公开(公告)号：US20060093581A1

公开(公告)日：2006-05-04

申请号：US11295596

申请日：2005-12-07

申请人： Alan Smith ,  Douglas Smith ,  Ramkumar Mandalam

发明人： Alan Smith ,  Douglas Smith ,  Ramkumar Mandalam

IPC分类号： A61K35/14 ,  C12N5/08

CPC分类号： C12N5/0655 ,  A61K35/15 ,  A61K35/17 ,  A61K35/32 ,  A61K2035/124 ,  C12N5/0636 ,  C12N5/0639 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/25 ,  C12N2501/59

摘要： A method for obtaining lineage committed human cells imbued with enhanced proliferative potential, biological function, or both, comprising culturing lineage committed human cells under physiologically acceptable liquid culture conditions, where the liquid culture medium is replaced at a rate and for a time sufficient to obtain the human lineage committed cells imbued with enhanced proliferative potential, biological function, or both; and isolating the cultured cells.

摘要翻译： 一种用于获得具有增强的增殖潜力，生物功能或两者具有增强的增殖潜力的人类细胞的方法，包括在生理上可接受的液体培养条件下培养谱系承诺的人细胞，其中液体培养基以足以获得的速率和时间 人类谱系承诺的细胞具有增强的增殖潜力，生物功能或两者; 并分离培养的细胞。

公开(公告)号：US20060089128A1

公开(公告)日：2006-04-27

申请号：US10499759

申请日：2002-12-19

申请人： Alan Smith ,  Julie Stuart

发明人： Alan Smith ,  Julie Stuart

IPC分类号： H04Q7/22

CPC分类号： H04W4/12 ,  H04L51/26 ,  H04L51/38 ,  H04W4/14 ,  H04W88/184

摘要： A method and system of transferring messages from a message source to a mobile station in a cellular system comprises assigning to each message a priority characteristic before the message is transmitted to mobile station. The message is then transmitted together with the assigned priority characteristic, depending on the priority characteristic. The priority characteristic is examined at the mobile station and the message is processed at the mobile station depending on the priority characteristic.

摘要翻译： 将消息从消息源传送到蜂窝系统中的移动站的方法和系统包括：在消息被发送到移动台之前向每个消息分配优先级特征。 然后根据优先级特性，将消息与分配的优先级特性一起发送。 在移动站检查优先级特征，并根据优先级特性在移动台处理消息。

公开(公告)号：US20060083773A1

公开(公告)日：2006-04-20

申请号：US11243952

申请日：2005-10-04

申请人： David Myung ,  Jaan Noolandi ,  Alan Smith ,  Curtis Frank ,  Christopher Ta ,  Yin Hu ,  Won-Gun Koh ,  Michael Carrasco

发明人： David Myung ,  Jaan Noolandi ,  Alan Smith ,  Curtis Frank ,  Christopher Ta ,  Yin Hu ,  Won-Gun Koh ,  Michael Carrasco

IPC分类号： A61K35/30 ,  A61F2/14

CPC分类号： A61K35/44 ,  A61F2/142 ,  A61F2/145 ,  A61L27/26 ,  A61L27/3804 ,  A61L27/3813 ,  A61L27/3839 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/602 ,  A61L2430/16 ,  C12N5/0621 ,  C12N2533/30 ,  C08L33/08 ,  C08L71/02

摘要： A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.

摘要翻译： 提供了可以作为植入物被应用于人造地替代或增加角膜的材料，例如人造角膜，角膜镶嵌物或角膜嵌体（体内镜片）。 人造角膜植入物具有双网络水凝胶，其中第一网络与第二网络互穿。 第一个网络和第二个网络是基于生物相容的聚合物。 至少一种网状聚合物是基于亲水性聚合物。 人造角膜或植入物具有上皮促进生物分子，其使用叠氮化物 - 活性酯化学接头共价连接到双网络水凝胶的表面。 角膜上皮细胞或角膜衍生细胞粘附于生物分子。 双网络具有生理扩散系数，以允许营养物质通过粘附细胞。

公开(公告)号：US20050274314A1

公开(公告)日：2005-12-15

申请号：US10868735

申请日：2004-06-15

申请人： William Norton ,  Alan Smith

发明人： William Norton ,  Alan Smith

IPC分类号： A01M29/06 ,  A01M29/08 ,  A01M29/00

CPC分类号： A01M29/06 ,  A01M29/08

摘要： An apparatus to repel non-raptorial birds and animals including but not limited to squirrels, rabbits, mice, rats, and deer from selected areas of a property. The apparatus, when placed in an area, convinces the birds and animals of the presence of a predator, a human being, and/or some other perceived threatening presence or a danger that self-motivates the birds and animals to avoid the area and prevents thus the contamination, defacing, and/or damage to the area from the bird feces or nesting and consumption and/or damage of garden plants, agricultural crops, trees, and/or shrubs by the other animals.

摘要翻译： 包括但不限于松鼠，兔子，小鼠，老鼠，以及从属性的某些区域的鹿的非强奸鸟类和动物的装置。 该装置在放置在一个区域时，说服鸟类和动物存在捕食者，人类和/或某些其他感知到的威胁存在或危及自动激励鸟类和动物以避免该区域并防止 从而使鸟类粪便的污染，污染和/或损害，或其他动物的花园植物，农作物，树木和/或灌木的嵌套和消耗和/或损坏。

公开(公告)号：US20050244942A1

公开(公告)日：2005-11-03

申请号：US11179865

申请日：2005-07-12

申请人： Catherine O'Riordan ,  Amy Helgeson ,  Alan Smith

发明人： Catherine O'Riordan ,  Amy Helgeson ,  Alan Smith

IPC分类号： C12N15/09 ,  C12N7/02 ,  C12N15/864

CPC分类号： C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10351 ,  C12N2750/14143 ,  C12N2750/14151 ,  Y10S435/803

摘要： The present invention relates to the purification of large scale quantities of active (infectious) adenovirus and AAV, especially for use in therapeutic applications. In particular, the invention provides improved methods for contacting such viruses with suitable chromatographic materials in a fashion such that any damage to the virus, particularly to surface components thereof, resulting from contact with such chromatographic materials is minimized or eliminated. The result is the ability to rapidly and efficiently purify commercial level quantities of active (infectious) virus suitable for use in therapeutic applications, e.g. gene transfer/therapy procedures.

摘要翻译： 本发明涉及大规模量的活性（感染性）腺病毒和AAV的纯化，特别是用于治疗应用。 特别地，本发明提供了使这种病毒与合适的色谱材料接触的改进方法，使得与这种色谱材料的接触导致的对病毒，特别是其表面组分的任何损害被最小化或消除。 其结果是能够快速有效地纯化商业级数量的适用于治疗应用的活性（感染性）病毒，例如， 基因转移/治疗程序。

公开(公告)号：US20050188273A1

公开(公告)日：2005-08-25

申请号：US10751355

申请日：2004-01-05

申请人： Dario Angelo ,  Alan Smith ,  Kevin Stewart ,  Thomas Sullivan

发明人： Dario Angelo ,  Alan Smith ,  Kevin Stewart ,  Thomas Sullivan

IPC分类号： G06F11/00

CPC分类号： G06F11/0775 ,  G06F11/0715

摘要： An apparatus and method are provided for context-sensitive error event notification. The apparatus and method include a monitor to detect an error event within a computer application, an analysis module to determine characteristics of the error event, an assembler to compose a context-sensitive message comprising a context-sensitive resource relating to the event characteristics, and a transmission module to transmit the message to a set of addressees. The context-sensitive message may include error characteristics, error-specific information from reference materials, error-specific links to related information repositories, and an error-associated search. The context-sensitive message is automatically transmitted to a set of addressees that are associated with the error event. The invention provides for faster error recovery and more effective problem resolution by automatically transmitting an error notification message that is timely, informative, and includes resources associated with the error event such that people can solve the problem.

摘要翻译： 为上下文敏感的错误事件通知提供了一种装置和方法。 该装置和方法包括用于检测计算机应用程序内的错误事件的监视器，用于确定错误事件的特征的分析模块，汇编器构成包含与事件特性相关的上下文相关资源的上下文相关消息，以及 传输模块，用于将消息传送到一组接收者。 上下文敏感消息可以包括错误特征，来自参考资料的特定于错误的信息，到相关信息存储库的特定于错误的链接以及与错误相关的搜索。 上下文相关消息被自动发送到与错误事件相关联的一组收件人。 本发明通过自动发送及时，翔实的错误通知消息来提供更快的错误恢复和更有效的问题解决，并且包括与错误事件相关联的资源，使得人们可以解决问题。

公开(公告)号：US20050099383A1

公开(公告)日：2005-05-12

申请号：US10780822

申请日：2004-02-18

申请人： Robert Nguyen ,  Alan Smith ,  Mike Insalaco

发明人： Robert Nguyen ,  Alan Smith ,  Mike Insalaco

IPC分类号： H04N7/01 ,  H04N7/24 ,  H04N5/335

CPC分类号： H04N21/8455 ,  H04N21/242 ,  H04N21/4143 ,  H04N21/42661 ,  H04N21/4305 ,  H04N21/4341 ,  H04N21/43615 ,  H04N21/4363 ,  H04N21/4381 ,  H04N21/64322

摘要： One embodiment of the invention relates to a signal conversion system for converting an asynchronous signal to an isochronous signal to permit displaying network-delivered digital content on a television device. A computing device acts as the source or storage of digital video content. A conversion device is communicatively coupled to the computing device to receive asynchronous digital video content. Either the conversion device or the computing device identifies two or more reference markers in the asynchronous video stream and determines a clock rate from the known time interval between the two or more reference markers and the amount of video content received between the two or more reference markers. The conversion device generates an isochronous digital video stream having the video content at an interval corresponding to the clock rate. The clock rate in the isochronous signal approximates an original clock rate for the digital video stream.

摘要翻译： 本发明的一个实施例涉及一种用于将异步信号转换为同步信号以允许在电视设备上显示网络传送的数字内容的信号转换系统。 计算设备充当数字视频内容的源或存储。 转换设备通信地耦合到计算设备以接收异步数字视频内容。 转换装置或计算装置都识别异步视频流中的两个或更多个参考标记，并且从两个或更多个参考标记之间的已知时间间隔和在两个或更多个参考标记之间接收的视频内容的量确定时钟速率 。 转换装置以与时钟速率对应的间隔产生具有视频内容的同步数字视频流。 等时信号中的时钟频率近似于数字视频流的原始时钟速率。

公开(公告)号：US20050071378A1

公开(公告)日：2005-03-31

申请号：US10674734

申请日：2003-09-30

申请人： Alan Smith

发明人： Alan Smith

IPC分类号： G06F9/445 ,  G06F17/30

CPC分类号： G06F9/445

摘要： A system and method of storing applications on removable memory or storage with a separate applications registry maintained on the removable memory. Upon insertion the data base on the removable memory or storage can be merged with the applications database on the computer system to form a virtual registry. Preferred embodiments of the present are directed to handheld computer devices such as calculators and personal digital assistants. Applications can be easily integrated with the computers system applications upon insertion of the memory containing the application preferably such that nothing need be stored on the computer to support those applications on the removable memory. Where there are multiple applications for a single data type, the system first associates the application most likely desired by the user to run the desired data type.

摘要翻译： 将可移动存储器或存储器上的应用程序存储在保存在可移动存储器上的单独应用注册器的系统和方法。 在插入时，可移动内存或存储上的数据库可以与计算机系统上的应用程序数据库合并，以形成虚拟注册表。 本发明的优选实施例涉及诸如计算器和个人数字助理的手持计算机设备。 在插入包含应用的存储器时，应用可以容易地与计算机系统应用集成，优选地，使得不需要在计算机上存储以支持可移动存储器上的那些应用。 在单个数据类型有多个应用程序的情况下，系统首先将用户最希望的应用程序关联以运行所需的数据类型。

公开(公告)号：US20050044596A1

公开(公告)日：2005-02-24

申请号：US10804844

申请日：2004-03-18

申请人： Alan Smith

发明人： Alan Smith

IPC分类号： C12N15/82 ,  A01H1/00 ,  A01H5/00

CPC分类号： C12N15/8231 ,  C12N15/8233 ,  C12N15/827 ,  C12N15/8289 ,  C12N15/829

摘要： The invention provides methods to confer sterility and enhanced floral properties to plants, and plants having those properties.

摘要翻译： 本发明提供赋予植物无菌性和增强花性的方法以及具有这些性质的植物。

公开(公告)号：US20050035280A1

公开(公告)日：2005-02-17

申请号：US10666453

申请日：2003-09-17

申请人： Alan Smith ,  Christopher Valente ,  Martin Rathgeber ,  Mark Siegler ,  James Fitzgibbon

发明人： Alan Smith ,  Christopher Valente ,  Martin Rathgeber ,  Mark Siegler ,  James Fitzgibbon

IPC分类号： G01D5/249 ,  G01D5/34 ,  G06M7/00 ,  H03M1/28

CPC分类号： G01D5/2497 ,  H03M1/282 ,  H03M1/287

摘要： A movable barrier operator includes an absolute position detector which provides a unique value for each position of the barrier along its path of travel. The absolute position detector employs multiple binary serial streams and one multiple clock stream. After the first five cycles of the clock stream, the binary streams can be decoded by a processor to produce an absolute position. Every clock edge produces a new absolute position along the path of travel.