公开(公告)号：US5714159A

公开(公告)日：1998-02-03

申请号：US740646

申请日：1996-10-31

申请人： Shalaby W. Shalaby

发明人： Shalaby W. Shalaby

IPC分类号： A61K47/48 ,  A61K9/00 ,  A61K47/34 ,  A61L31/06 ,  A61L31/14 ,  C08G63/66 ,  C08G63/664 ,  C08K5/00 ,  C08L67/00 ,  C08L67/02 ,  A61F2/00

CPC分类号： A61K9/0024 ,  A61K47/34 ,  A61L31/06 ,  A61L31/145 ,  C08G63/664

摘要： The present invention provides novel hydrogel-forming, self-solvating, absorbable polyester copolymers capable of selective, segmental association into compliant hydrogels upon contacting an aqueous environment. Methods of using the novel polyester copolymers of the invention in humans are also disclosed for providing a protective barrier to prevent post-surgical adhesion, treatment of defects in conduits such as blood vessels, and controlled release of a biologically active agent for modulating cellular events such as wound healing and tissue regeneration or therapeutic treatment of diseases such as infection of the periodontium, dry socket, bone, skin, vaginal, and nail infections

摘要翻译： 本发明提供了新颖的水凝胶形成，自溶性，可吸收的聚酯共聚物，其能够在与水性环境接触时能够选择性地，分段地缔合到顺应性水凝胶中。 还公开了将本发明的新型聚酯共聚物用于人体的方法，用于提供保护屏障以防止手术后粘连，治疗管道如血管中的缺陷，以及控制释放用于调节细胞事件的生物活性剂 作为伤口愈合和组织再生或治疗性治疗诸如牙周膜炎，干燥窝，骨骼，皮肤，阴道和指甲感染的疾病

公开(公告)号：US5522842A

公开(公告)日：1996-06-04

申请号：US212174

申请日：1994-03-11

申请人： Shalaby W. Shalaby

发明人： Shalaby W. Shalaby

IPC分类号： A61L17/12 ,  A61L17/14 ,  A61L24/04 ,  A61L27/18 ,  A61L27/34 ,  A61L29/08 ,  C08G63/91 ,  A61B17/04 ,  A61L17/00

CPC分类号： C08G63/912 ,  A61L17/12 ,  A61L17/145 ,  A61L24/046 ,  A61L27/18 ,  A61L27/34 ,  A61L29/085

摘要： Crystalline, low melting .epsilon.-Caprolactone polymers which undergo accelerated hydrolysis for use, for example, as absorbable coatings for surgical sutures; the polymers bearing basic amine functionalities, ionically or covalently linked to the ester chain, which induce autocatalyzed hydrolysis.

摘要翻译： 经过加速水解的结晶，低熔点ε-己内酯聚合物，例如用作外科缝合线的可吸收涂层; 具有碱性胺官​​能团的聚合物，其与酯链离子或共价连接，其诱导自动催化的水解。

公开(公告)号：US20240216583A1

公开(公告)日：2024-07-04

申请号：US18602655

申请日：2024-03-12

申请人： Poly-Med, Inc.

发明人： Michael Aaron Vaughn

IPC分类号： A61L27/52 ,  C08F222/38 ,  C08J3/075 ,  C08J3/24 ,  C08K5/20 ,  C08L33/26

CPC分类号： A61L27/52 ,  C08J3/075 ,  C08J3/246 ,  C08K5/20 ,  C08L33/26 ,  A61L2430/06 ,  C08F222/385 ,  C08J2433/02 ,  C08L2203/02

摘要： A double network hydrogel consists of a first network and a second network, where the first network is, or includes, a first polymer that is formed, at least in part, of —CH2—CH(OH)— units, and the second network is, or includes, a second polymer that is formed, at least in part, of carboxyl (COOH)-containing units or salts thereof, sulfonyl (SO3H)-containing units or salts thereof, and at least one of hydroxyl (OH)-containing units or amino (NH2)-containing units, where the hydrogel may be used as a cartilage replacement.

公开(公告)号：US12016764B2

公开(公告)日：2024-06-25

申请号：US16956524

申请日：2018-12-21

申请人： Poly-Med, Inc.

发明人： Jennifer Cartledge ,  Kenneth W. Clinkscales ,  Elizabeth Elvington ,  James Hyde ,  Brad Johns ,  Michael Scott Taylor

IPC分类号： A61F2/04

CPC分类号： A61F2/04 ,  A61F2002/048 ,  A61F2210/0004 ,  A61F2220/0008 ,  A61F2230/0091 ,  A61F2250/0067

摘要： Implantable medical devices have zones of high in vivo stability that are adjacent to zones of relatively low in vivo stability, so that when these medical devices are implanted into a host, the zones of low in vivo stability degrade first and allow the formation of independent segments of relatively intact high in vivo stability bands that are sufficiently small that they may pass from the host in a non-harmful manner.

公开(公告)号：US11639416B2

公开(公告)日：2023-05-02

申请号：US17047370

申请日：2019-04-05

申请人： POLY-MED, INC.

发明人： Michael Aaron Vaughn ,  Prabhjot Saini

IPC分类号： C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  C08G63/08 ,  B33Y70/00 ,  C08F283/01 ,  C08F283/02 ,  C08F297/00 ,  C08G63/64 ,  C08G63/91 ,  B33Y10/00 ,  B29C64/124 ,  B29K33/00 ,  B29K67/00 ,  B29K81/00 ,  B29K96/02 ,  B29K96/04 ,  B29K105/00

摘要： Compounds and compositions are provided which are useful in additive printing, particularly additive printing techniques such as stereolithography (SLA) wherein a macromer is photopolymerized to form a manufactured article. Representative compounds comprise a polyaxial central core (CC) and 2-4 arms of the formula (A)-(B) or (B)-(A) extending from the central core, where at least one of the arms comprise a light-reactive functional group (Q) and (A) is the free-radical polymerization product from monomers selected from trimethylene carbonate (T) and ε-caprolactone (C), while (B) is the free-radical polymerization product from monomers selected from glycolide, lactide and ρ-dioxanone.

公开(公告)号：US11486058B2

公开(公告)日：2022-11-01

申请号：US16823674

申请日：2020-03-19

申请人： Poly-Med, Inc.

发明人： Michael Scott Taylor ,  Seth Dylan McCullen

IPC分类号： D01F6/84 ,  D01D5/00 ,  D01F6/62 ,  D04H1/728 ,  D04H1/435 ,  D01D1/02

摘要： Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed with thermally unstable fibers to yield a stabilizing effect without altering morphological properties of a fiber system. Via this, one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state.

公开(公告)号：US11478348B2

公开(公告)日：2022-10-25

申请号：US16310786

申请日：2017-06-23

申请人： POLY-MED, INC.

发明人： Michael Scott Taylor ,  Jennifer Cartledge ,  Kenneth David Gray, Jr.

IPC分类号： A61F2/04

摘要： Medical implants that include a containment layer surrounding, or surrounded by, a biodegradable medical device provide the benefit that pieces formed during degradation of the medical device are held within a constrained place and thus do not causes injury to a hosts.

公开(公告)号：US20220071756A1

公开(公告)日：2022-03-10

申请号：US16956524

申请日：2018-12-21

申请人： Poly-Med, Inc.

发明人： Jennifer Cartledge ,  Kenneth W. Clinkscales ,  Elizabeth Elvington ,  James Hyde ,  Brad Johns ,  Michael Scott Taylor

IPC分类号： A61F2/04

摘要： Implantable medical devices have zones of high in vivo stability that are adjacent to zones of relatively low in vivo stability, so that when these medical devices are implanted into a host, the zones of low in vivo stability degrade first and allow the formation of independent segments of relatively intact high in vivo stability bands that are sufficiently small that they may pass from the host in a non-harmful manner.

公开(公告)号：US11197950B2

公开(公告)日：2021-12-14

申请号：US16931552

申请日：2020-07-17

申请人： Poly-Med, Inc.

发明人： Shalaby W. Shalaby

IPC分类号： A61L31/12 ,  A61F2/00 ,  A61L27/48 ,  A61L31/14 ,  D01D5/00 ,  A61L27/58 ,  A61B17/42 ,  A61B90/00

摘要： Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.

公开(公告)号：US20210317301A1

公开(公告)日：2021-10-14

申请号：US17227119

申请日：2021-04-09

申请人： Poly-Med, Inc.

发明人： David Shalaby ,  David Gravett ,  Michael Scott Taylor ,  Seth Dylan McCullen ,  Michael Aaron Vaughn

IPC分类号： C08L67/04 ,  C08L101/16

摘要： Disclosed herein are polyhydroxyalkanoate polymer blend compositions, and methods of making and using such compositions.