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    DISPENSING DEVICE WITH MEMBRANE BASED TRIGGER
    102.
    发明申请
    DISPENSING DEVICE WITH MEMBRANE BASED TRIGGER 有权

    公开(公告)号：US20230027746A1

    公开(公告)日：2023-01-26

    申请号：US17782355

    申请日：2020-12-11

    Applicant: Massachusetts Institute of Technology

    Inventor： Carlo Giovanni Traverso ,  Graham Arrick ,  Torben Sebastian Last

    IPC: A61M5/44

    Abstract: A device may be configured with a housing having a reservoir and an outlet separated by a heat rupturable membrane. The membrane may serve to separate a material held within the reservoir from the outlet until the membrane is ruptured. The membrane may include a heater configured to selectively rupture the membrane when actuated. The heater may be physically removed and/or thermally insulated from at least one of an environment surrounding the device and the reservoir.

    TRIGGERABLE HYDROGEL COMPOSITIONS AND RELATED METHODS
    106.
    发明申请
    TRIGGERABLE HYDROGEL COMPOSITIONS AND RELATED METHODS 有权

    公开(公告)号：US20220193240A1

    公开(公告)日：2022-06-23

    申请号：US17558867

    申请日：2021-12-22

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Carlo Giovanni Traverso ,  Jinyao Liu ,  Robert S. Langer

    IPC: A61K47/36 ,  A61K9/00 ,  A61K9/48 ,  A61K47/32

    Abstract: Triggerable hydrogel compositions and related methods are generally disclosed. In some embodiments, the compositions and related methods may be used for medical-related or other applications. For example, the compositions and methods described herein may be useful, for example, in biomedical applications such as articles for (e.g., gastric) retention. In some embodiments, methods for deploying and/or removing an article comprising the composition, such as an article for gastric retention, are provided. The article and/or composition may be removed internally from a subject by, for example, introducing at least one reagent (e.g., one reagent, two reagents) such that at least a portion of the composition disassociates. In certain embodiments, the composition comprises a polymer network comprising two or more interpenetrating polymers. In some cases, a first polymer comprises a first cross-link moiety configured to dissociate upon interaction with a reagent. For example, the composition may be administered to a subject such that it is retained at a location internal (e.g., gastric) to the subject. In some embodiments, a reagent may be administered to the subject (e.g., the subject drinks the reagent) such that the reagent interacts with the composition and at least a first cross-link moiety disassociates. In some embodiments, upon disassociation of one or more cross-link moieties of the polymer network, the composition is no longer retained at the location internal to the subject (e.g., dissociates such that it exits the subject). In some cases, the polymer network is configured (e.g., upon administration of the composition to a subject) such that the composition is retained at the location internal to the subject for greater than or equal to 24 hours.

    CLOSED-LOOP DETECTION AND TREATMENT OF RADIATION AND TOXIC AGENTS
    107.
    发明申请
    CLOSED-LOOP DETECTION AND TREATMENT OF RADIATION AND TOXIC AGENTS 有权

    公开(公告)号：US20220142566A1

    公开(公告)日：2022-05-12

    申请号：US17470942

    申请日：2021-09-09

    Applicant: Massachusetts Institute of Technology

    Inventor： Hen-Wei Huang ,  James Byrne ,  Carlo Giovanni Traverso

    IPC: A61B5/00 ,  A61B6/00 ,  A61B5/1473 ,  A61K31/4748 ,  A61M31/00 ,  A61M5/158

    Abstract: Articles, systems, and methods for rapid administration and active pharmaceutical compositions to subjects exposed to radiation and/or toxins are provided by this disclosure. There are currently few interventional technologies to protect against long-term morbidity and mortality from exposure to radiation and chemical warfare. Furthermore, as commercially available technologies such as additive manufacturing and small-scale chemical reactors have become more prevalent, the risk of misuse of such technologies by terrorists and rogue nation states to manufacture nuclear, radiologic, and chemical weapons continues to increase. Articles, systems, and methods described herein combine sensing technologies with drug release components, in order to provide an approach for rapid diagnosis of and response to exposure to radiation and toxic agents.

    Residence structures and related methods
    108.
    发明授权
    Residence structures and related methods 有权

    公开(公告)号：US11246829B2

    公开(公告)日：2022-02-15

    申请号：US16899447

    申请日：2020-06-11

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Andrew Bellinger ,  Shiyi Zhang ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Stacy Mo ,  Tyler Grant ,  Mousa Jafari ,  Dean Liang Glettig ,  Angela DiCiccio ,  Lowell L. Wood, Jr. ,  Philip A. Eckhoff

    IPC: A61K9/00 ,  A61K47/58 ,  A61K47/69 ,  C08G18/73 ,  C08G63/08 ,  C08G18/42 ,  A61K9/48 ,  A61K31/357 ,  A61K31/65 ,  A61K31/7048 ,  C08G83/00 ,  A61K47/32 ,  C08L33/02 ,  C08L33/08 ,  C08L33/14 ,  A61K47/10 ,  A61K47/34 ,  A61K47/40 ,  A61K47/42 ,  A61M31/00

    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

    Systems for electrical stimulation
    109.
    发明授权
    Systems for electrical stimulation 有权

    公开(公告)号：US11202903B2

    公开(公告)日：2021-12-21

    申请号：US16415417

    申请日：2019-05-17

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Robert S. Langer ,  Carlo Giovanni Traverso ,  Alex G. Abramson ,  David Dellal

    IPC: A61N1/05 ,  A61L31/02 ,  A61N1/36 ,  A61N1/372 ,  A61M25/01

    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In certain embodiments, the self-righting article a tissue-interfacing components. In some embodiments, each tissue-interfacing component may comprise an electrically-conductive portion configured for electrical communication with tissue and an insulative portion configured to not be in electrical communication with tissue.

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