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111.发明授权公开(公告)号：US09879217B2
公开(公告)日：2018-01-30
申请号：US14826720
申请日：2015-08-14
Applicant: Merial Inc.
Inventor： Hervé François Coupier
IPC: C12M1/00 , C12M3/00 , A01N1/02 , B01L3/00 , B01L9/00 , C12M1/12 , C12M1/34 , A61J1/10 , A61J1/14
CPC classification number: C12M45/22 , A01N1/0268 , A61J1/10 , A61J1/1462 , A61J1/1475 , B01L3/505 , B01L9/00 , B01L2300/021 , B01L2300/0681 , B01L2300/0809 , B01L2300/1894 , C12M23/14 , C12M23/26 , C12M37/00 , C12M37/02 , C12M37/04 , C12M41/44
Abstract: The disclosure provides a cell freezing and storage bag assembly and a method for using the assembly in banking eukaryotic cells for later seed train expansion. The bag is constructed principally of fluorinated ethylene propylene (FEP) fabric, and is designed to be filled such that the cell suspension has a very thin cross-section. The bag design includes at least an inlet conduit and an outlet or inoculation conduit, which can be sterilely welded to the source of the eukaryotic cells. The use of at least two sterile-weldable conduits allows for “closed system” filling of the bags, which significantly reduces the risk of contamination relative to other cell-banking methods. The bag also include a sleeve, which can be thermo-welded to form an enclosure, which protects the inlet and outlet conduits against contamination and mechanical damage during freezing, storage and subsequent thawing. In the method, once each bag is filled, its corresponding inlet conduit is sealed, and both the inlet and outlet conduits are enclosed within the bag's sleeve. This closed system method obviates the need for sterile environments (e.g. laminar flow unit).
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公开(公告)号：US20170339920A1
公开(公告)日：2017-11-30
申请号：US15620421
申请日：2017-06-12
Applicant: Merial Inc.
IPC: A01K13/00 , A61D7/00 , B05C17/00 , B05C17/005
CPC classification number: A01K13/003 , A61D7/00 , A61M5/19 , A61M5/2066 , A61M5/3007 , A61M5/3148 , A61M2005/2026 , A61M2005/3103 , A61M2005/3115 , A61M2005/3128
Abstract: The application discloses a multi-chamber, multi-formulation fluid delivery system, comprising a multi-chamber applicator in fluid communication with multi-chamber packaging. Applicators according to the instant disclosure have reduced squeeze-strength requirements, and are useful for dispensing fluids, including medicaments, to animals, including livestock animals. The multi-chamber packaging provides separate storage for formulations containing incompatible active ingredients, and is suitable for use with the multi-chamber applicator. The application also discloses methods for using the system to simultaneously deliver multiple active ingredients, at least some of which are not suitable for co-formulation, thus reducing the time, economic burden and animal stress involved with applying multiple, separate formulations to animals.
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公开(公告)号：US20170333397A1
公开(公告)日：2017-11-23
申请号：US15522647
申请日：2015-10-30
Applicant: MERIAL INC.
Inventor： James Pate , Natalya Shub
IPC: A61K31/415 , A61K9/00 , A01N47/02 , A61K31/215 , A01N43/40
CPC classification number: A61K31/415 , A01N43/40 , A01N47/02 , A01N49/00 , A61K9/0017 , A61K31/215
Abstract: The invention provides for spot-on formulations comprising fipronil in a high concentration for the treatment or prophylaxis of parasites of mammals and birds, and in particular, cats, dogs, horses, chickens, sheep and cattle with the aim of ridding these animals of all the parasites commonly encountered by birds and mammals. The invention also provides for effective and lasting destruction of ectoparasites, such as fleas, ticks, itch mites and lice, and of endoparasites, nematodes, such as filariae, and roundworms of the digestive tract of animals and humans.
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公开(公告)号：US20170290895A1
公开(公告)日：2017-10-12
申请号：US15480345
申请日：2017-04-05
Applicant: MERIAL INC.
Inventor： Laurent Fischer
CPC classification number: A61K39/0003 , A61K39/0233 , C07K14/43536 , C07K14/4354 , C07K16/20
Abstract: The present invention encompasses a vaccine composition and method of use for treating heartworm infestation in mammals. The vaccine composition includes chimeric antigens engineered and manufactured using the genetic code (i.e., the amino acid or protein sequence) of the target sequence. After introduction of the vaccine composition containing the target antigen into the host (e.g., a canine), the host will generate antibodies as part of its robust immune response to the antigen. As the antibodies circulate through the host's plasma, heartworm larvae will consume the antibodies as they feed on the plasma. The antibodies will then act on internal targets of the worm recognized as antigens.
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公开(公告)号：US20170290803A1
公开(公告)日：2017-10-12
申请号：US15632705
申请日：2017-06-26
Applicant: MERIAL, INC.
Inventor： Charles Meng , Loïc Le Hir de Fallois
IPC: A61K31/404 , C07D209/10 , C07D401/04 , C07D209/08
CPC classification number: A61K31/404 , C07D209/08 , C07D209/10 , C07D401/04 , C07D401/12 , H03K5/04 , H03K7/00
Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
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Patent Agency Ranking
116.发明授权公开(公告)号：US09770502B2
公开(公告)日：2017-09-26
申请号：US14682798
申请日：2015-04-09
Applicant: Merial, Inc.
Inventor： Michel Bublot , Teshome Mebatsion , Joyce Pritchard , Perry Linz
IPC: A61K39/17 , C12N7/00 , A61K39/12 , A61K39/245 , A61K39/00 , A61K39/295
CPC classification number: A61K39/17 , A61K39/12 , A61K39/295 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/552 , A61K2039/70 , C12N7/00 , C12N2710/16043 , C12N2710/16334 , C12N2710/16343 , C12N2710/20034 , C12N2720/10034 , C12N2720/10071 , C12N2760/18134 , C12N2760/18171
Abstract: The present invention provides recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain and express antigens of avian pathogens, recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain a mutated gC gene, compositions comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors, polyvalent vaccines comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors and one or more wild type viruses or recombinant vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant Gallid herpesvirus 3 (MDV-2) vectors.
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公开(公告)号：US09756852B2
公开(公告)日：2017-09-12
申请号：US14600651
申请日：2015-01-20
Applicant: MERIAL INC.
Inventor： James Pate , Natalya Shub
CPC classification number: A01N25/10 , A01N43/56 , A01N53/00 , A61K9/0014
Abstract: The invention is a pour-on antiparasitic formulation having superior water resistant properties. The pour-on formulation utilizes one or more polymers (water insoluble with or without water soluble) in the range of about 5 to about 40% w/w, one or more solvents in the range of about 50 to about 94% w/w, with or without additive (e.g., isopropanol or ethanol) in the range of about 5 to about 30% w/w, and optionally a plasticizer in the range of about 0.5 to about 25% w/w. The pour-on antiparasitic formulation features limited spreading when applied to animals (cattle, sheep, dogs and the like). The pour-on antiparasitic formulation further partially evaporates, leaving a water resistant polymer matrix that diffuses at least one active ingredient to the animal's skin.
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118.发明申请公开(公告)号：US20170246897A1
公开(公告)日：2017-08-31
申请号：US15498933
申请日：2015-10-30
Applicant: MERIAL INC.
Inventor： Andy Brehm , Julie Campbell , Ed Schindler
CPC classification number: B41M5/24 , A61J1/18 , A61J2200/44 , B41J3/4075 , B41M5/26 , B41M5/267
Abstract: This invention relates to an apparatus and method for applying writings and other markings to a frozen vial or ampoule, which is filled with biological material, and which is held at temperatures between about −70° C. and about −196° C. More particularly, the invention relates to a laser marking method that allows frozen vials to be labeled, while maintaining the integrity of the biological material contained therein.
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119.发明申请公开(公告)号：US20170239218A1
公开(公告)日：2017-08-24
申请号：US15441297
申请日：2017-02-24
Applicant: MERIAL INC.
Inventor： Loic Patrick Le Hir de Fallois , Charles Q. Meng , Susan Mancini Cady , Peter Cheifetz , Izabela Galeska
IPC: A61K31/415 , A61K9/00 , A61K47/10 , A01N43/80
CPC classification number: A61K31/415 , A01N43/80 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/107 , A61K31/42 , A61K31/422 , A61K47/10 , A61K47/14 , C07D261/04 , C07D413/04 , C07D471/04 , C07D491/107 , A01N25/02 , A01N25/22
Abstract: This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.
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公开(公告)号：US20170216422A1
公开(公告)日：2017-08-03
申请号：US15419418
申请日：2017-01-30
Applicant: MERIAL INC. , GENVEC INC. , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary of Homeland Security
Inventor： Justin Widener , Leszlie Woodyward , Leonardo Siger , Douglas Brough , Damodar Ettyreddy , Jason Gall , Duncan McVey , Tom Burrage
CPC classification number: A61K39/12 , A61K2039/5256 , A61K2039/552 , C12N7/00 , C12N15/86 , C12N2710/10034 , C12N2770/32134 , C12N2800/107
Abstract: The present invention encompasses FMDV vaccines or compositions. The invention encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.
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