanent linking, the process is repeated for each subsequent access.