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公开(公告)号：US10472611B2
公开(公告)日：2019-11-12
申请号：US16402175
申请日：2019-05-02
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: C12N15/85 , C12N5/074 , C12N5/0789 , C12N9/16 , C12N15/90 , C12N9/22 , C08K5/5399 , C12N15/87 , C12P21/00 , A61K35/28 , H01L31/048 , C12N5/077 , C08G77/08 , A61K35/12
Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号：US20190270968A1
公开(公告)日：2019-09-05
申请号：US16402175
申请日：2019-05-02
Applicant: Factor Bioscience Inc.
Inventor： Matthew ANGEL , Christopher ROHDE
IPC: C12N5/0789 , C12N5/077 , C12N9/16 , C12N15/90 , C12N9/22 , C08K5/5399 , C12N15/87 , C12P21/00 , A61K35/28 , H01L31/048
Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号：US10301599B2
公开(公告)日：2019-05-28
申请号：US16037597
申请日：2018-07-17
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号：US20190008985A1
公开(公告)日：2019-01-10
申请号：US15748132
申请日：2017-08-17
Applicant: Factor Bioscience Inc.
Inventor： Matthew ANGEL , Christopher ROHDE
IPC: A61K48/00 , A61K9/00 , C12N9/22 , A61P1/16 , A61P11/00 , A61P29/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P35/00
Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.
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公开(公告)号：US09969983B2
公开(公告)日：2018-05-15
申请号：US15844063
申请日：2017-12-15
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
CPC classification number: C12N5/0696 , C12N5/0018 , C12N5/0625 , C12N5/0647 , C12N5/0656 , C12N5/0657 , C12N5/0676 , C12N5/0695 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/84 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/608 , C12N2501/998 , C12N2506/09 , C12N2506/45
Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
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Patent Agency Ranking
公开(公告)号：US20180021412A1
公开(公告)日：2018-01-25
申请号：US15678491
申请日：2017-08-16
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: A61K38/39 , A61B18/18 , A61Q19/06 , A61Q19/00 , A61M35/00 , A61Q19/08 , A61K8/60 , A61K9/00 , A61K48/00 , A61K47/46 , A61K45/06 , A61K38/45 , A61K38/44 , A61K38/38 , A61K31/713 , A61K31/711 , A61K31/7105 , A61K31/7072 , A61K31/7068 , A61K31/575 , A61K31/573 , A61K9/127 , C12N15/87 , A61B18/00
CPC classification number: A61K38/39 , A61B18/18 , A61B2018/00452 , A61B2018/1807 , A61K8/606 , A61K9/0019 , A61K9/0021 , A61K9/127 , A61K31/573 , A61K31/575 , A61K31/7068 , A61K31/7072 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K38/38 , A61K38/44 , A61K38/45 , A61K45/06 , A61K47/46 , A61K48/00 , A61K48/005 , A61K2800/83 , A61K2800/91 , A61M35/00 , A61Q19/00 , A61Q19/008 , A61Q19/06 , A61Q19/08 , C12N15/87 , A61K2300/00
Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US09758797B2
公开(公告)日：2017-09-12
申请号：US15487088
申请日：2017-04-13
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: C07H21/04 , C12N9/14 , C12N15/90 , C12N9/22 , C12N15/10 , C12N15/86 , G01N33/50 , A61K48/00 , A61K38/46 , A01K67/00
CPC classification number: C12N15/907 , A61K31/7115 , A61K35/14 , A61K38/465 , A61K48/005 , A61K2035/124 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/1024 , C12N15/86 , C12N2800/80 , C12Y301/00 , C12Y301/21004 , G01N33/5014
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US09605277B2
公开(公告)日：2017-03-28
申请号：US15207167
申请日：2016-07-11
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: A61K48/00 , A01N63/00 , C12N15/90 , C08K5/5399 , H01L31/048 , C12N15/87 , C12P21/00 , C12N9/16 , C12N5/0789 , C12N5/077 , C08G77/08
CPC classification number: C12N5/0647 , A61K35/28 , A61K2035/124 , C08G77/08 , C08K5/5399 , C12N5/0657 , C12N9/16 , C12N9/22 , C12N15/87 , C12N15/907 , C12N2500/25 , C12N2500/44 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2501/2303 , C12N2501/26 , C12N2501/91 , C12N2501/998 , C12N2506/09 , C12N2800/80 , C12P21/00 , C12Y301/21 , H01L31/048 , Y02E10/50 , C08L83/04
Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号：US20170073644A1
公开(公告)日：2017-03-16
申请号：US15358818
申请日：2016-11-22
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: C12N5/074 , C12N5/077 , C12N5/071 , C12N5/0789
CPC classification number: C12N5/0696 , C12N5/0018 , C12N5/0625 , C12N5/0647 , C12N5/0656 , C12N5/0657 , C12N5/0676 , C12N5/0695 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/84 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/608 , C12N2501/998 , C12N2506/09 , C12N2506/45
Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
Abstract translation: 本发明部分地涉及从患者样品中产生组织特异性细胞的方法以及使用这些方法产生的组织特异性细胞。 公开了使用RNA重编程细胞的方法。 还公开了包含使用这些方法生产的细胞的治疗剂。
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公开(公告)号：US20160251649A1
公开(公告)日：2016-09-01
申请号：US15156806
申请日：2016-05-17
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
CPC classification number: C12N15/907 , A61K31/7115 , A61K35/14 , A61K38/465 , A61K48/005 , A61K2035/124 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/1024 , C12N15/86 , C12N2800/80 , C12Y301/00 , C12Y301/21004 , G01N33/5014
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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