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公开(公告)号：US20130176622A1
公开(公告)日：2013-07-11
申请号：US13739310
申请日：2013-01-11
IPC分类号： G02B27/42
CPC分类号： G02B27/4205 , G02B21/367 , G02B27/0075 , G02B27/1086 , G02B27/4211
摘要： An optical imaging system includes a first diffractive optical element that receives a multi-wavelength beam of light and separates the received beam of light into diffractive orders. The optical imaging system also includes a second diffractive optical element that includes panels displaced along the second diffractive element in at least one direction, where each panel is positioned to receive and pass the multi-wavelength beam of one of the diffractive orders. A refractive optical element is positioned to receive multi-wavelength beams of the diffractive orders that pass through the second diffractive element, and an optical lens that receives the multi-wavelength beams of the diffractive orders that pass through the refractive element and focuses each of the multi-wavelength beams of the diffractive orders to a different location on an image plane at the same time.
摘要翻译： 光学成像系统包括第一衍射光学元件，其接收多波长光束并将接收的光束分成衍射级。 光学成像系统还包括第二衍射光学元件，其包括沿着至少一个方向沿着第二衍射元件移位的面板，其中每个面板被定位成接收和通过衍射级之一的多波长光束。 折射光学元件被定位成接收穿过第二衍射元件的衍射级的多波长束，以及接收通过折射元件的衍射级的多波长束的光学透镜， 衍射的多波长光束同时在图像平面上的不同位置。
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92.发明申请METHOD AND SYSTEM FOR MAPPING SYNAPTIC CONNECTIVITY USING LIGHT MICROSCOPY 审中-公开使用光学显微镜绘制快速连接的方法和系统公开(公告)号：US20130058871A1
公开(公告)日：2013-03-07
申请号：US13561882
申请日：2012-07-30
申请人： Jinhyun Kim
发明人： Jinhyun Kim
IPC分类号： A61K38/16 , C12Q1/02 , C12N15/63 , A61K31/7088 , C07K14/00 , C07H21/04 , A61K48/00 , A61P35/00 , A61P31/00 , C07K14/435 , A61P25/00 , A61P25/28 , A61P25/16 , A61P25/30 , A61P25/24 , G06G7/48 , A61K49/00
CPC分类号： A01K67/0275 , A01K2207/05 , A01K2207/30 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/0393 , A61K38/00 , A61K49/0047 , A61K49/0056 , C07K14/705 , C07K14/70514 , C07K14/70571 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/60
摘要： A mammalian Green Fluorescent Protein (GFP) Reconstruction Across Synaptic Partners (mGRASP) method and system is provided by optimizing synaptic transmelectron microscopicbrane carriers for mammalian synapses. The method and system in one form integrates molecular and cellular approaches with a novel computational strategy to reliably reconstruct neurons in 3D. The method and system allows mGRASP to be applied to both long-range and local microcircuits, analysis of synaptic distribution at the level of single neurons and dendritic compartments within neural cells.
摘要翻译： 通过优化用于哺乳动物突触的突触传递电镜显微镜载体，提供了通过突变合作伙伴（mGRASP）的哺乳动物绿色荧光蛋白（GFP）重建方法和系统。 一种形式的方法和系统将分子和细胞方法与新颖的计算策略相结合，可靠地重建3D神经元。 该方法和系统允许mGRASP应用于远距离和局部微电路，分析神经细胞内单个神经元和树突状细胞层的突触分布。
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公开(公告)号：US08222423B2
公开(公告)日：2012-07-17
申请号：US12279440
申请日：2007-02-14
IPC分类号： C07D249/00 , C07C303/00
CPC分类号： A61K31/19 , A61K31/44 , A61K47/55 , C07C259/06 , C07D249/04 , C07D249/06 , C07D413/12
摘要： In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
摘要翻译： 鉴于需要开发新的治疗剂及其有效的合成方法，本发明提供用于抑制组蛋白脱乙酰酶的新型双功能，三官能或多功能化合物及其药学上可接受的盐和衍生物。 本发明还提供了治疗由组蛋白脱乙酰酶活性（例如增殖性疾病，癌症，炎性疾病，原生动物感染，脱发等）调节的病症的方法，包括向有需要的受试者施用治疗有效量的本发明化合物 。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US12105122B2
公开(公告)日：2024-10-01
申请号：US18160764
申请日：2023-01-27
IPC分类号： G01R15/22 , C07K14/195 , C07K14/435 , G01N21/64 , G01R19/00
CPC分类号： G01R15/22 , G01R19/0084 , C07K14/195 , C07K14/43504 , C07K2319/60 , G01N21/6486
摘要： A voltage indicator includes a polypeptide sequence comprising a voltage-sensitive opsin domain and a capture protein domain arranged and disposed to capture a fluorescent dye ligand. When the fluorescent dye ligand is captured and the voltage indicator is bound to a cell membrane, an increase in voltage across the cell membrane causes an increase in fluorescent emission.
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公开(公告)号：US12001004B2
公开(公告)日：2024-06-04
申请号：US17644649
申请日：2021-12-16
发明人： Robert Eric Betzig , Tsung-Li Liu , Daniel E. Milkie , Kai Wang , Wesley Legant
CPC分类号： G02B21/361 , G01N21/64 , G01N21/6428 , G01N21/6458 , G02B21/0032 , G02B21/0072 , G02B21/0076 , G02B21/06 , G02B21/367 , G02B26/06 , G02B27/0025 , G02B27/58 , G02B2207/114
摘要： A microscope directs light through an excitation objective to generate a lattice light sheet (LLS) within a sample. A detection objective collects signal light from the sample in response to the LLS and images the collected light onto a detector. Second and third light beams are imaged onto focal planes of the excitation objective and detection objective, respectively. One or more wavefront detectors determine wavefronts of light emitted from the sample and through the excitation objective in response to the imaged second light beam and emitted from the sample through the detection objective in response to the imaged third light beam. A wavefront of the first light beam is modified to reduce a sample-induced aberration of the LLS within the sample, and a wavefront of the signal light emitted from the sample is modified to reduce a sample-induced aberration of the signal light at the detector.
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公开(公告)号：US20230312931A1
公开(公告)日：2023-10-05
申请号：US18189835
申请日：2023-03-24
CPC分类号： C09B57/02 , G01N21/6428 , G01N21/6456 , G01N2021/6439
摘要： Fluorescent stains are described, which enable imaging of cellular structures without the need for genetic manipulation. Unique diaminobenzopyrylium dyes are disclosed, together with their use as live-cell mitochondrial stains.
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公开(公告)号：US20230304905A1
公开(公告)日：2023-09-28
申请号：US18188930
申请日：2023-03-23
发明人： Paul Tillberg , Boaz Mohar
CPC分类号： G01N1/30 , G01N1/36 , G02B21/34 , G01N2001/305
摘要： Methods of imaging biomolecules from a tissue sample are described, including methods for preparing a tissue sample for imaging using expansion microscopy, while achieving ultrahigh effective imaging resolution.
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公开(公告)号：US20230003987A1
公开(公告)日：2023-01-05
申请号：US17779076
申请日：2020-06-17
摘要： An optical microscope apparatus includes: a sample interrogation system configured to probe a sample location; and a light collection system configured to collect light output from a sample due to being probed by the sample interrogation system. The light collection system includes: a mirror positioned along an imaging axis that passes through the sample location; and an optical lens system including a plurality of optical lenses arranged along the imaging axis, at least one of the lenses being a multiplet optical lens.
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公开(公告)号：US20220365071A1
公开(公告)日：2022-11-17
申请号：US17483800
申请日：2021-09-23
发明人： Loren L. Looger , Yan Zhang , Eric R. Schreiter , Jeremy P. Hasseman , Ilya Kolb
摘要： Genetically encoded calcium indicator (GECI) polypeptides and the nucleic acid molecules encoding such polypeptides are provided.
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公开(公告)号：US11498932B2
公开(公告)日：2022-11-15
申请号：US17001332
申请日：2020-08-24
发明人： Luke D. Lavis , Claire Deo
IPC分类号： C07F7/08 , C07D405/14 , C07D405/04 , G01N21/78
摘要： The presently-disclosed subject matter includes fluorescent indicators, including bright and targetable red Ca2+ indicators. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance. Fluorescent indicators of the presently-disclosed subject matter include a compound of the formula:
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