公开(公告)号：US06815674B1

公开(公告)日：2004-11-09

申请号：US10453758

申请日：2003-06-03

申请人： Guenter F. Voss

发明人： Guenter F. Voss

IPC分类号： H01J4900

CPC分类号： H01J49/328 ,  B01D59/48

摘要： In one embodiment, a miniaturized structure and associated method function as a mass spectrometer or analyzer and may, with modification, function as an ion generator. The miniaturized structure has a pair of generally planar parallel spaced electrodes which have projecting walls cooperating to define an ion generating chamber and an exit aperture. By controlling the electric field which is oriented perpendicular to an applied magnetic field, the ion beam may be separated into a plurality beams based upon mass to charge ratio with a predetermined mass to charge ratio emerging from the exit of the apparatus and when the apparatus is functioning as a mass spectrometer or analyzer impinges on an ion collector which responsively transmits information to a cooperating processor. Where it is desired to have it function as an ionizer the ion collector disposed adjacent the ion exit is eliminated.

摘要翻译： 在一个实施方案中，小型化结构和相关方法用作质谱仪或分析仪，并且可以作为离子发生器发挥作用。 小型化结构具有一对大致平面的平行隔开的电极，其具有配合以限定离子产生室和出口孔的突出壁。 通过控制垂直于所施加的磁场的电场，离子束可以基于质荷比与从装置的出口引出的预定的质荷比分离成多个光束，并且当该装置是 作为质谱仪或分析仪用作离子收集器，其将信息反应地传送到协作处理器。 在需要使其具有离子发生器功能的情况下，消除了邻近离子出口设置的离子收集器。

公开(公告)号：US06815667B2

公开(公告)日：2004-11-09

申请号：US10362510

申请日：2003-02-25

申请人： Scott D. Tanner ,  Dmitry R. Bandura ,  Vladimir I. Baranov

发明人： Scott D. Tanner ,  Dmitry R. Bandura ,  Vladimir I. Baranov

IPC分类号： H01J4900

CPC分类号： H01J49/061 ,  H01J49/044

摘要： A mass spectrometer has an ion source for producing sample ions. The ions pass through an ion interface, to a reaction/collision cell section. An inn-neutral decoupling device is provided between the ion interface and the reaction/collision cell section, to provide substantial separation between ions and neutral particles, whereby only ions pass on to the reaction/collision cell section. The supersonic jet entering the spectrometer can have sufficient energy to cause the plasma gases, such as argon, to overcome the pressure differential between the reaction/collision cell and an upstream section of the spectrometer so as to penetrate into the reaction/collision cell; the decoupling device prevents this. The decoupling device can have offset apertures provided by plates or rods or other comparable arrangements, or can comprise a quadrupolar electrostatic deflector, an electrostatic sector deflector or a magnetic sector deflector.

摘要翻译： 质谱仪具有用于产生样品离子的离子源。 离子通过离子界面到反应/碰撞电池部分。 在离子界面和反应/碰撞电池部分之间提供了一个inn-neutral去耦装置，以提供离子和中性粒子之间的实质性分离，从而只有离子传递到反应/碰撞电池部分。 进入光谱仪的超音速喷射器可以具有足够的能量来引起诸如氩气的等离子体气体克服反应/碰撞池与光谱仪的上游部分之间的压力差，从而渗入反应/碰撞池中; 去耦设备防止这种情况。 去耦装置可以具有由板或杆或其他可比较的布置提供的偏移孔，或者可以包括四极静电偏转器，静电扇形偏转器或磁性扇形偏转器。

公开(公告)号：US06812456B2

公开(公告)日：2004-11-02

申请号：US10148083

申请日：2002-05-24

申请人： Per Andersson ,  Magnus Gustafsson ,  Anders Palm ,  Susanne Wallenborg ,  Cecilia Hellermark

发明人： Per Andersson ,  Magnus Gustafsson ,  Anders Palm ,  Susanne Wallenborg ,  Cecilia Hellermark

IPC分类号： H01J4900

CPC分类号： H01J49/0431 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01J19/0093 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2200/142 ,  B01L2300/069 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/16 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0418 ,  B01L2400/0633 ,  B01L2400/0688 ,  G01N33/54366 ,  G01N35/00069 ,  G01N2035/00504 ,  H01J49/0418

摘要： A microfluidic device in form of a disc comprising an MS-port for presentation of an MS-analyte to an EDI-MS apparatus, said MS-port is a part of a microchannel structure (I) comprising an inlet port for a sample, and comprises an EDI-area having a conductive layer (I) and an EDI-surface from which the MS-analyte is to be desorbed/ionised. The device is characterized in that layer (I) has a conductive connection and/or that there is a calibrator area in the proximity of each of said one, two or more MS-ports. In a typical variant the MS-port is in the form of a depression that is in fluid communication with upstream part of microchannel structure (I).

摘要翻译： 一种形式的微流体装置，包括用于向EDI-MS装置呈现MS分析物的MS端口，所述MS端口是包括用于样品的入口的微通道结构（I）的一部分，以及 包括具有导电层（I）的EDI区域和待分析/电离MS分析物的EDI表面。 该装置的特征在于，层（I）具有导电连接和/或在所述一个，两个或更多个MS端口中的每一个附近存在校准器区域。 在典型的变型中，MS端口是与微通道结构（I）的上游部分流体连通的凹陷的形式。

公开(公告)号：US06812454B2

公开(公告)日：2004-11-02

申请号：US10628145

申请日：2003-07-28

申请人： Marc Gonin

发明人： Marc Gonin

IPC分类号： H01J4900

CPC分类号： H01J49/40 ,  H01J49/025

摘要： A new detection scheme for time-of-flight mass spectrometers is disclosed. This detection scheme allows extending the dynamic range of spectrometers operating with a counting technique (TDC). The extended dynamic range is achieved by constructing a multiple anode detector wherein the individual anodes detect different fractions of the incoming particles. Different anode fractions are achieved by varying the size, physical location, and electrical/magnetic fields of the various anodes. An anode with a small anode fraction avoids saturation and allows an ion detector to render an accurate count of ions even for abundant species.

摘要翻译： 公开了一种新的飞行时间质谱仪检测方案。 该检测方案允许通过计数技术（TDC）扩展光谱仪的动态范围。 通过构建多阳极检测器来实现扩展的动态范围，其中各个阳极检测进入的颗粒的不同部分。 通过改变各种阳极的尺寸，物理位置和电/磁场来实现不同的阳极分数。 具有小阳极部分的阳极避免饱和，并且允许离子检测器即使对于丰富的物质也能提供精确的离子计数。

公开(公告)号：US06797943B2

公开(公告)日：2004-09-28

申请号：US10139635

申请日：2002-05-07

申请人： Karsten Lösch ,  Bengt Nölting

发明人： Karsten Lösch ,  Bengt Nölting

IPC分类号： H01J4900

CPC分类号： H01J49/40 ,  G01N27/622

摘要： Molecular ions are generated by ionization, said molecular ions are accumulated in an ion reservoir that is external to the drift chamber. Than said molecular ions are dissociated into fragment ions (i.e. fragmented ions) with electromagnetic radiation or electron beams or ion beams, and said fragment ions are ion-mobility spectrometrically analyzed. In an embodiment the apparatus comprises additionally a virtual impactor and a pyrolyzer. The process of fragmentation over time are detected and analyzed, and this information is used for the differentiation of hazardous biological samples from non-hazardous biological samples.

摘要翻译： 分子离子通过电离产生，所述分子离子积聚在漂移室外部的离子储存器中。 比分子离子用电磁辐射或电子束或离子束解离成碎片离子（即碎片离子），所述碎片离子进行光谱分析。 在一个实施例中，该装置还包括虚拟冲击器和热解器。 检测和分析随时间的碎片过程，该信息用于危险生物样品与非危险生物样品的分化。

公开(公告)号：US06794640B2

公开(公告)日：2004-09-21

申请号：US10301710

申请日：2002-11-22

申请人： Robert Harold Bateman ,  Jeff Brown ,  Anthony James Gilbert

发明人： Robert Harold Bateman ,  Jeff Brown ,  Anthony James Gilbert

IPC分类号： H01J4900

CPC分类号： H01J49/004 ,  H01J49/401 ,  H01J49/42

摘要： A mass spectrometer is disclosed comprising a mass selective ion trap such as a 3D quadrupole field ion trap upstream of a pusher electrode of an orthogonal acceleration Time of Flight mass analyzer. According to a first embodiment bunches of ions are released from the ion trap and the pusher electrode is energised after a delay time which is progressively varied. According to a second embodiment ions are released from the ion trap in reverse order of mass to charge ratio with the ions having the largest mass to charge ratio being released first. By appropriate release of the ions from the ion trap it is possible to ensure that substantially all of the ions arrive at the pusher electrode at substantially the same time. According to both embodiments it is possible to achieve a duty cycle approaching 100% across a large range of mass to charge ratios.

摘要翻译： 公开了一种质谱仪，其包括质量选择性离子阱，例如正交加速时间飞行质量分析仪的推进器电极上游的3D四极场离子阱。 根据第一实施例，一束离子从离子阱中释放出来，并且推进器电极在逐渐变化的延迟时间之后通电。 根据第二实施方案，离子从离子阱以与质荷比最大的离子的质荷比相反的顺序被释放。 通过从离子阱适当释放离子，可以确保基本上所有的离子基本上同时到达推动器电极。 根据两个实施例，可以实现在大范围的质荷比之间接近100％的占空比。

公开(公告)号：US06787761B2

公开(公告)日：2004-09-07

申请号：US09994575

申请日：2001-11-27

申请人： Curtis Hastings

发明人： Curtis Hastings

IPC分类号： H01J4900

CPC分类号： H01J49/0036 ,  G01N30/72 ,  G01N30/8624 ,  G01N30/8641 ,  H01J49/0431

摘要： High-intensity, spiked noise is reduced in chromatography-mass spectrometry data by applying a nonlinear filter such as a moving median filter to the data. The filter is applied to individual mass chromatograms, plots of ion abundance versus retention time for each detected mass-to-charge ratio, and the filtered chromatograms are combined to form a filtered total ion current chromatogram. Standard linear filters are not effective for reducing noise in liquid chromatography-mass spectrometry (LC-MS) data because they assume a normal distribution of noise. LC-MS noise, however, is not normally distributed.

摘要翻译： 通过对数据应用诸如移动中值滤波器的非线性滤波器，在色谱 - 质谱数据中降低了高强度，加标噪声。 将过滤器应用于单个质量色谱图，每种检测质量 - 电荷比的离子丰度曲线与保留时间曲线，并将滤出的色谱图合并形成过滤的总离子电流色谱图。 标准线性滤波器对于降低液相色谱 - 质谱（LC-MS）数据中的噪声无效，因为它们假设噪声的正态分布。 然而，LC-MS噪声不是正态分布的。

公开(公告)号：US06787760B2

公开(公告)日：2004-09-07

申请号：US09976505

申请日：2001-10-12

申请人： Mikhail Belov ,  Richard D. Smith ,  Harold R. Udseth

发明人： Mikhail Belov ,  Richard D. Smith ,  Harold R. Udseth

IPC分类号： H01J4900

CPC分类号： H01J49/4215 ,  H01J49/004

摘要： A method for enhancing the dynamic range of a mass spectrometer by first passing a sample of ions through the mass spectrometer having a quadrupole ion filter, whereupon the intensities of the mass spectrum of the sample are measured. From the mass spectrum, ions within this sample are then identified for subsequent ejection. As further sampling introduces more ions into the mass spectrometer, the appropriate rf voltages are applied to a quadrupole ion filter, thereby selectively ejecting the undesired ions previously identified. In this manner, the desired ions may be collected for longer periods of time in an ion trap, thus allowing better collection and subsequent analysis of the desired ions. The ion trap used for accumulation may be the same ion trap used for mass analysis, in which case the mass analysis is performed directly, or it may be an intermediate trap. In the case where collection is an intermediate trap, the desired ions are accumulated in the intermediate trap, and then transferred to a separate mass analyzer. The present invention finds particular utility where the mass analysis is performed in an ion trap mass spectrometer or a Fourier transform ion cyclotron resonance mass spectrometer.

摘要翻译： 首先使离子样品通过具有四极离子过滤器的质谱仪来提高质谱仪的动态范围的方法，由此测定样品的质谱强度。 从质谱中，然后鉴定该样品内的离子用于随后的喷射。 随着进一步的采样将更多的离子引入质谱仪中，将适当的rf电压施加到四极离子过滤器，从而选择性地排出先前识别的不需要的离子。 以这种方式，期望的离子可以在离子阱中收集较长时间，从而允许更好地收集和随后分析所需的离子。 用于积聚的离子阱可以是用于质量分析的相同的离子阱，在这种情况下，质量分析是直接进行的，或者它可以是中间阱。 在收集是中间阱的情况下，期望的离子积聚在中间阱中，然后转移到单独的质量分析器。 在离子阱质谱仪或傅里叶变换离子回旋共振质谱仪中进行质量分析的本发明具有特殊的用途。

公开(公告)号：US06737644B2

公开(公告)日：2004-05-18

申请号：US10131412

申请日：2002-04-25

申请人： Hiroto Itoi

发明人： Hiroto Itoi

IPC分类号： H01J4900

CPC分类号： H01J49/067 ,  H01J49/4215

摘要： A quadrupole mass spectrometer includes: an ion source for generating ions; a quadrupole mass filter for selectively passing object ions having a predetermined mass number among the ions from the ion source; an ion detector for detecting the object ions; an ion converging lens placed between the quadrupole mass filter and the ion detector; and a voltage source for applying an optimal voltage to the ion converging lens, wherein the voltage has a polarity opposite to that of the object ions and the absolute value of the voltage is larger than that of a voltage at which the converging efficiency of the object ions is the largest. With respect to the overall S/N ratio, the optimal state is achieved when the optimal converging voltage which is greater than the maximum converging voltage is applied to the ion converging lens.

摘要翻译： 四极质谱仪包括：用于产生离子的离子源; 四极质量过滤器，用于选择性地将来自离子源的离子中具有预定质量数的物体离子; 用于检测物体离子的离子检测器; 位于四极质量过滤器和离子检测器之间的离子会聚透镜; 以及用于向离子会聚透镜施加最佳电压的电压源，其中所述电压具有与所述物体离子的极性相反的极性，并且所述电压的绝对值大于所述物体的会聚效率的电压的绝对值 离子最大。 对于整体S / N比，当对离子会聚透镜施加大于最大会聚电压的最佳会聚电压时，实现最佳状态。

公开(公告)号：US06707037B2

公开(公告)日：2004-03-16

申请号：US10155334

申请日：2002-05-24

申请人： Craig M. Whitehouse

发明人： Craig M. Whitehouse

IPC分类号： H01J4900

CPC分类号： H01J49/40 ,  H01J49/0095 ,  H01J49/107 ,  H01J49/164

摘要： A Matrix Assisted Laser Desorption Ionization (MALDI) Source operated at atmospheric or vacuum pressure is interfaced to a multipole ion guide or ion funnel with alternating current (AC or RF) waveforms applied. The multipole ion guides or ion funnels are configured to focus transport, trap and/or separate ions produced from a MALDI ion source and direct the MALDI produced ions to a mass analyzer for MS or MS/MSn mass to charge analysis. The MALDI sample targets can be positioned at the entrance of a multipole ion guide or ion funnel with gas flow and electric fields configured to direct ions efficiently into the ion guide or ion funnel. Alternatively, the MALDI target can be positioned inside the multipole ion guide or ion funnel so that ions produced are immediately exposed to the RF focusing electric fields inside the ion guide or ion funnel. Ions produced by MALDI operated at atmospheric or intermediate vacuum pressures experience ion to neutral gas collisions as they are transported in the multipole ion guide or ion funnel in the presence of RF electric fields. The gas collisions serve to damp the ion trajectories toward the ion centerline, improving ion transport efficiency into and through vacuum. Ion mobility and mass to charge separation of ions can be performed in the multipole ion guide and ion funnel devices while transporting and focusing ions. When a moving belt is used to interface between Capillary Electrophoresis (CE) or Liquid Chromatography (LC) and a MALDI ion source, the moving belt can be configured to run through a multipole ion guide operated at atmospheric or vacuum pressure regions. Positive and negative ions produced with MALDI ionization can be simultaneously sampled from opposite ends of a multipole ion guide and mass to charge analyzed in parallel.

摘要翻译： 矩阵辅助激光解吸电离（MALDI）在大气压或真空压力下运行的源与应用交流（AC或RF）波形的多极离子导向器或离子漏斗接口。 多极离子导向器或离子漏斗被配置为聚焦从MALDI离子源产生的输送，捕集和/或分离的离子，并将MALDI产生的离子引导到用于MS或MS / MS质量的质量分析器进行电荷分析。 MALDI样品靶可以位于多极离子导向器或离子漏斗的入口处，气流和电场被配置为有效地将离子引导到离子导向器或离子漏斗中。 或者，MALDI靶可以位于多极离子导向器或离子漏斗内部，使得所产生的离子立即暴露于离子导向器或离子漏斗内部的RF聚焦电场。 在大气压或中等真空压力下操作的MALDI产生的离子在中和气体碰撞中经受离子，因为它们在RF电场存在的情况下在多极离子导向器或离子漏斗中运输。 气体碰撞用于将离子轨迹阻挡到离子中心线，提高离子传输效率并通过真空。 可以在多极离子导向器和离子漏斗装置中进行离子迁移率和离子质量分离，同时输送和聚焦离子。 当运动皮带用于毛细管电泳（CE）或液相色谱（LC）和MALDI离子源之间的相互作用时，移动带可以配置成穿过在大气压力或真空压力区域运行的多极离子导向器。 通过MALDI离子化产生的正离子和负离子可以从多极离子导向器的相对端同时采样，并将质量进行并行分析。