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114 条记录 (耗时 0.033 秒)

    Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue
    101.
    发明授权
    Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue 有权
    用于减少非内膜血管组织区域的矿物质含量的方法和装置

    公开(公告)号：US07670311B2

    公开(公告)日：2010-03-02

    申请号：US11267038

    申请日：2005-11-04

    申请人： Brent R. Constantz

    发明人： Brent R. Constantz

    IPC分类号： A61M31/00

    CPC分类号： A61B17/11 ,  A61B17/08 ,  A61B2017/00778 ,  A61B2017/00893 ,  A61B2017/1107 ,  A61N7/00

    摘要： Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue are provided. In the subject methods, an isolated local environment that includes the region to be demineralized is produced. The pH of the local environment is then reduced to a subphysiologic level, e.g. by flushing with an acidic dissolution fluid, for a period of time sufficient for the mineral content of the region to be reduced. The devices of the subject invention are characterized by comprising a means for producing an isolated local environment that includes a non-intimal region of vascular tissue. Also provided are kits for practicing the subject methods.

    摘要翻译： 提供了用于降低非内膜血管组织区域的矿物质含量的方法和装置。 在主题方法中，产生了包括待软化区域的孤立的局部环境。 然后将局部环境的pH降低至亚生理水平，例如 通过用酸性溶解流体冲洗一段足以减少该区域的矿物质含量的时间。 本发明的装置的特征在于包括用于产生包括血管组织的非内膜区域的分离的局部环境的装置。 还提供了用于实践主题方法的工具包。

    CALCIUM PHOSPHATE CEMENTS COMPRISING AUTOLOGOUS BONE
    103.
    发明申请
    CALCIUM PHOSPHATE CEMENTS COMPRISING AUTOLOGOUS BONE 有权
    包含自体骨的磷酸钙化合物

    公开(公告)号：US20080241206A1

    公开(公告)日：2008-10-02

    申请号：US11694807

    申请日：2007-03-30

    申请人： Brent R. Constantz

    发明人： Brent R. Constantz

    IPC分类号： A61K9/00

    CPC分类号： A61L27/365 ,  A61L27/12 ,  A61L27/3608 ,  A61L27/425

    摘要： Aspects of the invention include methods for producing flowable compositions, e.g. pastes, that set into calcium phosphate containing products, where the products include autologous bone. Aspects of the invention further include compositions produced by the methods, as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.

    摘要翻译： 本发明的方面包括用于生产可流动组合物的方法，例如。 糊剂，其中含有磷酸钙的产品，其中产品包括自体骨。 本发明的方面还包括通过该方法制备的组合物，以及制备该组合物的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括硬组织修复应用。

    Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occulation
    104.
    发明授权
    Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occulation 有权
    质子产生导管及其用于增强通过钙化血管闭塞所占据的血管部位的流体流动的方法

    公开(公告)号：US06719747B2

    公开(公告)日：2004-04-13

    申请号：US10358983

    申请日：2003-02-04

    申请人： Brent R. Constantz ,  John Ross

    发明人： Brent R. Constantz ,  John Ross

    IPC分类号： A61M3100

    CPC分类号： A61N1/306 ,  A61B17/22 ,  A61B18/00 ,  A61B18/1492 ,  A61B2017/22082

    摘要： Catheter devices and methods are provided for enhancing fluid flow through a vascular site occupied by a calcified lesion. The catheter devices of the subject invention at least include, at their distal end, a proton generating means, and in many embodiments also include a flushing means. In using the subject devices, the distal end of the catheter is placed proximal to the vascular occlusion and protons are generated, e.g., via proton generation from water, in a manner sufficient to reduce the pH of the vascular site in the region proximal to the occlusion. The subphysiologic pH is maintained for a period of time sufficient for fluid flow through the vascular site to be enhanced. Also provided are kits comprising the subject catheter devices for use in the subject methods.

    摘要翻译： 提供导管装置和方法用于增强通过钙化损伤占据的血管部位的流体流动。 本发明的导管装置至少在其远端包括质子产生装置，并且在许多实施例中还包括冲洗装置。 在使用本发明装置时，将导管的远端放置在血管闭塞附近，并且产生质子，例如，通过从水中产生质子，以足以降低近端的区域内的血管部位的pH值的方式产生质子 闭塞。 亚生物pH保持足够的时间足以使液体流过血管部位以增强。 还提供了包括用于本发明方法的主题导管装置的试剂盒。

    Calcium phosphate cements prepared from silicate solutions
    105.
    发明授权
    Calcium phosphate cements prepared from silicate solutions 有权
    由硅酸盐溶液制备的磷酸钙水泥

    公开(公告)号：US06375935B1

    公开(公告)日：2002-04-23

    申请号：US09561324

    申请日：2000-04-28

    申请人： Brent R. Constantz

    发明人： Brent R. Constantz

    IPC分类号： A61K716

    CPC分类号： A61L24/02 ,  A61K6/0612 ,  A61K6/0643 ,  A61K6/097 ,  A61L27/12 ,  Y10S514/951 ,  Y10S514/953 ,  A61K6/087 ,  C08L89/00

    摘要： Methods are provide for producing flowable compositions, e.g. pastes, that set into calcium phosphate products. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a solution of a soluble silicate, e.g. sodium silicate, and the combined liquids and solids are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g. bone defects.

    摘要翻译： 提供生产可流动组合物的方法，例如 糊剂，即磷酸钙产品。 在本发明的方法中，将包含钙源和磷酸盐源的干燥反应物与可溶性硅酸盐的溶液合并。 并将混合的液体和固体混合以产生可流动的组合物。 还提供了组合物本身以及用于制备它们的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括修复硬组织缺陷，例如， 骨缺损。

    Storage stable calcium phosphate cements
    108.
    发明授权
    Storage stable calcium phosphate cements 失效
    储存稳定的磷酸钙水泥

    公开(公告)号：US5964932A

    公开(公告)日：1999-10-12

    申请号：US111347

    申请日：1998-07-07

    申请人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

    发明人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

    IPC分类号： A61F2/00 ,  A61L27/12 ,  C04B12/02 ,  C04B20/10 ,  C04B28/34 ,  C04B40/06

    CPC分类号： C04B20/107 ,  A61L27/12 ,  C04B12/025 ,  C04B20/1077 ,  C04B28/34 ,  C04B28/344 ,  C04B40/06 ,  A61F2310/00293 ,  C04B2111/00836 ,  Y10S623/901 ,  Y10T428/2949 ,  Y10T428/2991 ,  Y10T428/2993

    摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calciumim phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.

    摘要翻译： 提供了两种组分的储存稳定的磷灰石水泥组合物，以及它们的生产方法。 受试者磷灰石水泥的干组分包括至少部分涂覆有部分中和的酸性磷酸钙的碱性钙源颗粒。 通过将碱性钙源颗粒与溶解的酸性磷酸盐在至少部分水性介质中组合来制备主体组合物的干组分，由此碱性钙源颗粒部分地涂覆有部分中和的酸性磷酸钙。 在酸性磷酸盐和碱性钙源之间的反应完成之后，通过从反应混合物中除去可用的水来终止反应。 在第一模式中，主体水泥可以通过在水性溶剂的存在下将酸性磷酸盐源与碱性钙源颗粒机械混合并在完成之前停止酸和碱之间的反应来制备。 或者，磷酸溶液可以与碱性磷酸钙颗粒浆料快速组合，使得部分中和的酸性磷酸钙在碱性磷酸钙颗粒的表面上沉淀。