公开(公告)号：US08796434B2

公开(公告)日：2014-08-05

申请号：US13054314

申请日：2009-07-15

Applicant: Gyula Dekany ,  Károly Ágoston ,  István Bajza ,  Marie Bøjstrup ,  Ignacio Fegueroa Pérez ,  Lars Kröger ,  Christoph H. Röhrig

Inventor： Gyula Dekany ,  Károly Ágoston ,  István Bajza ,  Marie Bøjstrup ,  Ignacio Fegueroa Pérez ,  Lars Kröger ,  Christoph H. Röhrig

IPC: C07H5/04 ,  C07H5/06 ,  C08B37/00 ,  C07H1/00 ,  C07H1/06 ,  C07H1/08

CPC classification number: C07H5/06 ,  C07H1/00

Abstract: α-Lactosamine hydrochloride, substantially free of β-lactosamine hydrochloride; a method of preparing α-lactosamine hydrochloride monohydrate from an anomeric mixture of lactosamine hydrochloride, including: preparing a solution including the anomeric mixture of lactosamine hydrochloride, water and at least one water-miscible organic solvent at a temperature of 0-100° C., and cooling the solution to cause crystallization of α-lactosamine hydrochloride monohydrate; a method of preparing anhydrous α-lactosamine hydrochloride; and use of α-lactosamine hydrochloride as a food supplement or intermediate in synthesis.

Abstract translation: α-乳糖胺盐酸盐，基本上不含β-乳糖胺盐酸盐; 一种从乳糖胺盐酸盐的端基异构体混合物制备α-乳糖胺盐酸盐一水合物的方法，包括：在0-100℃的温度下制备包括乳糖胺盐酸盐，水和至少一种水混溶性有机溶剂的端基异构体混合物的溶液 并冷却溶液使α-乳糖胺盐酸盐一水合物结晶; 制备无水α-乳糖胺盐酸盐的方法; 并使用盐酸α-乳糖胺作为食品添加剂或中间体。

公开(公告)号：US20130165406A1

公开(公告)日：2013-06-27

申请号：US13701085

申请日：2011-06-01

Applicant: Károly Ágoston ,  István Bajza ,  Gyula Dekany ,  Péter Trinka ,  Ágnes Ágoston ,  Gábor Kádár ,  Sándor Demkó ,  Ignacio Figueroa Pérez ,  Markus Hederos ,  Ferenc Horváth ,  Andreas Schroven ,  Ioannis Vrasidas ,  Piroska Kovács-Pénzes ,  Christian Risinger ,  László Kalmár ,  Gergely Pipa ,  Julien Boutet ,  Lars Kröger ,  Christoph Röhrig

Inventor： Károly Ágoston ,  István Bajza ,  Gyula Dekany ,  Péter Trinka ,  Ágnes Ágoston ,  Gábor Kádár ,  Sándor Demkó ,  Ignacio Figueroa Pérez ,  Markus Hederos ,  Ferenc Horváth ,  Andreas Schroven ,  Ioannis Vrasidas ,  Piroska Kovács-Pénzes ,  Christian Risinger ,  László Kalmár ,  Gergely Pipa ,  Julien Boutet ,  Lars Kröger ,  Christoph Röhrig

IPC: C07H3/06 ,  A23L1/30 ,  C07H1/06

CPC classification number: C07H3/06 ,  A23L5/00 ,  A23L7/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  C07H1/06

Abstract: The present invention relates to novel polymorphs of the trisaccharide 2′-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.

Abstract translation: 本发明涉及式（1）的三糖2'-O-岩藻糖基乳糖（2-FL）的新型多晶型物，制备所述多晶型物的方法及其在药物或营养组合物中的用途。

公开(公告)号：US20130035481A1

公开(公告)日：2013-02-07

申请号：US13579738

申请日：2011-02-21

Applicant: Ignacio Pérez Figueroa ,  Ferenc Horváth ,  Gyula Dekany ,  Károly Ágoston ,  Ágnes Ágoston ,  István Bajza ,  Julien Boutet ,  Markus Hederos ,  Piroska Kovács-Pénzes ,  Lars Kröger ,  Christoph Röhrig ,  Andreas Schroven ,  Ioannis Vrasidas ,  Christian Risinger

Inventor： Ignacio Pérez Figueroa ,  Ferenc Horváth ,  Gyula Dekany ,  Károly Ágoston ,  Ágnes Ágoston ,  István Bajza ,  Julien Boutet ,  Markus Hederos ,  Piroska Kovács-Pénzes ,  Lars Kröger ,  Christoph Röhrig ,  Andreas Schroven ,  Ioannis Vrasidas ,  Christian Risinger

IPC: C07H1/00 ,  C07H5/10 ,  C07H3/04 ,  C07H5/04

CPC classification number: A23L1/308 ,  A23L33/10 ,  A23L33/21 ,  A61K31/702 ,  C07H1/00 ,  C07H3/06 ,  C07H13/04 ,  C07H15/18

Abstract: The present invention relates to a method for preparation of the trisaccharide 6′-0-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6′-0-sialyllactose salts in pharmaceutical or nutritional compositions.

Abstract translation: 本发明涉及制备三糖6'-唾液酸乳糖（式（I））或其盐的方法，以及在药物或营养物质中合成和使用6'-O-唾液酸乳糖盐的中间体 组合物。

公开(公告)号：US20120309949A1

公开(公告)日：2012-12-06

申请号：US13579741

申请日：2011-02-21

Applicant: István Bajza ,  Gyula Dekany ,  Károly Ágoston ,  Ignacio Pérez Figueroa ,  Julien Boutet ,  Markus Hederos ,  Ferenc Horváth ,  Piroska Kovács-Pénzes ,  Lars Kröger ,  Christoph Röhrig ,  Andreas Schroven ,  Ioannis Vrasidas ,  Péter Trinka ,  László Kalmár ,  Irme Kovács ,  Sándor Demkó ,  Ágnes Ágoston ,  Christian Risinger

Inventor： István Bajza ,  Gyula Dekany ,  Károly Ágoston ,  Ignacio Pérez Figueroa ,  Julien Boutet ,  Markus Hederos ,  Ferenc Horváth ,  Piroska Kovács-Pénzes ,  Lars Kröger ,  Christoph Röhrig ,  Andreas Schroven ,  Ioannis Vrasidas ,  Péter Trinka ,  László Kalmár ,  Irme Kovács ,  Sándor Demkó ,  Ágnes Ágoston ,  Christian Risinger

IPC: C08B37/00 ,  C07H15/203

CPC classification number: C07H3/06 ,  A23L5/00 ,  A23L7/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23V2002/00 ,  C07H1/00 ,  C07H11/00 ,  C07H13/04 ,  C07H15/18 ,  A23V2250/28

Abstract: The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions.

Abstract translation: 本发明涉及一种特别是大规模制备四糖乳-N-新四糖（LNnt，式（I））的方法，以及合成中的中间体，一种LNnt的新晶型（多晶型物）和 在药物或营养组合物中的应用。

公开(公告)号：US12233079B2

公开(公告)日：2025-02-25

申请号：US17417029

申请日：2019-12-19

Applicant: Glycom A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs

IPC: A61K31/702 ,  A61K9/00 ,  A61K9/16 ,  A61K9/48 ,  A61K35/20 ,  A61K47/24 ,  A61K47/38 ,  A61K47/42 ,  A61K47/44 ,  A61P1/14

Abstract: A synthetic composition and method for use in providing a source of oligosaccharides to a human consuming a low-FODMAP diet, increasing the abundance of bifidobacteria in the colon of a human consuming a low-FODMAP diet, and/or reintroducing FODMAPs into the diet of a human consuming a low-FODMAP diet. The composition contains one or more human milk oligosaccharides.

公开(公告)号：US12054513B2

公开(公告)日：2024-08-06

申请号：US18057360

申请日：2022-11-21

Applicant: GLYCOM A/S

Inventor： Benjámin Podányi ,  Pierre Chassagne ,  Martin Matwiejuk ,  Markus Jondelius Hederos

IPC: C07H3/06 ,  A23L33/00 ,  C07H1/00 ,  C07H3/02

CPC classification number: C07H3/06 ,  C07H1/00 ,  C07H3/02 ,  A23L33/40

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US20240124509A1

公开(公告)日：2024-04-18

申请号：US18257979

申请日：2021-12-17

Applicant: GLYCOM A/S

Inventor： Martin MATWIEJUK

IPC: C07H7/033 ,  B01D15/36 ,  B01J41/07 ,  C07H1/06

CPC classification number: C07H7/033 ,  B01D15/363 ,  B01J41/07 ,  C07H1/06

Abstract: The present invention concerns a method for separating different oligosaccharides having at least one carboxylic acid group by contacting them with basic anion exchange resins.

公开(公告)号：US20240101587A1

公开(公告)日：2024-03-28

申请号：US18257986

申请日：2021-12-17

Applicant: Glycom A/S

Inventor： Nikolay KHANZHIN ,  Marco WIESER ,  Jesper THØGERSEN

IPC: C07H1/06 ,  C07H3/06

CPC classification number: C07H1/06 ,  C07H3/06

Abstract: Disclosed herein are systems and methods for the purification of human milk oligosaccharides (HMOs). The HMOs can be purified from a suspension containing one or more of a bacterial biomass, cell fragments, small particles, and biomolecules. Advantageously, the solution can be pre-treated prior to centrifuging to form a clarified supernatant containing purified HMOs.

公开(公告)号：US11896605B2

公开(公告)日：2024-02-13

申请号：US17353749

申请日：2021-06-21

Applicant: Glycom A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell ,  Emma Elison

IPC: A61K31/702 ,  A61K31/706 ,  A61P1/00 ,  A61K31/7016

CPC classification number: A61K31/702 ,  A61K31/7016 ,  A61P1/00

Abstract: This disclosure relates generally to compositions and methods for preventing or treating mast cell mediated visceral pain.

公开(公告)号：US20240043891A1

公开(公告)日：2024-02-08

申请号：US18258770

申请日：2021-12-21

Applicant: GLYCOM A/S

Inventor： Margit PEDERSEN

IPC: C12P19/18 ,  C12N9/10

CPC classification number: C12P19/18 ,  C12N9/1051 ,  C12Y204/01069 ,  C12Y204/01065

Abstract: The present invention relates to a genetically modified cell expressing an α-1,2-fucosyltransferase and an α-1,3-fucosyltransferase, and a transporter protein of the major facilitator superfamily (MFS) and to a method for recombinant production of human milk oligosaccharides (HMOs) using said genetically modified cell. More particularly, the invention provides a method for recombinant production of and a genetically modified cell capable of producing difucosyllactose (DFL) as the most abundant HMO, with a relatively low content of 3-fucosyllactose (3FL) and/or 2′-fucosyllactose (2′FL).