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101.
公开(公告)号:US20150192534A1
公开(公告)日:2015-07-09
申请号:US14392029
申请日:2013-09-19
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor: Hywel Morgan , Matthew Charles Mowlem , Xi Huang
Abstract: Apparatus (2) for sensing at least one parameter in water, which apparatus comprises: (i) a conductivity sensor (6) for sensing conductivity in the water; (ii) a dissolved oxygen sensor (4) for sensing dissolved oxygen in the water; (iii) a glass substrate (14); and (iv) the conductivity sensor (6) and the dissolved oxygen sensor (4) are fabricated on the glass substrate (14) using photolithography and etching.
Abstract translation: 用于感测水中的至少一个参数的装置(2),所述装置包括:(i)用于感测水中的电导率的电导率传感器(6) (ii)用于感测水中溶解氧的溶解氧传感器(4); (iii)玻璃基板(14); 和(iv)使用光刻和蚀刻在玻璃基板(14)上制造电导率传感器(6)和溶解氧传感器(4)。
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公开(公告)号:US20150037790A1
公开(公告)日:2015-02-05
申请号:US14325067
申请日:2014-07-07
Applicant: The University of Southampton
Inventor: Keith R. Fox , Tom Brown , Scott T. Kimber
IPC: C12Q1/68
CPC classification number: C12Q1/683 , C12Q2521/531 , C12Q2537/164
Abstract: This invention relates to methods for variant cytosine detection, and kits and probes for variant cytosine detection. In particular the variant cytosine detection is related to detection of methylated cytosine, hydroxymethylated cytosine, carboxycytosine and/or formylcytosine in nucleic acid.
Abstract translation: 本发明涉及用于变体胞嘧啶检测的方法,以及用于变体胞嘧啶检测的试剂盒和探针。 特别地,变体胞嘧啶检测与核酸中甲基化胞嘧啶,羟甲基化胞嘧啶,羧基胞嘧啶和/或甲酰胞嘧啶的检测有关。
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公开(公告)号:US20140356388A1
公开(公告)日:2014-12-04
申请号:US14366602
申请日:2012-12-21
Applicant: Retroscreen Virology Ltd. , University of Southampton
Inventor: Robert Lambkin-Williams , John Sidney Oxford, Prof. , Thomas Wilkinson
IPC: A61K39/145 , G01N33/50 , C12N7/00
CPC classification number: A61K39/145 , A61K39/12 , C07K14/005 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171 , G01N33/505 , G01N2500/10
Abstract: The present invention provides screening methods which may be regarded as in vitro or ex vivo methods of interrogating the immune system to understand what viral antigens are “seen” and responded to by T cells of the immune systems during viral infection. The screening methods further link in vitro or ex vivo responses to progression of infection in subjects.
Abstract translation: 本发明提供了筛选方法,其可以被认为是询问免疫系统的体外或离体方法,以了解在病毒感染期间由免疫系统的T细胞“看到”什么病毒抗原和反应。 筛选方法进一步联系体外或体外对受试者感染进展的反应。
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公开(公告)号:US20130245323A1
公开(公告)日:2013-09-19
申请号:US13889411
申请日:2013-05-08
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor: Robert Raja , John Meuring THOMAS
IPC: C07C249/04 , B01J27/187 , B01J27/185
CPC classification number: C07C249/04 , B01J27/1853 , B01J27/187 , B01J29/84 , B01J29/85 , B01J2229/18 , C07C2601/14 , C07C251/44
Abstract: A redox ammoximation process in which a ketone or aldehyde is reacted with ammonia and oxygen in the presence of a catalyst; wherein the catalyst is an aluminophosphate based redox catalyst having at least two different redox catalytic sites comprising different transition metal atoms.
Abstract translation: 一种氧化还原氨肟化方法,其中酮或醛在催化剂存在下与氨和氧反应; 其中所述催化剂是具有包含不同过渡金属原子的至少两种不同氧化还原催化位点的磷酸铝基氧化还原催化剂。
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105.
公开(公告)号:US20250155623A1
公开(公告)日:2025-05-15
申请号:US18835794
申请日:2023-02-02
Inventor: Peter KAZANSKY , Michael SHRIBAK
Abstract: A birefringent optical element for transforming an incident beam of light into two spatially separated output beams of light with orthogonal linear polarizations comprises: a transparent substrate with an input face for receiving the incident beam, an output face, and a uniform thickness between the input face and the output face, the substrate having a non-uniform birefringence in a plane parallel to the input face, the birefringence provided by a plurality of randomly positioned nanostructures within the substrate and configured to cause the incident beam to shear within the substrate into two output beams with orthogonal linear polarisations and wavefronts at an angle to one another so that the output beams leave the output face with a spatial separation along a shear direction parallel to the output face; wherein each nanostructure has an oblate spheroidal shape.
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公开(公告)号:US12259263B2
公开(公告)日:2025-03-25
申请号:US16996373
申请日:2020-08-18
Applicant: University of Southampton
Inventor: Andrei Donko , Ali Masoudi , Martynas Beresna , Gilberto Brambilla
Abstract: A sensor system includes a radiation source, an optical fiber, and a detection device. The radiation source is arranged to emit pulses of radiation. The optical fiber comprises a first end and a core. The first end is arranged to receive pulses of radiation output from the radiation source such that, in use, the pulses of radiation are coupled into the fiber. The core is arranged to support propagation of the pulses of radiation along the fiber. The core includes a plurality of reflectors each comprising a portion of the core having a refractive index which is different to the refractive index of adjacent regions of the core. Reflections of a pulse of radiation from adjacent reflectors output at the first end of the fiber are resolvable from each other in the time domain. The detection device is arranged to measure radiation output from the first end of the fiber and resolve radiation reflected at different locations in the core of the fiber.
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公开(公告)号:US20240358687A1
公开(公告)日:2024-10-31
申请号:US18651929
申请日:2024-05-01
Inventor: Philippe WIESEL , Freddy HEITZ , Gareth THOMAS , Christopher HANLEY , Kristy FORD
IPC: A61K31/437 , A61K31/4025 , A61K31/5377 , A61K35/17 , A61K38/19 , A61K39/00 , A61K39/245 , A61K39/395 , A61P35/00
CPC classification number: A61K31/437 , A61K31/4025 , A61K31/5377 , A61K35/17 , A61K38/191 , A61K39/245 , A61K39/3955 , A61P35/00 , A61K2039/505 , A61K2039/507
Abstract: The present invention is related to compounds, methods, compositions and uses that are able to restore responsiveness to immunotherapy, in particular immune check point inhibitors or anti-cancer vaccine or to anti-angiogenesis treatment.
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公开(公告)号:US20240309377A1
公开(公告)日:2024-09-19
申请号:US18540453
申请日:2023-12-14
Applicant: University of Southampton
Inventor: Igor Vorechovsky , Jana Kralovicova
IPC: C12N15/113 , C12N15/11 , C12Q1/6883
CPC classification number: C12N15/113 , C12N15/111 , C12Q1/6883 , C12N2310/11 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/3521 , C12N2320/33
Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
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公开(公告)号:US12072274B2
公开(公告)日:2024-08-27
申请号:US17276717
申请日:2019-09-16
Inventor: Hywel Morgan , Daniel Spencer , Timothy John Jay Inglis , Teagan Paton , Kieran Mulroney
IPC: G01N15/12 , C12Q1/18 , G01N15/02 , G01N15/0227 , G01N15/10 , G01N15/1031
CPC classification number: G01N15/12 , C12Q1/18 , G01N15/0227 , G01N15/1023 , G01N15/1031 , G01N2015/0294 , G01N2015/1006 , G01N2015/1029 , G01N2015/103
Abstract: A method of antimicrobial susceptibility testing comprises: preparing samples of microorganisms suspended in an electrolyte, comprising a first sample of the microorganisms unexposed to antimicrobial agents and a second sample of the microorganisms exposed to an antimicrobial agent; passing the first sample through an impedance flow cytometer to obtain a first impedance signal representing one or more components of impedance values of the unexposed microorganisms; passing the second sample through the impedance flow cytometer to obtain a second impedance signal representing one or more components of the impedance values of the exposed microorganisms; comparing the first impedance signal and the second impedance signal; and determining a susceptibility of the microorganisms to the antimicrobial agent based on any differences between the first impedance signal and second impedance signal.
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公开(公告)号:US12011436B2
公开(公告)日:2024-06-18
申请号:US16760910
申请日:2018-11-01
Inventor: Philippe Wiesel , Freddy Heitz , Gareth Thomas , Christopher Hanley , Kirsty Ford
IPC: A61K31/437 , A61K31/4025 , A61K31/5377 , A61K35/17 , A61K38/19 , A61K39/00 , A61K39/245 , A61K39/395 , A61P35/00
CPC classification number: A61K31/437 , A61K31/4025 , A61K31/5377 , A61K35/17 , A61K38/191 , A61K39/245 , A61K39/3955 , A61P35/00 , A61K2039/505 , A61K2039/507
Abstract: The present invention is related to compounds, methods, compositions and uses that are able to restore responsiveness to immunotherapy, in particular immune check point inhibitors or anti-cancer vaccine or to anti-angiogenesis treatment.
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