-
公开(公告)号:US20210100919A1
公开(公告)日:2021-04-08
申请号:US16970155
申请日:2019-02-14
申请人: CHILDREN'S NATIONAL MEDICAL CENTER , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC
IPC分类号: A61K49/00 , C07D403/12 , C09K11/06
摘要: Heptamethine cyanines for use as fluorescent markers of the biliary and renal systems are disclosed. Certain heptamethine cyanines exhibit renal system specificity, while others exhibit biliary system specificity. The compounds may be used for diagnostic purposes and/or for visualization of renal or biliary systems during surgery.
-
公开(公告)号:US20200283507A1
公开(公告)日:2020-09-10
申请号:US16854703
申请日:2020-04-21
申请人: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic , INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA
发明人: Karin Bok , Lorena Laura Garaicoechea , Viviana Parreno , Andrea Pamela Aguilar , Marina Bok , Lisbeth Kim Green , Stanislav Vladimirovich Sosnovtsev
IPC分类号: C07K16/10 , G01N33/569
摘要: Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.
-
公开(公告)号:US20200231658A1
公开(公告)日:2020-07-23
申请号:US16786267
申请日:2020-02-10
申请人: The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人: Mark Connors , Jinghe Huang , Byong Ha Kang , John Mascola , Elise Ishida , Tongqing Zhou , Peter Kwong , Anqi Zheng
IPC分类号: C07K16/10 , A61P31/18 , C07K16/28 , C07K16/46 , G01N33/569
摘要: Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
-
公开(公告)号:US20200230229A1
公开(公告)日:2020-07-23
申请号:US16338964
申请日:2017-10-03
申请人: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC
发明人: Peter Kwong , Rui Kong , Tongqing Zhou , John Mascola , Kai Xu , Michael Gordon Joyce , Cheng Cheng , Gwo-Yu Chuang , Kevin Liu , Baoshan Zhang , Li Ou , Wing-Pui Kong , Yongping Yang
IPC分类号: A61K39/21 , C12N7/00 , A61K47/64 , A61P31/18 , C07K14/005
摘要: Embodiments of immunogens based on the HIV-1 Env fusion peptide and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
-
公开(公告)号:US20200178964A1
公开(公告)日:2020-06-11
申请号:US16348855
申请日:2017-11-08
申请人: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC
摘要: A surgical clamp for aligning the margins of incised or wounded tissue has jaws with parallel clamping faces, and a handle for manipulating the clamp to align the margins of the tissue. The jaws are in a normally closed position, however they can be opened by compressing the handle to open the jaws. Prongs project from the inferior surface of the jaws. The clamp is positioned in a desired position over the margins of a wound to be closed, the prongs engage the margins of the wound to be aligned, and the jaws are closed by releasing compressive force on the handle. As the jaws close the prongs help move the tissue into alignment. Suture guide slots through the jaws assist in the placement of precisely placed sutures across the incision. The disclosed surgical clamp is particularly suited for selectively closing and reopening surgical incisions, such as a sclerotomy incision in the eye. Methods are disclosed for using the clamp during intraocular and other surgical or minimally invasive procedures. In one example the clamp is used during implantation into the retina of a scaffold on which choroid and retinal pigment epithelium cells and retina grow in a three-dimensional matrix that mimics the native structure of the retina.
-
公开(公告)号:US20200046747A1
公开(公告)日:2020-02-13
申请号:US16655004
申请日:2019-10-16
申请人: The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人: Marjan Huizing , May C. Malicdan , Nuria Carrillo
IPC分类号: A61K31/7008 , A61K47/20 , A61K9/50 , A61K9/127 , A61K9/00 , A61P9/00 , A61K45/06 , A61K31/7012 , A61K31/702 , A61K31/7088
摘要: Methods are disclosed for treating a subject with a vascular or cardiac disorder associated with oxidative stress. Methods are disclosed for treating a subject with GNE myopathy that has impaired cardiac function. These methods include administering to the subject a therapeutically effective amount of a sialic acid precursor, sialic acid, or one or more sialylated compounds, mannosamine, N-acetyl mannosamine or a derivative thereof. In other embodiments, methods are disclosed for detecting a disorder associated with oxidative stress.
-
公开(公告)号:US20190248880A1
公开(公告)日:2019-08-15
申请号:US16391101
申请日:2019-04-22
申请人: The United States of America, as represented by the Secretary, Department of Health and Human Servic
CPC分类号: C07K16/18 , A61K47/6811 , A61K47/6843 , A61K2039/505 , C07K14/78
摘要: Monoclonal antibodies and antibody fragments that specifically bind to matrilin-3, conjugates including these molecules, and nucleic acid molecules encoding the antibodies, antigen binding fragments and conjugates, are disclosed. Also disclosed are compositions including the disclosed antibodies, antigen binding fragments, conjugates, and nucleic acid molecules. Methods of treating or inhibiting a cartilage disorder in a subject, as well as methods of increasing chondrogenesis in cartilage tissue are further provided. The methods can be used, for example, for treating or inhibiting a growth plate disorder in a subject, such as a skeletal dysplasia or short stature.
-
98.
公开(公告)号:US20190248732A1
公开(公告)日:2019-08-15
申请号:US16390982
申请日:2019-04-22
申请人: The United States of America, as represented by the Secretary, Department of Health and Human Servi
发明人: Irving William Wainer , Weizhong Zhu , Khalid Chakir , Rui-Ping Xiao , Darrell R. Abernethy , Farideh M. Beigi Abhari
IPC分类号: C07C215/60
CPC分类号: C07C215/60
摘要: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
-
公开(公告)号:US20240189414A1
公开(公告)日:2024-06-13
申请号:US18530861
申请日:2023-12-06
申请人: Vernagen, LLC , The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人: Baek KIM , Jack Yoon , David Pak , Claire Yuhui Huang Kinney
CPC分类号: A61K39/12 , A61K9/5123 , C12N7/00
摘要: Provided herein are a Heartland virus vaccine composition including a messenger ribonucleic acid (mRNA) including an open reading frame (ORF) encoding Gn or Gc of Heartland virus, a Heartland virus vaccine composition comprising a messenger ribonucleic acid (mRNA) comprising an open reading frame (ORF) encoding Gn or Gc of Heartland virus fused with human collagen type I alpha 1 (COL1A1) signal peptide, and a method of inducing immune response against Heartland virus by administering an effective amount of the Heartland virus vaccine composition to a subject in need thereof.
-
公开(公告)号:US20230381293A1
公开(公告)日:2023-11-30
申请号:US18031602
申请日:2021-10-14
申请人: The United States of America, as represented by the Secretary, Department of Health and Human Serv , The University of North Carolina at Chapel Hill , Board of Regents, the University of Texas System
发明人: Peter Kwong , Raffaello Verardi , Yaroslav Tsybovsky , Jason Gorman , Gwo-Yu Chuang , Li Ou , Lisa Lindesmith , Ralph Baric , George Georgiou , Inga Rimkute , Mario Roederer
IPC分类号: A61K39/145 , A61P37/04 , G01N33/68
CPC分类号: A61K39/145 , A61P37/04 , G01N33/6854 , A61K2039/5258
摘要: Recombinant Norovirus Virus-Like Particles (VLPs) formed from recombinant Norovirus VP1 proteins, and methods of their use and production are disclosed. In several embodiments, the Recombinant Norovirus VLPs can be used to generate an immune response to Norovirus VP1 protein in a subject. In additional embodiments, an effective amount of the recombinant Norovirus VLPs can be administered to a subject in a method of inhibiting a Norovirus infection.
-
-
-
-
-
-
-
-
-