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101.
公开(公告)号:US12059673B2
公开(公告)日:2024-08-13
申请号:US17472854
申请日:2021-09-13
摘要: Method for converting organic material into catalyst for biological hydrosynthesis, comprising providing organic material comprising at least one source of readily available carbon, at least one complex carbon-containing compound and at least one source of protein and contacting the organic material with preparatory catalyst is provided. The organic material is subjected to a size reduction process to produce size-reduced organic material and a solid to liquid ratio of the size-reduced organic material is adjusted to form organic material slurry. The organic material slurry is subjected to a fermentation process to produce amended organic material, by applying a process catalyst to at least a portion of the organic material slurry. A liquid is recovered from the amended organic material and transferred to a fermentation chamber, where it is subjected to a fermentation process to produce amended liquid by applying balancing catalyst to the liquid. The amended liquid is the catalyst.
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102.
公开(公告)号:US12059441B2
公开(公告)日:2024-08-13
申请号:US16860377
申请日:2020-04-28
IPC分类号: A61K35/741 , C12N1/20 , C12P7/6409
CPC分类号: A61K35/741 , C12N1/20 , C12P7/6409
摘要: Disclosed herein are probiotic bacterial strains or species that produce short chain fatty acids (SCFA), such as butyrate, and compositions comprising the same. The bacterial strains or compositions prepared thereby are used in preparing food, supplements, compositions, and other consumables to provide health benefits, including therapeutic applications, for a variety of disorders, including metabolic, immune, intestinal, and inflammatory disorders. Thus, also disclosed herein are methods of treating a subject suffering from a disorder, such as a metabolic disorder, an immune disorder, an intestinal disorder, or an inflammatory disorder with a composition comprising the probiotic bacterial strains or species disclosed herein. Uses of a bacterial strain or species and a composition comprising them provided in a nutritional product or medicament to improve health or prevent or treat a variety of disorders in a subject are also disclosed.
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公开(公告)号:US20240263205A1
公开(公告)日:2024-08-08
申请号:US18358637
申请日:2023-07-25
发明人: Alexander TRAVIS
IPC分类号: C12P19/32
CPC分类号: C12P19/32
摘要: The present invention relates to a system for production of ATP. This system is comprised of a support and one or more enzymes coupled to that support which are capable of collectively producing ATP from glucose or fructose metabolism. The present invention is additionally directed to a device, which includes the system, and to a method for carrying out a reaction involving the conversion of ATP to ADP using the system.
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104.
公开(公告)号:US20240263199A1
公开(公告)日:2024-08-08
申请号:US18604597
申请日:2024-03-14
申请人: Jiangnan University
发明人: Xueqin Lv , Long Liu , Jian Chen , Guocheng Du , Jianghua Li , Yanfeng Liu , Tiantian Liu
CPC分类号: C12P7/56 , C12N1/185 , C12N9/0006 , C12N15/905 , C12Y101/01027 , C12Y101/05005 , C12R2001/865
摘要: The present disclosure discloses a method for improving production of L-lactic acid (L-LA) by Saccharomyces cerevisiae based on regulation and control of ethanol metabolic flux, and belongs to the technical field of microorganisms. According to the present disclosure, acid-resistant Saccharomyces cerevisiae TJG16 is used as a production strain, an ethanol dehydrogenase gene adhA derived from Bacillus subtilis is introduced to promote conversion of ethanol into acetaldehyde, and a lactate aldolase gene BAL derived from Brucella sp. is introduced to promote synthesis of lactic acid from the acetaldehyde. Moreover, an acetaldehyde dehydrogenase gene ALD6 is knocked out to prevent synthesis of acetic acid from the acetaldehyde, a transcriptional regulatory factor encoding gene GAL80 for regulating and controlling galactose is knocked out, and lactate dehydrogenase LDH is integrated, so that the L-LA is finally increased.
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105.
公开(公告)号:US20240263182A1
公开(公告)日:2024-08-08
申请号:US18582362
申请日:2024-02-20
申请人: PRECIGEN, INC.
发明人: Xinhua ZHAO , Mark Anton HELD , Tina HUYNH , Lily Yuin CHAO , Na TRINH , Matthias Helmut SCHMALISCH , Bryan YEH , James KEALEY , Kevin Lee DIETZEL
IPC分类号: C12N15/52 , C12N1/20 , C12N9/04 , C12N9/10 , C12N9/88 , C12N15/74 , C12P5/02 , C12P7/16 , C12P7/18
CPC分类号: C12N15/52 , C12N1/20 , C12N9/0006 , C12N9/1022 , C12N9/88 , C12N15/74 , C12P5/023 , C12P7/16 , C12P7/18 , C12Y101/01304 , C12Y202/01006 , C12Y401/01004 , C12Y401/01005
摘要: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.
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106.
公开(公告)号:US20240262935A1
公开(公告)日:2024-08-08
申请号:US18404003
申请日:2024-01-04
申请人: Ynsect
发明人: Nathalie BEREZINA , Antoine HUBERT , Fabrice BERRO , Jean-Gabriel LEVON , Karine LE ROUX , Cecilia SOCOLSKY , Lorena SANCHEZ , Sophie LAURENT
CPC分类号: C08B37/003 , C07K14/43563 , C08B37/0003 , C08L5/08 , C12P19/26 , C12P21/06
摘要: The invention relates to chitin, a hydrolysate and a method for the production of at least one desired product from insects. More specifically, the invention relates to a method for the production of at least one desired product from insects, comprising an insect cuticle pressing step, followed by the enzymatic hydrolysis of the insect cuticles using a proteolytic enzyme.
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公开(公告)号:US20240262868A1
公开(公告)日:2024-08-08
申请号:US18688056
申请日:2023-02-23
发明人: Xia Yang , Zhenrui He
CPC分类号: C07K14/001 , A61K8/606 , C12N15/63 , C12P19/34 , C07K2319/20
摘要: Polypeptides and uses thereof are provided. The polypeptide includes an N-terminal sequence and a C-terminal sequence, wherein the N-terminal sequence includes one or more repeating units including the amino acid sequence shown in SEQ ID NO. 1. The use of a human structural material for tissue filling and augmentation is provided in the present disclosure, which is expected to have a wide range of applications in the fields such as breast augmentation, rhinoplasty and mid-face filling as it does not require transplantation from the human body, yet has the natural advantages of using human tissue for filling.
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公开(公告)号:US12054777B2
公开(公告)日:2024-08-06
申请号:US16852663
申请日:2020-04-20
IPC分类号: C12Q1/68 , C12P19/34 , C12Q1/6869 , C12Q1/6883 , G01N33/48
CPC分类号: C12Q1/6883 , C12Q1/6869 , G01N33/48 , C12Q2600/156 , G01N2800/387
摘要: Disclosed is a method to achieve digital quantification of DNA (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated. By counting the number of sequence tags mapped to a predefined window in each chromosome, the over- or under-representation of any chromosome in maternal plasma DNA contributed by an aneuploid fetus can be detected. This method does not require the differentiation of fetal versus maternal DNA. The median count of autosomal values is used as a normalization constant to account for differences in total number of sequence tags is used for comparison between samples and between chromosomes.
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公开(公告)号:US12054721B2
公开(公告)日:2024-08-06
申请号:US17473058
申请日:2021-09-13
发明人: Holly Jessen , Brian Rush , Jeanette Huryta , Beth Mastel , Alan Berry , Debbie Yaver , Michael Catlett , Michelle Barnhart
CPC分类号: C12N15/52 , C12N1/18 , C12N9/0006 , C12N9/1096 , C12N9/88 , C12N9/93 , C12N15/81 , C12N15/815 , C12P7/42 , C12Y101/01059 , C12Y206/01001 , C12Y206/01018 , C12Y206/01019 , C12Y401/01031
摘要: The present application discloses genetically modified yeast cells comprising an active 3-HP fermentation pathway, and the use of these cells to produce 3-HP.
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公开(公告)号:US20240254525A1
公开(公告)日:2024-08-01
申请号:US18433739
申请日:2024-02-06
CPC分类号: C12P13/04 , C12N15/52 , C12N15/70 , C12Y101/01103 , C12Y101/03013 , C12Y203/01029 , C12Y401/02 , C12Y403/01 , C12N2800/101
摘要: The present disclosure relates to a method for the incorporation of formaldehyde into biomass comprising the following enzymatically catalyzed steps: (1) condensation of pyruvate with formaldehyde into 4-hydroxy-2-oxobutanoic acid (HOB); (2) amination of the thus produced 4-hydroxy-2-oxobutanoic acid (HOB) to produce homoserine; (3) conversion of thus produced homoserine to threonine; (4) conversion of the thus produced threonine into glycine and acetaldehyde or acetyl-CoA; (5) condensation of the thus produced glycine with formaldehyde to produce serine; and (6) conversion of the thus produced serine to produce pyruvate, wherein said pyruvate can then be used as a substrate in step (1). The disclosure also relates to enzymes for catalyzing the corresponding enzymatic reactions and recombinant microorganisms which express the enzymes for catalyzing the corresponding enzymatic reactions.
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