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214 条记录 (耗时 0.029 秒)

    Medical device having a coating layer with structural elements therein and method of making the same
    92.
    发明申请
    Medical device having a coating layer with structural elements therein and method of making the same 审中-公开
    具有其中具有结构元件的涂层的医疗装置及其制造方法

    公开(公告)号：US20060025848A1

    公开(公告)日：2006-02-02

    申请号：US10902747

    申请日：2004-07-29

    申请人： Jan Weber ,  Tom Holman

    发明人： Jan Weber ,  Tom Holman

    IPC分类号： A61F2/06

    CPC分类号： A61F2/82 ,  A61F2250/0067 ,  A61L31/08 ,  A61L31/127

    摘要： The invention pertains to coated medical devices, such as stents and balloon catheters, for delivering a biologically active material to body tissue of a patient. The medical device has a coating layer comprising a biocompatible polymer, non-polymer material, or biologically active material disposed on its surface, and at least one structural element embedded within the coating layer. The structural elements reduce the compressibility of the coating layer. The structural element may be any shape or configuration. A biologically active material may be dispersed within the coating layer or structural elements. Methods for making such medical devices are also disclosed.

    摘要翻译： 本发明涉及用于将生物活性物质递送到患者的身体组织的涂覆医疗装置，例如支架和球囊导管。 该医疗装置具有包含生物相容性聚合物，非聚合物材料或设置在其表面上的生物活性材料的涂层和至少一个嵌入该涂层内的结构元件。 结构元件降低了涂层的压缩性。 结构元件可以是任何形状或构造。 生物活性材料可以分散在涂层或结构元件内。 还公开了制造这种医疗装置的方法。

    Biomimetic organic/inorganic composites, processes for their production, and methods of use
    93.
    发明申请
    Biomimetic organic/inorganic composites, processes for their production, and methods of use 有权
    仿生有机/无机复合材料，其生产工艺和使用方法

    公开(公告)号：US20040131562A1

    公开(公告)日：2004-07-08

    申请号：US10691002

    申请日：2003-10-22

    发明人： Laurie B. Gower ,  Matthew J. Olszta ,  Elliot P. Douglas ,  Sivakumar Munisamy ,  Donna L. Wheeler

    IPC分类号： A61K007/16 ,  A61C005/00

    CPC分类号： A61L27/24 ,  A61L27/446 ,  A61L27/46 ,  A61L31/127 ,  A61L31/128 ,  A61L31/146 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/813 ,  Y10S530/814 ,  Y10S530/815 ,  Y10S530/817

    摘要： The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the organic matrix. Advantageously, once solidified, a high mineral content can be achieved, with the inorganic mineral crystals embedded within the collagen fibers (intrafibrillarly) and oriented such that they are aligned along the long axes of the fibers of the organic matrix, thereby closely mimicking the natural structure of bone. The present invention further concerns a method of treating a patient suffering from a bone defect by applying a biomimetic composite to the bone defect site.

    摘要翻译： 本发明涉及一种复合材料，其包含有机流体 - 可溶胀的纤维基质如胶原和矿物相如碳酸钙或磷酸盐矿物相用作骨仿生体。 在另一方面，本发明涉及一种制备涉及将酸性聚合物包含在过饱和矿化溶液中的复合物的方法，以便诱导无机矿物的无定形液相前体，然后将其吸收（通过毛细管作用 ）进入有机基质。 有利地，一旦固化，可以实现高矿物质含量，其中无机矿物晶体嵌入胶原纤维内（纤维内）并定向成使得它们沿着有机基质的纤维的长轴排列，从而紧密地模仿天然 骨结构。 本发明还涉及通过将仿生复合材料应用于骨缺损部位来治疗患有骨缺损的患者的方法。

    Biomimetic organic/inorganic composites, processes for their production, and methods of use
    94.
    发明申请
    Biomimetic organic/inorganic composites, processes for their production, and methods of use 有权
    仿生有机/无机复合材料，其生产工艺和使用方法

    公开(公告)号：US20030232071A1

    公开(公告)日：2003-12-18

    申请号：US10418843

    申请日：2003-04-18

    发明人： Laurie B. Gower ,  Matthew J. Olszta ,  Elliot P. Douglas ,  Sivakumar Munisamy ,  Donna L. Wheeler

    IPC分类号： A61K009/70 ,  A61F013/00

    CPC分类号： A61L31/128 ,  A61L27/24 ,  A61L27/446 ,  A61L27/46 ,  A61L31/127 ,  A61L31/146 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/813 ,  Y10S530/814 ,  Y10S530/815 ,  Y10S530/817

    摘要： The subject invention concerns a composite comprising an organic fluid-swellable matrix, such as collagen, and mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the interstices of the organic matrix, and subsequently mineralizes via solidification and crystallization of the precursor phase. The present invention further concerns a method of treating a patient suffering from a bone defect by applying a biomimetic composite to the bone defect site.

    摘要翻译： 本发明涉及一种复合材料，其包含有机流体 - 可溶胀基质，例如胶原蛋白，和矿物相如碳酸钙或磷酸盐矿物相，用作骨仿生体。 在另一方面，本发明涉及一种制备涉及将酸性聚合物包含在过饱和矿化溶液中的复合物的方法，以便诱导无机矿物的无定形液相前体，然后将其吸收（通过毛细管作用 ）进入有机基质的间隙，随后通过固化和前体相的结晶矿化。 本发明还涉及通过将仿生复合材料应用于骨缺损部位来治疗患有骨缺损的患者的方法。

    Reinforced tissue implants and methods of manufacture and use
    96.
    发明申请
    Reinforced tissue implants and methods of manufacture and use 有权
    增强组织植入物及其制造和使用方法

    公开(公告)号：US20020120348A1

    公开(公告)日：2002-08-29

    申请号：US09747489

    申请日：2000-12-21

    发明人： Mora Carolynne Melican ,  Yufu Li ,  Kelly R. Brown ,  Iksoo Chun ,  John McAllen III ,  Alireza Rezania ,  Angelo G. Scopelianos ,  Murty N. Vyakarnam

    IPC分类号： A61F002/02

    CPC分类号： A61F2/0045 ,  A61F2/0063 ,  A61L27/446 ,  A61L27/46 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61L31/127 ,  A61L31/128 ,  A61L31/129 ,  A61L31/146 ,  A61L31/148

    摘要： A biocompatible tissue implant, as well as methods for making and using such an implant, is provided. Preferably, the tissue implant is bioabsorbable. The tissue implant comprises one or more layers of a bioabsorbable polymeric foam having pores with an open cell structure. The tissue implant also includes a reinforcement component which contributes both to the mechanical and the handling properties of the implant. Preferably, the reinforcement component of the instant invention is bioabsorbable as well. The tissue implant of the present invention can be used in connection with the surgical repair of soft tissue injury, such as injury to the pelvic floor.

    摘要翻译： 提供生物相容性组织植入物，以及制造和使用这种植入物的方法。 优选地，组织植入物是生物可吸收的。 组织植入物包括一层或多层具有开放孔结构的孔的生物可吸收聚合物泡沫。 组织植入物还包括增强部件，其有助于植入物的机械和处理性能。 优选地，本发明的增强组分也是生物可吸收的。 本发明的组织植入物可用于软组织损伤的手术修复，例如对盆底的损伤。