公开(公告)号：US20220176278A1

公开(公告)日：2022-06-09

申请号：US17682221

申请日：2022-02-28

Applicant: EMD Millipore Corporation

Inventor： Jonathan Steen ,  Mikhail Kozlov ,  Herbert Lutz ,  Joseph Parrella ,  Elizabeth M. Goodrich ,  Bala Raghunath

IPC: B01D29/90 ,  B01D61/14 ,  B01D63/04 ,  B01D63/12 ,  B01D29/52 ,  B01D29/60

Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

公开(公告)号：US11305271B2

公开(公告)日：2022-04-19

申请号：US15677526

申请日：2017-08-15

Applicant: EMD Millipore Corporation

Inventor： David Yavorsky ,  John Amara ,  Joaquin Umana ,  William Cataldo ,  Mikhail Kozlov ,  Matthew Stone

IPC: B01D15/36 ,  B01J20/28 ,  B01J47/12 ,  B01J39/26 ,  C12N7/02 ,  B01J47/014 ,  B01J47/127 ,  B01D15/38 ,  C07K1/18 ,  B01J41/20 ,  B01D15/32 ,  B01J20/285 ,  B01J20/287 ,  B01J20/32 ,  C07K16/00 ,  C12N7/00 ,  G01N30/52

Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).

公开(公告)号：US20220032235A1

公开(公告)日：2022-02-03

申请号：US17432122

申请日：2020-02-20

Applicant: EMD Millipore Corporation

Inventor： Kevin Rautio ,  Sean Foley ,  Stephen G. Hunt ,  Bumchul Lee ,  Nathan Landry

IPC: B01D63/08

Abstract: Single-use integral chromatography unit having an inlet and an outlet, and comprising one or more plates or pairs of filter plates interposable between a pair of end plates. In certain embodiments, each of the filter plates comprises a polymeric framework with one or more membranes supported therein. The filter plates and end plates may be assembled to form a substantially fixed, substantially water-tight, integral stack. Fluid entering the unit through a common inlet passes the membrane or membranes of each filter plate substantially contemporaneously prior to exiting the unit through a common outlet (cf, “parallel” flow). The assembly is a modular design, as multiple pairs of plates can be stacked in a suitable holder to form a single chromatography unit.

公开(公告)号：US20210388036A1

公开(公告)日：2021-12-16

申请号：US17388090

申请日：2021-07-29

Applicant: EMD Millipore Corporation

Inventor： Nanying Bian ,  Neil Soice ,  Shari Spector ,  Kara Levine

IPC: C07K14/31 ,  B01D15/38 ,  B01J20/286 ,  B01J20/32

Abstract: The present invention relates to chromatography ligands having improved caustic stability, e.g., ligands based on immunoglobulin-binding proteins such as, Staphylococcal protein A, as well as methods of making and using such ligands.

公开(公告)号：US11192070B2

公开(公告)日：2021-12-07

申请号：US16862137

申请日：2020-04-29

Applicant: EMD Millipore Corporation

Inventor： Salvatore Giglia ,  David Nhiem

IPC: B01D65/10 ,  G01N15/08

Abstract: A method of integrity testing a porous material is disclosed, providing a porous material suitable for filtration to be tested, said porous material having a first surface and a second surface; wetting said porous material with a wetting liquid; providing a gas stream comprising at least first and second gases humidified with said wetting liquid below the saturation vapor pressure of said wetting liquid and wherein said humidified gas stream has a humidity of 50-99%; introducing said gas stream to said first surface of said porous material; causing said first and second gases to flow through said porous material; measuring the concentration of at least one of said first and second gases in the permeate stream exiting said second surface of said porous material; and comparing the measured concentration to a predetermined concentration.

公开(公告)号：US20210355606A1

公开(公告)日：2021-11-18

申请号：US17290024

申请日：2019-10-31

Applicant: EMD Millipore Corporation

Inventor： Onur Y. Kas ,  Thang Nguyen ,  Nitin Satav ,  Martin Cuddy

IPC: D01D5/00 ,  D04H1/728

Abstract: Provided herein are electrospirming apparatuses and methods for efficient production of nanofiber structures.

公开(公告)号：US20210260504A1

公开(公告)日：2021-08-26

申请号：US17315721

申请日：2021-05-10

Applicant: EMD Millipore Corporation

Inventor： Jonathan Steen ,  Mikhail Kozlov ,  Herbert Lutz ,  Joseph Parrella ,  Elizabeth M. Goodrich ,  Bala Raghunath

IPC: B01D29/90 ,  B01D61/14 ,  B01D63/08 ,  B01D29/52 ,  B01D29/60

Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

公开(公告)号：USD928947S1

公开(公告)日：2021-08-24

申请号：US29662885

申请日：2018-09-10

Applicant: EMD Millipore Corporation

Designer： John Gugliotti

公开(公告)号：US20210253994A1

公开(公告)日：2021-08-19

申请号：US17262957

申请日：2019-05-15

Applicant: EMD Millipore Corporation

Inventor： Laurent Jourdainne ,  Sebastien Cirou

IPC: C12M1/34 ,  C12M1/12 ,  C12M3/00

Abstract: The invention concerns an installation for treating biological liquid by viral inactivation, comprising a main supply valve (4) for suppling biological liquid to treat, a first line (2) downstream of said valve and provided with a first main tank (7), a second line (3) downstream of said valve and provided with a second main tank (14), said second line being in parallel with said first line, and a third main tank (11) disposed at an outlet both from said first line and said second line and configured to be successively supplied by said first main tank and by said second main tank; said installation being configured such that in each of said first, second and third main treatment tanks, a determined volume of acid and a determined volume of base are introduced at least so as to adjust a pH of said biological liquid and to regulate a rate of drainage flow of said third main treatment tank so as to provide a continuous rate of flow of treated biological liquid at an outlet from said installation.

公开(公告)号：US11040310B2

公开(公告)日：2021-06-22

申请号：US16207895

申请日：2018-12-03

Applicant: EMD Millipore Corporation

Inventor： Herbert Lutz ,  Joseph Parrella ,  Bala Raghunath

IPC: B01D61/14 ,  B01D61/18 ,  B01D63/08 ,  B01D65/02 ,  C07K1/34

Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.