公开(公告)号：US07749736B2

公开(公告)日：2010-07-06

申请号：US11555642

申请日：2006-11-01

Applicant: Igor Kordunsky ,  Jeffrey A. Goldman ,  Michael J. Finney

Inventor： Igor Kordunsky ,  Jeffrey A. Goldman ,  Michael J. Finney

IPC: C12P19/34 ,  C12Q1/68

CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1822 ,  G01N21/276 ,  G01N21/6452 ,  G01N2201/0446

Abstract: A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement.

Abstract translation: 提供了用于分析位于热循环仪中的多个孔中的样品的荧光检测装置和使用方法。 在一个实施例中，该装置包括可附接到热循环仪的支撑结构和可移动地安装在支撑结构上的检测模块。 检测模块包括一个或多个通道，每个通道具有设置在检测模块内的激发光发生器和发射光检测器。 当支撑结构附接到热循环仪并且检测模块安装在支撑结构上时，检测模块可移动以便定位成与多个井中的不同井的光通信。 检测模块可从支撑结构移除，以方便更换。

公开(公告)号：US20090268194A1

公开(公告)日：2009-10-29

申请号：US12427280

申请日：2009-04-21

Applicant: Mamoru TOMITA

Inventor： Mamoru TOMITA

IPC: G01N33/48

CPC classification number: G01N21/07 ,  G01N21/59 ,  G01N35/00584 ,  G01N35/025 ,  G01N2035/00148 ,  G01N2201/0415 ,  G01N2201/0446 ,  G01N2201/1247

Abstract: A blood analysis apparatus is provided. The blood analysis apparatus includes: a chip holding portion having an aperture which allows light to pass therethrough and holding a μ-TAS chip for holding a measurement liquid; a rotary body on which the chip holding portion is mounted; a light source; and a light-receiving unit. A measurement position of the rotary body at which the measurement liquid is to be measured with the light from the light source is set by: rotating the rotary body to obtain a light value of light which is emitted from the light source and received by the light-receiving unit through the aperture; and setting a rotational position of the rotary body where the light value is a threshold value or more, as the measurement position.

Abstract translation: 提供血液分析装置。 血液分析装置包括：具有允许光通过并且保持用于保持测量液体的mu-TAS芯片的孔的芯片保持部分; 旋转体，其上安装有芯片保持部; 光源; 和光接收单元。 利用来自光源的光来测量测量液体的旋转体的测量位置是通过旋转旋转体来获得从光源发射并被光接收的光的光值 - 接收单元通过孔径; 并且将光值为阈值以上的旋转体的旋转位置设定为测量位置。

公开(公告)号：US20070132831A1

公开(公告)日：2007-06-14

申请号：US11302695

申请日：2005-12-13

Applicant: Daniel Chu

Inventor： Daniel Chu

IPC: B41J15/14

CPC classification number: G01N21/253 ,  G01N2201/0446 ,  G01N2201/1042

Abstract: Scanning of a microarray is performed through a mask that exposes a plurality, but not all, of the sites of the microarray, and either the mask is movable relative to the microarray or the microarray is movable relative to the mask, or both. The mask is useful as a means of restricting the illumination of sites on the microarray to those that can be illuminated while the scan head is traveling at a steady, target velocity, blocking the passage of light between the scan head and the microarray at those points in the scan head trajectory where the scan head is either accelerating or decelerating. The mask is also useful for reducing background noise in the microarray image by preventing light spillage to sites adjacent to those being scanned.

Abstract translation: 微阵列的扫描通过暴露微阵列的多个但不是全部的掩模进行，并且掩模相对于微阵列是可移动的，或者微阵列相对于掩模或两者都是可移动的。 该掩模可用作将扫描头以稳定的目标速度行进的情况下将微阵列上的部位的照明限制在可照亮的位置的手段，阻止在那些点处扫描头和微阵列之间的光通过 在扫描头轨迹中扫描头正在加速或减速。 该掩模也可用于通过防止光泄漏到与扫描的那些相邻的位置来减少微阵列图像中的背景噪声。

公开(公告)号：US07148043B2

公开(公告)日：2006-12-12

申请号：US10431708

申请日：2003-05-08

Applicant: Igor Kordunsky ,  Jeffrey A. Goldman ,  Michael J. Finney

Inventor： Igor Kordunsky ,  Jeffrey A. Goldman ,  Michael J. Finney

IPC: C12P19/34 ,  C12Q1/68

CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1822 ,  G01N21/276 ,  G01N21/6452 ,  G01N2201/0446

Abstract: A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement.

Abstract translation: 提供了用于分析位于热循环仪中的多个孔中的样品的荧光检测装置和使用方法。 在一个实施例中，该装置包括可附接到热循环仪的支撑结构和可移动地安装在支撑结构上的检测模块。 检测模块包括一个或多个通道，每个通道具有设置在检测模块内的激发光发生器和发射光检测器。 当支撑结构附接到热循环仪并且检测模块安装在支撑结构上时，检测模块可移动以便定位成与多个井中的不同井的光通信。 检测模块可从支撑结构移除，以方便更换。

公开(公告)号：US20040224317A1

公开(公告)日：2004-11-11

申请号：US10431708

申请日：2003-05-08

Applicant: MJ Research

Inventor： Igor Kordunsky ,  Jeffrey A. Goldman ,  Michael J. Finney

IPC: C12Q001/68 ,  C12M001/34

CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1822 ,  G01N21/276 ,  G01N21/6452 ,  G01N2201/0446

Abstract: A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement.

Abstract translation: 提供了用于分析位于热循环仪中的多个孔中的样品的荧光检测装置和使用方法。 在一个实施例中，该装置包括可附接到热循环仪的支撑结构和可移动地安装在支撑结构上的检测模块。 检测模块包括一个或多个通道，每个通道具有设置在检测模块内的激发光发生器和发射光检测器。 当支撑结构附接到热循环仪并且检测模块安装在支撑结构上时，检测模块可移动以便定位成与多个井中的不同井的光通信。 检测模块可从支撑结构移除，以方便更换。

公开(公告)号：US06768122B2

公开(公告)日：2004-07-27

申请号：US10160251

申请日：2002-06-04

Applicant: Chen-Yuan Dong ,  Peter T. C. So ,  Sunney I. Chan

Inventor： Chen-Yuan Dong ,  Peter T. C. So ,  Sunney I. Chan

IPC: G01N2164

CPC classification number: G01N21/6452 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/0446 ,  G01N2201/0453

Abstract: A multiphoton excitaion microscope for simultaneously detecting differently colored fluorescence materials on biochips includes a multiphoton excitation source, objectives, and a plurality of detection channels. The biochip is hybridized and labeled with fluorescence materials for expressing hybridized biological signals. The multiphoton excitation source is focused to a light spot on the biochip to excite the fluorescence materials bound thereon. After that, the fluorescence emission at different wavelengths from the different fluorescent materials can be detected by the plural detection channels.

Abstract translation: 用于在生物芯片上同时检测不同颜色的荧光材料的多光子激发显微镜包括多光子激发源，物镜和多个检测通道。 将生物芯片杂交并用用于表达杂交的生物信号的荧光材料标记。 多光子激发源被聚焦到生物芯片上的光点以激发结合在其上的荧光材料。 之后，可以通过多个检测通道检测来自不同荧光材料的不同波长的荧光发射。

公开(公告)号：US06693709B2

公开(公告)日：2004-02-17

申请号：US10266062

申请日：2002-10-07

Applicant: Mark Wechsler ,  Howard H. Barney ,  Roger A. Kaye ,  David G. Ogle ,  Michael M. Lacy ,  Calvin Y. Chow ,  Kimberly L. Crawford ,  Dean G. Hafeman

Inventor： Mark Wechsler ,  Howard H. Barney ,  Roger A. Kaye ,  David G. Ogle ,  Michael M. Lacy ,  Calvin Y. Chow ,  Kimberly L. Crawford ,  Dean G. Hafeman

IPC: G01J330

CPC classification number: G01N21/33 ,  G01N21/253 ,  G01N21/31 ,  G01N35/028 ,  G01N2201/0231 ,  G01N2201/0446 ,  G01N2201/1222 ,  G01N2201/127

Abstract: The present invention relates to a photometric device for measuring optical parameters. The invention functions in the ultraviolet light range through use of a monochromator and splits the test light in multiple channels by a rotor assembly, including a mirror.

Abstract translation: 本发明涉及一种用于测量光学参数的测光装置。 本发明通过使用单色仪在紫外光范围内起作用，并通过包括反射镜的转子组件在多个通道中分离测试光。

公开(公告)号：US5772967A

公开(公告)日：1998-06-30

申请号：US237239

申请日：1994-05-02

Applicant: Jon C. Wannlund ,  Jerry W. Smith

Inventor： Jon C. Wannlund ,  Jerry W. Smith

IPC: B01L3/00 ,  C12M1/20 ,  G01N21/03 ,  G01N21/76

CPC classification number: B01L3/5025 ,  B01L3/50255 ,  G01N21/03 ,  G01N21/76 ,  G01N2021/0325 ,  G01N2021/0328 ,  G01N2021/0357 ,  G01N2021/1768 ,  G01N2201/0446 ,  Y10T436/111666 ,  Y10T436/25375

Abstract: Apparatus for performing and measuring chemical reactions includes a reaction test apparatus having reaction wells wherein reactants are controllably mixed, and exposure apparatus which receives and positions the reaction test apparatus adjacent a photographic film. Each of the reaction wells includes at least two reaction chambers, arranged in a side by side fashion. All but the final reaction chamber have upwardly sloping sides, so that liquid placed in one reaction chamber can flow to the next reaction chamber when the apparatus is tilted. In a preferred embodiment, the reaction wells are supported in a plate that is structurally integral with the wells but separates the wells from each other. The test plate is retained in the exposure apparatus, and liquid is controllably flowed from one reaction chamber to the next by tilting the exposure apparatus. The apparatus of the invention is particularly suited for measuring reactions that produce luminescence of short duration, as the reactants can be conveniently mixed in darkness, while the film is being exposed.

Abstract translation: 用于进行和测量化学反应的装置包括具有可反应混合反应物的反应孔的反应试验装置，以及将反应试验装置接收并定位在照相胶片附近的曝光装置。 每个反应井包括至少两个以并排排列的反应室。 除最终反应室之外的所有反应室都具有向上倾斜的侧面，使得当设备倾斜时，放置在一个反应​​室中的液体可以流到下一个反应室。 在优选的实施方案中，将反应孔支撑在与孔结构一体的板中，但将孔彼此分离。 测试板保持在曝光装置中，并且通过倾斜曝光装置可控地从一个反应室流向液体。 本发明的装置特别适用于测量产生短持续时间的发光的反应，因为反应物可以在黑暗中方便地混合，同时曝光该膜。

公开(公告)号：US5307144A

公开(公告)日：1994-04-26

申请号：US984535

申请日：1992-12-01

Applicant: Tamura Hiroshi ,  Tanaka Shigenori

Inventor： Tamura Hiroshi ,  Tanaka Shigenori

IPC: G01N21/01 ,  B01L3/00 ,  B01L7/02 ,  C12M1/34 ,  G01N21/03 ,  G01N21/25 ,  G01N21/59 ,  G01N21/75 ,  G01N21/27

CPC classification number: B01L3/50851 ,  B01L3/50853 ,  B01L7/02 ,  G01N21/031 ,  G01N21/253 ,  G01N2021/0325 ,  G01N21/0332 ,  G01N2201/0446 ,  Y10S436/809

Abstract: The present invention intends to generally maintain the microplate having added test samples in wells therein at even temperature for measuring biochemical or biological reaction accompanying changes in absorbance such as enzyme reaction. Monochromatic lights with various wave lengths from a light source 3 are transmitted through the test samples added to a plurality of wells in a microplate 1 to measure absorbance of the test sample. For this end, a metal plate 2 with good heat conductivity is substantially contacted with the bottom of each well in the microplate 1 and a perforated board 7 is disposed with an air space over the microplate 1 at the starting position thereof. Warmed air heated by a heater 17 is blown onto the microplate 1 through the perforated board 7 and is circulated along the metal plate 2 within a chamber 9.

Abstract translation: 本发明旨在通常在均匀温度下保持在孔中加入测试样品的微板，用于随着吸光度如酶反应的变化而测量生物化学或生物反应。 来自光源3的具有各种波长的单色光通过添加到微板1中的多个孔的测试样品传输，以测量测试样品的吸光度。 为此，具有良好导热性的金属板2基本上与微板1中的每个孔的底部接触，并且多孔板7在微孔板1的起始位置处设置有空气空间。 通过加热器17加热的暖气被穿孔板7吹送到微量板1上，并在室9内沿着金属板2循环。

公开(公告)号：US5234665A

公开(公告)日：1993-08-10

申请号：US700567

申请日：1991-05-15

Applicant: Masato Ohta ,  Yasuhiko Yokomori ,  Toshiyuki Furuta ,  Hideo Suda ,  Naoki Ozawa ,  Shogo Kida

Inventor： Masato Ohta ,  Yasuhiko Yokomori ,  Toshiyuki Furuta ,  Hideo Suda ,  Naoki Ozawa ,  Shogo Kida

IPC: G01N21/17 ,  G01N21/25 ,  G01N21/59 ,  G01N21/82 ,  G01N33/543

CPC classification number: G01N21/253 ,  G01N21/82 ,  G01N2021/5957 ,  G01N2201/0446

Abstract: An aggregation pattern detecting apparatus includes a microplate having a plurality of reactive vessels in which aggregation patterns are formed, a light source arranged above the microplate, and a light sensor arrangement positioned below the microplate. The microplate is removably fastened to a main body, and a movable frame is movably supported on the main body. The light source and light sensor arrangement are carried on the movable frame for movement therewith. A driving mechanism effects movement of the movable frame and is controlled by a main control section. A reference plate is provided separately from the microplate, and has a plurality of through holes therein which correspond to the reactive vessels of the microplate. The reference plate is removably fastenable to the main body at the normal operative position of the microplate. With the reference plate in this position, the distance from a starting point of the driving mechanism to the through holes of the reference plate is measured and stored in the main control section. Based on these stored distances, the main control section determines appropriate operational positions for the light sensor.

Abstract translation: 聚集图案检测装置包括具有形成聚集图案的多个反应性血管的微孔板，布置在微孔板上方的光源和位于微板下方的光传感器装置。 微板可拆卸地固定在主体上，可移动的框架可移动地支撑在主体上。 光源和光传感器装置承载在可移动框架上以与其一起运动。 驱动机构实现可动框架的移动，由主控制部控制。 参考板与微孔板分开设置，并且在其中具有多个对应于微孔板的反应性容器的通孔。 参考板可移除地在微板的正常操作位置处紧固到主体。 在该位置的参考板上，测量从驱动机构的起点到参考板的通孔的距离并将其存储在主控制部分中。 基于这些存储的距离，主控制部分确定光传感器的适当操作位置。