公开(公告)号：US20150037366A1

公开(公告)日：2015-02-05

申请号：US14384681

申请日：2013-03-13

Applicant: JAMES COOK UNIVERSITY

Inventor： Alex Loukas ,  Severine Navarro

IPC: C07K14/435 ,  A61K39/00 ,  A61K45/06

CPC classification number: C07K14/4354 ,  A61K38/57 ,  A61K39/0003 ,  A61K45/06

Abstract: A method for reducing or alleviating inflammation in a subject includes administering to the subject a therapeutically effective amount of: (a) Ac-TMP-1 or a biologically active fragment or variant of Ac-TMP-1; (b) Ac-TMP-2 or a biologically active fragment or variant of Ac-TMP-2; or (c) a combination of (a) and (b), to thereby reduce or alleviate inflammation in the subject. A method for preventing or treating asthma or inflammatory bowel disease in a subject includes administering to the subject a therapeutically effective amount of: (a) Ac-TMP-1 or a biologically active fragment or variant of Ac-TMP-1; (b) Ac-TMP-2 or a biologically active fragment or variant of Ac-TMP-2; or (c) a combination of (a) and (b), to thereby prevent or treat asthma or inflammatory bowel disease in the subject. The subject may be a mammal, inclusive of humans.

Abstract translation: 用于减轻或减轻受试者炎症的方法包括向受试者施用治疗有效量的：（a）Ac-TMP-1或Ac-TMP-1的生物活性片段或变体; （b）Ac-TMP-2或Ac-TMP-2的生物活性片段或变体; 或（c）（a）和（b）的组合，从而减少或缓解受试者的炎症。 用于预防或治疗受试者哮喘或炎症性肠病的方法包括向受试者施用治疗有效量的：（a）Ac-TMP-1或Ac-TMP-1的生物活性片段或变体; （b）Ac-TMP-2或Ac-TMP-2的生物活性片段或变体; 或（c）（a）和（b）的组合，从而预防或治疗受试者的哮喘或炎症性肠病。 受试者可以是哺乳动物，包括人类。

公开(公告)号：US08835424B2

公开(公告)日：2014-09-16

申请号：US12779449

申请日：2010-05-13

Applicant: James Cook ,  Shengming Huang ,  Rahul Edwankar ,  Ojas A. Namjoshi ,  Zhi-Jian Wang

Inventor： James Cook ,  Shengming Huang ,  Rahul Edwankar ,  Ojas A. Namjoshi ,  Zhi-Jian Wang

IPC: A61K31/5517 ,  C07D487/02

CPC classification number: C07D243/12 ,  C07D243/20 ,  C07D243/24 ,  C07D471/04 ,  C07D487/04 ,  C07D487/06 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

Abstract: In preferred embodiments, the present invention provides methods of treatment and pharmaceutical compositions for the suppression, alleviation and prevention of the often chronic, severe and debilitating pain that can accompany inflammatory diseases and neuropathic insults, pain that is often unresponsive to conventional analgesic treatment. The preferred embodiments of the present invention further relate to methods of treatment and pharmaceutical compositions using benzodiazepine derivatives that provide suppression, alleviation and prevention of neuropathic pain, migraine-related pain and inflammatory pain with reduced sedative and ataxic side effects.

Abstract translation: 在优选的实施方案中，本发明提供治疗方法和用于抑制，缓解和预防常伴有炎性疾病和神经性损伤的常规慢性，严重和衰弱性疼痛的药物组合物，其通常对常规镇痛治疗无反应。 本发明的优选实施方案还涉及使用苯并二氮杂衍生物的治疗方法和药物组合物，其提供抑制，缓解和预防神经性疼痛，偏头痛相关疼痛和炎症性疼痛，同时具有降低的镇静和共济失调副作用。

公开(公告)号：US20130330340A1

公开(公告)日：2013-12-12

申请号：US13985130

申请日：2012-02-20

Applicant: Stephen R. Hamilton ,  W. James Cook ,  Sujatha Gomathinayagam

Inventor： Stephen R. Hamilton ,  W. James Cook ,  Sujatha Gomathinayagam

IPC: C07K14/705 ,  C07K16/46

CPC classification number: C07K14/70578 ,  C07K14/7151 ,  C07K16/46 ,  C07K2319/30 ,  C12N9/1051 ,  C12N9/2402 ,  C12Y204/01101 ,  C12Y302/01113

Abstract: Production of recombinant Tumor Necrosis Factor Receptor fused to the Fc region of an antibody (TNFRII-Fc fragment fusion protein) in a glycoengineered yeast strain that is capable of producing sialylated N-glycans and O-glycans is described. Compositions of TNFRII-Fc fragment fusion protein comprising dystroglycan type O-glycans and sialylated N- and O-glycans with only terminal N-acetylneuraminic acid (NANA) residues in an α2,6-linkage are provided. In particular aspects, methods are provided for modulating the in vivo pharmacokinetics of the TNFRII-Fc fragment fusion protein by altering the O-glycan structure on the molecule.

Abstract translation: 描述了能够产生唾液酸化N-聚糖和O-聚糖的糖工程化酵母菌株中与抗体Fc区（TNFRII-Fc片段融合蛋白）融合的重组肿瘤坏死因子受体的产生。 提供包含赖氨酸聚糖型O-聚糖和唾液酸化N-和O-聚糖的TNFRII-Fc片段融合蛋白的组合物，其仅具有α2,6键中的末端N-乙酰神经氨酸（NANA）残基。 在具体方面，提供了通过改变分子上的O-聚糖结构来调节TNFRII-Fc片段融合蛋白的体内药代动力学的方法。

公开(公告)号：US20130267586A1

公开(公告)日：2013-10-10

申请号：US13879130

申请日：2011-10-13

Applicant: Donald Barton McPhail ,  Graeme James Cook ,  Richard Charles Hartley

Inventor： Donald Barton McPhail ,  Graeme James Cook ,  Richard Charles Hartley

IPC: C07D311/62 ,  C07D309/40

CPC classification number: C07D311/62 ,  C07D309/40 ,  C07D311/26

Abstract: The present invention provides compounds of the formula Formula I or a salt thereof: and the uses of such compounds for the treatment of a disease or disorder involving oxidative damage, for preventing UV damage to the skin of a mammal and for preventing or reversing the effects of ageing, or for treating or preventing dry skin.

Abstract translation: 本发明提供式I化合物或其盐，以及这些化合物用于治疗涉及氧化损伤的疾病或病症的用途，用于预防对哺乳动物的皮肤的紫外线损伤以及用于预防或逆转其效果 的老化，或用于治疗或预防干性皮肤。

公开(公告)号：US08543982B2

公开(公告)日：2013-09-24

申请号：US11812945

申请日：2007-06-22

Applicant: James Zeanah ,  Charles Abbott ,  Nik Boyd ,  Albert Cohen ,  James Cook ,  Michael Grandcolas ,  Sikun Lan ,  Bonnie Lindsley ,  Grigor Markarian ,  Leslie Moss

Inventor： James Zeanah ,  Charles Abbott ,  Nik Boyd ,  Albert Cohen ,  James Cook ,  Michael Grandcolas ,  Sikun Lan ,  Bonnie Lindsley ,  Grigor Markarian ,  Leslie Moss

IPC: G06F9/44 ,  G06Q40/00

CPC classification number: G06Q20/30 ,  G06Q20/32 ,  G06Q20/322 ,  G06Q20/3227 ,  G06Q20/3552 ,  G06Q40/00 ,  G07F19/206

Abstract: A financial institution can provide financial services to a plurality of remote devices, such as personal computers, personal data assistants, screen phones, automatic teller machines, external service providers, and internally to staff terminals and individual branches. By separating the components of the system into independent components, the system and method can be developed and tested on a component level rather than the entire system level, thereby reducing the development and maintenance cycle time. The system and method operate in sessions and can employ a dialog component for gathering information from a customer, a rule broker component for providing answers to the various legal and regulatory rules in a particular country, a language man component for selecting appropriate language, a transaction executor component for performing transactions, and a presentation manager component for formatting outputs to the customer.

公开(公告)号：US08364222B2

公开(公告)日：2013-01-29

申请号：US12678646

申请日：2008-09-19

Applicant: Richard James Cook ,  Timothy Frederick Watson ,  Frederic Festy

Inventor： Richard James Cook ,  Timothy Frederick Watson ,  Frederic Festy

IPC: A61B5/00

CPC classification number: A61B5/14542 ,  A61B1/3137 ,  A61B5/1459

Abstract: The invention relates to an apparatus and a method for imaging the vascular structure and vascular blood flow of an organ or tissue and, in particular, relates to a selective wavelength epi-illumination endoscopic imaging apparatus to image vascular tissues and real time capillary blood flow in vivo. The invention also relates to determining the blood oxygen content of the organ or tissue.

Abstract translation: 本发明涉及一种用于对器官或组织的血管结构和血管血流进行成像的装置和方法，具体涉及用于对血管组织进行成像和实时毛细血管血流的选择性波长外照射内窥镜成像装置 体内。 本发明还涉及确定器官或组织的血氧含量。

公开(公告)号：US08206949B2

公开(公告)日：2012-06-26

申请号：US12084591

申请日：2006-11-10

Applicant: Piotr Bobrowicz ,  W. James Cook ,  Warren Kett

Inventor： Piotr Bobrowicz ,  W. James Cook ,  Warren Kett

IPC: C12P21/06 ,  C12N1/15 ,  C12N1/19 ,  A01N43/78 ,  C07D277/26

CPC classification number: C07K16/32 ,  C07K2317/41 ,  C12P21/005

Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.

Abstract translation: 描述了一种用于生产具有减少量的O-连接糖基化的蛋白质组合物的方法。 该方法包括在存在Pmt介导的O-连接糖基化的抑制剂和/或在一种或多种α-1,2-甘露糖苷酶的存在下培养的细胞中产生蛋白质。

公开(公告)号：US20100311122A1

公开(公告)日：2010-12-09

申请号：US12863468

申请日：2009-02-09

Applicant: Byung-Kwon Choi ,  Piotr Bobrowicz ,  W. James Cook

Inventor： Byung-Kwon Choi ,  Piotr Bobrowicz ,  W. James Cook

IPC: C12P21/00 ,  C12N1/19 ,  C12N9/00

CPC classification number: C12N9/90 ,  C07K14/4725 ,  C12N9/1051 ,  C12N15/815 ,  C12N15/85 ,  C12N2800/102 ,  C12P21/005

Abstract: Lower eukaryote host cells in which the function of at least one endogenous gene encoding a chaperone protein, such as a Protein Disulphide Isomerase (PDI), has been reduced or eliminated and at least one mammalian homolog of the chaperone protein is expressed are described. In particular aspects, the host cells further include a deletion or disruption of one or more O-protein mannosyltransferase genes, and/or overexpression of an endogenous or exogenous Ca2+ ATPase. These host cells are useful for producing recombinant glycoproteins in large amounts and for producing recombinant glycoproteins that have reduced O-glycosylation.

Abstract translation: 描述了其中至少一个编码分子伴侣蛋白（例如蛋白质二硫键异构酶（PDI））的内源基因的功能已经被还原或消除并且伴侣蛋白的至少一个哺乳动物同系物被表达的低等真核生物宿主细胞。 在特定方面，宿主细胞还包括一个或多个O-蛋白质甘露糖基转移酶基因的缺失或破坏，和/或内源或外源Ca2 + ATP酶的过度表达。 这些宿主细胞可用于大量生产重组糖蛋白和用于产生具有降低的O-糖基化的重组糖蛋白。

公开(公告)号：US20100136010A1

公开(公告)日：2010-06-03

申请号：US12288465

申请日：2008-10-21

Applicant: Rosana Kappeller-Libermann ,  David White ,  Keith E. Robison ,  Kyle J. MacBeth ,  Joseph M. Carroll ,  William James Cook ,  Rachel E. Meyers ,  Miyoung Chun ,  Mark J. Williamson

Inventor： Rosana Kappeller-Libermann ,  David White ,  Keith E. Robison ,  Kyle J. MacBeth ,  Joseph M. Carroll ,  William James Cook ,  Rachel E. Meyers ,  Miyoung Chun ,  Mark J. Williamson

IPC: A61K39/395 ,  A61K38/45 ,  A61K38/46 ,  A61K38/48 ,  C12Q1/68 ,  G01N33/53 ,  C12Q1/34 ,  C12P21/00 ,  C12N5/10 ,  C12N5/00 ,  A61K38/00 ,  A61K38/17 ,  A61K31/713 ,  A61K31/7088 ,  C07K14/435 ,  C07K16/40 ,  C07H21/04 ,  A61P31/12 ,  A61P9/00 ,  A61P35/00 ,  A61P19/08 ,  A61P7/00

CPC classification number: G01N33/5008 ,  A61K38/00 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/6489 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/57426 ,  G01N33/5761 ,  G01N33/5767 ,  G01N33/68 ,  G01N2333/916 ,  G01N2333/96486 ,  G01N2500/04

Abstract: The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract translation: 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US07464501B2

公开(公告)日：2008-12-16

申请号：US10915242

申请日：2004-08-10

Applicant: Shigeki Arimoto ,  Louis William Berklich, Jr. ,  Beau James Cook, Jr.

Inventor： Shigeki Arimoto ,  Louis William Berklich, Jr. ,  Beau James Cook, Jr.

IPC: E05D15/06

CPC classification number: E05F15/646 ,  E05Y2900/516

Abstract: A sliding window assembly for use with a motor vehicle such as the rear window of the cab of a pickup type truck. A guide structure mounts a sliding pane for longitudinal sliding movement generally parallel to the plane of the pane between an open position and a closed position, and a lateral thrust mechanism is provided to move the pane laterally relative to the plane of the pane into the closed position wherein the exposed face of the pane is flush with a surrounding vehicle surface.

Abstract translation: 一种与机动车辆一起使用的滑动窗组件，例如拾取式卡车的驾驶室的后窗。 引导结构安装滑动窗格，用于在打开位置和关闭位置之间大致平行于窗格平面的纵向滑动运动，并且提供横向推力机构以使窗格相对于窗格的平面横向移动到关闭位置 其中所述窗格的暴露面与周围的车辆表面齐平。