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161 条记录 (耗时 0.036 秒)

    Engineered spray-dried lipid-based microparticles for cellular targeting
    91.
    发明申请
    Engineered spray-dried lipid-based microparticles for cellular targeting 审中-公开
    用于细胞靶向的工程化的喷雾干燥的基于脂质的微粒

    公开(公告)号：US20020103165A1

    公开(公告)日：2002-08-01

    申请号：US09515359

    申请日：2000-02-29

    申请人： ALLIANCE PHARMACEUTICAL CORP.,

    发明人： Adrian Bot ,  Luis Dellamary ,  Dan Smith ,  Catherine M. Woods

    IPC分类号： A61K031/665

    CPC分类号： C07K16/00 ,  A61K9/0075 ,  A61K9/1617 ,  A61K2039/505 ,  C07K2317/52 ,  C07K2317/77 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y02A50/466 ,  Y02A50/471 ,  Y02A50/475 ,  Y02A50/481 ,  Y02A50/489

    摘要： In accordance with the present invention there are provided novel Spray-Dried Lipid Microparticles (SDLM) that are comprised of lipid, a ligand and agent. The ligand is specific for a cell surface receptor, thereby enabling targeting of the agent to cells bearing receptors specific for the targeting ligand. In invention embodiments wherein the receptor internalizes upon ligand binding, there are provided compositions and methods for the introduction of agent into specifically targeted cells. In a particular embodiment, the ligand is specific for antigen presenting cells (APC) and the agent is a defined antigen. In this manner, immune responses can be induced against specific antigens, including those which are normally not very antigenic due to the fact that they are inefficiently internalized by APC.

    摘要翻译： 根据本发明，提供由脂质，配体和试剂组成的新型喷雾干燥脂质微粒（SDLM）。 配体对于细胞表面受体是特异性的，从而使得能够将试剂靶向具有靶向配体特异性受体的细胞。 在其中受体在配体结合时内化的发明实施方案中，提供了用于将试剂引入特异性靶向细胞的组合物和方法。 在一个具体实施方案中，配体对抗原呈递细胞（APC）是特异性的，并且该试剂是确定的抗原。 以这种方式，可以针对特定抗原诱导免疫应答，包括那些通常不是非常抗原的抗原，因为它们由APC无效地内化。

    Cloning and expression of a DNA sequence encoding a 41 kDa cryptosporidium parvum oocyst wall protein
    92.
    发明授权
    Cloning and expression of a DNA sequence encoding a 41 kDa cryptosporidium parvum oocyst wall protein 失效
    克隆和表达编码41kDa隐孢子虫卵囊壁蛋白的DNA序列

    公开(公告)号：US06277973B1

    公开(公告)日：2001-08-21

    申请号：US09451117

    申请日：1999-11-30

    申请人： Mark C. Jenkins ,  Ron Fayer ,  James Trout

    发明人： Mark C. Jenkins ,  Ron Fayer ,  James Trout

    IPC分类号： C07H2102

    CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K2319/00 ,  Y02A50/488 ,  Y02A50/489

    摘要： Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colostrum that may be used to confer passive immunity against the parasite. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.

    摘要翻译： 已经开发了用于免疫动物以防止隐孢子虫病的重组蛋白质。 这些蛋白质可以有效地免疫多种动物对小隐孢子虫，特别是用于生产可能被用于赋予对寄生虫的被动免疫的超免疫初乳。 已经开发了编码这些蛋白质的分离的DNA序列。 可以将DNA序列插入到重组DNA分子中，例如用于转化细胞和产生蛋白质的克隆载体或表达载体。