公开(公告)号：US07582736B2

公开(公告)日：2009-09-01

申请号：US11972130

申请日：2008-01-10

Applicant: Bin Liu ,  James D. Marks

Inventor： Bin Liu ,  James D. Marks

IPC: C12P21/08

CPC classification number: C07K16/3069 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77

Abstract: This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The antibodies can also be formulated as chimeric molecules to direct an effector (e.g. a cytotoxin, an imaging reagent, a drug, etc.) to a prostate tumor site.

Abstract translation: 本发明提供了新型前列腺癌特异性内化人抗体。 抗体本身可用于预防前列腺癌细胞的生长和/或增殖。 抗体还可以配制成嵌合分子以将效应物（例如细胞毒素，成像试剂，药物等）引导至前列腺肿瘤部位。

公开(公告)号：US20080280891A1

公开(公告)日：2008-11-13

申请号：US11819494

申请日：2007-06-27

Applicant: Martha Kelly ,  Younghee Lee ,  Bin Liu ,  Ted Fujimoto ,  Joel Freundlich ,  Bruce D. Dorsey ,  Gary A. Flynn ,  Arifa Husain ,  William R. Moore, Jr.

Inventor： Martha Kelly ,  Younghee Lee ,  Bin Liu ,  Ted Fujimoto ,  Joel Freundlich ,  Bruce D. Dorsey ,  Gary A. Flynn ,  Arifa Husain ,  William R. Moore, Jr.

IPC: A61K31/541 ,  A61K31/404 ,  C07D209/42 ,  C07D401/02 ,  C07D417/14 ,  A61K31/44 ,  A61P35/00 ,  A61K31/4439 ,  A61K31/5377 ,  C07D413/14

CPC classification number: A61K31/404 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/541 ,  C07D213/74 ,  C07D231/56 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D413/12 ,  C07D498/04

Abstract: The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3-R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6-10 carbons in the ring portion, an optionally-substituted 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, an optionally-substituted 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, prostate, non-small cell lung and colon. They are additionally useful in the treatment of proliferative retinopathies such as diabetic neuropathy and macular degeneration.

Abstract translation: 本发明涉及新型化合物及其盐，其合成及其作为抗癌剂的用途。 化合物包括式I化合物及其溶剂合物，水合物及其药学上可接受的盐，其中A 1是N或CR 1; N 3或N 3是N或CR 3; A <5>为N或CR 5; 在说明书中定义了R 1，R 3，R 6和L 6; n为0或1; 并且X是在环部分中具有6-10个碳的任选取代的芳基，在环部分中具有1-3个氮原子的任选取代的6元杂芳基，任选取代的5元杂芳基具有0 -4个氮原子，并且在环部分中任选具有1个硫原子或1个氧原子，或任选取代的杂芳基，其中6元环稠合到5元环或6元环 其中在每种情况下，1,2,3或4个环原子是独立地选自氮，氧和硫的杂原子。 它们对广泛的癌症尤其是白血病，前列腺，非小细胞肺和结肠有效。 它们还可用于治疗增殖性视网膜病变，例如糖尿病性神经病变和黄斑变性。

公开(公告)号：US20080247864A1

公开(公告)日：2008-10-09

申请号：US12068519

申请日：2008-02-07

Applicant: Shun-Chen Chang ,  Chia-Ming Hsu ,  Wen-Bin Liu ,  Shir-Harn Yeh

Inventor： Shun-Chen Chang ,  Chia-Ming Hsu ,  Wen-Bin Liu ,  Shir-Harn Yeh

IPC: F04D29/66

CPC classification number: F04D29/66 ,  F04D25/0613

Abstract: A fan includes an impeller and a fan frame. The fan frame has a main body and at least one sound absorber, wherein the main body has a passage for receiving the impeller, a plurality of flanges are disposed on a periphery of the main body, a recess is defined between the two adjacent flanges, an aperture is disposed on a wall of the main body corresponding to the recess so as to allow the recess to communicate with the passage, and the sound absorber is disposed in the recess. Also, a cover is assembled in the min body and covers the sound absorber within the recess.

Abstract translation: 风扇包括叶轮和风扇框架。 风扇框架具有主体和至少一个吸声器，其中主体具有用于容纳叶轮的通道，多个凸缘设置在主体的周边上，在两个相邻的凸缘之间限定凹部， 孔对应于凹部设置在主体的壁上，以允许凹部与通道连通，并且吸声器设置在凹部中。 此外，盖子组装在最小主体中并且覆盖凹部内的吸声器。

公开(公告)号：US20080181547A1

公开(公告)日：2008-07-31

申请号：US11960490

申请日：2007-12-19

Applicant: Zhin-Chang CHEN ,  Hong-Tu Zhou ,  Jian-Bin Liu

Inventor： Zhin-Chang CHEN ,  Hong-Tu Zhou ,  Jian-Bin Liu

IPC: H02K5/167 ,  F16C35/02

CPC classification number: F16C35/02 ,  H02K1/187 ,  H02K5/163 ,  H02K11/33 ,  H02K2211/03

Abstract: A motor and its bearing supporting structure are disclosed. The bearing supporting structure supporting a shaft includes a bushing, a bearing and at least one first limiting assembly. The bushing has an opening and an accommodating space. The bearing supports at least a portion of the shaft and is disposed in the accommodating space. The first limiting assembly is disposed at a connection of the bearing and the bushing.

Abstract translation: 公开了一种电动机及其轴承支撑结构。 支撑轴的轴承支撑结构包括衬套，轴承和至少一个第一限制组件。 衬套具有开口和容纳空间。 所述轴承支撑所述轴的至少一部分并且设置在所述容纳空间中。 第一限位组件设置在轴承和衬套的连接处。

公开(公告)号：US07356594B2

公开(公告)日：2008-04-08

申请号：US10678976

申请日：2003-10-03

Applicant: Charbel Khawand ,  Jianping W. Miller ,  Jean Khawand ,  Bin Liu

Inventor： Charbel Khawand ,  Jianping W. Miller ,  Jean Khawand ,  Bin Liu

IPC: G06F15/173 ,  G06F13/00

CPC classification number: H04L67/14 ,  H04L69/329

Abstract: An IPC protocol/network allows for intelligent targeting of nodes in order to reduce overhead and provide for improved power management. The IPC server keeps track of the IPC network's node activity and using an operational state table (2000) it can determine which node can handle a service request (e.g., MP3 decode). By keeping track of the current operational condition of the nodes within the network, the processors can have better battery life and application latency can be improved. The IPC server will keep track not only of which nodes can handle which services, but it will also know which node can handle the service request given its knowledge of the operational state of each of the nodes.

Abstract translation: IPC协议/网络允许节点的智能目标，以减少开销并提供改进的电源管理。 IPC服务器跟踪IPC网络的节点活动并使用操作状态表（2000），它可以确定哪个节点可以处理服务请求（例如，MP3解码）。 通过跟踪网络中节点的当前操作条件，处理器可以具有更好的电池寿命并且可以提高应用延迟。 IPC服务器不仅将跟踪哪些节点可以处理哪些服务，而且还将知道哪个节点可以处理服务请求，因为它知道每个节点的操作状态。

公开(公告)号：US07335744B2

公开(公告)日：2008-02-26

申请号：US11021438

申请日：2004-12-21

Applicant: Bin Liu ,  James D. Marks

Inventor： Bin Liu ,  James D. Marks

IPC: C12P21/08

CPC classification number: C07K16/3069 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77

Abstract: This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The antibodies can also be formulated as chimeric molecules to direct an effector (e.g. a cytotoxin, an imaging reagent, a drug, etc.) to a prostate tumor site.

Abstract translation: 本发明提供了新型前列腺癌特异性内化人抗体。 抗体本身可用于预防前列腺癌细胞的生长和/或增殖。 抗体还可以配制成嵌合分子以将效应物（例如细胞毒素，成像试剂，药物等）引导至前列腺肿瘤部位。

公开(公告)号：US20070284501A1

公开(公告)日：2007-12-13

申请号：US11735246

申请日：2007-04-13

Applicant: Bin Liu

Inventor： Bin Liu

IPC: B60S9/02

CPC classification number: B66F5/00 ,  B60B33/0002 ,  B60B33/001 ,  B60B33/0021 ,  B60B33/0039 ,  B60B33/0049 ,  B60B33/0057 ,  B60B33/0068 ,  B60B33/0073 ,  B60B33/045 ,  B60G3/01 ,  B60G11/16 ,  B66F13/00 ,  F16F1/127

Abstract: A shock-absorbing wheel mounting structure used in a horizontal jack is disclosed. The wheel mounting structure includes an axial sleeve (4) affixed to a rear wheel mount (5) of the horizontal jack (100), and a shaft (2), vertically slideably mounted in the axial sleeve (4) and riveted to a bracket (1). The bracket (1) supports a wheel (71). A compression spring (3) is sleeved onto the shaft (2) and stopped between a stop flange around the periphery of the shaft (2) and the top wall of the axial sleeve (4). This arrangement serves to impart a downward pressure to the shaft (2) relative to the axial sleeve (4).

Abstract translation: 公开了一种在水平千斤顶中使用的减震轮安装结构。 车轮安装结构包括固定到水平千斤顶（100）的后轮安装件（5）上的轴向套筒（4）和可垂直地可滑动地安装在轴向套筒（4）中并铆接到支架 （1）。 支架（1）支撑轮（71）。 压缩弹簧（3）套在轴（2）上并且停在围绕轴（2）的周边的止动凸缘和轴向套筒（4）的顶壁之间。 这种布置用于相对于轴向套筒（4）向轴（2）施加向下的压力。

公开(公告)号：US20070237876A1

公开(公告)日：2007-10-11

申请号：US11624777

申请日：2007-01-19

Applicant: Anthony Kinney ,  Edgar Cahoon ,  Howard Damude ,  William Hitz ,  Zhan-Bin Liu ,  Charles Kolar

Inventor： Anthony Kinney ,  Edgar Cahoon ,  Howard Damude ,  William Hitz ,  Zhan-Bin Liu ,  Charles Kolar

IPC: A01H5/00 ,  A01H5/10 ,  A23D7/00 ,  A23L2/38 ,  C11B11/00

CPC classification number: C12N9/0083 ,  A21D2/165 ,  A23D9/00 ,  A23K20/158 ,  A23K50/40 ,  A23K50/80 ,  A23L11/01 ,  A23L11/03 ,  A23L11/05 ,  A23L11/07 ,  A23L33/12 ,  A23V2002/00 ,  A23V2300/21 ,  C12N9/1029 ,  C12N15/8247 ,  Y02A40/818 ,  A23V2250/1876 ,  A23V2250/1882

Abstract: Oilseed plants which have been transformed to produce very long chain polyunsaturated fatty acids, recombinant constructs used in such transformations, methods for producing such fatty acids in a plant are described and uses of oils and seeds obtained from such transformed plants in a variety of food and feed applications are described.

Abstract translation: 已经转化以产生非常长链多不饱和脂肪酸的油籽植物，用于这种转化的重组构建体，在植物中生产这种脂肪酸的方法，以及从这些转化植物获得的油和种子在多种食物中的应用，以及 描述饲料应用。

公开(公告)号：US07271753B1

公开(公告)日：2007-09-18

申请号：US11436824

申请日：2006-05-18

Applicant: Pradeep Padukone ,  Bin Liu

Inventor： Pradeep Padukone ,  Bin Liu

IPC: H03M1/62

CPC classification number: G11B5/58 ,  G11B5/6005 ,  G11B5/6029 ,  H03M1/1014 ,  H03M1/12

Abstract: Methods of calibrating an analog front end (AFE) of a read/write channel include measuring a first magnitude of a test signal, measuring a second magnitude of an output signal of the AFE generated in response to the test signal, and comparing the first magnitude and the second magnitude to generate a measure of a gain of the AFE at a frequency of the test signal. A data storage device includes a read/write head configured to generate an analog input signal, an AFE coupled to the read/write head and configured to amplify and filter the analog input signal, a test signal generator configured to generate a test signal having a frequency substantially equal to a fundamental frequency of the analog input signal or any of its harmonics, and an attenuator coupled between the test signal generator and the AFE.

Abstract translation: 校准读/写通道的模拟前端（AFE）的方法包括测量测试信号的第一幅度，测量响应于测试信号产生的AFE的输出信号的第二幅度，并且比较第一幅度 以及第二幅度以产生在测试信号的频率处的AFE的增益的量度。 数据存储装置包括被配置为产生模拟输入信号的读/写头，耦合到读/写头并被配置为放大和滤波模拟输入信号的AFE，被配置为产生测试信号的测试信号发生器， 频率基本上等于模拟输入信号或其任何谐波的基频，以及耦合在测试信号发生器和AFE之间的衰减器。

公开(公告)号：US20070163005A1

公开(公告)日：2007-07-12

申请号：US11622573

申请日：2007-01-12

Applicant: ZHAN-BIN LIU ,  JOHAN STOOP

Inventor： ZHAN-BIN LIU ,  JOHAN STOOP

IPC: A01H5/00 ,  C07H21/04 ,  C12N9/10 ,  C12N15/82 ,  C12N5/04

CPC classification number: C12N15/8234 ,  C12N15/8245

Abstract: The promoters of a soybean seed maturation protein PM29 and a soybean late-embryogenesis abundant protein LEA3 and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in plants are described.

Abstract translation: 描述了大豆种子成熟蛋白PM29和大豆晚胚发生丰富蛋白LEA3及其片段的启动子及其在促进植物中一种或多种异源核酸片段表达的用途。