公开(公告)号：US20160238573A1

公开(公告)日：2016-08-18

申请号：US14923273

申请日：2015-10-26

申请人： Genentech, Inc.

发明人： Cadapakam VENKATRAMANI ,  Mohammad AL-SAYAH

IPC分类号： G01N30/46 ,  G01N30/74 ,  B01D15/40 ,  B01D15/18 ,  B01D15/14 ,  B01D15/32

CPC分类号： G01N30/463 ,  B01D15/14 ,  B01D15/1878 ,  B01D15/1885 ,  B01D15/325 ,  B01D15/3833 ,  B01D15/40 ,  G01N30/462 ,  G01N30/74 ,  G01N30/88 ,  G01N2030/8813 ,  G01N2030/8877

摘要： Provided are two-dimensional chromatography systems and methods for separating and/or analyzing complex mixtures of organic compounds. In particularly, a two-dimensional reversed-phase liquid chromatography (RPLC)-supercritical fluid chromatography (SFC) system is described including a trapping column at the interface which collects the analytes eluted from the first dimension chromatography while letting the RPLC mobile phase pass through. The peaks of interest from the RPLC dimension column are effectively focused as sharp concentration pulses on the trapping column, which is subsequently injected onto the second dimension SFC column. The system can be used for simultaneous achiral and chiral analysis of pharmaceutical compounds. The first dimension RPLC separation provides the achiral purity result, and the second dimension SFC separation provides the chiral purity result (enantiomeric excess).

摘要翻译： 提供了用于分离和/或分析有机化合物的复杂混合物的二维色谱系统和方法。 特别地，描述了二维反相液相色谱（RPLC） - 超临界流体色谱（SFC）系统，其包括在界面处的捕集柱，其收集从第一维层析洗脱的分析物，同时使RPLC流动相通过 。 来自RPLC尺寸列的感兴趣的峰值被有效地聚焦在捕集柱上的尖锐浓度脉冲，随后将其注入到第二维度SFC柱上。 该系统可用于药物化合物的同时手性和手性分析。 第一维RPLC分离提供了手性纯度结果，第二维SFC分离提供手性纯度结果（对映体过量）。

公开(公告)号：US20160216240A1

公开(公告)日：2016-07-28

申请号：US14915794

申请日：2013-09-02

申请人： SHIMADZU CORPORATION

发明人： Etsuho KAMATA ,  Toshinobu YANAGISAWA ,  Yasuhiro MITO ,  Kenichi MISHIMA

IPC分类号： G01N30/86 ,  G01N30/74

CPC分类号： G01N30/8634 ,  G01N30/74

摘要： A data processing system for a chromatograph including a standard sample data storage section; a standard sample sensitivity factor calculator; a post-correction standard sample chromatogram strength calculator; a specific designated retention time and specific designated wavelength setter; a measurement sample data storage section; a measurement sample sensitivity factor calculator; and a post-correction measurement sample chromatogram creator.

摘要翻译： 一种用于色谱仪的数据处理系统，包括标准样品数据存储部分; 标准样本敏感度因子计算器; 校正后标准样品色谱图强度计算器; 具体指定保留时间和具体指定波长设定器; 测量样本数据存储部分; 测量样本灵敏度因子计算器; 和校正后测量样品色谱图创建器。

公开(公告)号：US20160202218A1

公开(公告)日：2016-07-14

申请号：US14988854

申请日：2016-01-06

申请人： SHIMADZU CORPORATION

发明人： Michiaki Owa

IPC分类号： G01N30/34 ,  G01N30/74 ,  G01N30/16

CPC分类号： G01N30/34 ,  B01D15/40 ,  C07K1/16 ,  G01N30/16 ,  G01N30/74 ,  Y02P20/544

摘要： A back pressure valve configured to switch between a pressurized state and a released state open to an atmosphere is used as a back pressure valve in a supercritical fluid chromatograph. Switching from a state of supercritical fluid chromatography analysis to liquid chromatography is performed by stopping a pump that supplies a supercritical fluid, continuously operating a pump that supplies a solvent used as a modifier, and bringing the back pressure valve into the released state.

摘要翻译： 在超临界流体色谱仪中使用配置为在加压状态和向大气开放的释放状态之间切换的背压阀作为背压阀。 从超临界流体色谱分析状态切换到液相色谱法是通过停止提供超临界流体的泵，连续操作供给用作改性剂的溶剂的泵，并使背压阀进入释放状态来进行的。

公开(公告)号：US20160168986A1

公开(公告)日：2016-06-16

申请号：US14908175

申请日：2014-07-23

申请人： BP EXPLORATION OPERATING COMPANY LIMITED

发明人： Shuan Raymond HURST ,  Roderic Lewis JONES

IPC分类号： E21B49/08 ,  G01N30/74 ,  G01N21/33

CPC分类号： E21B49/08 ,  C09K8/528 ,  E21B37/06 ,  E21B2049/085 ,  G01N21/33 ,  G01N30/74

摘要： A computer-implemented method and corresponding system for determining the concentration of one or more scale inhibiting polymers in a fluid received from one or more porous and permeable hydrocarbon-bearing rock formations is provided. Each polymer comprises a different chemical marker and the fluid comprises a plurality of commingled said scale inhibiting polymers. The method comprises receiving first input data representing a measured absorption spectrum, within a predetermined wavelength range, of the commingled scale inhibiting polymers, wherein the measured absorption spectrum is measured using a detector after chromatographic separation of the fluid; receiving second input data representing reference absorption spectra, the reference absorption spectra comprising: a) an absorption spectrum, over the predetermined wavelength range, of each of the scale inhibiting polymers; and b) baseline reference absorption spectra of other chemicals having absorbance values within the predetermined wavelength range that are expected to be present in the fluid; inputting the first and second input data into a computer program; and operating the computer program. The computer program is operated to, at each of a plurality of discrete time steps over an elution time from the separation, determine a factor for each reference absorption spectrum that results in a modelled spectrum comprising a best-fit linear combination of the second input data to the first input data. For each scale inhibiting polymer, the computer program also operates to use the factors corresponding to the absorption spectrum of said scale inhibiting polymer that have been determined for a predetermined number of said discrete time steps to determine an indication of the concentration of the scale inhibiting polymer.

摘要翻译： 提供了一种用于确定从一个或多个多孔和可渗透的含烃岩层接收的流体中的一种或多种防垢聚合物的浓度的计算机实现的方法和相应的系统。 每个聚合物包含不同的化学标记，并且流体包含多个混合的阻垢聚合物。 该方法包括接收代表混合阻垢聚合物的预定波长范围内的测量吸收光谱的第一输入数据，其中在流体色谱分离之后使用检测器测量测量的吸收光谱; 接收表示参考吸收光谱的第二输入数据，所述参考吸收光谱包括：a）每种抑垢聚合物的预定波长范围的吸收光谱; 和b）预期存在于流体中的预定波长范围内的吸光度值的其它化学品的基准参考吸收光谱; 将第一和第二输入数据输入计算机程序; 并操作计算机程序。 计算机程序在从分离出的洗脱时间的多个离散时间步长中的每一个处操作，确定每个参考吸收光谱的因子，其导致包含第二输入数据的最佳拟合线性组合的建模频谱 到第一个输入数据。 对于每种防垢聚合物，计算机程序还操作以使用与已经确定了预定数量的所述离散时间步骤所确定的所述防垢聚合物的吸收光谱相对应的因子来确定抑垢聚合物浓度的指示 。

公开(公告)号：US20160146766A1

公开(公告)日：2016-05-26

申请号：US14783826

申请日：2014-03-12

申请人： Oksana Iryna LESZCZYSZYN ,  Paul G. CLARKE ,  Mark NICHOLLS ,  E. Neil LEWIS

发明人： Oksana Iryna LESZCZYSZYN ,  Paul G. CLARKE ,  Mark NICHOLLS ,  E. Neil LEWIS

IPC分类号： G01N30/74 ,  C07K1/16 ,  B01D15/10 ,  G01N27/453 ,  G01N15/14 ,  G01N30/00

CPC分类号： H01J37/32807 ,  B01D15/10 ,  B01D15/247 ,  C07K1/16 ,  F16B7/0406 ,  G01N15/1404 ,  G01N27/44721 ,  G01N27/44739 ,  G01N27/453 ,  G01N30/0005 ,  G01N30/74 ,  G01N30/82 ,  G01N2030/027 ,  H01J37/32357 ,  H01J2237/334 ,  Y10T403/66

摘要： The invention relates to analysing and controlling collection of liquid eluate output from a separation process, in particular by use of a measure of suspended material in the eluate based on a light scattering detection method. Exemplary embodiments include a method (300) of controlling collection of a sample of a liquid eluate output from a separation process, the method comprising: exposing (306) the liquid eluate to light from a light source; detecting (307) light from the light source scattered by suspended material in the eluate at a detector; and beginning and ending collection (310) of the sample when a measure of the suspended material derived from the detected scattered light enters and leaves a predetermined range.

摘要翻译： 本发明涉及分析和控制来自分离过程的液体洗脱物输出的收集，特别是通过使用基于光散射检测方法的洗脱液中的悬浮物质的测量。 示例性实施例包括控制从分离过程输出的液体洗脱液样品的收集的方法（300），所述方法包括：将液体洗脱液（306）从光源曝光（306）; 在来自检测器的洗脱液中由悬浮物质散射的光源检测（307）光; 以及当从检测到的散射光导出的悬浮物质的测量进入并且离开预定范围时，样本的开始和结束收集（310）。

公开(公告)号：US09341606B2

公开(公告)日：2016-05-17

申请号：US14193941

申请日：2014-02-28

申请人： Weatherford Switzerland Trading and Development GmbH

发明人： Dennis D. Coleman ,  John Boettcher ,  Gavin Atlas Steele, IV

IPC分类号： G01N30/88 ,  G01N30/02 ,  G01N1/44 ,  G01N31/12 ,  G01N33/00 ,  G01N30/84 ,  G01N30/74 ,  G01N30/66

CPC分类号： G01N30/06 ,  G01N30/66 ,  G01N30/74 ,  G01N30/84 ,  G01N30/88 ,  G01N33/0011 ,  G01N33/0047 ,  G01N2030/025 ,  G01N2030/8854 ,  Y10T436/214 ,  Y10T436/25875

摘要： An apparatus for preparing a gas sample for analysis includes a separation unit configured to separate the gas sample into one or more component samples. A thermal conductivity detector detects the output of the one or more component sample from the separation unit. At least one component sample is collected in a component sample collection unit having a sample collector. The sample collection unit has an outlet for distributing the at least one component sample from the sample collector for analysis.

摘要翻译： 用于制备用于分析的气体样品的装置包括分离单元，其被配置为将气体样品分离成一个或多个组分样品。 热导率检测器检测来自分离单元的一个或多个组分样品的输出。 将至少一种组分样品收集在具有样品收集器的组分样品收集单元中。 样品收集单元具有用于从样品收集器分配至少一种组分样品用于分析的出口。

公开(公告)号：US09244011B2

公开(公告)日：2016-01-26

申请号：US14358951

申请日：2012-11-05

申请人： LUNA INNOVATIONS INCORPORATED

发明人： Mark E. Froggatt

IPC分类号： G01N21/43 ,  G01N21/53 ,  G01N21/45 ,  G01N27/447 ,  B01D57/02 ,  G01N30/74

CPC分类号： G01N21/53 ,  B01D57/02 ,  G01N21/45 ,  G01N27/44721 ,  G01N2030/746

摘要： An optical interrogation system, e.g., an OFDR-based system, measures local changes of index of refraction of a medium contained within a light guiding tube and includes an optical interferometric interrogator, optical detection circuitry, and a data processor. The data processor initiates a sweep of the light source and guide light from an interrogating light source into a medium contained by a tube which restricts movement of particles provided into the tube, where the medium is subjected to a driving force that overcomes resistance to movement of particles through the medium in the tube. The optical interferometric interrogator provides an optical interference pattern associated with a group of particles having moved in the tube as a result of the driving force. Based on the optical interference pattern, the data processor identifies a current location of the group of particles in the tube.

摘要翻译： 光学询问系统，例如基于OFDR的系统，测量包含在导光管内的介质的折射率的局部变化，并且包括光学干涉询问器，光学检测电路和数据处理器。 数据处理器启动光源的扫描并将光从询问光源引导到由管包含的介质中，该介质限制了设置在管中的颗粒的移动，其中介质受到驱动力，该驱动力克服 颗粒通过管中的介质。 光学干涉询问器提供与由于驱动力而在管中移动的一组颗粒相关联的光学干涉图案。 基于光学干涉图案，数据处理器识别管中的一组颗粒的当前位置。

公开(公告)号：US20150374677A1

公开(公告)日：2015-12-31

申请号：US14754339

申请日：2015-06-29

申请人： Malle Schmidt ,  Malle Päri ,  Marit Laos ,  Ants Maasalu ,  Kalle Kaljuste

发明人： Malle Schmidt ,  Malle Päri ,  Marit Laos ,  Ants Maasalu ,  Kalle Kaljuste

IPC分类号： A61K31/451 ,  G01N30/74 ,  C07D211/42 ,  C07D211/52 ,  C07D211/24

CPC分类号： A61K31/451 ,  C07D211/24 ,  C07D211/42 ,  C07D211/52 ,  G01N30/88 ,  G01N2030/8872

摘要： This invention provides an isolated compound having the structure: or a salt thereof.The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1-propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine 1-oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridne, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine.This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof. This invention further provides a process for producing a pridopidine drug product comprising obtaining a pridopidine drug substance and mixing the pridopidine drug substance with suitable excipients so as to produce the pridopidine drug product. This invention also provides a process for producing a pridopidine drug product. This invention also provides a process of distributing a pridopidine drug product.

摘要翻译： 本发明提供具有以下结构的分离的化合物：或其盐。 本发明还提供了制备4-（3-（甲基磺酰基）苯基）-1-丙基哌啶-4-醇，1-（3,3-双（3-（甲基磺酰基）苯基）丙基）-4-（ 3-（甲基磺酰基）苯基）哌啶酮，1,4-双（（3-（1-丙基哌啶-4-基）苯基）磺酰基）丁烷，（3R，4S）-4-（3-（甲基磺酰基）苯基） 1-丙基哌啶-3-醇，4-（3-（甲基磺酰基）苯基）-1-丙基哌啶1-氧化物，1-（2-甲基戊基）-4-（3-（甲基磺酰基）苯基）哌啶，4-（3 - （甲基亚磺酰基）苯基）-1-丙基-1,2,3,6-四氢吡啶和4-（3-（甲基磺酰基）苯基）-1-丙基-1,2,3,6-四氢吡啶。 本发明还提供了一种杂质或其盐作为用于检测药物组合物中微量杂质的参考标准，其包含派多啶或其药学上可接受的盐。 本发明进一步提供了一种制备哌多啶药物产物的方法，包括获得一种丙泊德哌啶药物，并将该丙泊德吡啶药物与合适的赋形剂混合，以产生格列方啶药物产品。 本发明还提供了制备格列方啶药物的方法。 本发明还提供了分布丙泊德苷药物的方法。

公开(公告)号：US20150260695A1

公开(公告)日：2015-09-17

申请号：US14660574

申请日：2015-03-17

申请人： Prism Analytical Technologies, Inc.

发明人： Martin L. Spartz ,  Anthony S. Bonanno ,  Peter P. Behnke

IPC分类号： G01N30/74 ,  G01J3/42

CPC分类号： G01J3/42 ,  G01N21/031 ,  G01N21/33 ,  G01N21/3504 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/64 ,  G01N21/65 ,  G01N30/74 ,  G01N30/8606 ,  G01N30/8641 ,  G01N2021/3595 ,  G01N2030/008 ,  G01N2030/025 ,  G01N2030/743

摘要： Components resolved in time by a separator accumulate in a sample cell and are analyzed by electromagnetic radiation-based spectroscopic techniques. The sample cell can be configured for multiple path absorption and can be heated. The separator can be a gas chromatograph or another suitable device, for example a distillation-based separator. The method and system described herein can include other mechanical elements, controls, procedures for handling background and sample data, protocols for species identification and/or quantification, automation, computer interfaces, algorithms, software or other features.

摘要翻译： 通过分离器在时间上分解的组分累积在样品池中并且通过基于电磁辐射的光谱技术进行分析。 样品池可以配置为多路径吸收并可加热。 分离器可以是气相色谱仪或另一合适的装置，例如基于蒸馏的分离器。 本文描述的方法和系统可以包括其他机械元件，控制，用于处理背景和样本数据的程序，用于物种识别和/或定量的协议，自动化，计算机接口，算法，软件或其他特征。

公开(公告)号：US20150253296A1

公开(公告)日：2015-09-10

申请号：US14432227

申请日：2013-09-30

申请人： METROHM AG

发明人： Björn Christensen ,  Sven Hoffmann ,  Thomas Moritz

IPC分类号： G01N30/74

CPC分类号： G01N30/74

摘要： A method for detecting analytes in flow rate analysis and chromatography is described. The method comprises the following steps: a) providing one or more light sources, an optical wave guide, a container containing a specimen with one or more analytes, and one or more detectors; b) exposing the container containing the specimen to light of one or various, defined wavelengths and/or wavelength ranges; and c) detecting the resulting light waves by one or more detectors after the specimen container is exposed to light of one or various defined wavelengths and/or wavelength ranges, wherein the specimen is irradiated by transferring the light waves through an non-flexible or non-flexibly arranged optical wave guide before the light waves enter the specimen container. The non-flexible or non-flexibly arranged optical wave guide is not susceptible to interference and permits selective irradiation with one or more wavelengths sequentially or simultaneously without requiring much time.

摘要翻译： 描述了用于检测流速分析和色谱分析物的方法。 该方法包括以下步骤：a）提供一个或多个光源，光波导，含有一个或多个分析物的样本的容器和一个或多个检测器; b）将容纳样品的容器暴露于一种或多种定义的波长和/或波长范围的光; 以及c）在将样本容器暴露于一个或多个限定的波长和/或波长范围的光之后，通过一个或多个检测器检测所得到的光波，其中通过将光波转移通过非柔性或非波长范围来照射样品 在光波进入样品容器之前，设置光导波导。 非柔性或非灵活布置的光波导不易受干扰，并且允许以一个或多个波长顺序地或同时地选择性地照射而不需要太多时间。