公开(公告)号：US10106647B2

公开(公告)日：2018-10-23

申请号：US14916140

申请日：2014-09-04

申请人： The Penn State Research Foundation

发明人： Jian Yang ,  Jinshan Guo

IPC分类号： C08G63/52 ,  C08G63/12 ,  A61L27/34 ,  C08G18/68 ,  C08G18/73 ,  C08G18/46 ,  A61L27/46 ,  C08G63/685 ,  A61L27/56

摘要： In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises the reaction product of (i) citric acid, a citrate, or an ester of citric acid with (ii) a polyol, and (iii) a monomer comprising one or more alkyne moieties and/or azide moieties. The reaction product, in some instances, comprises a polymer. Further, in some cases, a composition described herein comprises a plurality of polymers. In some embodiments, the polymers are selected to be reactive with one another through a click chemistry reaction scheme to form a polymer network. In another aspect, medical implants and medical devices are described herein, the implants and devices comprising a polymer or polymer network described herein.

公开(公告)号：US10085651B2

公开(公告)日：2018-10-02

申请号：US14383787

申请日：2013-03-13

申请人： The Penn State Research Foundation

发明人： Kim Kopenhaver Doheny ,  Charles Palmer

IPC分类号： A61B5/024 ,  A61B5/08 ,  A61B5/00 ,  G06F19/00 ,  A61B5/0205

摘要： Embodiments are presented herein that provide early prediction of the development of necrotizing enterocolitis by a preterm infant through analysis of the high frequency component of heart rate variability, optionally with analysis of respiration rate. Methods of treatment following prediction area also reported.

公开(公告)号：US20180265906A1

公开(公告)日：2018-09-20

申请号：US15993901

申请日：2018-05-31

申请人： The Penn State Research Foundation

发明人： Stephen J. Benkovic ,  Frank Salinas

IPC分类号： C12P19/34 ,  C12Q1/6806 ,  C12Q1/686 ,  C12Q1/6844 ,  C12N15/10

CPC分类号： C12P19/34 ,  C12N15/1027 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q1/686 ,  C12Q2521/507 ,  C12Q2521/513 ,  C12Q2527/125

摘要： A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity polymerase to permit the replication and amplification of the target nucleic acid sequence. In preferred embodiments, the polymerase comprises a polymerase holoenzyme. In further preferred embodiments, the recombination factor is bacteriophage T4 UvsX protein or homologs from other species, and the polymerase holoenzyme comprises a polymerase enzyme, a clamp protein and a clamp loader protein, derived from viral, bacteriophage, prokaryotic, archaebacterial, or eukaryotic systems.

公开(公告)号：US10013477B2

公开(公告)日：2018-07-03

申请号：US15282947

申请日：2016-09-30

申请人： The Penn State Research Foundation

发明人： Jianbo Ye ,  Jia Li ,  James Z. Wang

IPC分类号： G06F17/30 ,  G06N99/00

CPC分类号： G06F16/285 ,  G06N20/00

摘要： Computationally efficient accelerated D2-clustering algorithms are disclosed for clustering discrete distributions under the Wasserstein distance with improved scalability. Three first-order methods include subgradient descent method with re-parametrization, alternating direction method of multipliers (ADMM), and a modified version of Bregman ADMM. The effects of the hyper-parameters on robustness, convergence, and speed of optimization are thoroughly examined. A parallel algorithm for the modified Bregman ADMM method is tested in a multi-core environment with adequate scaling efficiency subject to hundreds of CPUs, demonstrating the effectiveness of AD2-clustering.

公开(公告)号：US09963751B2

公开(公告)日：2018-05-08

申请号：US15355643

申请日：2016-11-18

申请人： THE PENN STATE RESEARCH FOUNDATION

发明人： Jianming Hu

IPC分类号： A61K39/00 ,  C07K14/005 ,  C07K14/03 ,  C07K14/125 ,  C07K14/18 ,  C12Q1/70 ,  C12Q1/68

CPC分类号： C12Q1/70 ,  C12Q1/6816 ,  C12Q1/706 ,  C12Q2525/307

摘要： Provided are compositions and methods for identifying test agents as candidate for use in reducing hepatitis B virus (HBV). The methods involve a) introducing at least one test agent into mammalian cells, the cells having one or more plasmids that encode an HBV genome, wherein the genome includes a segment encoding a mutated HBV core (HBc), wherein the HBc mutation is L60A, I126A, K96A or a combination thereof. The test agent is allowed to be in contact with the mammalian cells for a period of time. Subsequently, amounts of HBV cccDNA in the mammalian cells are determined. The method can be performed in vitro or in vivo. A reduction in cccDNA relative to a control indicates the test agent in the test container is a candidate for reducing HBV in an individual. Cell cultures divided into reaction containers that each contain a distinct test agent are also included.

公开(公告)号：US09918966B2

公开(公告)日：2018-03-20

申请号：US15244671

申请日：2016-08-23

申请人： The Penn State Research Foundation

发明人： Gavin P. Robertson ,  Chandagalu D. Raghavendra Gowda ,  Dhimant H. Desai ,  Shantu G. Amin

IPC分类号： A61K31/095 ,  A61K31/415 ,  A61K45/06 ,  A61K9/127 ,  A61K9/00 ,  A61K38/06 ,  C07D231/12 ,  C07D231/42 ,  C07D231/10

CPC分类号： A61K31/415 ,  A61K9/0014 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/095 ,  A61K38/063 ,  A61K45/06 ,  C07D231/10 ,  C07D231/12 ,  C07D231/42 ,  A61K2300/00

摘要： Compositions and pharmaceutical compositions including one or more selenium-containing COX-2 inhibitors are provided according to aspects of the present invention. Methods of treating a subject having or suspected of having cancer are provided according to aspects of the present invention which include administering a therapeutically effective amount of a pharmaceutical composition including a selenium-containing COX-2 inhibitor.

公开(公告)号：US09912045B2

公开(公告)日：2018-03-06

申请号：US15273790

申请日：2016-09-23

申请人： THE PENN STATE RESEARCH FOUNDATION

发明人： Douglas H. Werner ,  Zhihao Jiang

IPC分类号： H01Q1/12 ,  H01Q1/38 ,  H01Q15/02 ,  H01Q1/27 ,  H01Q1/48 ,  H01Q1/52 ,  H01Q15/00 ,  H01Q1/24

CPC分类号： H01Q1/273 ,  H01Q1/241 ,  H01Q1/48 ,  H01Q1/52 ,  H01Q15/0013 ,  H01Q15/0086

摘要： An antenna includes a first body having an array of resonators; a spacer adjacent to the first body, and a second body adjacent to the spacer such that the spacer is between the first and second bodies. The first body can be configured as an artificial metasurface ground plane and the second body can be configured as a monopole.

公开(公告)号：US09904869B2

公开(公告)日：2018-02-27

申请号：US15395331

申请日：2016-12-30

申请人： The Penn State Research Foundation

发明人： James Z. Wang ,  Xin Lu ,  Poonam Suryanarayan ,  Reginald B. Adams, Jr. ,  Jia Li ,  Michelle Newman

IPC分类号： G06K9/46 ,  G06T7/60

CPC分类号： G06K9/4671 ,  G06F17/30259 ,  G06F17/30268 ,  G06K9/00302 ,  G06K9/00684 ,  G06K9/00711 ,  G06K9/46 ,  G06K9/4604 ,  G06K9/52 ,  G06K9/6267 ,  G06T7/60 ,  G06T11/206 ,  G06T2207/10004

摘要： Shape features in natural images influence emotions aroused in human beings. An in-depth statistical analysis helps to understand the relationship between shapes and emotions. Through experimental results on the International Affective Picture System (IAPS) dataset, evidence is presented as to the significance of roundness-angularity and simplicity-complexity on predicting emotional content in images. Shape features are combined with other state-of-the-art features to show a gain in prediction and classification accuracy. Emotions are modeled from a dimensional perspective in order to predict valence and arousal ratings, which have advantages over modeling the traditional discrete emotional categories. Images are distinguished vis-a-vis strong emotional content from emotionally neutral images with high accuracy. All of the methods and steps disclosed herein are implemented on a programmed digital computer, which may be a stand-alone machine or integrated into another piece of equipment such as a digital still or video camera including, in all embodiments, portable devices such as smart phones.

公开(公告)号：US09885015B2

公开(公告)日：2018-02-06

申请号：US15367382

申请日：2016-12-02

申请人： The Penn State Research Foundation

发明人： Gong Chen ,  Lei Zhang ,  Jiuchao Yin ,  Ningxin Ma

IPC分类号： A61K31/192 ,  A61K31/175 ,  A61K31/4418 ,  A61K31/4545 ,  A61K31/506 ,  A61K33/14 ,  C12N5/0793 ,  A61K31/375

CPC分类号： C12N5/0619 ,  A61K31/192 ,  A61K31/375 ,  A61K31/4418 ,  A61K31/4545 ,  A61K31/506 ,  A61K33/14 ,  C12N2506/08 ,  A61K2300/00

摘要： Provided are compositions, articles and methods that relate to promoting neurogenesis or neuroregeneration in mammalian nervous system. Embodiments relate to use of groups of compounds that contain Crizotinib (Cri), Flurbiprofen, Lithium Chloride (Li), Vitamin C (VC), Ceritinib (Cer) or Pirfenidone (PFD). In certain implementations glial cells are converted into functional neurons.

公开(公告)号：US09850292B2

公开(公告)日：2017-12-26

申请号：US14400904

申请日：2013-05-17

申请人： THE JOHNS HOPKINS UNIVERSITY ,  The Penn State Research Foundation

发明人： Mark Donowitz ,  Nicholas Constantine Zachos ,  Damian Brett Van Rossum ,  Randen Patterson

IPC分类号： C07K14/47 ,  A61K45/06 ,  A61K35/741 ,  A61K38/17 ,  A61K38/00

CPC分类号： C07K14/4705 ,  A61K35/741 ,  A61K38/00 ,  A61K38/1709 ,  A61K45/06 ,  C07K14/47 ,  A61K2300/00

摘要： A synthetic peptide modeled on the IRCX binding area of NHE3, is a competitive inhibitor of the IRCX and both stimulates basal NHE3 activity and prevents elevated Ca2+ and cAMP inhibition of NHE3. Methods of its preparation and use in the prevention and/or treatment of gastrointestinal disease, such as diarrhea are provided.