公开(公告)号：US10265425B2

公开(公告)日：2019-04-23

申请号：US15186764

申请日：2016-06-20

Applicant: STC.UNM

Inventor： Yubin Miao ,  Haixun Guo

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/08 ,  C07K14/685 ,  G01N33/574 ,  G01N33/60 ,  A61K9/00 ,  A61K45/06

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

公开(公告)号：US20190103481A1

公开(公告)日：2019-04-04

申请号：US16191197

申请日：2018-11-14

Applicant: STC.UNM

Inventor： Steven R.J. Brueck ,  Seung-Chang Lee ,  Christian Wetzel ,  Mark Durniak

IPC: H01L29/778 ,  H01L29/78 ,  H01L29/08 ,  H01L29/06 ,  H01L21/02 ,  H01S5/32 ,  H01L29/04 ,  H01L29/66 ,  H01L29/423 ,  H01L29/205 ,  H01S5/343 ,  H01L33/00 ,  H01S5/02 ,  H01L33/24 ,  H01L29/40 ,  H01S5/227 ,  H01S5/22 ,  H01L33/32

Abstract: A transistor comprises a substrate comprising a Group III/V compound semiconductor material having a cubic crystalline phase structure positioned on a hexagonal crystalline phase layer having a first region and a second region, the cubic crystalline phase structure being positioned between the first region and the second region of the hexagonal crystalline phase layer. A source region and a drain region are both positioned in the Group III/V compound semiconductor material. A channel region is in the Group III/V compound semiconductor material. A gate is over the channel region. An optional backside contact can also be formed. A source contact and electrode are positioned to provide electrical contact to the source region. A drain contact and electrode are positioned to provide electrical contact to the drain region. Methods of forming transistors are also disclosed.

公开(公告)号：US10238758B2

公开(公告)日：2019-03-26

申请号：US15261890

申请日：2016-09-10

Applicant: STC.UNM

Inventor： Yubin Miao

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/08 ,  C07K7/56 ,  A61K38/17 ,  A61K38/00

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue, suggesting favorable selective activity of compounds according to the present invention, which can be used as effective therapeutic agents against melanoma, including metastatic melanoma. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are useful to initiate therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic and therapeutic tools for a number of conditions and diseases states, especially melanoma.

公开(公告)号：US20190089161A1

公开(公告)日：2019-03-21

申请号：US16186812

申请日：2018-11-12

Applicant: STC.UNM

Inventor： Andrea A. MAMMOLI ,  Yasser YASAEI

IPC: H02J3/38 ,  H02J7/00

CPC classification number: H02J3/382 ,  H02J3/381 ,  H02J3/383 ,  H02J3/386 ,  H02J3/387 ,  H02J7/0068

Abstract: The present invention is an apparatus and method for using aggregated loads from a plurality of distributed energy resources to perform a function at a power distribution feeder. The invention includes a plurality of distributed energy resources, wherein at least one distributed energy resource includes a renewable energy resource, a communication network, a control device, a power distribution feeder coupled to the control device, and an energy storage system coupled to the power distribution feeder. The control device sends a signal to the plurality of distributed energy resources via the communication network. The signal is a request to switch a status of one or more of the distributed energy resources if one or more distributed energy resources is within a predetermined condition. Loads from the one or more of the distributed energy resources that switched status are aggregated to perform a function at the power distribution feeder.

公开(公告)号：US20190064111A1

公开(公告)日：2019-02-28

申请号：US16107792

申请日：2018-08-21

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  STC.UNM

Inventor： Timothy J. Boyle ,  Khalid Mikhiel Hattar ,  Fernando Henry Garzon ,  Stephen J. Bauer

IPC: G01N27/62 ,  H01J37/08

Abstract: Ion-doped metal or ceramic nanoparticles can be added into, for example, a component that upon exposure to an environmental stimulus, will release the ion and ‘tattle’ on any impending destruction.

公开(公告)号：US10216965B2

公开(公告)日：2019-02-26

申请号：US15109747

申请日：2014-12-23

Applicant: STC.UNM ,  Case Western Reserve University

Inventor： James Plusquellic ,  Swarup Bhunia

IPC: G06F21/75 ,  G11C23/00 ,  G06F7/58 ,  H04L9/08 ,  G09C1/00 ,  G06F21/60 ,  G11C13/00 ,  G11C16/10 ,  G11C16/26

Abstract: This disclosure describes techniques for generating physically unclonable functions (PUF) from non-volatile memory cells. The PUFs leverage resistance variations in non-volatile memory cells. Resistance variations in array of non-volatile memory cells may be produce a bitstring during an enrollment process. The bitstring may be stored in the non-volatile memory array. Regeneration may include retrieving the bitstring from the non-volatile memory array.

公开(公告)号：US20190056184A1

公开(公告)日：2019-02-21

申请号：US15768829

申请日：2016-10-17

Applicant: STC.UNM

Inventor： Sang Eon Han ,  Sang M. Han

IPC: F28F13/18 ,  F24S70/20 ,  F25B23/00

CPC classification number: F28F13/185 ,  F24S70/20 ,  F25B23/003 ,  F28F2245/06 ,  F28F2270/00 ,  Y02E10/40 ,  Y10T428/24802 ,  Y10T428/24893 ,  Y10T428/24942

Abstract: The present prevention provides a surface coating for cooling a surface by light scattering comprising a plurality of successive layers, each of the layers may be comprised of a plurality of spheres arranged to form a structure comprised of packed spheres. Each layer may have a different arrangement of packed spheres to create to a different light scattering property in each of the layers. The coating of the structures may also be formed by randomly packed spheres and the spheres may have a uniform diameter.

公开(公告)号：US20190026457A1

公开(公告)日：2019-01-24

申请号：US16067757

申请日：2017-01-11

Applicant: STC.UNM

Inventor： James PLUSQUELLIC ,  Wenjie CHE ,  Dylan ISMARI

IPC: G06F21/44 ,  G06F21/73 ,  H04L9/32 ,  H04L9/08 ,  H04L9/06

Abstract: An authentication protocol using a Hardware-Embedded Delay PUF (“HELP”), which derives randomness from within-die path delay variations that occur along the paths within a hardware implementation of a cryptographic primitive, for example, the Advanced Encryption Standard (“AES”) algorithm or Secure Hash Algorithm 3 (“SHA-3”). The digitized timing values which represent the path delays are stored in a database on a secure server (verifier) as an alternative to storing PUF response bitstrings thereby enabling the development of an efficient authentication protocol that provides both privacy and mutual authentication.

公开(公告)号：US10184930B2

公开(公告)日：2019-01-22

申请号：US15039825

申请日：2014-11-26

Applicant: STC.UNM

Inventor： Steven R. J. Brueck ,  Jeremy Scott Edwards ,  Alexander Neumann ,  Yuliya Kuznetsova ,  Edgar A. Mendoza

IPC: G01N21/00 ,  G01N33/487 ,  C12Q1/6869 ,  B01L3/00 ,  C23C16/34 ,  C23C16/455 ,  C23C16/50 ,  G01N21/65

Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

公开(公告)号：US20180318269A1

公开(公告)日：2018-11-08

申请号：US16033008

申请日：2018-07-11

Applicant: STC.UNM

Inventor： Eric R. Prossnitz ,  Geetanjali Sharma ,  Matthias Barton ,  Matthias R. Meyer

IPC: A61K31/436 ,  A61K31/4355 ,  A61K31/16 ,  A61K31/435 ,  A61K31/437

CPC classification number: A61K31/436 ,  A61K31/16 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/7088 ,  A61K38/28 ,  G01N2800/042

Abstract: The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).