公开(公告)号：US08343175B2

公开(公告)日：2013-01-01

申请号：US12767731

申请日：2010-04-26

申请人： Richard C. Ewers ,  Vahid Saadat ,  Kenneth J. Michlitsch ,  Chris A. Rothe ,  Rodney C. Brenneman ,  Cang C. Lam ,  Eugene G. Chen

发明人： Richard C. Ewers ,  Vahid Saadat ,  Kenneth J. Michlitsch ,  Chris A. Rothe ,  Rodney C. Brenneman ,  Cang C. Lam ,  Eugene G. Chen

IPC分类号： A61B17/08

CPC分类号： A61B1/0055 ,  A61B1/00135 ,  A61B1/018 ,  A61B1/2736 ,  A61B1/31 ,  A61B17/00234 ,  A61B17/0218 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B17/062 ,  A61B17/0625 ,  A61B17/0644 ,  A61B17/29 ,  A61B17/295 ,  A61B17/3421 ,  A61B17/3468 ,  A61B17/3478 ,  A61B2017/00269 ,  A61B2017/003 ,  A61B2017/00353 ,  A61B2017/00827 ,  A61B2017/0404 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0443 ,  A61B2017/0451 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0461 ,  A61B2017/0462 ,  A61B2017/0464 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/061 ,  A61B2017/06176 ,  A61B2017/0649 ,  A61B2017/2905 ,  A61B2017/2927 ,  A61B2017/2943 ,  A61B2017/3445 ,  A61B2017/3488 ,  A61B2090/3614 ,  A61F5/0086

摘要： Apparatus and methods are provided for forming a gastrointestinal tissue fold by engaging tissue at a first tissue contact point and moving the first tissue contact point from a position initially distal to, or in line with, a second tissue contact point to a position proximal of the second contact point, thereby forming the tissue fold, and extending an anchor assembly through the tissue fold from a vicinity of the second tissue contact point. Adjustable anchor assemblies; as well as anchor delivery systems, shape-lockable guides and methods for endoluminally performing medical procedures, such as gastric reduction, treatment of gastroesophageal reflux disease, resection of lesions, and treatment of bleeding sites; are also provided.

公开(公告)号：US08333012B2

公开(公告)日：2012-12-18

申请号：US12575674

申请日：2009-10-08

申请人： Chris A. Rothe ,  Isidro M. Gandionco ,  Edmund Tam ,  Vahid Saadat ,  David Miller ,  Zachary J. Malchano ,  Veerappan Swaminathan

发明人： Chris A. Rothe ,  Isidro M. Gandionco ,  Edmund Tam ,  Vahid Saadat ,  David Miller ,  Zachary J. Malchano ,  Veerappan Swaminathan

IPC分类号： H01R43/00

CPC分类号： A61B1/018 ,  A61B1/0008 ,  A61B1/00087 ,  A61B1/00089 ,  A61B1/05 ,  A61B1/3137 ,  A61N1/05 ,  Y10T29/49117 ,  Y10T29/49124 ,  Y10T29/49155 ,  Y10T29/49222

摘要： Electrode placement and connection systems are described which allow for the electrical connection and maintenance of one or more electrodes positioned on a substrate which is subjected to a variety of mechanical stresses. Such a system may include an imaging hood having an aperture through which transparent fluid is flowed and one or more electrodes positioned along or about the hood. As the hood is configured between a low-profile and opened configuration, these electrodes may remain electrically coupled despite the mechanical stresses subjected to the electrodes and the connections thereto.

摘要翻译： 描述了电极放置和连接系统，其允许位于经受各种机械应力的基板上的一个或多个电极的电连接和维护。 这样的系统可以包括具有孔的成像罩，透明液体通过所述孔流动，并且一个或多个电极沿着或围绕罩定位。 由于罩被配置在低轮廓和打开的构型之间，尽管机械应力受到电极及其连接，但是这些电极可以保持电耦合。

公开(公告)号：US08087413B2

公开(公告)日：2012-01-03

申请号：US11035702

申请日：2005-01-14

申请人： Vahid Saadat ,  Ruey-Feng Peh ,  Richard C. Ewers ,  Eugene G. Chen

发明人： Vahid Saadat ,  Ruey-Feng Peh ,  Richard C. Ewers ,  Eugene G. Chen

IPC分类号： A61B19/00 ,  A61B17/08 ,  A61B17/04 ,  A61F2/04 ,  A61L17/00

CPC分类号： A61B17/0469 ,  A61B17/00491 ,  A61B17/0401 ,  A61B17/0487 ,  A61B17/1114 ,  A61B2017/00349 ,  A61B2017/00495 ,  A61B2017/0406 ,  A61B2017/0454 ,  A61B2017/0464

摘要： The attenuation or isolation of environmental parameters on a gastric lumen is described herein. Once tissue plications are formed into a gastric lumen or sleeve within a stomach, the newly formed lumen is subjected to a multitude of fluctuating stresses or pressure from food or fluids passing therethrough, from naturally-occurring contractions, and/or from changes in pH levels from caustic stomach acids and hormones. The tissue interface between these plications can be isolated from such environmental fluctuations, or the fluctuations can be attenuated, by a number of methods. One example is to place a gastric stent or sleeve within the newly formed lumen. Another example is to utilize multiple rows of anchors, clips, or sutures along the interface. Alternatively, bio-adhesives can be dispensed to buttress the tissue interface. In another variation, the tissue can be approximated in different configurations which effectively reduce or isolate the adhered tissue region.

摘要翻译： 本文描述了在胃腔上的环境参数的衰减或分离。 一旦组织消融在胃内形成胃腔或套管，则新形成的内腔经受来自通过其的食物或液体的多种波动的应力或压力，从天然存在的收缩和/或pH水平的变化 从苛性胃酸和激素。 可以通过多种方法将这些斑点之间的组织界面与这种环境波动隔离，或者波动可以减弱。 一个例子是将胃支架或套管放置在新形成的内腔内。 另一个例子是沿着界面使用多行锚，剪辑或缝线。 或者，可以分配生物粘合剂以支撑组织界面。 在另一个实施方式中，可以以有效地减少或隔离粘附的组织区域的不同配置来近似组织。

公开(公告)号：US08078266B2

公开(公告)日：2011-12-13

申请号：US12026455

申请日：2008-02-05

申请人： Vahid Saadat ,  Edmund Tam ,  Chris A. Rothe ,  David Miller ,  Ruey-Feng Peh

发明人： Vahid Saadat ,  Edmund Tam ,  Chris A. Rothe ,  David Miller ,  Ruey-Feng Peh

IPC分类号： A61B6/00

CPC分类号： A61B1/00089 ,  A61B1/0008 ,  A61B1/00147 ,  A61B1/00165 ,  A61B1/015 ,  A61B1/018 ,  A61B1/05 ,  A61B1/051 ,  A61B1/12 ,  A61B1/3137 ,  A61B1/32 ,  A61B5/6851 ,  A61B6/503 ,  A61B17/29 ,  A61B18/00 ,  A61B18/18

摘要： Flow reduction hood systems are described which facilitate the visualization of tissue regions through a clear fluid. Such a system may include an imaging hood having one or more layers covering the distal opening and defines one or more apertures which control the infusion and controlled retention of the clearing fluid into the hood. In this manner, the amount of clearing fluid may be limited and the clarity of the imaging of the underlying tissue through the fluid within the hood may be maintained for relatively longer periods of time by inhibiting, delaying, or preventing the infusion of surrounding blood into the viewing field. The aperture size may be controlled to decrease or increase through selective inflation of the membrane or other mechanisms.

摘要翻译： 描述了减少排气罩系统，其通过透明流体促进组织区域的可视化。 这样的系统可以包括具有覆盖远端开口的一层或多层的成像罩，并且限定一个或多个孔，其控制输液并将清除流体控制在罩中。 以这种方式，可以限制清除液体的量，并且可以通过抑制，延迟或防止将周围血液输注到相对更长的时间段内，使通过罩内的流体的潜在组织的成像清晰度 视野。 可以通过膜或其它机构的选择性膨胀来控制孔径尺寸以减小或增加。

公开(公告)号：US07887538B2

公开(公告)日：2011-02-15

申请号：US11375265

申请日：2006-03-13

申请人： Jeffery L. Bleich ,  Vahid Saadat ,  Steven A. Spisak ,  John E. Ashley

发明人： Jeffery L. Bleich ,  Vahid Saadat ,  Steven A. Spisak ,  John E. Ashley

IPC分类号： A61B17/00

CPC分类号： A61B17/1659 ,  A61B17/00234 ,  A61B17/02 ,  A61B17/1671 ,  A61B17/1757 ,  A61B17/320016 ,  A61B17/32002 ,  A61B17/3421 ,  A61B2017/00261 ,  A61B2017/00867 ,  A61B2017/32006 ,  A61B2017/3488 ,  A61B2090/08021

摘要： A method for modifying tissue in a patient may involve one or more of the following steps: advancing at least a distal portion of at least one elongate, at least partially flexible tissue modification device into a patient and between one or more target tissues and one or more non-target tissues; positioning at least one tissue modifying member of the tissue modification device adjacent the target tissue such that the tissue modifying member(s) face the target tissue and do not face the non-target tissue; applying an anchoring force to the tissue modification device at or near the distal portion or a proximal portion of the device; applying a tensioning force to the tissue modification device at or near an opposite end of the device relative to the end to which anchoring force is applied, while maintaining the anchoring force, to urge the tissue modifying member(s) against the target tissue; and modifying the target tissue, using the tissue modifying member(s), while preventing the tissue modifying member(s) from extending significantly beyond the target tissue toward the proximal or distal portion of the tissue modification device during tissue modification.

摘要翻译： 用于修改患者组织的方法可以涉及一个或多个以下步骤：将至少一个细长的，至少部分柔性的组织改变装置的至少远端部分推进到患者体内，并将一个或多个靶组织与一个或多个靶组织 更多的非靶组织; 将所述组织改变装置的至少一个组织修改构件定位成邻近所述目标组织，使得所述组织修改构件面向所述靶组织并且不面向所述非靶组织; 在组件修改装置的远端部分或近端部分处或附近施加锚定力; 在保持锚固力的同时相对于施加锚定力的端部在装置的相对端处或附近施加张紧力，以促使组织修改构件抵靠目标组织; 以及在组织改变期间，使组织改变部件改变目标组织，同时防止组织改变部件显着地超出目标组织向组织改变装置的近端或远端部分延伸。

公开(公告)号：US07844064B2

公开(公告)日：2010-11-30

申请号：US11754823

申请日：2007-05-29

申请人： Amir Abolfathi ,  Vahid Saadat ,  Loc X. Phan

发明人： Amir Abolfathi ,  Vahid Saadat ,  Loc X. Phan

IPC分类号： H04R25/00

CPC分类号： H04R25/606 ,  A61C5/00 ,  A61C8/0093 ,  A61C8/0098 ,  B33Y70/00 ,  B33Y80/00 ,  H04R1/46 ,  H04R3/04 ,  H04R25/554 ,  H04R25/602 ,  H04R25/604 ,  H04R2225/31 ,  H04R2225/67 ,  H04R2420/07 ,  H04R2460/01 ,  H04R2460/13

摘要： Methods and apparatus for transmitting vibrations via an electronic and/or transducer assembly through a tooth or teeth are disclosed herein. The assembly may be attached, adhered, or otherwise embedded into or upon a removable oral appliance to form a hearing aid assembly. Such an oral appliance may be a custom-made device. The electronic and transducer assembly may receive incoming sounds either directly or through a receiver to process and amplify the signals and transmit the processed sounds via a vibrating transducer element coupled to a tooth or other bone structure, such as the maxillary, mandibular, or palatine bone structure.

摘要翻译： 本文公开了通过电子和/或换能器组件通过齿或齿传递振动的方法和装置。 组件可以附接，粘附或以其它方式嵌入到可移除的口腔器具中或之上，以形成助听器组件。 这种口腔器具可以是定制的装置。 电子和换能器组件可以直接或通过接收器接收输入声音，以处理和放大信号，并经由耦合到牙齿或其它骨结构（例如上颌骨，下颌骨或腭骨）的振动换能器元件传送经处理的声音 结构体。

公开(公告)号：US07753853B2

公开(公告)日：2010-07-13

申请号：US12110585

申请日：2008-04-28

申请人： Vahid Saadat

发明人： Vahid Saadat

IPC分类号： A61B5/00

CPC分类号： A61B5/14542 ,  A61B5/1459 ,  A61B5/6848

摘要： Left atrial access apparatus and methods are described herein. Different parameters, such as oxygen saturation difference, between the left and right atrial chambers is utilized to guide a needle or catheter into a desired position within the heart. Various sensing elements can be utilized to detect the physiological parameter difference, such as oxygen levels, in the left atrium. The sensor can be carried by the needle, at its tip or along its body, and can measure the physiological parameter levels contained in the blood, fluid, or tissue.

摘要翻译： 本文描述了左心房接入装置和方法。 使用左心房和右心房之间的不同参数（例如氧饱和度差异）将针或导管引导到心脏内的期望位置。 可以使用各种感测元件来检测左心房中的生理参数差异，例如氧水平。 传感器可以由针头，其尖端或沿其身体携带，并且可以测量包含在血液，流体或组织中的生理参数水平。

公开(公告)号：US20090227999A1

公开(公告)日：2009-09-10

申请号：US12465903

申请日：2009-05-14

申请人： N. Parker Willis ,  Zachary J. Malchano ,  Chris A. Rothe ,  Vahid Saadat ,  Ruey-Feng Peh ,  David Miller ,  Edmund Tam

发明人： N. Parker Willis ,  Zachary J. Malchano ,  Chris A. Rothe ,  Vahid Saadat ,  Ruey-Feng Peh ,  David Miller ,  Edmund Tam

IPC分类号： A61B18/14 ,  A61B18/20 ,  A61N7/00

CPC分类号： A61B18/1492 ,  A61B1/00089 ,  A61B1/012 ,  A61B2017/00106 ,  A61B2018/00214 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00809 ,  A61B2018/00839 ,  A61B2018/1472 ,  A61B2218/002

摘要： Visual electrode ablation systems are described herein which include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. An electric current may be passed through the fluid such that it passes directly to the tissue region being imaged and the electrical energy is conducted through the fluid without the need for a separate ablation probe or instrument to ablate the tissue being viewed.

摘要翻译： 本文描述了视觉电极消融系统，其包括部署导管和可展开成扩展构型的附接成像罩。 在使用中，成像罩被放置在通常填充有不透明体液如血液的体腔中的待成像组织区域附近或邻近。 半透明或透明的液体（例如盐水）可被泵送到成像罩中，直到流体移动任何血液，从而留下通过展开导管中的成像元件成像的组织的清晰区域。 电流可以通过流体，使得其直接通过被成像的组织区域，并且电能通过流体传导，而不需要单独的消融探针或器械来烧蚀被观察的组织。

公开(公告)号：US07562660B2

公开(公告)日：2009-07-21

申请号：US11622442

申请日：2007-01-11

申请人： Vahid Saadat

发明人： Vahid Saadat

IPC分类号： A61B19/00

CPC分类号： A61B18/00 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0487 ,  A61B17/122 ,  A61B17/1285 ,  A61B17/29 ,  A61B18/1442 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/24 ,  A61B90/39 ,  A61B2017/00084 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2017/0409 ,  A61B2017/0412 ,  A61B2017/0414 ,  A61B2017/0427 ,  A61B2017/0437 ,  A61B2017/044 ,  A61B2017/0451 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0461 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/2945 ,  A61B2018/00023 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/00273 ,  A61B2018/00369 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1432 ,  A61B2018/1435 ,  A61B2090/064 ,  A61F2/2445 ,  A61F2/2451 ,  A61F2/2454 ,  A61N7/00 ,  A61N7/02

摘要： Apparatus and methods are provided for thermally and/or mechanically treating tissue, such as valvular structures, to reconfigure or shrink the tissue in a controlled manner. Mechanical clips are implanted over the leaflets of a valve, e.g., in the heart, either alone or after thermal treatment to cause the valve to close more tightly. The clips are delivered by a catheter and may be configured to traverse directly over the valve itself or to lie partially over the periphery of the valve to prevent obstruction of the valve channel. The clips can be coated with drugs or a radiopaque coating. Alternatively, individual anchors with a tensioning element, like a suture, may be used to approximate the valves towards each other. The catheter can also incorporate sensors or energy delivery devices, e.g., transducers, on its distal end.

摘要翻译： 提供了用于热和/或机械处理组织（例如瓣结构）的设备和方法，以受控的方式重新配置或收缩组织。 将机械夹子单独地或在热处理之后植入在瓣膜的小叶上，例如在心脏中，以使阀门更紧密地闭合。 夹子由导管递送，并且可以被配置成直接在阀本身上移动或部分地位于阀的周边上以防止阀通道的阻塞。 夹子可以涂上药物或不透射线的涂层。 或者，可以使用具有诸如缝合线的张紧元件的单个锚定件来朝向彼此近似阀。 导管还可以在其远端上并入传感器或能量输送装置，例如换能器。

公开(公告)号：US20080214889A1

公开(公告)日：2008-09-04

申请号：US11877386

申请日：2007-10-23

申请人： Vahid Saadat ,  Ruey-Feng Peh ,  Edmund A. Tam ,  Chris A. Rothe

发明人： Vahid Saadat ,  Ruey-Feng Peh ,  Edmund A. Tam ,  Chris A. Rothe

IPC分类号： A61B17/295 ,  A61B1/313 ,  A61B17/34

CPC分类号： A61B17/02 ,  A61B1/00089 ,  A61B1/005 ,  A61B1/3137 ,  A61B6/503 ,  A61B8/0883 ,  A61B17/3439 ,  A61B2017/0237

摘要： Methods and apparatus for preventing tissue migration or tissue “tenting” during transseptal access procedures are described. The underlying tissue wall may be temporarily engaged via any number of mechanisms, e.g., engaging teeth or projections, threaded needle, vacuum, etc., and one or more instruments may be passed through the tissue wall while maintaining engagement with the tissue to provide a counter-traction force. The procedure may be accomplished while under direct visualization within an imaging hood placed against the tissue surface and purged of blood.

摘要翻译： 描述了在经验过程中防止组织移动或组织“隆起”的方法和装置。 下面的组织壁可以通过任何数量的机构临时接合，例如，接合的齿或突起，螺纹针，真空等，并且一个或多个器械可以通过组织壁，同时保持与组织的接合，以提供 反牵引力。 该过程可以在在靠着组织表面放置并被清除血液的成像罩内直接可视化的情况下完成。